{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:04:22Z","timestamp":1792706662291,"version":"4.5.0"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1038\/s41593-021-00908-3","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T16:02:31Z","timestamp":1629993751000},"page":"1367-1376","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":337,"title":["Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction"],"prefix":"10.1038","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7839-2858","authenticated-orcid":false,"given":"Richard","family":"Karlsson Linn\u00e9r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-3001","authenticated-orcid":false,"given":"Travis T.","family":"Mallard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9321-657X","authenticated-orcid":false,"given":"Peter B.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-5699","authenticated-orcid":false,"given":"Sandra","family":"Sanchez-Roige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-0004","authenticated-orcid":false,"given":"James W.","family":"Madole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan N.","family":"Driver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly E.","family":"Poore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-6067","authenticated-orcid":false,"given":"Ronald","family":"de Vlaming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7852-9244","authenticated-orcid":false,"given":"Andrew D.","family":"Grotzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorim J.","family":"Tielbeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0394-777X","authenticated-orcid":false,"given":"Emma C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Brin","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trey","family":"Ideker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7694-6391","authenticated-orcid":false,"given":"Hang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8820-2659","authenticated-orcid":false,"given":"Rachel L.","family":"Kember","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle A.","family":"Pasman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin J. H.","family":"Verweij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajiang J.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-7930","authenticated-orcid":false,"given":"Scott","family":"Vrieze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"COGA Collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernice","family":"Porjesz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Hesselbrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana M.","family":"Foroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpana","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Edenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John I.","family":"Nurnberger Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kuperman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn L.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chella","family":"Kamarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini K.","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bierut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen K.","family":"Bucholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Schuckit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Tischfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Almasy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M.","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Goate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manav","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Slesinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Wetherill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Xuei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbing","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J.","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H.","family":"Plawecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Lourens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Acion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Chorlian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivan","family":"Kinreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayathri","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey P.","family":"Anokhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivia V.","family":"McCutcheon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Saccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazil","family":"Aliev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemin","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Parsian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1018-0450","authenticated-orcid":false,"given":"Henry