{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:29:58Z","timestamp":1792477798365,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2020,8,2]]},"DOI":"10.1038\/s41593-020-0664-0","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T12:03:36Z","timestamp":1595246616000},"page":"939-951","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["AHR is a Zika virus host factor and a candidate target for antiviral therapy"],"prefix":"10.1038","volume":"23","author":[{"given":"Federico","family":"Giovannoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Manganeli","family":"Polonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda F.","family":"Torti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-6986","authenticated-orcid":false,"given":"Zhaorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Romorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda S.","family":"Rodriguez Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Rothhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3188-2785","authenticated-orcid":false,"given":"Andreia","family":"Barroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily C.","family":"Tjon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana M.","family":"Sanmarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisa C.","family":"Takenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohamad Sadegh","family":"Modaresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Guti\u00e9rrez-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1gela Ghabdan","family":"Zanluqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilton Barreto","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-5234","authenticated-orcid":false,"given":"Carolina Demarchi","family":"Munhoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa B.","family":"Damonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sherr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Gehrke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-8866","authenticated-orcid":false,"given":"Jean Pierre Schatzmann","family":"Peron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-7176","authenticated-orcid":false,"given":"Cybele C.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-0736","authenticated-orcid":false,"given":"Francisco J.","family":"Quintana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"664_CR1","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1016\/S0140-6736(17)31450-2","volume":"390","author":"D Baud","year":"2017","unstructured":"Baud, D., Gubler, D. J., Schaub, B., Lanteri, M. C. & Musso, D. An update on Zika virus infection. Lancet 390, 2099\u20132109 (2017).","journal-title":"Lancet"},{"key":"664_CR2","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1128\/CMR.00072-15","volume":"29","author":"D Musso","year":"2016","unstructured":"Musso, D. & Gubler, D. J. Zika virus. Clin. Microbiol. Rev. 29, 487\u2013524 (2016).","journal-title":"Clin. Microbiol. Rev."},{"key":"664_CR3","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/nature22401","volume":"546","author":"NR Faria","year":"2017","unstructured":"Faria, N. R. et al. Establishment and cryptic transmission of Zika virus in Brazil and the Americas. Nature 546, 406\u2013410 (2017).","journal-title":"Nature"},{"key":"664_CR4","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S0140-6736(16)30902-3","volume":"388","author":"GVA Fran\u00e7a","year":"2016","unstructured":"Fran\u00e7a, G. V. A. et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet 388, 891\u2013897 (2016).","journal-title":"Lancet"},{"key":"664_CR5","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/S0140-6736(16)00562-6","volume":"387","author":"VM Cao-Lormeau","year":"2016","unstructured":"Cao-Lormeau, V. M. et al. Guillain\u2013Barr\u00e9 syndrome outbreak associated with Zika virus infection in French Polynesia: a case\u2013control study. Lancet 387, 1531\u20131539 (2016).","journal-title":"Lancet"},{"key":"664_CR6","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/nrd.2017.33","volume":"16","author":"V Boldescu","year":"2017","unstructured":"Boldescu, V., Behnam, M. A. M., Vasilakis, N. & Klein, C. D. Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond. Nat. Rev. Drug Discov. 16, 565\u2013586 (2017).","journal-title":"Nat. Rev. Drug Discov."