{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T23:26:46Z","timestamp":1793575606125,"version":"4.5.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92268204"],"award-info":[{"award-number":["92268204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502855"],"award-info":[{"award-number":["82502855"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Medical Research Fund"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1038\/s41593-026-02422-w","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:02:19Z","timestamp":1789981339000},"page":"2753-2768","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1"],"prefix":"10.1038","volume":"29","author":[{"given":"Zhiqing","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shencai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bochong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0881-6808","authenticated-orcid":false,"given":"Wenquan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9413-0492","authenticated-orcid":false,"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-0302","authenticated-orcid":false,"given":"Weiguo","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-3395","authenticated-orcid":false,"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9335-5147","authenticated-orcid":false,"given":"Qiancheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-4781","authenticated-orcid":false,"given":"Xiaochun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"2422_CR1","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S1474-4422(17)30362-9","volume":"16","author":"WD Johnson","year":"2017","unstructured":"Johnson, W. D. & Griswold, D. P. Traumatic brain injury: a global challenge. Lancet Neurol. 16, 949\u2013950 (2017).","journal-title":"Lancet Neurol."},{"key":"2422_CR2","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.neuron.2012.11.021","volume":"76","author":"K Blennow","year":"2012","unstructured":"Blennow, K., Hardy, J. & Zetterberg, H. The neuropathology and neurobiology of traumatic brain injury. Neuron 76, 886\u2013899 (2012).","journal-title":"Neuron"},{"key":"2422_CR3","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","volume":"21","author":"AIR Maas","year":"2022","unstructured":"Maas, A. I. R. et al. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol. 21, 1004\u20131060 (2022).","journal-title":"Lancet Neurol."},{"key":"2422_CR4","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.neuron.2017.07.010","volume":"95","author":"YN Jassam","year":"2017","unstructured":"Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B. & El Khoury, J. Neuroimmunology of traumatic brain injury: time for a paradigm shift. Neuron 95, 1246\u20131265 (2017).","journal-title":"Neuron"},{"key":"2422_CR5","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","volume":"21","author":"A Salhotra","year":"2020","unstructured":"Salhotra, A., Shah, H. N., Levi, B. & Longaker, M. T. Mechanisms of bone development and repair. Nat. Rev. Mol. Cell Biol. 21, 696\u2013711 (2020).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2422_CR6","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/nm1593","volume":"13","author":"M Zaidi","year":"2007","unstructured":"Zaidi, M. Skeletal remodeling in health and disease. Nat. Med. 13, 791\u2013801 (2007).","journal-title":"Nat. Med."},{"key":"2422_CR7","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.cmet.2024.04.008","volume":"36","author":"M Zaidi","year":"2024","unstructured":"Zaidi, M., Zaidi, S. & Yuen, T. Understanding osteokine biology. Cell Metab. 36, 888\u2013890 (2024).","journal-title":"Cell Metab."},{"key":"2422_CR8","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1172\/JCI18399","volume":"112","author":"M Riminucci","year":"2003","unstructured":"Riminucci, M. et al. FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J. Clin. Invest. 112, 683\u2013692 (2003).","journal-title":"J. Clin. Invest."},{"key":"2422_CR9","doi-asserted-by":"publisher","first-page":"e1008361","DOI":"10.1371\/journal.pgen.1008361","volume":"16","author":"CR Diegel","year":"2020","unstructured":"Diegel, C. R. et al. An osteocalcin-deficient mouse strain without endocrine abnormalities. PLoS Genetics 16, e1008361 (2020).","journal-title":"PLoS Genetics"},{"key":"2422_CR10","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s42255-024-00989-x","volume":"6","author":"T Shi","year":"2024","unstructured":"Shi, T. et al. Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer\u2019s disease progression. Nature Metab. 