R.","family":"Kranzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-1859","authenticated-orcid":false,"given":"Joel","family":"Gelernter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen Mullan","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5599-6237","authenticated-orcid":false,"given":"Elliot M.","family":"Tucker-Drob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-1837","authenticated-orcid":false,"given":"Irwin D.","family":"Waldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3634-0747","authenticated-orcid":false,"given":"Abraham A.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1557-6737","authenticated-orcid":false,"given":"K. Paige","family":"Harden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7413-0412","authenticated-orcid":false,"given":"Philipp D.","family":"Koellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1636-893X","authenticated-orcid":false,"given":"Danielle M.","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"908_CR1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41562-019-0810-4","volume":"4","author":"LS Richmond-Rakerd","year":"2020","unstructured":"Richmond-Rakerd, L. S. et al. Clustering of health, crime and social-welfare inequality in 4 million citizens from two nations. Nat. Hum. Behav. 4, 255\u2013264 (2020).","journal-title":"Nat. Hum. Behav."},{"key":"908_CR2","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1353\/eca.2017.0005","volume":"2017","author":"A Case","year":"2017","unstructured":"Case, A. & Deaton, A. Mortality and morbidity in the 21st century. Brookings Pap. Econ. Act. 2017, 397\u2013476 (2017).","journal-title":"Brookings Pap. Econ. Act."},{"key":"908_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/h0093906","volume":"80","author":"TM Achenbach","year":"1966","unstructured":"Achenbach, T. M. The classification of children\u2019s psychiatric symptoms: a factor-analytic study. Psychol. Monogr. 80, 1\u201337 (1966).","journal-title":"Psychol. Monogr."},{"key":"908_CR4","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1001\/archpsyc.61.9.922","volume":"61","author":"BM Hicks","year":"2004","unstructured":"Hicks, B. M., Krueger, R. F., Iacono, W. G., McGue, M. & Patrick, C. J. Family transmission and heritability of externalizing disorders: a twin-family study. Arch. Gen. Psychiatry 61, 922\u2013928 (2004).","journal-title":"Arch. Gen. Psychiatry"},{"key":"908_CR5","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1037\/0021-843X.111.3.411","volume":"111","author":"RF Krueger","year":"2002","unstructured":"Krueger, R. F. et al. Etiologic connections among substance dependence, antisocial behavior and personality: modeling the externalizing spectrum. J. Abnorm. Psychol. 111, 411\u2013424 (2002).","journal-title":"J. Abnorm. Psychol."},{"key":"908_CR6","doi-asserted-by":"publisher","first-page":"D1005","DOI":"10.1093\/nar\/gky1120","volume":"47","author":"A Buniello","year":"2018","unstructured":"Buniello, A. et al. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res. 47, D1005\u2013D1012 (2018).","journal-title":"Nucleic Acids Res."},{"key":"908_CR7","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/7854_2020_144","volume":"47","author":"AC Swann","year":"2020","unstructured":"Swann, A. C., Lijffijt, M., O\u2019Brien, B. & Mathew, S. J. Impulsivity and suicidal behavior. Curr. Top. Behav. Neurosci. 47, 179\u2013195 (2020).","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"908_CR8","doi-asserted-by":"publisher","unstructured":"Zhou, H. et al. Association of OPRM1 functional coding variant with opioid use disorder: a genome-wide association study. JAMA Psychiatry https:\/\/doi.org\/10.1001\/jamapsychiatry.2020.1206 (2020).","DOI":"10.1001\/jamapsychiatry.2020.1206"},{"key":"908_CR9","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1176\/appi.ajp.2019.18080957","volume":"176","author":"N Mullins","year":"2019","unstructured":"Mullins, N. et al. GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores. Am. J. Psychiatry 176, 651\u2013660 (2019).","journal-title":"Am. J. Psychiatry"},{"key":"908_CR10","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/s41562-019-0566-x","volume":"3","author":"AD Grotzinger","year":"2019","unstructured":"Grotzinger, A. D. et al. Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits. Nat. Hum. Behav. 3, 513\u2013525 (2019).","journal-title":"Nat. Hum. Behav."