{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:18:08Z","timestamp":1794028688431,"version":"4.8.0"},"reference-count":158,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000065","name":"U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS115544"],"award-info":[{"award-number":["R01NS115544"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS111961"],"award-info":[{"award-number":["R01NS111961"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1038\/s41593-025-01973-8","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:03:19Z","timestamp":1749790999000},"page":"1418-1435","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Myelin\u2013axon interface vulnerability in Alzheimer\u2019s disease revealed by subcellular proteomics and imaging of human and mouse brain"],"prefix":"10.1038","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0108-8166","authenticated-orcid":false,"given":"Yifei","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3956-3279","authenticated-orcid":false,"given":"Iguaracy","family":"Pinheiro-de-Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-8617","authenticated-orcid":false,"given":"Mykhaylo","family":"Slobodyanyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tram","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Kanyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas A.","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Braker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Huttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-4447","authenticated-orcid":false,"given":"Peng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-3462","authenticated-orcid":false,"given":"TuKiet T.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8294-2995","authenticated-orcid":false,"given":"Evangelia","family":"Petsalaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2299-2309","authenticated-orcid":false,"given":"J\u00fcri","family":"Reimand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-0195","authenticated-orcid":false,"given":"Angus C.","family":"Nairn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-243X","authenticated-orcid":false,"given":"Jaime","family":"Grutzendler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"1973_CR1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41582-020-0375-x","volume":"16","author":"C Lubetzki","year":"2020","unstructured":"Lubetzki, C., Sol-Foulon, N. & Desmazieres, A. Nodes of Ranvier during development and repair in the CNS. Nat. Rev. Neurol. 16, 426\u2013439 (2020).","journal-title":"Nat. Rev. Neurol."},{"key":"1973_CR2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-neuro-100120-122621","volume":"44","author":"KA Nave","year":"2021","unstructured":"Nave, K. A. & Werner, H. B. Ensheathment and myelination of axons: evolution of glial functions. Annu. Rev. Neurosci. 44, 197\u2013219 (2021).","journal-title":"Annu. Rev. Neurosci."},{"key":"1973_CR3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev-neuro-080317-061853","volume":"41","author":"M Monje","year":"2018","unstructured":"Monje, M. Myelin plasticity and nervous system function. Annu. Rev. Neurosci. 41, 61\u201376 (2018).","journal-title":"Annu. Rev. Neurosci."},{"key":"1973_CR4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41593-018-0120-6","volume":"21","author":"RA Hill","year":"2018","unstructured":"Hill, R. A., Li, A. M. & Grutzendler, J. Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain. Nat. Neurosci. 21, 683\u2013695 (2018).","journal-title":"Nat. Neurosci."},{"key":"1973_CR5","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1126\/science.1254960","volume":"346","author":"IA McKenzie","year":"2014","unstructured":"McKenzie, I. A. et al. Motor skill learning requires active central myelination. Science 346, 318\u2013322 (2014).","journal-title":"Science"},{"key":"1973_CR6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41593-019-0582-1","volume":"23","author":"S Pan","year":"2020","unstructured":"Pan, S. et al. Preservation of a remote fear memory requires new myelin formation. Nat. Neurosci. 23, 487\u2013499 (2020).","journal-title":"Nat. Neurosci."},{"key":"1973_CR7","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18632-0","volume":"11","author":"N Snaidero","year":"2020","unstructured":"Snaidero, N. et al. Myelin replacement triggered by single-cell demyelination in mouse cortex. Nat. Commun. 11, 4901 (2020).","journal-title":"Nat. Commun."},{"key":"1973_CR8","doi-asserted-by":"crossref","first-page":"e23329","DOI":"10.7554\/eLife.23329","volume":"6","author":"IL Arancibia-Carcamo","year":"2017","unstructured":"Arancibia-Carcamo, I. L. et al. Node of Ranvier length as a potential regulator of myelinated axon conduction speed. eLife 6, e23329 (2017).","journal-title":"eLife"},{"key":"1973_CR9","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41593-022-01052-2","volume":"25","author":"JK Knowles","year":"2022","unstructured":"Knowles, J. K. et al. Maladaptive myelination promotes generalized epilepsy progression. Nat. Neurosci. 25, 596\u2013606 (2022).","journal-title":"Nat. Neurosci."},{"key":"1973_CR10","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cell.2020.06.038","volume":"182","author":"WT Chen","year":"2020","unstructured":"Chen, W. T. et al. Spatial transcriptomics and in situ sequencing to study Alzheimer\u2019s disease. Cell 182, 976\u2013991 e19 (2020).","journal-title":"Cell"},{"key":"1973_CR11","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","volume":"570","author":"H Mathys","year":"2019","unstructured":"Mathys, H. et al. Single-cell transcriptomic analysis of Alzheimer\u2019s disease. Nature 570, 332\u2013337 (2019).","journal-title":"Nature"},{"key":"1973_CR12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41593-020-00764-7","volume":"24","author":"K Leng","year":"2021","unstructured":"Leng, K. et al. Molecular characterization of selectively vulnerable neurons in Alzheimer\u2019s disease. Nat. Neurosci. 24, 276\u2013287 (2021).","journal-title":"Nat. Neurosci."},{"key":"1973_CR13","doi-asserted-by":"crossref","first-page":"25800","DOI":"10.1073\/pnas.2008762117","volume":"117","author":"SF Lau","year":"2020","unstructured":"Lau, S. F. et al. Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer\u2019s disease. Proc. Natl Acad. Sci. USA 117, 25800\u201325809 (2020).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1973_CR14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41591-019-0695-9","volume":"26","author":"Y Zhou","year":"2020","unstructured":"Zhou, Y. et al. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer\u2019s disease. Nat. Med. 26, 131\u2013142 (2020).","journal-title":"Nat. Med."