},{"key":"664_CR7","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/ni.2229","volume":"13","author":"N Yan","year":"2012","unstructured":"Yan, N. & Chen, Z. J. Intrinsic antiviral immunity. Nat. Immunol. 13, 214\u2013222 (2012).","journal-title":"Nat. Immunol."},{"key":"664_CR8","doi-asserted-by":"publisher","first-page":"9322","DOI":"10.1073\/pnas.142287799","volume":"99","author":"AA Perelygin","year":"2002","unstructured":"Perelygin, A. A. et al. Positional cloning of the murine flavivirus resistance gene. Proc. Natl Acad. Sci. USA 99, 9322\u20139327 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"664_CR9","doi-asserted-by":"crossref","unstructured":"Giovannoni, F. et al. Dengue non-structural protein 5 polymerase complexes with promyelocytic leukemia protein (PML) isoforms III and IV to disrupt PML-nuclear bodies in infected cells. Front. Cell. Infect. Microbiol. 9, 284 (2019).","DOI":"10.3389\/fcimb.2019.00284"},{"key":"664_CR10","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0035-9203(54)90006-1","volume":"48","author":"FN Macnamara","year":"1954","unstructured":"Macnamara, F. N. Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria. Trans. R. Soc. Trop. Med. Hyg. 48, 139\u2013145 (1954).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"664_CR11","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.stem.2016.07.019","volume":"19","author":"Q Liang","year":"2016","unstructured":"Liang, Q. et al. Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy. Cell Stem Cell 19, 663\u2013671 (2016).","journal-title":"Cell Stem Cell"},{"key":"664_CR12","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.stem.2016.02.016","volume":"18","author":"H Tang","year":"2016","unstructured":"Tang, H. et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell 18, 587\u2013590 (2016).","journal-title":"Cell Stem Cell"},{"key":"664_CR13","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1038\/s41418-019-0324-7","volume":"26","author":"L Liu","year":"2019","unstructured":"Liu, L. et al. Protection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitors. Cell Death Differ. 26, 2607\u20132621 (2019).","journal-title":"Cell Death Differ."},{"key":"664_CR14","doi-asserted-by":"publisher","first-page":"e01082","DOI":"10.1002\/cti2.1082","volume":"8","author":"FM Lum","year":"2019","unstructured":"Lum, F. M. et al. Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women. Clin. Transl. Immunol. 8, e01082 (2019).","journal-title":"Clin. Transl. Immunol."},{"key":"664_CR15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.immuni.2017.12.012","volume":"48","author":"C Gutierrez-Vazquez","year":"2018","unstructured":"Gutierrez-Vazquez, C. & Quintana, F. J. Regulation of the immune response by the aryl hydrocarbon receptor. Immunity 48, 19\u201333 (2018).","journal-title":"Immunity"},{"key":"664_CR16","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature10491","volume":"478","author":"CA Opitz","year":"2011","unstructured":"Opitz, C. A. et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478, 197\u2013203 (2011).","journal-title":"Nature"},{"key":"664_CR17","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nature18296","volume":"534","author":"FR Cugola","year":"2016","unstructured":"Cugola, F. R. et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 534, 267\u2013271 (2016).","journal-title":"Nature"},{"key":"664_CR18","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/s41577-019-0125-8","volume":"19","author":"V Rothhammer","year":"2019","unstructured":"Rothhammer, V. & Quintana, F. J. The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease. Nat. Rev. Immunol. 19, 184\u2013197 (2019).","journal-title":"Nat. Rev. Immunol."},{"key":"664_CR19","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/s41586-018-0119-x","volume":"557","author":"V Rothhammer","year":"2018","unstructured":"Rothhammer, V. et al. Microglial control of astrocytes in response to microbial metabolites. Nature 557, 724\u2013728 (2018).","journal-title":"Nature"},{"key":"664_CR20","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/nm.4106","volume":"22","author":"V Rothhammer","year":"2016","unstructured":"Rothhammer, V. et al. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat. Med 22, 586\u2013597 (2016).","journal-title":"Nat. Med"},{"key":"664_CR21","first-page":"1657","volume":"53","author":"M Yamaguchi","year":"2018","unstructured":"Yamaguchi, M. & Hankinson, O. 2,3,7,8-Tetrachlorodibenzopdioxin suppresses the growth of human liver cancer HepG2 cells in vitro: involvement of cell signaling factors. Int J. Oncol. 53, 1657\u20131666 (2018).","journal-title":"Int J. Oncol."},{"key":"664_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1124\/mol.111.073643","volume":"81","author":"EY Choi","year":"2012","unstructured":"Choi, E. Y., Lee, H., Dingle, R. W., Kim, K. B. & Swanson, H. I. Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor. Mol. Pharm. 81, 3\u201311 (2012).","journal-title":"Mol. Pharm."},{"key":"664_CR23","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/s41564-018-0244-1","volume":"3","author":"RB Richardson","year":"2018","unstructured":"Richardson, R. B. et al. A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication. Nat. Microbiol. 3, 1214\u20131223 (2018).","journal-title":"Nat. Microbiol."},{"key":"664_CR24","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1146\/annurev-immunol-042617-053142","volume":"36","author":"A Elong Ngono","year":"2018","unstructured":"Elong Ngono, A. & Shresta, S. Immune response to dengue and zika. Annu. Rev. Immunol. 36, 279\u2013308 (2018).","journal-title":"Annu. Rev. Immunol."},{"key":"664_CR25","doi-asserted-by":"publisher","first-page":"31304","DOI":"10.1074\/jbc.M308975200","volume":"279","author":"LM Pfeffer","year":"2004","unstructured":"Pfeffer, L. M. et al. Role of nuclear factor-\u03baB in the antiviral action of interferon and interferon-regulated gene expression. J. Biol. Chem. 279, 31304\u201331311 (2004).","journal-title":"J. Biol. Chem."},{"key":"664_CR26","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.cbi.2010.01.038","volume":"184","author":"S Luecke","year":"2010","unstructured":"Luecke, S., Wincent, E., Backlund, M., Rannug, U. & Rannug, A. Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor kappaB. Chem. Biol. Interact. 184, 466\u2013473 (2010).","journal-title":"Chem. Biol. Interact."},{"key":"664_CR27","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/ni.3422","volume":"17","author":"T Yamada","year":"2016","unstructured":"Yamada, T. et al. Constitutive aryl hydrocarbon receptor signaling constrains type I interferon\u2013mediated antiviral innate defense. Nat. Immunol. 17, 687\u2013694 (2016).","journal-title":"Nat. Immunol."},{"key":"664_CR28","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.cell.2010.04.018","volume":"141","author":"E Dixit","year":"2010","unstructured":"Dixit, E. et al. Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141, 668\u2013681 (2010).","journal-title":"Cell"},{"key":"664_CR29","doi-asserted-by":"publisher","first-page":"E2058","DOI":"10.1073\/pnas.1716937115","volume":"115","author":"KM Franz","year":"2018","unstructured":"Franz, K. M., Neidermyer, W. J., Tan, Y.-J., Whelan, S. P. J. & Kagan, J. C. STING-dependent translation inhibition restricts RNA virus replication. Proc. Natl Acad. Sci. USA 115, E2058\u2013E2067 (2018).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"664_CR30","doi-asserted-by":"publisher","first-page":"26702","DOI":"10.1074\/jbc.M111.316869","volume":"287","author":"S Hubackova","year":"2012","unstructured":"Hubackova, S., Krejcikova, K., Bartek, J. & Hodny, Z. Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells. J. Biol. Chem. 287, 26702\u201326714 (2012).","journal-title":"J. Biol. Chem."},{"key":"664_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-016-0240-y","volume":"14","author":"EA Stanford","year":"2016","unstructured":"Stanford, E. A. et al. The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. BMC Biol. 14, 20 (2016).","journal-title":"BMC Biol."},{"key":"664_CR32","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.cell.2015.10.046","volume":"163","author":"S Taguwa","year":"2015","unstructured":"Taguwa, S. et al. Defining Hsp70 subnetworks in dengue virus replication reveals key vulnerability in flavivirus infection. Cell 163, 1108\u20131123 (2015).","journal-title":"Cell"},{"key":"664_CR33","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.cell.2009.12.017","volume":"139","author":"AL Brass","year":"2009","unstructured":"Brass, A. L. et al. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, west nile virus, and dengue virus. Cell 139, 1243\u20131254 (2009).","journal-title":"Cell"},{"key":"664_CR34","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/nature18625","volume":"535","author":"R Zhang","year":"2016","unstructured":"Zhang, R. et al. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature 535, 164\u2013168 (2016).","journal-title":"Nature"},{"key":"664_CR35","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nature18631","volume":"535","author":"CD Marceau","year":"2016","unstructured":"Marceau, C. D. et al. Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens. Nature 535, 159\u2013163 (2016).","journal-title":"Nature"},{"key":"664_CR36","doi-asserted-by":"publisher","first-page":"14729","DOI":"10.1074\/jbc.M114.633065","volume":"290","author":"Q Zhou","year":"2015","unstructured":"Zhou, Q., Lavorgna, A., Bowman, M., Hiscott, J. & Harhaj, E. W. Aryl hydrocarbon receptor interacting protein targets IRF7 to suppress antiviral signaling and the induction of type I interferon. J. Biol. Chem. 290, 14729\u201314739 (2015).","journal-title":"J. Biol. Chem."},{"key":"664_CR37","doi-asserted-by":"publisher","first-page":"e1007246","DOI":"10.1371\/journal.ppat.1007246","volume":"14","author":"K Nganou-Makamdop","year":"2018","unstructured":"Nganou-Makamdop, K. et al. Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication. PLoS Pathog. 14, e1007246 (2018).","journal-title":"PLoS Pathog."},{"key":"664_CR38","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature14452","volume":"523","author":"N Gagliani","year":"2015","unstructured":"Gagliani, N. et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature 523, 221\u2013225 (2015).","journal-title":"Nature"},{"key":"664_CR39","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/s41593-019-0370-y","volume":"22","author":"MC Takenaka","year":"2019","unstructured":"Takenaka, M. C. et al. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat. Neurosci. 22, 729\u2013740 (2019).","journal-title":"Nat. Neurosci."},{"key":"664_CR40","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/nature21080","volume":"542","author":"C Schiering","year":"2017","unstructured":"Schiering, C. et al. Feedback control of AHR signalling regulates intestinal immunity. Nature 542, 242\u2013245 (2017).","journal-title":"Nature"},{"key":"664_CR41","doi-asserted-by":"crossref","unstructured":"Yockey, L. J. et al. Type I interferons instigate fetal demise after Zika virus infection. Sci. Immunol. 3, eaao1680 (2018).","DOI":"10.1126\/sciimmunol.aao1680"},{"key":"664_CR42","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.bcp.2008.09.037","volume":"77","author":"I Hernandez-Ochoa","year":"2009","unstructured":"Hernandez-Ochoa, I., Karman, B. N. & Flaws, J. A. The role of the aryl hydrocarbon receptor in the female reproductive system. Biochem. Pharmacol. 77, 547\u2013559 (2009).","journal-title":"Biochem. Pharmacol."},{"key":"664_CR43","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00281-013-0395-3","volume":"35","author":"BP Lawrence","year":"2013","unstructured":"Lawrence, B. P. & Vorderstrasse, B. A. New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection. Semin. Immunopathol. 35, 615\u2013626 (2013).","journal-title":"Semin. Immunopathol."},{"key":"664_CR44","doi-asserted-by":"publisher","first-page":"659","DOI":"10.4049\/jimmunol.1201341","volume":"190","author":"JLH Wheeler","year":"2012","unstructured":"Wheeler, J. L. H., Martin, K. C. & Lawrence, B. P. Novel cellular targets of AHR underlie alterations in neutrophilic inflammation and inducible nitric oxide synthase expression during influenza virus infection. J. Immunol. 190, 659\u2013668 (2012).","journal-title":"J. Immunol."},{"key":"664_CR45","doi-asserted-by":"publisher","first-page":"4446","DOI":"10.4049\/jimmunol.1402044","volume":"194","author":"B Winans","year":"2015","unstructured":"Winans, B. et al. Linking the aryl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced aberrant antiviral CD8+ T cell responses. J. Immunol. 194, 4446\u20134457 (2015).","journal-title":"J. Immunol."