6, 531\u2013549 (2024).","journal-title":"Nature Metab."},{"key":"2422_CR11","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nature21697","volume":"543","author":"I Mosialou","year":"2017","unstructured":"Mosialou, I. et al. MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature 543, 385\u2013390 (2017).","journal-title":"Nature"},{"key":"2422_CR12","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.cmet.2024.03.006","volume":"36","author":"W Liang","year":"2024","unstructured":"Liang, W. et al. An integrated multi-omics analysis reveals osteokines involved in global regulation. Cell Metab. 36, 1144\u20131163.e1147 (2024).","journal-title":"Cell Metab."},{"key":"2422_CR13","doi-asserted-by":"publisher","first-page":"282","DOI":"10.2106\/JBJS.G.01613","volume":"91","author":"D Cadosch","year":"2009","unstructured":"Cadosch, D. et al. Humoral factors enhance fracture-healing and callus formation in patients with traumatic brain injury. J. Bone Joint Surg. Am. 91, 282\u2013288 (2009).","journal-title":"J. Bone Joint Surg. Am."},{"key":"2422_CR14","doi-asserted-by":"publisher","first-page":"689","DOI":"10.5435\/00124635-200911000-00003","volume":"17","author":"CA Cipriano","year":"2009","unstructured":"Cipriano, C. A., Pill, S. G. & Keenan, M. A. Heterotopic ossification following traumatic brain injury and spinal cord injury. J. Am. Acad. Orth. Surg. 17, 689\u2013697 (2009).","journal-title":"J. Am. Acad. Orth. Surg."},{"key":"2422_CR15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41413-023-00310-8","volume":"12","author":"W Lu","year":"2024","unstructured":"Lu, W. et al. Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles. Bone Res. 12, 11 (2024).","journal-title":"Bone Res."},{"key":"2422_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26302-y","volume":"12","author":"W Xia","year":"2021","unstructured":"Xia, W. et al. Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors. Nat. Commun. 12, 6043 (2021).","journal-title":"Nat. Commun."},{"key":"2422_CR17","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1210\/er.2012-1026","volume":"34","author":"SL Dallas","year":"2013","unstructured":"Dallas, S. L., Prideaux, M. & Bonewald, L. F. The osteocyte: an endocrine cell\u2026 and more. Endocrine Rev. 34, 658\u2013690 (2013).","journal-title":"Endocrine Rev."},{"key":"2422_CR18","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nrn3407","volume":"14","author":"Y Xiong","year":"2013","unstructured":"Xiong, Y., Mahmood, A. & Chopp, M. Animal models of traumatic brain injury. Nat. Rev. Neurosci. 14, 128\u2013142 (2013).","journal-title":"Nat. Rev. Neurosci."},{"key":"2422_CR19","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/nprot.2006.116","volume":"1","author":"CV Vorhees","year":"2006","unstructured":"Vorhees, C. V. & Williams, M. T. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat. Protoc. 1, 848\u2013858 (2006).","journal-title":"Nat. Protoc."},{"key":"2422_CR20","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.neuron.2015.05.041","volume":"87","author":"PM George","year":"2015","unstructured":"George, P. M. & Steinberg, G. K. Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments. Neuron 87, 297\u2013309 (2015).","journal-title":"Neuron"},{"key":"2422_CR21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nrneurol.2017.13","volume":"13","author":"DW Simon","year":"2017","unstructured":"Simon, D. W. et al. The far-reaching scope of neuroinflammation after traumatic brain injury. Nat. Rev. Neurol. 13, 171\u2013191 (2017).","journal-title":"Nat. Rev. Neurol."},{"key":"2422_CR22","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.it.2021.04.003","volume":"42","author":"AC Bolte","year":"2021","unstructured":"Bolte, A. C. & Lukens, J. R. Neuroimmune cleanup crews in brain injury. Trends Immunol. 42, 480\u2013494 (2021).","journal-title":"Trends Immunol."},{"key":"2422_CR23","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1038\/s41593-022-01199-y","volume":"25","author":"A Zambusi","year":"2022","unstructured":"Zambusi, A. et al. TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury. Nat. Neurosci. 25, 1608\u20131625 (2022).","journal-title":"Nat. Neurosci."