},{"key":"1973_CR15","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/s41593-019-0539-4","volume":"22","author":"A Grubman","year":"2019","unstructured":"Grubman, A. et al. A single-cell atlas of entorhinal cortex from individuals with Alzheimer\u2019s disease reveals cell-type-specific gene expression regulation. Nat. Neurosci. 22, 2087\u20132097 (2019).","journal-title":"Nat. Neurosci."},{"key":"1973_CR16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41593-021-00999-y","volume":"25","author":"ECB Johnson","year":"2022","unstructured":"Johnson, E. C. B. et al. Large-scale deep multi-layer analysis of Alzheimer\u2019s disease brain reveals strong proteomic disease-related changes not observed at the RNA level. Nat. Neurosci. 25, 213\u2013225 (2022).","journal-title":"Nat. Neurosci."},{"key":"1973_CR17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41591-020-0815-6","volume":"26","author":"ECB Johnson","year":"2020","unstructured":"Johnson, E. C. B. et al. Large-scale proteomic analysis of Alzheimer\u2019s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nat. Med. 26, 769\u2013780 (2020).","journal-title":"Nat. Med."},{"key":"1973_CR18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13024-021-00474-z","volume":"16","author":"B Bai","year":"2021","unstructured":"Bai, B. et al. Proteomic landscape of Alzheimer\u2019s disease: novel insights into pathogenesis and biomarker discovery. Mol. Neurodegener. 16, 55 (2021).","journal-title":"Mol. Neurodegener."},{"key":"1973_CR19","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-40208-x","volume":"14","author":"M Askenazi","year":"2023","unstructured":"Askenazi, M. et al. Compilation of reported protein changes in the brain in Alzheimer\u2019s disease. Nat. Commun. 14, 4466 (2023).","journal-title":"Nat. Commun."},{"key":"1973_CR20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/1756285611433772","volume":"5","author":"MC Mayer","year":"2012","unstructured":"Mayer, M. C. & Meinl, E. Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more. Ther. Adv. Neurol. Disord. 5, 147\u2013159 (2012).","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"1973_CR21","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1038\/nn.3858","volume":"17","author":"KJ Chang","year":"2014","unstructured":"Chang, K. J. et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat. Neurosci. 17, 1673\u20131681 (2014).","journal-title":"Nat. Neurosci."},{"key":"1973_CR22","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/nn.3859","volume":"17","author":"TS Ho","year":"2014","unstructured":"Ho, T. S. et al. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. Nat. Neurosci. 17, 1664\u20131672 (2014).","journal-title":"Nat. Neurosci."},{"key":"1973_CR23","doi-asserted-by":"crossref","first-page":"a020479","DOI":"10.1101\/cshperspect.a020479","volume":"8","author":"M Simons","year":"2015","unstructured":"Simons, M. & Nave, K. A. Oligodendrocytes: myelination and axonal support. Cold Spring Harb. Perspect. Biol. 8, a020479 (2015).","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"1973_CR24","doi-asserted-by":"crossref","first-page":"11832","DOI":"10.1073\/pnas.1811013115","volume":"115","author":"DJ Dutta","year":"2018","unstructured":"Dutta, D. J. et al. Regulation of myelin structure and conduction velocity by perinodal astrocytes. Proc. Natl Acad. Sci. USA 115, 11832\u201311837 (2018).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1973_CR25","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41586-022-05491-6","volume":"612","author":"P Yuan","year":"2022","unstructured":"Yuan, P. et al. PLD3 affects axonal spheroids and network defects in Alzheimer\u2019s disease. Nature 612, 328\u2013337 (2022).","journal-title":"Nature"},{"key":"1973_CR26","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/nn.4325","volume":"19","author":"S Safaiyan","year":"2016","unstructured":"Safaiyan, S. et al. Age-related myelin degradation burdens the clearance function of microglia during aging. Nat. Neurosci. 19, 995\u2013998 (2016).","journal-title":"Nat. Neurosci."},{"key":"1973_CR27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/jamaneurol.2016.3232","volume":"74","author":"DC Dean","year":"2017","unstructured":"Dean, D. C. et al. Association of amyloid pathology with myelin alteration in preclinical Alzheimer disease. JAMA Neurol. 74, 41\u201349 (2017).","journal-title":"JAMA Neurol."},{"key":"1973_CR28","doi-asserted-by":"crossref","first-page":"101767","DOI":"10.1016\/j.nicl.2019.101767","volume":"22","author":"Q Wang","year":"2019","unstructured":"Wang, Q. et al. Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u2019s disease. Neuroimage Clin. 22, 101767 (2019).","journal-title":"Neuroimage Clin."},{"key":"1973_CR29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-018-0515-3","volume":"6","author":"SE Nasrabady","year":"2018","unstructured":"Nasrabady, S. E. et al. White matter changes in Alzheimer\u2019s disease: a focus on myelin and oligodendrocytes. Acta Neuropathol. Commun. 6, 22 (2018).","journal-title":"Acta Neuropathol. Commun."},{"key":"1973_CR30","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1093\/brain\/awy229","volume":"141","author":"MA Araque Caballero","year":"2018","unstructured":"Araque Caballero, M. A. et al. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer\u2019s disease. Brain 141, 3065\u20133080 (2018).","journal-title":"Brain"},{"key":"1973_CR31","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41583-023-00711-y","volume":"24","author":"EM Kramer-Albers","year":"2023","unstructured":"Kramer-Albers, E. M. & Werner, H. B. Mechanisms of axonal support by oligodendrocyte-derived extracellular vesicles. Nat. Rev. Neurosci. 24, 474\u2013486 (2023).","journal-title":"Nat. Rev. Neurosci."},{"key":"1973_CR32","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s43587-025-00823-3","volume":"5","author":"Y Cai","year":"2025","unstructured":"Cai, Y. et al. Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer\u2019s disease. Nat. Aging 5, 504\u2013527 (2025).","journal-title":"Nat. Aging"},{"key":"1973_CR33","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1002\/pmic.201200279","volume":"12","author":"N Hashimoto","year":"2012","unstructured":"Hashimoto, N. et al. Proteomic analysis of ganglioside-associated membrane molecules: substantial basis for molecular clustering. Proteomics 12, 3154\u20133163 (2012).","journal-title":"Proteomics"},{"key":"1973_CR34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nmeth.4533","volume":"15","author":"DZ Bar","year":"2018","unstructured":"Bar, D. Z. et al. Biotinylation by antibody recognition\u2014a method for proximity labeling. Nat. Methods 15, 127\u2013133 (2018).","journal-title":"Nat. Methods"},{"key":"1973_CR35","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/jnen\/nlw093","volume":"75","author":"JM Vallat","year":"2016","unstructured":"Vallat, J. M. et al. Contactin-associated protein 1 (CNTNAP1) mutations induce characteristic lesions of the paranodal region. J. Neuropathol. Exp. Neurol. 