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How the basal ganglia engage spinal motor networks has remained elusive. Medullary\n                    <jats:italic>Chx10<\/jats:italic>\n                    gigantocellular (Gi) neurons are required for turning gait programs, suggesting that turning gaits organized by the basal ganglia are executed via this descending pathway. Performing deep brainstem recordings of\n                    <jats:italic>Chx10<\/jats:italic>\n                    Gi Ca\n                    <jats:sup>2+<\/jats:sup>\n                    activity in adult mice, we show that striatal projection neurons initiate turning gaits via a dominant crossed pathway to\n                    <jats:italic>Chx10<\/jats:italic>\n                    Gi neurons on the contralateral side. Using intersectional viral tracing and cell-type-specific modulation, we uncover the principal basal ganglia\u2013spinal cord pathway for locomotor asymmetries in mice: basal ganglia\u2009\u2192\u2009pontine reticular nucleus, oral part (PnO)\u2009\u2192\u2009\n                    <jats:italic>Chx10<\/jats:italic>\n                    Gi\u2009\u2192\u2009spinal cord. Modulating the restricted PnO\u2009\u2192\u2009\n                    <jats:italic>Chx10<\/jats:italic>\n                    Gi pathway restores turning competence upon striatal damage, suggesting that dysfunction of this pathway may contribute to debilitating turning deficits observed in Parkinson\u2019s disease. Our results reveal the stratified circuit architecture underlying a critical motor program.\n                  <\/jats:p>","DOI":"10.1038\/s41593-024-01569-8","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T06:02:36Z","timestamp":1707717756000},"page":"716-727","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Basal ganglia\u2013spinal cord pathway that commands locomotor gait asymmetries in mice"],"prefix":"10.1038","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0027-9748","authenticated-orcid":false,"given":"Jared M.","family":"Cregg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simrandeep K.","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-2904","authenticated-orcid":false,"given":"Roberto","family":"Leiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-469X","authenticated-orcid":false,"given":"Ole","family":"Kiehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"1569_CR1","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/j.neuron.2021.03.017","volume":"109","author":"L McElvain","year":"2021","unstructured":"McElvain, L. et al. 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