},{"key":"664_CR46","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cotox.2017.01.012","volume":"2","author":"S Safe","year":"2017","unstructured":"Safe, S., Cheng, Y. & Jin, U. H. The aryl hydrocarbon receptor (AhR) as a drug target for cancer chemotherapy. Curr. Opin. Toxicol. 2, 24\u201329 (2017).","journal-title":"Curr. Opin. Toxicol."},{"key":"664_CR47","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1089\/jir.2010.0111","volume":"31","author":"M-C Geoffroy","year":"2011","unstructured":"Geoffroy, M.-C. & Chelbi-Alix, M. K. Role of promyelocytic leukemia protein in host antiviral defense. J. Interferon Cytokine Res. 31, 145\u2013158 (2011).","journal-title":"J. Interferon Cytokine Res."},{"key":"664_CR48","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.cotox.2018.01.004","volume":"10","author":"AM Franchini","year":"2018","unstructured":"Franchini, A. M. & Lawrence, B. P. Environmental exposures are hidden modifiers of anti-viral immunity. Curr. Opin. Toxicol. 10, 54\u201359 (2018).","journal-title":"Curr. Opin. Toxicol."},{"key":"664_CR49","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.1016\/j.celrep.2018.03.001","volume":"22","author":"LB Thackray","year":"2018","unstructured":"Thackray, L. B. et al. Oral antibiotic treatment of mice exacerbates the disease severity of multiple flavivirus infections. Cell Rep. 22, 3440\u20133453.e3446 (2018).","journal-title":"Cell Rep."},{"key":"664_CR50","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1126\/science.aar7201","volume":"359","author":"S Manfredo Vieira","year":"2018","unstructured":"Manfredo Vieira, S. et al. Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 359, 1156\u20131161 (2018).","journal-title":"Science"},{"key":"664_CR51","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1158\/0008-5472.CAN-11-1831","volume":"72","author":"NP Judd","year":"2012","unstructured":"Judd, N. P. et al. ERK1\/2 regulation of CD44 modulates oral cancer aggressiveness. Cancer Res. 72, 365\u2013374 (2012).","journal-title":"Cancer Res."},{"key":"664_CR52","unstructured":"Bosch, I. et al. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum. Sci. Transl. Med. 9, ii: eaan1589 (2017)."},{"key":"664_CR53","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1111\/tmi.12857","volume":"22","author":"JF Chan","year":"2017","unstructured":"Chan, J. F. et al. Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5\u2032-untranslated region of Zika virus. Trop. Med. Int. Health 22, 594\u2013603 (2017).","journal-title":"Trop. Med. Int. Health"},{"key":"664_CR54","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3201\/eid1408.080287","volume":"14","author":"RS Lanciotti","year":"2008","unstructured":"Lanciotti, R. S. et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg. Infect. Dis. 14, 1232\u20131239 (2008).","journal-title":"Emerg. Infect. Dis."},{"key":"664_CR55","doi-asserted-by":"crossref","unstructured":"Soumillon, M., Cacchiarelli, D., Semrau, S., van Oudenaarden, A. & Mikkelsen, T. S. Characterization of Directed Differentiation by High-throughput Single-cell RNA-Seq (Cold Spring Harbor Laboratory, 2014).","DOI":"10.1101\/003236"}],"updated-by":[{"DOI":"10.1038\/s41593-020-0700-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000}}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41593-020-0664-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41593-020-0664-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41593-020-0664-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T15:22:19Z","timestamp":1650208939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41593-020-0664-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,20]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8,2]]}},"alternative-id":["664"],"URL":"https:\/\/doi.org\/10.1038\/s41593-020-0664-0","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,20]]},"assertion":[{"value":"31 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2020","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41593-020-0700-0","URL":"https:\/\/doi.org\/10.1038\/s41593-020-0700-0","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"F.J.Q. is a member of the Scientific Advisory Board of Kyn Therapeutics. D.S. is a co-founder of and holds equity in Hercules Pharmaceuticals, The Netherlands. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}