75, 1155\u20131159 (2016).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"1973_CR36","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/cne.902840310","volume":"284","author":"U Bartsch","year":"1989","unstructured":"Bartsch, U., Kirchhoff, F. & Schachner, M. Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice. J. Comp. Neurol. 284, 451\u2013462 (1989).","journal-title":"J. Comp. Neurol."},{"key":"1973_CR37","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/j.1471-4159.2006.04319.x","volume":"100","author":"RH Quarles","year":"2007","unstructured":"Quarles, R. H. Myelin-associated glycoprotein (MAG): past, present and beyond. J. Neurochem. 100, 1431\u20131448 (2007).","journal-title":"J. Neurochem."},{"key":"1973_CR38","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.mcn.2005.12.001","volume":"31","author":"M Erb","year":"2006","unstructured":"Erb, M. et al. Unraveling the differential expression of the two isoforms of myelin-associated glycoprotein in a mouse expressing GFP-tagged S-MAG specifically regulated and targeted into the different myelin compartments. Mol. Cell. Neurosci. 31, 613\u2013627 (2006).","journal-title":"Mol. Cell. Neurosci."},{"key":"1973_CR39","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cell.2019.12.029","volume":"180","author":"J Li","year":"2020","unstructured":"Li, J. et al. Cell-surface proteomic profiling in the fly brain uncovers wiring regulators. Cell 180, 373\u2013386 e15 (2020).","journal-title":"Cell"},{"key":"1973_CR40","doi-asserted-by":"crossref","first-page":"e77019","DOI":"10.7554\/eLife.77019","volume":"11","author":"VI Gargareta","year":"2022","unstructured":"Gargareta, V. I. et al. Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice. eLife 11, e77019 (2022).","journal-title":"eLife"},{"key":"1973_CR41","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13983-9","volume":"11","author":"M Paczkowska","year":"2020","unstructured":"Paczkowska, M. et al. Integrative pathway enrichment analysis of multivariate omics data. Nat. Commun. 11, 735 (2020).","journal-title":"Nat. Commun."},{"key":"1973_CR42","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49986-4","volume":"15","author":"M Slobodyanyuk","year":"2024","unstructured":"Slobodyanyuk, M. et al. Directional integration and pathway enrichment analysis for multi-omics data. Nat. Commun. 15, 5690 (2024).","journal-title":"Nat. Commun."},{"key":"1973_CR43","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.stemcr.2023.02.012","volume":"18","author":"R Tsuchimochi","year":"2023","unstructured":"Tsuchimochi, R. et al. Viral delivery of L1CAM promotes axonal extensions by embryonic cerebral grafts in mouse brain. Stem Cell Rep. 18, 899\u2013914 (2023).","journal-title":"Stem Cell Rep."},{"key":"1973_CR44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00441-012-1345-4","volume":"349","author":"MK Schafer","year":"2012","unstructured":"Schafer, M. K. & Frotscher, M. Role of L1CAM for axon sprouting and branching. Cell Tissue Res. 349, 39\u201348 (2012).","journal-title":"Cell Tissue Res."},{"key":"1973_CR45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mcn.2005.06.006","volume":"30","author":"K Itoh","year":"2005","unstructured":"Itoh, K. et al. Disrupted Schwann cell-axon interactions in peripheral nerves of mice with altered L1-integrin interactions. Mol. Cell. Neurosci. 30, 131\u2013136 (2005).","journal-title":"Mol. Cell. Neurosci."},{"key":"1973_CR46","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s12035-022-03163-0","volume":"60","author":"D Guo","year":"2023","unstructured":"Guo, D. et al. A disintegrin and metalloproteinase 10 (ADAM10) is essential for oligodendrocyte precursor development and myelination in the mouse brain. Mol. Neurobiol. 60, 1675\u20131689 (2023).","journal-title":"Mol. Neurobiol."},{"key":"1973_CR47","doi-asserted-by":"crossref","first-page":"8448","DOI":"10.1523\/JNEUROSCI.1841-07.2007","volume":"27","author":"YY Chen","year":"2007","unstructured":"Chen, Y. Y. et al. Targeting of retinal axons requires the metalloproteinase ADAM10. J. Neurosci. 27, 8448\u20138456 (2007).","journal-title":"J. Neurosci."},{"key":"1973_CR48","doi-asserted-by":"crossref","first-page":"e12748","DOI":"10.7554\/eLife.12748","volume":"5","author":"PH Kuhn","year":"2016","unstructured":"Kuhn, P. H. et al. Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. eLife 5, e12748 (2016).","journal-title":"eLife"},{"key":"1973_CR49","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5058","volume":"5","author":"E Romi","year":"2014","unstructured":"Romi, E. et al. ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A. Nat. Commun. 5, 4058 (2014).","journal-title":"Nat. Commun."},{"key":"1973_CR50","doi-asserted-by":"crossref","first-page":"173017","DOI":"10.1016\/j.pbb.2020.173017","volume":"198","author":"A Bregin","year":"2020","unstructured":"Bregin, A. et al. Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system. Pharmacol. Biochem. Behav. 198, 173017 (2020).","journal-title":"Pharmacol. Biochem. Behav."},{"key":"1973_CR51","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1242\/jcs.096149","volume":"125","author":"K Thelen","year":"2012","unstructured":"Thelen, K. et al. Translation of the cell adhesion molecule ALCAM in axonal growth cones \u2013 regulation and functional importance. J. Cell Sci. 125, 1003\u20131014 (2012).","journal-title":"J. Cell Sci."},{"key":"1973_CR52","doi-asserted-by":"crossref","first-page":"e40493","DOI":"10.1371\/journal.pone.0040493","volume":"7","author":"K Thelen","year":"2012","unstructured":"Thelen, K. et al. Depending on its nano-spacing, ALCAM promotes cell attachment and axon growth. PLoS ONE 7, e40493 (2012).","journal-title":"PLoS ONE"},{"key":"1973_CR53","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1038\/nn.4160","volume":"18","author":"K Sharma","year":"2015","unstructured":"Sharma, K. et al. Cell type- and brain region-resolved mouse brain proteome. Nat. Neurosci. 18, 1819\u20131831 (2015).","journal-title":"Nat. Neurosci."},{"key":"1973_CR54","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/carcin\/bgad015","volume":"44","author":"J Zhang","year":"2023","unstructured":"Zhang, J. et al. ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis. Carcinogenesis 44, 242\u2013251 (2023).","journal-title":"Carcinogenesis"},{"key":"1973_CR55","doi-asserted-by":"crossref","first-page":"9039","DOI":"10.1073\/pnas.0602916103","volume":"103","author":"T Zhou","year":"2006","unstructured":"Zhou, T. et al. A mammalian NudC-like protein essential for dynein stability and cell viability. Proc. Natl Acad. Sci. USA 103, 9039\u20139044 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1973_CR56","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41596-020-0292-x","volume":"15","author":"M Efremova","year":"2020","unstructured":"Efremova, M. et al. CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes. Nat. Protoc. 