},{"key":"908_CR11","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1017\/S0033291713000585","volume":"44","author":"KS Kendler","year":"2013","unstructured":"Kendler, K. S. & Myers, J. The boundaries of the internalizing and externalizing genetic spectra in men and women. Psychol. Med. 44, 647\u2013655 (2013).","journal-title":"Psychol. Med."},{"key":"908_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.3211","volume":"47","author":"BK Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan, B. K. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291\u2013295 (2015).","journal-title":"Nat. Genet."},{"key":"908_CR13","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41588-018-0269-7","volume":"51","author":"D Demontis","year":"2019","unstructured":"Demontis, D. et al. Discovery of the first genome-wide significant risk loci for attention deficit\/hyperactivity disorder. Nat. Genet. 51, 63\u201375 (2019).","journal-title":"Nat. Genet."},{"key":"908_CR14","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1038\/s41593-018-0275-1","volume":"21","author":"RK Walters","year":"2018","unstructured":"Walters, R. K. et al. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat. Neurosci. 21, 1656\u20131669 (2018).","journal-title":"Nat. Neurosci."},{"key":"908_CR15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1176\/appi.ajp.2018.18040369","volume":"176","author":"S Sanchez-Roige","year":"2018","unstructured":"Sanchez-Roige, S. et al. Genome-wide association study meta-analysis of the alcohol use disorders identification test in two population-based cohorts. Am. J. Psychiatry 176, 107\u2013118 (2018).","journal-title":"Am. J. Psychiatry"},{"key":"908_CR16","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/s41593-018-0206-1","volume":"21","author":"JA Pasman","year":"2018","unstructured":"Pasman, J. A. et al. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat. Neurosci. 21, 1161\u20131170 (2018).","journal-title":"Nat. Neurosci."},{"key":"908_CR17","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41588-018-0309-3","volume":"51","author":"R Karlsson Linn\u00e9r","year":"2019","unstructured":"Karlsson Linn\u00e9r, R. et al. Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nat. Genet. 51, 245\u2013257 (2019).","journal-title":"Nat. Genet."},{"key":"908_CR18","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/s41588-018-0307-5","volume":"51","author":"M Liu","year":"2019","unstructured":"Liu, M. et al. Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nat. Genet. 51, 237\u2013244 (2019).","journal-title":"Nat. Genet."},{"key":"908_CR19","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2019.11.020","volume":"179","author":"PH Lee","year":"2019","unstructured":"Lee, P. H. et al. Genomic relationships, novel loci and pleiotropic mechanisms across eight psychiatric disorders. Cell 179, 1469\u20131482 (2019).","journal-title":"Cell"},{"key":"908_CR20","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/ng.3736","volume":"49","author":"M-T Lo","year":"2016","unstructured":"Lo, M.-T. et al. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nat. Genet. 49, 152\u2013156 (2016).","journal-title":"Nat. Genet."},{"key":"908_CR21","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1017\/S0033291718002982","volume":"49","author":"T Rosenstr\u00f6m","year":"2019","unstructured":"Rosenstr\u00f6m, T. et al. Joint factorial structure of psychopathology and personality. Psychol. Med. 49, 2158\u20132167 (2019).","journal-title":"Psychol. Med."},{"key":"908_CR22","unstructured":"Townsend, P. Health and Deprivation: Inequality and the North (Croom Helm, 1988)."},{"key":"908_CR23","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/ng.2213","volume":"44","author":"J Yang","year":"2012","unstructured":"Yang, J. et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet. 44, 369\u2013375 (2012).","journal-title":"Nat. Genet."},{"key":"908_CR24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41562-020-00936-2","volume":"5","author":"J de la Fuente","year":"2021","unstructured":"de la Fuente, J., Davies, G., Grotzinger, A. D., Tucker-Drob, E. M. & Deary, I. J. A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data. Nat. Hum. Behav. 5, 49\u201358 (2021).","journal-title":"Nat. Hum. Behav."},{"key":"908_CR25","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1111\/acer.12792","volume":"39","author":"AB Hart","year":"2015","unstructured":"Hart, A. B. & Kranzler, H. R. Alcohol dependence genetics: lessons learned from genome-wide association studies (GWAS) and post-GWAS analyses. Alcohol. Clin. Exp. Res. 39, 1312\u20131327 (2015).","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"908_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01261-5","volume":"8","author":"K Watanabe","year":"2017","unstructured":"Watanabe, K., Taskesen, E., van Bochoven, A. & Posthuma, D. Functional mapping and annotation of genetic associations with FUMA. Nat. Commun. 