{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:42:20Z","timestamp":1793403740081,"version":"4.5.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1038\/s41593-018-0324-9","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T10:16:14Z","timestamp":1547115374000},"page":"421-435","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":236,"title":["Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury"],"prefix":"10.1038","volume":"22","author":[{"given":"Tian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5739-5192","authenticated-orcid":false,"given":"Yiming","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaranda Ruxandra","family":"Badea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa J.","family":"Rolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoshuai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choogon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Megraw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wutian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1716-6974","authenticated-orcid":false,"given":"Guixue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-493X","authenticated-orcid":false,"given":"Yi","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"324_CR1","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","volume":"3","author":"CS Ahuja","year":"2017","unstructured":"Ahuja, C. S. et al. Traumatic spinal cord injury. Nat. Rev. Dis. Primers 3, 17018 (2017).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"324_CR2","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1152\/physrev.1996.76.2.319","volume":"76","author":"ME Schwab","year":"1996","unstructured":"Schwab, M. E. & Bartholdi, D. Degeneration and regeneration of axons in the lesioned spinal cord. Physiol. Rev. 76, 319\u2013370 (1996).","journal-title":"Physiol. Rev."},{"key":"324_CR3","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/nrn2480","volume":"9","author":"RJ Franklin","year":"2008","unstructured":"Franklin, R. J. & Ffrench-Constant, C. Remyelination in the CNS: from biology to therapy. Nat. Rev. Neurosci. 9, 839\u2013855 (2008).","journal-title":"Nat. Rev. Neurosci."},{"key":"324_CR4","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/35000219","volume":"403","author":"MS Chen","year":"2000","unstructured":"Chen, M. S. et al. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434\u2013439 (2000).","journal-title":"Nature"},{"key":"324_CR5","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nrn1195","volume":"4","author":"MT Filbin","year":"2003","unstructured":"Filbin, M. T. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat. Rev. Neurosci. 4, 703\u2013713 (2003).","journal-title":"Nat. Rev. Neurosci."},{"key":"324_CR6","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1523\/JNEUROSCI.2615-05.2006","volume":"26","author":"MR Kotter","year":"2006","unstructured":"Kotter, M. R., Li, W. W., Zhao, C. & Franklin, R. J. Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation. J. Neurosci. 26, 328\u2013332 (2006).","journal-title":"J. Neurosci."},{"key":"324_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00401-015-1521-1","volume":"131","author":"YA Syed","year":"2016","unstructured":"Syed, Y. A. et al. Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination. Acta Neuropathol. 131, 281\u2013298 (2016).","journal-title":"Acta Neuropathol."},{"key":"324_CR8","doi-asserted-by":"publisher","first-page":"8077","DOI":"10.4049\/jimmunol.181.11.8077","volume":"181","author":"SB Jeon","year":"2008","unstructured":"Jeon, S. B., Yoon, H. J., Park, S. H., Kim, I. H. & Park, E. J. Sulfatide, a major lipid component of myelin sheath, activates inflammatory responses as an endogenous stimulator in brain-resident immune cells. J. Immunol. 181, 8077\u20138087 (2008).","journal-title":"J. Immunol."},{"key":"324_CR9","doi-asserted-by":"publisher","first-page":"e9380","DOI":"10.1371\/journal.pone.0009380","volume":"5","author":"X Sun","year":"2010","unstructured":"Sun, X. et al. Myelin activates FAK\/Akt\/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system. PLoS One 5, e9380 (2010).","journal-title":"PLoS One"},{"key":"324_CR10","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1002\/glia.22774","volume":"63","author":"X Wang","year":"2015","unstructured":"Wang, X. et al. Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris. Glia 63, 635\u2013651 (2015).","journal-title":"Glia"},{"key":"324_CR11","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.expneurol.2009.04.024","volume":"225","author":"I Napoli","year":"2010","unstructured":"Napoli, I. & Neumann, H. Protective effects of microglia in multiple sclerosis. Exp. Neurol. 225, 24\u201328 (2010).","journal-title":"Exp. Neurol."},{"key":"324_CR12","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/brain\/awn109","volume":"132","author":"H Neumann","year":"2009","unstructured":"Neumann, H., Kotter, M. R. & Franklin, R. J. Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132, 288\u2013295 (2009).","journal-title":"Brain"},{"key":"324_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-016-0233-3","volume":"9","author":"L Guo","year":"2016","unstructured":"Guo, L. et al. Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media. Mol. Brain 9, 48 (2016).","journal-title":"Mol. Brain"},{"key":"324_CR14","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/brain\/aww298","volume":"140","author":"G Ponath","year":"2017","unstructured":"Ponath, G. et al. Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology. Brain 140, 399\u2013413 (2017).","journal-title":"Brain"},{"key":"324_CR15","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s12975-011-0109-x","volume":"2","author":"MT Ng","year":"2011","unstructured":"Ng, M. T., Stammers, A. T. & Kwon, B. K. Vascular disruption and the role of angiogenic proteins after spinal cord injury. Transl. Stroke Res. 2, 474\u2013491 (2011).","journal-title":"Transl. Stroke Res."},{"key":"324_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/jnr.10759","volume":"74","author":"WD Whetstone","year":"2003","unstructured":"Whetstone, W. D., Hsu, J. Y., Eisenberg, M., Werb, Z. & Noble-Haeusslein, L. J. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J. Neurosci. Res. 74, 227\u2013239 (2003).","journal-title":"J. Neurosci. Res."},{"key":"324_CR17","doi-asserted-by":"publisher","first-page":"e1005603","DOI":"10.1371\/journal.ppat.1005603","volume":"12","author":"M Rengarajan","year":"2016","unstructured":"Rengarajan, M., Hayer, A. & Theriot, J. A. Endothelial cells use a formin-dependent phagocytosis-like process to internalize the bacterium listeria monocytogenes. PLoS Pathog. 12, e1005603 (2016).","journal-title":"PLoS Pathog."},{"key":"324_CR18","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1242\/jcs.108.3.967","volume":"108","author":"L Dini","year":"1995","unstructured":"Dini, L. et al. Phagocytosis of apoptotic bodies by liver endothelial cells. J. Cell. Sci. 108, 967\u2013973 (1995).","journal-title":"J. Cell. Sci."},{"key":"324_CR19","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1002\/hep.1840060505","volume":"6","author":"AM Steffan","year":"1986","unstructured":"Steffan, A. M., Gendrault, J. L., McCuskey, R. S., McCuskey, P. A. & Kirn, A. Phagocytosis, an unrecognized property of murine endothelial liver cells. Hepatology 6, 830\u2013836 (1986).","journal-title":"Hepatology"},{"key":"324_CR20","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nprot.2010.6","volume":"5","author":"I Arnaoutova","year":"2010","unstructured":"Arnaoutova, I. & Kleinman, H. K. In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract. Nat. Protoc. 5, 628\u2013635 (2010).","journal-title":"Nat. Protoc."},{"key":"324_CR21","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/jemt.1123","volume":"54","author":"ME Smith","year":"2001","unstructured":"Smith, M. E. Phagocytic properties of microglia in vitro: implications for a role in multiple sclerosis and EAE. Microsc. Res. Tech. 54, 81\u201394 (2001).","journal-title":"Microsc. Res. Tech."},{"key":"324_CR22","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1242\/jcs.040717","volume":"122","author":"A Gaultier","year":"2009","unstructured":"Gaultier, A. et al. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J. Cell. Sci. 122, 1155\u20131162 (2009).","journal-title":"J. Cell. Sci."