15, 1484\u20131506 (2020).","journal-title":"Nat. Protoc."},{"key":"1973_CR57","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S. et al. Inference and analysis of cell-cell communication using CellChat. Nat. Commun. 12, 1088 (2021).","journal-title":"Nat. Commun."},{"key":"1973_CR58","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-30755-0","volume":"13","author":"D Dimitrov","year":"2022","unstructured":"Dimitrov, D. et al. Comparison of methods and resources for cell-cell communication inference from single-cell RNA-seq data. Nat. Commun. 13, 3224 (2022).","journal-title":"Nat. Commun."},{"key":"1973_CR59","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.202000034","volume":"21","author":"P Weidemuller","year":"2021","unstructured":"Weidemuller, P. et al. Transcription factors: bridge between cell signaling and gene regulation. Proteomics 21, e2000034 (2021).","journal-title":"Proteomics"},{"key":"1973_CR60","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","volume":"17","author":"R Browaeys","year":"2020","unstructured":"Browaeys, R., Saelens, W. & Saeys, Y. NicheNet: modeling intercellular communication by linking ligands to target genes. Nat. Methods 17, 159\u2013162 (2020).","journal-title":"Nat. Methods"},{"key":"1973_CR61","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0306-4522(88)90242-4","volume":"27","author":"AJ Dwork","year":"1988","unstructured":"Dwork, A. J., Schon, E. A. & Herbert, J. Nonidentical distribution of transferrin and ferric iron in human brain. Neuroscience 27, 333\u2013345 (1988).","journal-title":"Neuroscience"},{"key":"1973_CR62","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/ana.410260115","volume":"26","author":"MR Gerber","year":"1989","unstructured":"Gerber, M. R. & Connor, J. R. Do oligodendrocytes mediate iron regulation in the human brain? Ann. Neurol. 26, 95\u201398 (1989).","journal-title":"Ann. Neurol."},{"key":"1973_CR63","first-page":"3614","volume":"43","author":"VT Cheli","year":"2023","unstructured":"Cheli, V. T. et al. Transferrin receptor is necessary for proper oligodendrocyte iron homeostasis and development. J. Neurosci. 43, 3614\u20133629 (2023).","journal-title":"J. Neurosci."},{"key":"1973_CR64","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/1673-5374.126960","volume":"8","author":"Y Li","year":"2013","unstructured":"Li, Y. et al. Transferrin receptor and ferritin-H are developmentally regulated in oligodendrocyte lineage cells. Neural Regen. Res. 8, 6\u201312 (2013).","journal-title":"Neural Regen. Res."},{"key":"1973_CR65","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11064-004-1826-2","volume":"24","author":"A Espinosa de los Monteros","year":"1999","unstructured":"Espinosa de los Monteros, A. et al. Transferrin is an essential factor for myelination. Neurochem. Res. 24, 235\u2013248 (1999).","journal-title":"Neurochem. Res."},{"key":"1973_CR66","doi-asserted-by":"crossref","first-page":"7300","DOI":"10.1523\/JNEUROSCI.0900-21.2021","volume":"41","author":"BS Mietto","year":"2021","unstructured":"Mietto, B. S. et al. Schwann cells provide iron to axonal mitochondria and its role in nerve regeneration. J. Neurosci. 41, 7300\u20137313 (2021).","journal-title":"J. Neurosci."},{"key":"1973_CR67","doi-asserted-by":"crossref","first-page":"e1002853","DOI":"10.1371\/journal.pgen.1002853","volume":"8","author":"X Zhu","year":"2012","unstructured":"Zhu, X. et al. Mutations in a P-type ATPase gene cause axonal degeneration. PLoS Genet. 8, e1002853 (2012).","journal-title":"PLoS Genet."},{"key":"1973_CR68","doi-asserted-by":"crossref","first-page":"103869","DOI":"10.1016\/j.isci.2022.103869","volume":"25","author":"N Kaneshiro","year":"2022","unstructured":"Kaneshiro, N. et al. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer\u2019s disease. iScience 25, 103869 (2022).","journal-title":"iScience"},{"key":"1973_CR69","doi-asserted-by":"crossref","first-page":"16132","DOI":"10.1074\/jbc.M115.656496","volume":"290","author":"T Cali","year":"2015","unstructured":"Cali, T. et al. A novel mutation in isoform 3 of the plasma membrane Ca2+ pump impairs cellular Ca2+ homeostasis in a patient with cerebellar ataxia and laminin subunit 1\u0251 mutations. J. Biol. Chem. 290, 16132\u201316141 (2015).","journal-title":"J. Biol. Chem."},{"key":"1973_CR70","doi-asserted-by":"crossref","first-page":"E524","DOI":"10.1073\/pnas.1614336114","volume":"114","author":"MA Lecuyer","year":"2017","unstructured":"Lecuyer, M. A. et al. Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis. Proc. Natl Acad. Sci. USA 114, E524\u2013E533 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1973_CR71","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1001\/jamaneurol.2020.3536","volume":"78","author":"BW Kunkle","year":"2021","unstructured":"Kunkle, B. W. et al. Novel Alzheimer disease risk loci and pathways in African American individuals using the African Genome Resources Panel: a meta-analysis. JAMA Neurol. 78, 102\u2013113 (2021).","journal-title":"JAMA Neurol."},{"key":"1973_CR72","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/hmg\/ddp464","volume":"19","author":"L Zhao","year":"2010","unstructured":"Zhao, L. et al. Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjogren syndrome. Hum. Mol. Genet. 19, 25\u201335 (2010).","journal-title":"Hum. Mol. Genet."},{"key":"1973_CR73","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.2147\/OTT.S297332","volume":"14","author":"S Rao","year":"2021","unstructured":"Rao, S. et al. Biological function of HYOU1 in tumors and other diseases. Onco Targets Ther. 14, 1727\u20131735 (2021).","journal-title":"Onco Targets Ther."},{"key":"1973_CR74","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41401-021-00635-2","volume":"43","author":"ZY Zhu","year":"2022","unstructured":"Zhu, Z. Y. et al. Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP\/PS1 murine model of Alzheimer\u2019s disease via inhibition of ACSL4-dependent ferroptosis. Acta Pharmacol. Sin. 43, 39\u201349 (2022).","journal-title":"Acta Pharmacol. Sin."