8, 1826 (2017).","journal-title":"Nat. Commun."},{"key":"908_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pcbi.1004219","volume":"11","author":"CA de Leeuw","year":"2015","unstructured":"de Leeuw, C. A., Mooij, J. M., Heskes, T. & Posthuma, D. MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput. Biol. 11, 1\u201319 (2015).","journal-title":"PLoS Comput. Biol."},{"key":"908_CR28","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41593-020-0603-0","volume":"23","author":"NYA Sey","year":"2020","unstructured":"Sey, N. Y. A. et al. A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles. Nat. Neurosci. 23, 583\u2013593 (2020).","journal-title":"Nat. Neurosci."},{"key":"908_CR29","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/ng.3367","volume":"47","author":"ER Gamazon","year":"2015","unstructured":"Gamazon, E. R. et al. A gene-based association method for mapping traits using reference transcriptome data. Nat. Genet. 47, 1091\u20131098 (2015).","journal-title":"Nat. Genet."},{"key":"908_CR30","doi-asserted-by":"publisher","first-page":"e95076","DOI":"10.1172\/jci.insight.95076","volume":"3","author":"AB Jaykumar","year":"2018","unstructured":"Jaykumar, A. B. et al. Role of Alstr\u00f6m syndrome 1 in the regulation of blood pressure and renal function. JCI Insight 3, e95076 (2018).","journal-title":"JCI Insight"},{"key":"908_CR31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","volume":"558","author":"BB Sun","year":"2018","unstructured":"Sun, B. B. et al. Genomic atlas of the human plasma proteome. Nature 558, 73\u201379 (2018).","journal-title":"Nature"},{"key":"908_CR32","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/nm.3933","volume":"21","author":"YR Li","year":"2015","unstructured":"Li, Y. R. et al. Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. Nat. Med. 21, 1018\u20131027 (2015).","journal-title":"Nat. Med."},{"key":"908_CR33","first-page":"2562","volume":"39","author":"S Sanchez-Roige","year":"2019","unstructured":"Sanchez-Roige, S. et al. Genome-wide association studies of impulsive personality traits (BIS-11 and UPPS-P) and drug experimentation in up to 22,861 adult research participants identify loci in the CACNA1I and CADM2 genes. J. Neurosci. 39, 2562\u20132572 (2019).","journal-title":"J. Neurosci."},{"key":"908_CR34","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1038\/s41588-019-0516-6","volume":"51","author":"B Zhao","year":"2019","unstructured":"Zhao, B. et al. Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits. Nat. Genet. 51, 1637\u20131644 (2019).","journal-title":"Nat. Genet."},{"key":"908_CR35","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1086\/383283","volume":"74","author":"HJ Edenberg","year":"2004","unstructured":"Edenberg, H. J. et al. Variations in GABRA2, encoding the \u03b12 subunit of the GABAA receptor, are associated with alcohol dependence and with brain oscillations. Am. J. Hum. Genet. 74, 705\u2013714 (2004).","journal-title":"Am. J. Hum. Genet."},{"key":"908_CR36","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s10519-005-9041-8","volume":"36","author":"DM Dick","year":"2006","unstructured":"Dick, D. M. et al. The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behav. Genet. 36, 577\u2013590 (2006).","journal-title":"Behav. Genet."},{"key":"908_CR37","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuron.2019.03.013","volume":"102","author":"RS Duman","year":"2019","unstructured":"Duman, R. S., Sanacora, G. & Krystal, J. H. Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments. Neuron 102, 75\u201390 (2019).","journal-title":"Neuron"},{"key":"908_CR38","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/sj.mp.4001362","volume":"8","author":"P Brambilla","year":"2003","unstructured":"Brambilla, P., Perez, J., Barale, F., Schettini, G. & Soares, J. C. GABAergic dysfunction in mood disorders. Mol. Psychiatry 8, 721\u2013737 (2003).","journal-title":"Mol. Psychiatry"},{"key":"908_CR39","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/nature17671","volume":"533","author":"A Okbay","year":"2016","unstructured":"Okbay, A. et al. Genome-wide association study identifies 74 loci associated with educational attainment. Nature 533, 539\u2013542 (2016).","journal-title":"Nature"},{"key":"908_CR40","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/s41380-017-0001-5","volume":"24","author":"WD Hill","year":"2019","unstructured":"Hill, W. D. et al. A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. Mol. Psychiatry 24, 169\u2013181 (2019).","journal-title":"Mol. Psychiatry"},{"key":"908_CR41","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1038\/s41588-019-0497-5","volume":"51","author":"N Schrode","year":"2019","unstructured":"Schrode, N. et al. Synergistic effects of common schizophrenia risk variants. Nat. Genet. 