},{"key":"2422_CR24","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/nature10812","volume":"483","author":"B Coste","year":"2012","unstructured":"Coste, B. et al. Piezo proteins are pore-forming subunits of mechanically activated channels. Nature 483, 176\u2013181 (2012).","journal-title":"Nature"},{"key":"2422_CR25","doi-asserted-by":"publisher","first-page":"e47454","DOI":"10.7554\/eLife.47454","volume":"8","author":"W Sun","year":"2019","unstructured":"Sun, W. et al. The mechanosensitive Piezo1 channel is required for bone formation. eLife 8, e47454 (2019).","journal-title":"eLife"},{"key":"2422_CR26","doi-asserted-by":"publisher","first-page":"10859","DOI":"10.1038\/s41467-025-65636-9","volume":"16","author":"YJ Hu","year":"2025","unstructured":"Hu, Y. J. et al. Piezo1-mediated mechanotransduction controls osteocyte maturation and dendrite development via a YAP-CCN-Src signaling axis. Nat. Commun. 16, 10859 (2025).","journal-title":"Nat. Commun."},{"key":"2422_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202400061","volume":"4","author":"R Hao","year":"2024","unstructured":"Hao, R. et al. A novel piezo1 agonist promoting mesenchymal stem cell proliferation and osteogenesis to attenuate disuse osteoporosis. Small Science 4, 2400061 (2024).","journal-title":"Small Science"},{"key":"2422_CR28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2202269119","volume":"119","author":"TD Wijerathne","year":"2022","unstructured":"Wijerathne, T. D., Ozkan, A. D. & Lacroix, J. J. Yoda1\u2019s energetic footprint on Piezo1 channels and its modulation by voltage and temperature. Proc. Natl Acad. Sci. USA 119, e2202269119 (2022).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2422_CR29","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cell.2021.12.003","volume":"185","author":"CS Wang","year":"2022","unstructured":"Wang, C. S., Kavalali, E. T. & Monteggia, L. M. BDNF signaling in context: From synaptic regulation to psychiatric disorders. Cell 185, 62\u201376 (2022).","journal-title":"Cell"},{"key":"2422_CR30","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/s41586-023-06436-3","volume":"620","author":"AB Schroer","year":"2023","unstructured":"Schroer, A. B. et al. Platelet factors attenuate inflammation and rescue cognition in ageing. Nature 620, 1071\u20131079 (2023).","journal-title":"Nature"},{"key":"2422_CR31","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41586-023-06492-9","volume":"621","author":"L Chantranupong","year":"2023","unstructured":"Chantranupong, L. et al. Dopamine and glutamate regulate striatal acetylcholine in decision-making. Nature 621, 577\u2013585 (2023).","journal-title":"Nature"},{"key":"2422_CR32","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.3390\/cells9092020","volume":"9","author":"JY Kim","year":"2020","unstructured":"Kim, J. Y. et al. Heat shock protein 70 (HSP70) induction: chaperonotherapy for neuroprotection after brain injury. Cells 9, 2020 (2020).","journal-title":"Cells"},{"key":"2422_CR33","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/jnc.12781","volume":"130","author":"B Eroglu","year":"2014","unstructured":"Eroglu, B. et al. Therapeutic inducers of the HSP70\/HSP110 protect mice against traumatic brain injury. J. Neurochem. 130, 626\u2013641 (2014).","journal-title":"J. Neurochem."},{"key":"2422_CR34","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.immuni.2013.11.010","volume":"39","author":"C Garlanda","year":"2013","unstructured":"Garlanda, C., Dinarello, C. A. & Mantovani, A. The interleukin-1 family: back to the future. Immunity 39, 1003\u20131018 (2013).","journal-title":"Immunity"},{"key":"2422_CR35","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1001\/jama.1997.03550020068040","volume":"278","author":"BD Jordan","year":"1997","unstructured":"Jordan, B. D. et al. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. JAMA 278, 136\u2013140 (1997).","journal-title":"JAMA"},{"key":"2422_CR36","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.neuron.2012.11.020","volume":"76","author":"RW Mahley","year":"2012","unstructured":"Mahley, R. W. & Huang, Y. Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron 76, 871\u2013885 (2012).","journal-title":"Neuron"},{"key":"2422_CR37","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/nature11087","volume":"485","author":"RD Bell","year":"2012","unstructured":"Bell, R. D. et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512\u2013516 (2012).","journal-title":"Nature"},{"key":"2422_CR38","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1126\/science.3283935","volume":"240","author":"RW Mahley","year":"1988","unstructured":"Mahley, R. W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240, 622\u2013630 (1988).","journal-title":"Science"},{"key":"2422_CR39","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.cmet.2022.02.006","volume":"34","author":"K Lu","year":"2022","unstructured":"Lu, K. et al. Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression. Cell Metab. 34, 441\u2013457.e447 (2022).","journal-title":"Cell Metab."},{"key":"2422_CR40","doi-asserted-by":"publisher","first-page":"413","DOI":"10.4103\/1673-5374.245334","volume":"14","author":"HA Kinder","year":"2019","unstructured":"Kinder, H. A., Baker, E. W. & West, F. D. The pig as a preclinical traumatic brain injury model: current models, functional outcome measures, and translational detection strategies. Neural Regen. Res. 14, 413\u2013424 (2019).","journal-title":"Neural Regen. Res."},{"key":"2422_CR41","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nature22067","volume":"544","author":"JM Castellano","year":"2017","unstructured":"Castellano, J. M. et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature 544, 488\u2013492 (2017).","journal-title":"Nature"},{"key":"2422_CR42","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/TA.0000000000001957","volume":"85","author":"Y Suto","year":"2018","unstructured":"Suto, Y. et al. A concomitant bone fracture delays cognitive recovery from traumatic brain injury. J. Trauma Acute Care Surg. 85, 275\u2013284 (2018).","journal-title":"J. Trauma Acute Care Surg."},{"key":"2422_CR43","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1038\/jcbfm.2015.56","volume":"35","author":"SR Shultz","year":"2015","unstructured":"Shultz, S. R. et al. Tibial fracture exacerbates traumatic brain injury outcomes and neuroinflammation in a novel mouse model of multitrauma. J. Cereb. Blood Flow Metab. 35, 1339\u20131347 (2015).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2422_CR44","doi-asserted-by":"publisher","first-page":"e166577","DOI":"10.1172\/JCI166577","volume":"133","author":"HY Dar","year":"2023","unstructured":"Dar, H. Y. et al. Callus \u03b3\u03b4 T cells and microbe-induced intestinal Th17 cells improve fracture healing in mice. J. Clin. Invest. 133, e166577 (2023).","journal-title":"J. Clin. Invest."},{"key":"2422_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1074207","volume":"14","author":"M Haffner-Luntzer","year":"2023","unstructured":"Haffner-Luntzer, M. et al. Altered early immune response after fracture and traumatic brain injury. Front. Immunol. 14, 1074207 (2023).","journal-title":"Front. Immunol."},{"key":"2422_CR46","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1001\/jama.2022.0089","volume":"327","author":"K Bowman","year":"2022","unstructured":"Bowman, K., Matney, C. & Berwick, D. M. Improving traumatic brain injury care and research: a report from the National Academies of Sciences, Engineering, and Medicine. JAMA 327, 419\u2013420 (2022).","journal-title":"JAMA"},{"key":"2422_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7514","volume":"6","author":"T Matsuda","year":"2015","unstructured":"Matsuda, T. et al. TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nature Commun. 6, 6514 (2015).","journal-title":"Nature Commun."},{"key":"2422_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7606","volume":"6","author":"KO Cho","year":"2015","unstructured":"Cho, K. O. et al. Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nat. Commun. 6, 6606 (2015).","journal-title":"Nat. Commun."},{"key":"2422_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113372","volume":"331","author":"JB Redell","year":"2020","unstructured":"Redell, J. B. et al. Traumatic brain injury and hippocampal neurogenesis: Functional implications. Exp. Neurol. 331, 113372 (2020).","journal-title":"Exp. Neurol."},{"key":"2422_CR50","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/B978-0-444-63521-1.00049-2","volume":"128","author":"J Grafman","year":"2015","unstructured":"Grafman, J. & Salazar, A. M. The ebb and flow of traumatic brain injury research. Handbook Clin. Neurol. 128, 795\u2013802 (2015).","journal-title":"Handbook Clin. Neurol."},{"key":"2422_CR51","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.cell.2019.01.044","volume":"176","author":"MT Joy","year":"2019","unstructured":"Joy, M. T. et al. CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury. Cell 176, 1143\u20131157.e1113 (2019).","journal-title":"Cell"},{"key":"2422_CR52","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/d41586-018-05155-4","volume":"557","author":"N Gray","year":"2018","unstructured":"Gray, N., Le Bot, N. & Heemels, M. T. Regeneration. Nature 557, 321 (2018).","journal-title":"Nature"},{"key":"2422_CR53","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1016\/j.cmet.2022.09.025","volume":"34","author":"X Lv","year":"2022","unstructured":"Lv, X., Gao, F. & Cao, X. Skeletal interoception in bone homeostasis and pain. Cell Metab. 