},{"key":"1973_CR75","doi-asserted-by":"crossref","first-page":"10021","DOI":"10.3390\/ijms241210021","volume":"24","author":"B Jia","year":"2023","unstructured":"Jia, B. et al. ACSL4-mediated ferroptosis and its potential role in central nervous system diseases and injuries. Int. J. Mol. Sci. 24, 10021 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"1973_CR76","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.3390\/ijms24065532","volume":"24","author":"L Hohn","year":"2023","unstructured":"Hohn, L. et al. Extracellular matrix changes in subcellular brain fractions and cerebrospinal fluid of Alzheimer\u2019s disease patients. Int. J. Mol. Sci. 24, 5532 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"1973_CR77","doi-asserted-by":"crossref","first-page":"eadk6911","DOI":"10.1126\/sciadv.adk6911","volume":"10","author":"Q Zhang","year":"2024","unstructured":"Zhang, Q. et al. Human brain glycoform coregulation network and glycan modification alterations in Alzheimer\u2019s disease. Sci. Adv. 10, eadk6911 (2024).","journal-title":"Sci. Adv."},{"key":"1973_CR78","doi-asserted-by":"crossref","first-page":"e0188218","DOI":"10.1371\/journal.pone.0188218","volume":"12","author":"TH Chu","year":"2017","unstructured":"Chu, T. H. et al. Axonal and myelinic pathology in 5xFAD Alzheimer\u2019s mouse spinal cord. PLoS ONE 12, e0188218 (2017).","journal-title":"PLoS ONE"},{"key":"1973_CR79","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s41551-022-00912-3","volume":"6","author":"D Sarkar","year":"2022","unstructured":"Sarkar, D. et al. Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy. Nat. Biomed. Eng. 6, 1057\u20131073 (2022).","journal-title":"Nat. Biomed. Eng."},{"key":"1973_CR80","doi-asserted-by":"crossref","first-page":"e1794232024","DOI":"10.1523\/JNEUROSCI.1794-23.2024","volume":"44","author":"TW Chapman","year":"2024","unstructured":"Chapman, T. W. et al. Oligodendrocyte maturation alters the cell death mechanisms that cause demyelination. J. Neurosci. 44, e1794232024 (2024).","journal-title":"J. Neurosci."},{"key":"1973_CR81","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1126\/science.280.5369.1610","volume":"280","author":"I Griffiths","year":"1998","unstructured":"Griffiths, I. et al. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 280, 1610\u20131613 (1998).","journal-title":"Science"},{"key":"1973_CR82","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1002\/jnr.21984","volume":"87","author":"Y Ogawa","year":"2009","unstructured":"Ogawa, Y. & Rasband, M. N. Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins. J. Neurosci. Res. 87, 3502\u20133510 (2009).","journal-title":"J. Neurosci. Res."},{"key":"1973_CR83","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neurobiolaging.2003.03.001","volume":"25","author":"G Bartzokis","year":"2004","unstructured":"Bartzokis, G. Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer\u2019s disease. Neurobiol. Aging 25, 5\u201318 (2004).","journal-title":"Neurobiol. Aging"},{"key":"1973_CR84","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.neuron.2021.05.012","volume":"109","author":"JF Chen","year":"2021","unstructured":"Chen, J. F. et al. Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer\u2019s disease. Neuron 109, 2292\u20132307 e5 (2021).","journal-title":"Neuron"},{"key":"1973_CR85","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41586-023-06120-6","volume":"618","author":"C Depp","year":"2023","unstructured":"Depp, C. et al. Myelin dysfunction drives amyloid-\u03b2 deposition in models of Alzheimer\u2019s disease. Nature 618, 349\u2013357 (2023).","journal-title":"Nature"},{"key":"1973_CR86","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/s41593-024-01682-8","volume":"27","author":"S Kedia","year":"2024","unstructured":"Kedia, S. et al. T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis. Nat. Neurosci. 27, 1468\u20131474 (2024).","journal-title":"Nat. Neurosci."},{"key":"1973_CR87","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cub.2018.01.017","volume":"28","author":"F Auer","year":"2018","unstructured":"Auer, F., Vagionitis, S. & Czopka, T. Evidence for myelin sheath remodeling in the CNS revealed by in vivo imaging. Curr. Biol. 28, 549\u2013559 e3 (2018).","journal-title":"Curr. Biol."},{"key":"1973_CR88","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/s41593-024-01642-2","volume":"27","author":"LA Osso","year":"2024","unstructured":"Osso, L. A. & Hughes, E. G. Dynamics of mature myelin. Nat. Neurosci. 27, 1449\u20131461 (2024).","journal-title":"Nat. Neurosci."},{"key":"1973_CR89","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1074\/jbc.M111.315051","volume":"287","author":"Q Guo","year":"2012","unstructured":"Guo, Q. et al. Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. J. Biol. Chem. 287, 2437\u20132445 (2012).","journal-title":"J. Biol. Chem."},{"key":"1973_CR90","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s11064-009-0022-9","volume":"34","author":"SD Skaper","year":"2009","unstructured":"Skaper, S. D. et al. Oligodendrocytes are a novel source of amyloid peptide generation. Neurochem. Res. 34, 2243\u20132250 (2009).","journal-title":"Neurochem. Res."},{"key":"1973_CR91","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1750-1326-1-5","volume":"1","author":"H Zheng","year":"2006","unstructured":"Zheng, H. & Koo, E. H. The amyloid precursor protein: beyond amyloid. Mol. Neurodegener. 1, 5 (2006).","journal-title":"Mol. Neurodegener."},{"key":"1973_CR92","doi-asserted-by":"crossref","first-page":"e3002727","DOI":"10.1371\/journal.pbio.3002727","volume":"22","author":"RM Rajani","year":"2024","unstructured":"Rajani, R. M. et al. Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer\u2019s disease. PLoS Biol. 22, e3002727 (2024).","journal-title":"PLoS Biol."},{"key":"1973_CR93","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/s41593-024-01730-3","volume":"27","author":"AO Sasmita","year":"2024","unstructured":"Sasmita, A. O. et al. Oligodendrocytes produce amyloid-\u03b2 and contribute to plaque formation alongside neurons in Alzheimer\u2019s disease model mice. Nat. Neurosci. 27, 1668\u20131674 (2024).","journal-title":"Nat. Neurosci."},{"key":"1973_CR94","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","volume":"13","author":"JL Jankowsky","year":"2004","unstructured":"Jankowsky, J. L. et al. Mutant presenilins specifically elevate the levels of the 42 residue \u03b2-amyloid peptide in vivo: evidence for augmentation of a 42-specific \u03b3 secretase. Hum. Mol. Genet 13, 159\u2013170 (2004).","journal-title":"Hum. Mol. Genet"},{"key":"1973_CR95","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cub.2018.02.068","volume":"28","author":"RG Almeida","year":"2018","unstructured":"Almeida, R. G. et al. Myelination of neuronal cell bodies when myelin supply exceeds axonal demand. Curr. Biol. 28, 1296\u20131305 e5 (2018).","journal-title":"Curr. Biol."},{"key":"1973_CR96","doi-asserted-by":"crossref","first-page":"eaam7816","DOI":"10.1126\/scitranslmed.aam7816","volume":"9","author":"MK Fard","year":"2017","unstructured":"Fard, M. K. et al. BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Sci. Transl. Med. 9, eaam7816 (2017).","journal-title":"Sci. Transl. Med."