51, 1475\u20131485 (2019).","journal-title":"Nat. Genet."},{"key":"908_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09718-5","volume":"10","author":"T Ge","year":"2019","unstructured":"Ge, T., Chen, C.-Y., Ni, Y., Feng, Y.-C. A. & Smoller, J. W. Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nat. Commun. 10, 1776 (2019).","journal-title":"Nat. Commun."},{"key":"908_CR43","doi-asserted-by":"publisher","unstructured":"Derzon, J. H. The correspondence of family features with problem, aggressive, criminal and violent behavior: a meta-analysis. J. Exp. Criminol. https:\/\/doi.org\/10.1007\/s11292-010-9098-0 (2010).","DOI":"10.1007\/s11292-010-9098-0"},{"key":"908_CR44","doi-asserted-by":"publisher","unstructured":"O\u2019Brien, D. T., Farrell, C. & Welsh, B. C. Broken (windows) theory: a meta-analysis of the evidence for the pathways from neighborhood disorder to resident health outcomes and behaviors. Soc. Sci. Med. https:\/\/doi.org\/10.1016\/j.socscimed.2018.11.015 (2019).","DOI":"10.1016\/j.socscimed.2018.11.015"},{"key":"908_CR45","doi-asserted-by":"publisher","unstructured":"Chang, L. Y., Wang, M. Y. & Tsai, P. S. Neighborhood disadvantage and physical aggression in children and adolescents: a systematic review and meta-analysis of multilevel studies. Aggress. Behav. https:\/\/doi.org\/10.1002\/ab.21641 (2016).","DOI":"10.1002\/ab.21641"},{"key":"908_CR46","doi-asserted-by":"publisher","first-page":"S739","DOI":"10.1016\/j.euroneuro.2017.06.069","volume":"29","author":"L Davis","year":"2019","unstructured":"Davis, L. Psychiatric genomics, phenomics and ethics research in a 270,000-person Biobank (BioVU). Eur. Neuropsychopharmacol. 29, S739\u2013S740 (2019).","journal-title":"Eur. Neuropsychopharmacol."},{"key":"908_CR47","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1126\/science.aax3710","volume":"365","author":"AI Young","year":"2019","unstructured":"Young, A. I., Benonisdottir, S., Przeworski, M. & Kong, A. Deconstructing the sources of genotype\u2013phenotype associations in humans. Science 365, 1396\u20131400 (2019).","journal-title":"Science"},{"key":"908_CR48","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1126\/science.aan6877","volume":"359","author":"A Kong","year":"2018","unstructured":"Kong, A. et al. The nature of nurture: effects of parental genotypes. Science 359, 424\u2013428 (2018).","journal-title":"Science"},{"key":"908_CR49","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ajhg.2019.06.006","volume":"105","author":"S Selzam","year":"2019","unstructured":"Selzam, S. et al. Comparing within- and between-family polygenic score prediction. Am. J. Hum. Genet. 105, 351\u2013363 (2019).","journal-title":"Am. J. Hum. Genet."},{"key":"908_CR50","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nature13595","volume":"511","author":"S Ripke","year":"2014","unstructured":"Ripke, S. et al. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421\u2013427 (2014).","journal-title":"Nature"},{"key":"908_CR51","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/s41588-019-0397-8","volume":"51","author":"EA Stahl","year":"2019","unstructured":"Stahl, E. A. et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat. Genet. 51, 793\u2013803 (2019).","journal-title":"Nat. Genet."},{"key":"908_CR52","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","volume":"50","author":"NR Wray","year":"2018","unstructured":"Wray, N. R. et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet. 50, 668\u2013681 (2018).","journal-title":"Nat. Genet."},{"key":"908_CR53","doi-asserted-by":"publisher","first-page":"1242\u20131250","DOI":"10.1001\/jamapsychiatry.2017.3069","volume":"74","author":"JJ Tielbeek","year":"2017","unstructured":"Tielbeek, J. J. et al. Genome-wide association studies of a broad spectrum of antisocial behavior. JAMA Psychiatry 74, 1242\u20131250 (2017).","journal-title":"JAMA Psychiatry"},{"key":"908_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09480-8","volume":"10","author":"HR Kranzler","year":"2019","unstructured":"Kranzler, H. R. et al. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nat. Commun. 10, 1499 (2019).","journal-title":"Nat. Commun."