},{"key":"324_CR23","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1365-2249.2003.02330.x","volume":"135","author":"SP Hart","year":"2004","unstructured":"Hart, S. P., Smith, J. R. & Dransfield, I. Phagocytosis of opsonized apoptotic cells: roles for \u2018old-fashioned\u2019 receptors for antibody and complement. Clin. Exp. Immunol. 135, 181\u2013185 (2004).","journal-title":"Clin. Exp. Immunol."},{"key":"324_CR24","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1084\/jem.46.2.291","volume":"46","author":"FS Jones","year":"1927","unstructured":"Jones, F. S. The effect of heat on antibodies. J. Exp. Med. 46, 291\u2013301 (1927).","journal-title":"J. Exp. Med."},{"key":"324_CR25","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/S0006-3495(00)76602-1","volume":"78","author":"AW Vermeer","year":"2000","unstructured":"Vermeer, A. W. & Norde, W. The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein. Biophys. J. 78, 394\u2013404 (2000).","journal-title":"Biophys. J."},{"key":"324_CR26","unstructured":"Tooze, S. A., Abada, A. & Elazar, Z. Endocytosis and autophagy: exploitation or cooperation?. Cold Spring Harb. Perspect. Biol. 6, a018358 (2014)."},{"key":"324_CR27","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1089\/jir.2008.0027","volume":"29","author":"SL Deshmane","year":"2009","unstructured":"Deshmane, S. L., Kremlev, S., Amini, S. & Sawaya, B. E. Monocyte chemoattractant protein-1 (MCP-1): an overview. J. Interferon. Cytokine Res. 29, 313\u2013326 (2009).","journal-title":"J. Interferon. Cytokine Res."},{"key":"324_CR28","doi-asserted-by":"publisher","first-page":"13882","DOI":"10.1523\/JNEUROSCI.2524-13.2013","volume":"33","author":"C Soderblom","year":"2013","unstructured":"Soderblom, C. et al. Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury. J. Neurosci. 33, 13882\u201313887 (2013).","journal-title":"J. Neurosci."},{"key":"324_CR29","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1089\/neu.2014.3703","volume":"32","author":"Y Zhu","year":"2015","unstructured":"Zhu, Y., Soderblom, C., Trojanowsky, M., Lee, D. H. & Lee, J. K. Fibronectin matrix assembly after spinal cord injury. J. Neurotrauma 32, 1158\u20131167 (2015).","journal-title":"J. Neurotrauma"},{"key":"324_CR30","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1016\/S0021-9258(17)35666-1","volume":"261","author":"RA Ignotz","year":"1986","unstructured":"Ignotz, R. A. & Massagu\u00e9, J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem. 261, 4337\u20134345 (1986).","journal-title":"J. Biol. Chem."},{"key":"324_CR31","doi-asserted-by":"publisher","first-page":"E45","DOI":"10.3390\/jcm5040045","volume":"5","author":"S Piera-Velazquez","year":"2016","unstructured":"Piera-Velazquez, S., Mendoza, F. A. & Jimenez, S. A. Endothelial to mesenchymal transition (endomt) in the pathogenesis of human fibrotic diseases. J. Clin. Med. 5, E45 (2016).","journal-title":"J. Clin. Med."},{"key":"324_CR32","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1038\/nn.2946","volume":"14","author":"EA Winkler","year":"2011","unstructured":"Winkler, E. A., Bell, R. D. & Zlokovic, B. V. Central nervous system pericytes in health and disease. Nat. Neurosci. 14, 1398\u20131405 (2011).","journal-title":"Nat. Neurosci."},{"key":"324_CR33","doi-asserted-by":"publisher","first-page":"e13149","DOI":"10.7554\/eLife.13149","volume":"5","author":"MA Lopes Pinheiro","year":"2016","unstructured":"Lopes Pinheiro, M. A. et al. Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration. eLife 5, e13149 (2016).","journal-title":"eLife"},{"key":"324_CR34","doi-asserted-by":"publisher","first-page":"11993","DOI":"10.1073\/pnas.1001948107","volume":"107","author":"ME Vargas","year":"2010","unstructured":"Vargas, M. E., Watanabe, J., Singh, S. J., Robinson, W. H. & Barres, B. A. Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury. Proc. Natl Acad. Sci. USA 107, 11993\u201311998 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"324_CR35","doi-asserted-by":"publisher","first-page":"E8072","DOI":"10.1073\/pnas.1710566114","volume":"114","author":"A Brosius Lutz","year":"2017","unstructured":"Brosius Lutz, A. et al. Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury. Proc. Natl Acad. Sci. USA 114, E8072\u2013E8080 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"324_CR36","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1083\/jcb.201503019","volume":"210","author":"JA Gomez-Sanchez","year":"2015","unstructured":"Gomez-Sanchez, J. A. et al. Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves. J. Cell. Biol. 210, 153\u2013168 (2015).","journal-title":"J. Cell. Biol."},{"key":"324_CR37","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1083\/jcb.153.3.543","volume":"153","author":"M Hellstr\u00f6m","year":"2001","unstructured":"Hellstr\u00f6m, M. et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J. Cell. Biol. 153, 543\u2013553 (2001).","journal-title":"J. Cell. Biol."},{"key":"324_CR38","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nm.4331","volume":"23","author":"Y Li","year":"2017","unstructured":"Li, Y. et al. Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat. Med. 23, 733\u2013741 (2017).","journal-title":"Nat. Med."},{"key":"324_CR39","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1189\/jlb.3RU0816-352RR","volume":"101","author":"F Wu","year":"2017","unstructured":"Wu, F., Liu, L. & Zhou, H. Endothelial cell activation in central nervous system inflammation. J. Leukoc. Biol. 101, 1119\u20131132 (2017).","journal-title":"J. Leukoc. Biol."},{"key":"324_CR40","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s00441-012-1336-5","volume":"349","author":"H Kawano","year":"2012","unstructured":"Kawano, H. et al. Role of the lesion scar in the response to damage and repair of the central nervous system. Cell Tissue Res. 349, 169\u2013180 (2012).","journal-title":"Cell Tissue Res."},{"key":"324_CR41","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/BF01418478","volume":"76","author":"E Fernandez","year":"1985","unstructured":"Fernandez, E. & Pallini, R. Connective tissue scarring in experimental spinal cord lesions: significance of dural continuity and role of epidural tissues. Acta Neurochir. (Wien) 76, 145\u2013148 (1985).","journal-title":"Acta Neurochir. (Wien)"},{"key":"324_CR42","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","volume":"170","author":"B Hinz","year":"2007","unstructured":"Hinz, B. et al. The myofibroblast: one function, multiple origins. Am. J. Pathol. 170, 1807\u20131816 (2007).","journal-title":"Am. J. Pathol."},{"key":"324_CR43","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.nbd.2014.10.024","volume":"74","author":"Y Zhu","year":"2015","unstructured":"Zhu, Y. et al. Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury. Neurobiol. Dis. 74, 114\u2013125 (2015).","journal-title":"Neurobiol. Dis."},{"key":"324_CR44","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1460-9568.1994.tb00278.x","volume":"6","author":"A Logan","year":"1994","unstructured":"Logan, A. et al. Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat. Eur. J. Neurosci. 6, 355\u2013363 (1994).","journal-title":"Eur. J. Neurosci."},{"key":"324_CR45","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/jnr.22552","volume":"89","author":"N Yoshioka","year":"2011","unstructured":"Yoshioka, N. et al. Small molecule inhibitor of type I transforming growth factor-\u03b2 receptor kinase ameliorates the inhibitory milieu in injured brain and promotes regeneration of nigrostriatal dopaminergic axons. J. Neurosci. Res. 89, 381\u2013393 (2011).","journal-title":"J. Neurosci. Res."},{"key":"324_CR46","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.brainres.2004.03.028","volume":"1012","author":"DB Fee","year":"2004","unstructured":"Fee, D. B. et al. Traumatic brain injury increases TGF beta RII expression on endothelial cells. Brain Res. 1012, 52\u201359 (2004).","journal-title":"Brain Res."},{"key":"324_CR47","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0079-6123(02)37019-5","volume":"137","author":"W Young","year":"2002","unstructured":"Young, W. Spinal cord contusion models. Prog. Brain. Res. 137, 231\u2013255 (2002).","journal-title":"Prog. Brain. Res."},{"key":"324_CR48","doi-asserted-by":"publisher","first-page":"5193","DOI":"10.1523\/JNEUROSCI.3734-15.2016","volume":"36","author":"H Wu","year":"2016","unstructured":"Wu, H. et al. Caveolin-1 is critical for lymphocyte trafficking into central nervous system during experimental autoimmune encephalomyelitis. J. Neurosci. 