},{"key":"1973_CR97","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1242\/dev.120.5.1097","volume":"120","author":"BA Barres","year":"1994","unstructured":"Barres, B. A., Lazar, M. A. & Raff, M. C. A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development. Development 120, 1097\u20131108 (1994).","journal-title":"Development"},{"key":"1973_CR98","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0092-8674(92)90531-G","volume":"70","author":"BA Barres","year":"1992","unstructured":"Barres, B. A. et al. Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70, 31\u201346 (1992).","journal-title":"Cell"},{"key":"1973_CR99","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1073\/pnas.0601082103","volume":"103","author":"GP Garcia-Fresco","year":"2006","unstructured":"Garcia-Fresco, G. P. et al. Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons. Proc. Natl Acad. Sci. USA 103, 5137\u20135142 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1973_CR100","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-1636-8","volume":"10","author":"T Quintela-Lopez","year":"2019","unstructured":"Quintela-Lopez, T. et al. A\u03b2 oligomers promote oligodendrocyte differentiation and maturation via integrin \u03b21 and Fyn kinase signaling. Cell Death Dis. 10, 445 (2019).","journal-title":"Cell Death Dis."},{"key":"1973_CR101","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41593-023-01271-1","volume":"26","author":"TW Chapman","year":"2023","unstructured":"Chapman, T. W. et al. Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice. Nat. Neurosci. 26, 555\u2013569 (2023).","journal-title":"Nat. Neurosci."},{"key":"1973_CR102","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","volume":"26","author":"H Oakley","year":"2006","unstructured":"Oakley, H. et al. Intraneuronal \u03b2-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation. J. Neurosci. 26, 10129\u201310140 (2006).","journal-title":"J. Neurosci."},{"key":"1973_CR103","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","volume":"28","author":"G Feng","year":"2000","unstructured":"Feng, G. et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28, 41\u201351 (2000).","journal-title":"Neuron"},{"key":"1973_CR104","doi-asserted-by":"crossref","first-page":"D258","DOI":"10.1093\/nar\/gkh066","volume":"32","author":"MA Harris","year":"2004","unstructured":"Harris, M. A. et al. The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res. 32, D258\u2013D261 (2004).","journal-title":"Nucleic Acids Res."},{"key":"1973_CR105","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1002\/glia.21064","volume":"58","author":"AS Dhaunchak","year":"2010","unstructured":"Dhaunchak, A. S. et al. A proteome map of axoglial specializations isolated and purified from human central nervous system. Glia 58, 1949\u20131960 (2010).","journal-title":"Glia"},{"key":"1973_CR106","doi-asserted-by":"crossref","unstructured":"Binder, J. X. et al. COMPARTMENTS: unification and visualization of protein subcellular localization evidence. Database (Oxford) 2014, bau012 (2014).","DOI":"10.1093\/database\/bau012"},{"key":"1973_CR107","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk, D. et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47, D607\u2013D613 (2019).","journal-title":"Nucleic Acids Res."},{"key":"1973_CR108","doi-asserted-by":"crossref","first-page":"e13984","DOI":"10.1371\/journal.pone.0013984","volume":"5","author":"D Merico","year":"2010","unstructured":"Merico, D. et al. Enrichment map: a network-based method for gene-set enrichment visualization and interpretation. PLoS ONE 5, e13984 (2010).","journal-title":"PLoS ONE"},{"key":"1973_CR109","doi-asserted-by":"crossref","first-page":"W191","DOI":"10.1093\/nar\/gkz369","volume":"47","author":"U Raudvere","year":"2019","unstructured":"Raudvere, U. et al. g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Res. 47, W191\u2013W198 (2019).","journal-title":"Nucleic Acids Res."},{"key":"1973_CR110","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","volume":"30","author":"A Kramer","year":"2014","unstructured":"Kramer, A. et al. Causal analysis approaches in Ingenuity Pathway Analysis. Bioinformatics 30, 523\u2013530 (2014).","journal-title":"Bioinformatics"},{"key":"1973_CR111","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuron.2016.05.016","volume":"91","author":"AS Saab","year":"2016","unstructured":"Saab, A. S. et al. Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism. Neuron 91, 119\u2013132 (2016).","journal-title":"Neuron"},{"key":"1973_CR112","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.expneurol.2015.10.006","volume":"276","author":"I Micu","year":"2016","unstructured":"Micu, I. et al. The molecular physiology of the axo-myelinic synapse. Exp. Neurol. 276, 41\u201350 (2016).","journal-title":"Exp. Neurol."},{"key":"1973_CR113","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41586-021-04369-3","volume":"603","author":"AC Yang","year":"2022","unstructured":"Yang, A. C. et al. A human brain vascular atlas reveals diverse mediators of Alzheimer\u2019s risk. Nature 603, 885\u2013892 (2022).","journal-title":"Nature"},{"key":"1973_CR114","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25, 25\u201329 (2000).","journal-title":"Nat. Genet."},{"key":"1973_CR115","doi-asserted-by":"crossref","first-page":"D687","DOI":"10.1093\/nar\/gkab1028","volume":"50","author":"M Gillespie","year":"2022","unstructured":"Gillespie, M. et al. The reactome pathway knowledgebase 2022. Nucleic Acids Res. 50, D687\u2013D692 (2022).","journal-title":"Nucleic Acids Res."},{"key":"1973_CR116","doi-asserted-by":"crossref","first-page":"W193","DOI":"10.1093\/nar\/gkm226","volume":"35","author":"J Reimand","year":"2007","unstructured":"Reimand, J. et al. g:Profiler\u2013a web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res. 35, W193\u2013W200 (2007).","journal-title":"Nucleic Acids Res."},{"key":"1973_CR117","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","volume":"14","author":"J Reimand","year":"2019","unstructured":"Reimand, J. et al. Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap. Nat. Protoc. 14, 482\u2013517 (2019).","journal-title":"Nat. Protoc."},{"key":"1973_CR118","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41576-023-00586-w","volume":"24","author":"L Heumos","year":"2023","unstructured":"Heumos, L. et al. Best practices for single-cell analysis across modalities. Nat. Rev. Genet. 24, 550\u2013572 (2023).","journal-title":"Nat. Rev. Genet."},{"key":"1973_CR119","doi-asserted-by":"crossref","first-page":"e9923","DOI":"10.15252\/msb.20209923","volume":"17","author":"D Turei","year":"2021","unstructured":"Turei, D. et al. Integrated intra- and intercellular signaling knowledge for multicellular omics analysis. Mol. Syst. Biol. 17, e9923 (2021).","journal-title":"Mol. Syst. Biol."