},{"key":"908_CR55","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ng.3406","volume":"47","author":"BK Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan, B. K. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236\u20131241 (2015).","journal-title":"Nat. Genet."},{"key":"908_CR56","doi-asserted-by":"publisher","first-page":"eaap8757","DOI":"10.1126\/science.aap8757","volume":"360","author":"V Anttila","year":"2018","unstructured":"Anttila, V. et al. Analysis of shared heritability in common disorders of the brain. Science 360, eaap8757 (2018).","journal-title":"Science"},{"key":"908_CR57","doi-asserted-by":"publisher","first-page":"e1005765","DOI":"10.1371\/journal.pgen.1005765","volume":"12","author":"SH Gage","year":"2016","unstructured":"Gage, S. H., Smith, G. D., Ware, J. J., Flint, J. & Munaf\u00f2, M. R. G\u2009=\u2009E: what GWAS can tell us about the environment. PLoS Genet. 12, e1005765 (2016).","journal-title":"PLoS Genet."},{"key":"908_CR58","first-page":"153","volume":"124","author":"D Fox","year":"2019","unstructured":"Fox, D. Subversive science. Penn State Law Rev. 124, 153\u2013191 (2019).","journal-title":"Penn State Law Rev."},{"key":"908_CR59","doi-asserted-by":"crossref","unstructured":"American Society of Human Genetics. ASHG denounces attempts to link genetics and racial supremacy. Am. J. Hum. Genet. 103, 636 (2018).","DOI":"10.1016\/j.ajhg.2018.10.011"},{"key":"908_CR60","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.socscimed.2013.07.017","volume":"96","author":"EP Kvaale","year":"2013","unstructured":"Kvaale, E. P., Gottdiener, W. H. & Haslam, N. Biogenetic explanations and stigma: a meta-analytic review of associations among laypeople. Soc. Sci. Med. 96, 95\u2013103 (2013).","journal-title":"Soc. Sci. Med."},{"key":"908_CR61","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1177\/0963721413485087","volume":"22","author":"EM Tucker-Drob","year":"2013","unstructured":"Tucker-Drob, E. M., Briley, D. A. & Harden, K. P. Genetic and environmental influences on cognition across development and context. Curr. Dir. Psychol. Sci. 22, 349\u2013355 (2013).","journal-title":"Curr. Dir. Psychol. Sci."},{"key":"908_CR62","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"A Auton","year":"2015","unstructured":"Auton, A. et al. A global reference for human genetic variation. Nature 526, 68\u201374 (2015).","journal-title":"Nature"},{"key":"908_CR63","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/ejhg.2011.39","volume":"19","author":"J Yang","year":"2011","unstructured":"Yang, J. et al. Genomic inflation factors under polygenic inheritance. Eur. J. Hum. Genet. 19, 807\u2013812 (2011).","journal-title":"Eur. J. Hum. Genet."},{"key":"908_CR64","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1038\/ng.3643","volume":"48","author":"S McCarthy","year":"2016","unstructured":"McCarthy, S. et al. A reference panel of 64,976 haplotypes for genotype imputation. Nat. Genet. 48, 1279\u20131283 (2016).","journal-title":"Nat. Genet."},{"key":"908_CR65","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/nature14962","volume":"526","author":"K Walter","year":"2015","unstructured":"Walter, K. et al. The UK10K project identifies rare variants in health and disease. Nature 526, 82\u201390 (2015).","journal-title":"Nature"},{"key":"908_CR66","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1038\/nprot.2014.071","volume":"9","author":"TW Winkler","year":"2014","unstructured":"Winkler, T. W. et al. Quality control and conduct of genome-wide association meta-analyses. Nat. Protoc. 9, 1192\u20131212 (2014).","journal-title":"Nat. Protoc."},{"key":"908_CR67","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190\u20132191 (2010).","journal-title":"Bioinformatics"},{"key":"908_CR68","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8","volume":"4","author":"CC Chang","year":"2015","unstructured":"Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015).","journal-title":"Gigascience"},{"key":"908_CR69","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","volume":"88","author":"J Yang","year":"2011","unstructured":"Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76\u201382 (2011).","journal-title":"Am. J. Hum. Genet."},{"key":"908_CR70","doi-asserted-by":"publisher","first-page":"13790","DOI":"10.1073\/pnas.1404623111","volume":"111","author":"CA Rietveld","year":"2014","unstructured":"Rietveld, C. A. et al. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. Proc. Natl Acad. Sci. USA 111, 13790\u201313794 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"908_CR71","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/ng.3552","volume":"48","author":"A Okbay","year":"2016","unstructured":"Okbay, A. et al. Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses. Nat. Genet. 48, 624\u2013633 (2016).","journal-title":"Nat. Genet."},{"key":"908_CR72","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1017\/thg.2012.137","volume":"16","author":"KM Harris","year":"2013","unstructured":"Harris, K. M., Halpern, C. T., Haberstick, B. C. & Smolen, A. The National Longitudinal Study of Adolescent Health (Add Health) sibling pairs data. Twin Res. Hum. Genet. 16, 391\u2013398 (2013).","journal-title":"Twin Res. Hum. Genet."},{"key":"908_CR73","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s10519-014-9692-4","volume":"45","author":"MB McQueen","year":"2015","unstructured":"McQueen, M. B. et al. The National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pairs genome-wide data. Behav. Genet. 45, 12\u201323 (2015).","journal-title":"Behav. Genet."},{"key":"908_CR74","first-page":"228","volume":"19","author":"H Begleiter","year":"1995","unstructured":"Begleiter, H. The Collaborative Study on the Genetics of Alcoholism. Alcohol Health Res. World 19, 228\u2013236 (1995).","journal-title":"Alcohol Health Res. World"},{"key":"908_CR75","first-page":"214","volume":"26","author":"HJ Edenberg","year":"2002","unstructured":"Edenberg, H. J. The collaborative study on the genetics of alcoholism: an update. Alcohol Res. Health 26, 214\u2013218 (2002).","journal-title":"Alcohol Res. Health"},{"key":"908_CR76","doi-asserted-by":"publisher","unstructured":"Bucholz, K. K. et al. Comparison of parent, peer, psychiatric and cannabis use influences across stages of offspring alcohol involvement: evidence from the COGA Prospective Study. Alcohol. Clin. Exp. Res. https:\/\/doi.org\/10.1111\/acer.13293 (2017).","DOI":"10.1111\/acer.13293"},{"key":"908_CR77","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1111\/jcpp.12416","volume":"56","author":"ME Calkins","year":"2016","unstructured":"Calkins, M. E. et al. The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative. J. Child Psychol. Psychiatry 56, 1356\u20131369 (2016).","journal-title":"J. Child Psychol. Psychiatry"},{"key":"908_CR78","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.neuroimage.2015.03.056","volume":"124","author":"TD Satterthwaite","year":"2016","unstructured":"Satterthwaite, T. D. et al. The Philadelphia Neurodevelopmental Cohort: a publicly available resource for the study of normal and abnormal brain development in youth. Neuroimage 124, 1115\u20131119 (2016).","journal-title":"Neuroimage"},{"key":"908_CR79","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","volume":"562","author":"C Bycroft","year":"2018","unstructured":"Bycroft, C. et al. The UK Biobank resource with deep phenotyping and genomic data. Nature 562, 203\u2013209 (2018).","journal-title":"Nature"},{"key":"908_CR80","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09718-5","volume":"10","author":"T Ge","year":"2019","unstructured":"Ge, T., Chen, C.-Y., Ni, Y., Feng, Y.-C. A. & Smoller, J. W. Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nat. Commun. 10, 1776 (2019).","journal-title":"Nat. Commun."},{"key":"908_CR81","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ajhg.2015.09.001","volume":"97","author":"BJ Vilhj\u00e1lmsson","year":"2015","unstructured":"Vilhj\u00e1lmsson, B. J. et al. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. Am. J. Hum. Genet. 97, 576\u2013592 (2015).","journal-title":"Am. J. Hum. Genet."},{"key":"908_CR82","doi-asserted-by":"publisher","first-page":"e1003348","DOI":"10.1371\/journal.pgen.1003348","volume":"9","author":"F Dudbridge","year":"2013","unstructured":"Dudbridge, F. Power and predictive accuracy of polygenic risk scores. PLoS Genet. 9, e1003348 (2013).","journal-title":"PLoS Genet."},{"key":"908_CR83","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/nature09298","volume":"467","author":"DM Altshuler","year":"2010","unstructured":"Altshuler, D. M., Gibbs, R. A. & Peltonen, L. Integrating common and rare genetic variation in diverse human populations. Nature 467, 52\u201358 (2010).","journal-title":"Nature"},{"key":"908_CR84","doi-asserted-by":"publisher","first-page":"e0175508","DOI":"10.1371\/journal.pone.0175508","volume":"12","author":"W-Q Wei","year":"2017","unstructured":"Wei, W.-Q. et al. Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record. PLoS ONE 12, e0175508 (2017).","journal-title":"PLoS ONE"},{"key":"908_CR85","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1093\/nar\/30.1.38","volume":"30","author":"T Hubbard","year":"2002","unstructured":"Hubbard, T. et al. The Ensembl genome database project. Nucleic Acids Res. 30, 38\u201341 (2002).","journal-title":"Nucleic Acids Res."