36, 5193\u20135199 (2016).","journal-title":"J. Neurosci."},{"key":"324_CR49","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1038\/nm1664","volume":"13","author":"S Mi","year":"2007","unstructured":"Mi, S. et al. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat. Med. 13, 1228\u20131233 (2007).","journal-title":"Nat. Med."},{"key":"324_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-24","volume":"8","author":"M Gitik","year":"2011","unstructured":"Gitik, M., Liraz-Zaltsman, S., Oldenborg, P. A., Reichert, F. & Rotshenker, S. Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRP\u03b1 (signal regulatory protein-\u03b1) on phagocytes. J. Neuroinflammation 8, 24 (2011).","journal-title":"J. Neuroinflammation"},{"key":"324_CR51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.nbd.2016.01.017","volume":"89","author":"AR Hackett","year":"2016","unstructured":"Hackett, A. R. et al. STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury. Neurobiol. Dis. 89, 10\u201322 (2016).","journal-title":"Neurobiol. Dis."},{"key":"324_CR52","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger, A. M., Lohse, M. & Usadel, B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30, 2114\u20132120 (2014).","journal-title":"Bioinformatics"},{"key":"324_CR53","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-4-r36","volume":"14","author":"D Kim","year":"2013","unstructured":"Kim, D. et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome. Biol. 14, R36 (2013).","journal-title":"Genome. Biol."},{"key":"324_CR54","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li, H. et al. The sequence alignment\/map format and SAMtools. Bioinformatics 25, 2078\u20132079 (2009).","journal-title":"Bioinformatics"},{"key":"324_CR55","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders, S., Pyl, P. T. & Huber, W. HTSeq--a Python framework to work with high-throughput sequencing data. Bioinformatics 31, 166\u2013169 (2015).","journal-title":"Bioinformatics"},{"key":"324_CR56","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"324_CR57","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/biostatistics\/kxs033","volume":"14","author":"H Wu","year":"2013","unstructured":"Wu, H., Wang, C. & Wu, Z. A new shrinkage estimator for dispersion improves differential expression detection in RNA-seq data. Biostatistics 14, 232\u2013243 (2013).","journal-title":"Biostatistics"},{"key":"324_CR58","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57, 289\u2013300 (1995).","journal-title":"J. R. Stat. Soc. B"},{"key":"324_CR59","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1158\/0008-5472.CAN-11-3247","volume":"72","author":"X Wang","year":"2012","unstructured":"Wang, X. et al. MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation. Cancer Res. 72, 2867\u20132878 (2012).","journal-title":"Cancer Res."},{"key":"324_CR60","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/glia.20925","volume":"58","author":"J Wu","year":"2010","unstructured":"Wu, J., Wrathall, J. R. & Schachner, M. Phosphatidylinositol 3-kinase\/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes. Glia 58, 315\u2013328 (2010).","journal-title":"Glia"}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41593-018-0324-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41593-018-0324-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41593-018-0324-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T19:15:41Z","timestamp":1720898141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41593-018-0324-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,21]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["324"],"URL":"https:\/\/doi.org\/10.1038\/s41593-018-0324-9","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734888686.793569124","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.734888686.793558531","asserted-by":"object"}]},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,21]]},"assertion":[{"value":"28 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}