},{"key":"1973_CR120","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler, A. et al. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411\u2013420 (2018).","journal-title":"Nat. Biotechnol."},{"key":"1973_CR121","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuron.2016.09.016","volume":"92","author":"P Yuan","year":"2016","unstructured":"Yuan, P. et al. TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. Neuron 92, 252\u2013264 (2016).","journal-title":"Neuron"},{"key":"1973_CR122","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1083\/jcb.201809107","volume":"218","author":"LK Schroeder","year":"2019","unstructured":"Schroeder, L. K. et al. Dynamic nanoscale morphology of the ER surveyed by STED microscopy. J. Cell Biol. 218, 83\u201396 (2019).","journal-title":"J. Cell Biol."},{"key":"1973_CR123","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cub.2007.01.071","volume":"17","author":"MG Voas","year":"2007","unstructured":"Voas, M. G. et al. \u0251II-spectrin is essential for assembly of the nodes of Ranvier in myelinated axons. Curr. Biol. 17, 562\u2013568 (2007).","journal-title":"Curr. Biol."},{"key":"1973_CR124","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.201308116","volume":"203","author":"C Zhang","year":"2013","unstructured":"Zhang, C. et al. Membrane domain organization of myelinated axons requires \u03b2II spectrin. J. Cell Biol. 203, 437\u2013443 (2013).","journal-title":"J. Cell Biol."},{"key":"1973_CR125","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1523\/JNEUROSCI.3647-17.2018","volume":"38","author":"K Susuki","year":"2018","unstructured":"Susuki, K. et al. Glial \u03b2II spectrin contributes to paranode formation and maintenance. J. Neurosci. 38, 6063\u20136075 (2018).","journal-title":"J. Neurosci."},{"key":"1973_CR126","doi-asserted-by":"crossref","first-page":"E394","DOI":"10.1073\/pnas.1313769110","volume":"111","author":"G Colakoglu","year":"2014","unstructured":"Colakoglu, G. et al. Contactin-1 regulates myelination and nodal\/paranodal domain organization in the central nervous system. Proc. Natl Acad. Sci. USA 111, E394\u2013E403 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1973_CR127","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0896-6273(01)00296-3","volume":"30","author":"ME Boyle","year":"2001","unstructured":"Boyle, M. E. et al. Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve. Neuron 30, 385\u2013397 (2001).","journal-title":"Neuron"},{"key":"1973_CR128","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.1523\/JNEUROSCI.19-17-07516.1999","volume":"19","author":"MN Rasband","year":"1999","unstructured":"Rasband, M. N. et al. Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J. Neurosci. 19, 7516\u20137528 (1999).","journal-title":"J. Neurosci."},{"key":"1973_CR129","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuron.2005.10.019","volume":"48","author":"DL Sherman","year":"2005","unstructured":"Sherman, D. L. et al. Neurofascins are required to establish axonal domains for saltatory conduction. Neuron 48, 737\u2013742 (2005).","journal-title":"Neuron"},{"key":"1973_CR130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/glia.10284","volume":"44","author":"MN Rasband","year":"2003","unstructured":"Rasband, M. N., Taylor, C. M. & Bansal, R. Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons. Glia 44, 173\u2013182 (2003).","journal-title":"Glia"},{"key":"1973_CR131","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/s41588-021-00886-z","volume":"53","author":"MA Cousin","year":"2021","unstructured":"Cousin, M. A. et al. Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome. Nat. Genet. 53, 1006\u20131021 (2021).","journal-title":"Nat. Genet."},{"key":"1973_CR132","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0940-9602(02)80006-1","volume":"184","author":"S Dolapchieva","year":"2002","unstructured":"Dolapchieva, S., Eggers, R. & Kuhnel, W. Expression of neural cell adhesion molecule (NCAM) in the peripheral nerve fibers demonstrated by postembedding immunogold method on ultrathin sections. A preliminary study. Ann. Anat. 184, 137\u2013140 (2002).","journal-title":"Ann. Anat."},{"key":"1973_CR133","doi-asserted-by":"crossref","first-page":"e52378","DOI":"10.7554\/eLife.52378","volume":"9","author":"CH Liu","year":"2020","unstructured":"Liu, C. H. et al. Nodal \u03b2 spectrins are required to maintain Na+ channel clustering and axon integrity. eLife 9, e52378 (2020).","journal-title":"eLife"},{"key":"1973_CR134","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1471-4159.1989.tb10930.x","volume":"52","author":"C Brunner","year":"1989","unstructured":"Brunner, C. et al. Differential ultrastructural localization of myelin basic protein, myelin\/oligodendroglial glycoprotein, and 2\u2032,3\u2032-cyclic nucleotide 3\u2032-phosphodiesterase in the CNS of adult rats. J. Neurochem. 52, 296\u2013304 (1989).","journal-title":"J. Neurochem."},{"key":"1973_CR135","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4067\/S0716-97602013000300004","volume":"46","author":"AD Roth","year":"2013","unstructured":"Roth, A. D. et al. Septin 7: actin cross-organization is required for axonal association of Schwann cells. Biol. Res. 46, 243\u2013249 (2013).","journal-title":"Biol. Res."},{"key":"1973_CR136","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/mcne.2002.1105","volume":"20","author":"O Pavlou","year":"2002","unstructured":"Pavlou, O. et al. Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members. Mol. Cell. Neurosci. 20, 367\u2013381 (2002).","journal-title":"Mol. Cell. Neurosci."},{"key":"1973_CR137","doi-asserted-by":"crossref","first-page":"e202211031","DOI":"10.1083\/jcb.202211031","volume":"222","author":"N Kozar-Gillan","year":"2023","unstructured":"Kozar-Gillan, N. et al. LGI3\/2-ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period. J. Cell Biol. 222, e202211031 (2023).","journal-title":"J. Cell Biol."},{"key":"1973_CR138","doi-asserted-by":"crossref","first-page":"e17119","DOI":"10.7554\/eLife.17119","volume":"5","author":"J Patzig","year":"2016","unstructured":"Patzig, J. et al. Septin\/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction. eLife 5, e17119 (2016).","journal-title":"eLife"},{"key":"1973_CR139","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1523\/JNEUROSCI.2736-20.2020","volume":"41","author":"N Sukhanov","year":"2021","unstructured":"Sukhanov, N. et al. Differential contribution of Cadm1-Cadm3 cell adhesion molecules to peripheral myelinated axons. J. Neurosci. 41, 1393\u20131400 (2021).","journal-title":"J. Neurosci."