},{"key":"908_CR86","doi-asserted-by":"publisher","first-page":"D440","DOI":"10.1093\/nar\/gkm883","volume":"36","author":"TGO Consortium","year":"2007","unstructured":"Consortium, T. G. O. The Gene Ontology project in 2008. Nucleic Acids Res. 36, D440\u2013D444 (2007).","journal-title":"Nucleic Acids Res."},{"key":"908_CR87","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","volume":"27","author":"A Liberzon","year":"2011","unstructured":"Liberzon, A. et al. Molecular signatures database (MSigDB) 3.0. Bioinformatics 27, 1739\u20131740 (2011).","journal-title":"Bioinformatics"},{"key":"908_CR88","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nature13185","volume":"508","author":"JA Miller","year":"2014","unstructured":"Miller, J. A. et al. Transcriptional landscape of the prenatal human brain. Nature 508, 199\u2013206 (2014).","journal-title":"Nature"},{"key":"908_CR89","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ng.2653","volume":"45","author":"J Lonsdale","year":"2013","unstructured":"Lonsdale, J. et al. The Genotype-Tissue Expression (GTEx) project. Nat. Genet. 45, 580\u2013585 (2013).","journal-title":"Nat. Genet."},{"key":"908_CR90","doi-asserted-by":"publisher","first-page":"eaat8464","DOI":"10.1126\/science.aat8464","volume":"362","author":"D Wang","year":"2018","unstructured":"Wang, D. et al. Comprehensive functional genomic resource and integrative model for the human brain. Science 362, eaat8464 (2018).","journal-title":"Science"},{"key":"908_CR91","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature19847","volume":"538","author":"H Won","year":"2016","unstructured":"Won, H. et al. Chromosome conformation elucidates regulatory relationships in developing human brain. Nature 538, 523\u2013527 (2016).","journal-title":"Nature"},{"key":"908_CR92","doi-asserted-by":"publisher","first-page":"eaat4311","DOI":"10.1126\/science.aat4311","volume":"362","author":"P Rajarajan","year":"2018","unstructured":"Rajarajan, P. et al. Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk. Science 362, eaat4311 (2018).","journal-title":"Science"},{"key":"908_CR93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-018-03621-1","volume":"9","author":"AN Barbeira","year":"2018","unstructured":"Barbeira, A. N. et al. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat. Commun. 9, 1\u201320 (2018).","journal-title":"Nat. Commun."},{"key":"908_CR94","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504 (2003).","journal-title":"Genome Res."},{"key":"908_CR95","doi-asserted-by":"publisher","first-page":"e1008239","DOI":"10.1371\/journal.pcbi.1008239","volume":"16","author":"A Singhal","year":"2020","unstructured":"Singhal, A. et al. Multiscale community detection in Cytoscape. PLoS Comput. Biol. 16, e1008239 (2020).","journal-title":"PLoS Comput. Biol."}],"updated-by":[{"DOI":"10.1038\/s41593-024-01853-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000}}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41593-021-00908-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41593-021-00908-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41593-021-00908-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T08:07:22Z","timestamp":1733558842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41593-021-00908-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,26]]},"references-count":95,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["908"],"URL":"https:\/\/doi.org\/10.1038\/s41593-021-00908-3","relation":{"correction":[{"id-type":"doi","id":"10.1038\/s41593-024-01853-7","asserted-by":"object"}]},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,26]]},"assertion":[{"value":"16 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41593-024-01853-7","URL":"https:\/\/doi.org\/10.1038\/s41593-024-01853-7","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"H.R.K. is a member of the American Society of Clinical Psychopharmacology\u2019s Alcohol Clinical Trials Initiative, which was supported in the last 3 years by AbbVie, Alkermes, Ethypharm, Indivior, Lilly, Lundbeck, Otsuka, Pfizer, Arbor and Amygdala Neurosciences. H.R.K. and J.G. are named as inventors on PCT patent application no. 15\/878,640 entitled \u2018genotype-guided dosing of opioid agonists,\u2019 filed on 24 January 2018. J.G. did paid editorial work for the journal Complex Psychiatry. The authors declare no other competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}