},{"key":"1973_CR140","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/cm.21736","volume":"80","author":"AK Martens","year":"2023","unstructured":"Martens, A. K. et al. Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice. Cytoskeleton (Hoboken) 80, 290\u2013302 (2023).","journal-title":"Cytoskeleton (Hoboken)"},{"key":"1973_CR141","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cell.2004.11.012","volume":"120","author":"T Yoshimura","year":"2005","unstructured":"Yoshimura, T. et al. GSK-3\u03b2 regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 120, 137\u2013149 (2005).","journal-title":"Cell"},{"key":"1973_CR142","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/jdb7030017","volume":"7","author":"D Oliver","year":"2019","unstructured":"Oliver, D. et al. Integrins have cell-type-specific roles in the development of motor neuron connectivity. J. Dev. Biol. 7, 17 (2019).","journal-title":"J. Dev. Biol."},{"key":"1973_CR143","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18956-x","volume":"11","author":"N Apostolo","year":"2020","unstructured":"Apostolo, N. et al. Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer. Nat. Commun. 11, 5171 (2020).","journal-title":"Nat. Commun."},{"key":"1973_CR144","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.mcn.2012.05.007","volume":"50","author":"A Ray","year":"2012","unstructured":"Ray, A. & Treloar, H. B. IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Mol. Cell. Neurosci. 50, 238\u2013249 (2012).","journal-title":"Mol. Cell. Neurosci."},{"key":"1973_CR145","doi-asserted-by":"crossref","first-page":"7911","DOI":"10.1523\/JNEUROSCI.1314-16.2016","volume":"36","author":"G Vardar","year":"2016","unstructured":"Vardar, G. et al. Distinct functions of syntaxin-1 in neuronal maintenance, synaptic vesicle docking, and fusion in mouse neurons. J. Neurosci. 36, 7911\u20137924 (2016).","journal-title":"J. Neurosci."},{"key":"1973_CR146","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1016\/j.celrep.2020.02.026","volume":"30","author":"P De Rossi","year":"2020","unstructured":"De Rossi, P. et al. Neuronal BIN1 regulates presynaptic neurotransmitter release and memory consolidation. Cell Rep. 30, 3520\u20133535 e7 (2020).","journal-title":"Cell Rep."},{"key":"1973_CR147","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/dneu.22481","volume":"77","author":"PJ Barrecheguren","year":"2017","unstructured":"Barrecheguren, P. J. et al. SNARE proteins play a role in motor axon guidance in vertebrates and invertebrates. Dev. Neurobiol. 77, 963\u2013974 (2017).","journal-title":"Dev. Neurobiol."},{"key":"1973_CR148","doi-asserted-by":"crossref","first-page":"10021","DOI":"10.3390\/ijms221810021","volume":"22","author":"A Parcerisas","year":"2021","unstructured":"Parcerisas, A. et al. The hidden side of NCAM family: NCAM2, a key cytoskeleton organization molecule regulating multiple neural functions. Int. J. Mol. Sci. 22, 10021 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"1973_CR149","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.nbd.2011.01.030","volume":"42","author":"RH King","year":"2011","unstructured":"King, R. H. et al. Ndrg1 in development and maintenance of the myelin sheath. Neurobiol. Dis. 42, 368\u2013380 (2011).","journal-title":"Neurobiol. Dis."},{"key":"1973_CR150","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/glia.24108","volume":"70","author":"D Marechal","year":"2022","unstructured":"Marechal, D. et al. N-myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination. Glia 70, 321\u2013336 (2022).","journal-title":"Glia"},{"key":"1973_CR151","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/dneu.22017","volume":"72","author":"M Higurashi","year":"2012","unstructured":"Higurashi, M. et al. Localized role of CRMP1 and CRMP2 in neurite outgrowth and growth cone steering. Dev. Neurobiol. 72, 1528\u20131540 (2012).","journal-title":"Dev. Neurobiol."},{"key":"1973_CR152","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/glia.23129","volume":"65","author":"T Ishimoto","year":"2017","unstructured":"Ishimoto, T. et al. Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain. Glia 65, 727\u2013739 (2017).","journal-title":"Glia"},{"key":"1973_CR153","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-28720-y","volume":"13","author":"M Meschkat","year":"2022","unstructured":"Meschkat, M. et al. White matter integrity in mice requires continuous myelin synthesis at the inner tongue. Nat. Commun. 13, 1163 (2022).","journal-title":"Nat. Commun."},{"key":"1973_CR154","doi-asserted-by":"crossref","first-page":"6607","DOI":"10.1523\/JNEUROSCI.5147-09.2010","volume":"30","author":"R Thomas","year":"2010","unstructured":"Thomas, R. et al. LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition. J. Neurosci. 30, 6607\u20136612 (2010).","journal-title":"J. Neurosci."},{"key":"1973_CR155","first-page":"2139","volume":"14","author":"V Balaji","year":"2018","unstructured":"Balaji, V. et al. Pathological missorting of endogenous MAPT\/Tau in neurons caused by failure of protein degradation systems. Autophagy 14, 2139\u20132154 (2018).","journal-title":"Autophagy"},{"key":"1973_CR156","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3390\/biom13040594","volume":"13","author":"GI Aparicio","year":"2023","unstructured":"Aparicio, G. I. et al. Endogenous glycoprotein GPM6a is involved in neurite outgrowth in rat dorsal root ganglion neurons. Biomolecules 13, 594 (2023).","journal-title":"Biomolecules"},{"key":"1973_CR157","doi-asserted-by":"crossref","first-page":"102050","DOI":"10.1016\/j.pneurobio.2021.102050","volume":"202","author":"F Schneider","year":"2021","unstructured":"Schneider, F. et al. Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function. Prog. Neurobiol. 202, 102050 (2021).","journal-title":"Prog. Neurobiol."},{"key":"1973_CR158","doi-asserted-by":"crossref","DOI":"10.1038\/srep25828","volume":"6","author":"S Thakurela","year":"2016","unstructured":"Thakurela, S. et al. The transcriptome of mouse central nervous system myelin. Sci. Rep. 6, 25828 (2016).","journal-title":"Sci. Rep."}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41593-025-01973-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41593-025-01973-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41593-025-01973-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T18:03:57Z","timestamp":1751825037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41593-025-01973-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,13]]},"references-count":158,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["1973"],"URL":"https:\/\/doi.org\/10.1038\/s41593-025-01973-8","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,13]]},"assertion":[{"value":"5 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}