34, 1914\u20131931 (2022).","journal-title":"Cell Metab."},{"key":"2422_CR54","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.tem.2010.02.004","volume":"21","author":"A Zengin","year":"2010","unstructured":"Zengin, A., Zhang, L., Herzog, H., Baldock, P. A. & Sainsbury, A. Neuropeptide Y and sex hormone interactions in humoral and neuronal regulation of bone and fat. Trends Endocrinol. Metab. 21, 411\u2013418 (2010).","journal-title":"Trends Endocrinol. Metab."},{"key":"2422_CR55","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3803\/EnM.2023.1895","volume":"39","author":"JK Nowicki","year":"2024","unstructured":"Nowicki, J. K. & Jakubowska-Pietkiewicz, E. Osteocalcin: beyond bones. Endocrinol. Metab. 39, 399\u2013406 (2024).","journal-title":"Endocrinol. Metab."},{"key":"2422_CR56","doi-asserted-by":"publisher","unstructured":"Gao, F. et al. Mechanical loading-induced change of bone homeostasis is mediated by PGE2-driven hypothalamic interoception. Res. Square https:\/\/doi.org\/10.21203\/rs.3.rs-3325498\/v1 (2023).","DOI":"10.21203\/rs.3.rs-3325498\/v1"},{"key":"2422_CR57","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.bone.2012.10.013","volume":"54","author":"J Klein-Nulend","year":"2013","unstructured":"Klein-Nulend, J., Bakker, A. D., Bacabac, R. G., Vatsa, A. & Weinbaum, S. Mechanosensation and transduction in osteocytes. Bone 54, 182\u2013190 (2013).","journal-title":"Bone"},{"key":"2422_CR58","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.clinbiomech.2008.12.007","volume":"24","author":"T Wehner","year":"2009","unstructured":"Wehner, T., Claes, L. & Simon, U. Internal loads in the human tibia during gait. Clin. Biomech. 24, 299\u2013302 (2009).","journal-title":"Clin. Biomech."},{"key":"2422_CR59","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1016\/j.jbiomech.2007.05.024","volume":"40","author":"S Sasimontonkul","year":"2007","unstructured":"Sasimontonkul, S., Bay, B. K. & Pavol, M. J. Bone contact forces on the distal tibia during the stance phase of running. J. Biomech. 40, 3503\u20133509 (2007).","journal-title":"J. Biomech."},{"key":"2422_CR60","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1089\/neu.2012.2498","volume":"29","author":"B Mouzon","year":"2012","unstructured":"Mouzon, B. et al. Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes. J. Neurotrauma 29, 2761\u20132773 (2012).","journal-title":"J. Neurotrauma"},{"key":"2422_CR61","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1089\/neu.2018.6303","volume":"36","author":"HA Kinder","year":"2019","unstructured":"Kinder, H. A. et al. Traumatic brain injury results in dynamic brain structure changes leading to acute and chronic motor function deficits in a pediatric piglet model. J. Neurotrauma 36, 2930\u20132942 (2019).","journal-title":"J. Neurotrauma"},{"key":"2422_CR62","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1089\/neu.2012.2594","volume":"30","author":"S Sullivan","year":"2013","unstructured":"Sullivan, S. et al. Behavioral deficits and axonal injury persistence after rotational head injury are direction dependent. J. Neurotrauma 30, 538\u2013545 (2013).","journal-title":"J. Neurotrauma"},{"key":"2422_CR63","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1089\/neu.2013.2913","volume":"30","author":"S Sullivan","year":"2013","unstructured":"Sullivan, S. et al. Improved behavior, motor, and cognition assessments in neonatal piglets. J. Neurotrauma 30, 1770\u20131779 (2013).","journal-title":"J. Neurotrauma"},{"key":"2422_CR64","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nm.4312","volume":"23","author":"T Shichita","year":"2017","unstructured":"Shichita, T. et al. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat. Med. 23, 723\u2013732 (2017).","journal-title":"Nat. Med."},{"key":"2422_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03124-z","volume":"9","author":"O Duchamp de Lageneste","year":"2018","unstructured":"Duchamp de Lageneste, O. et al. Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nat. Commun. 9, 773 (2018).","journal-title":"Nat. Commun."},{"key":"2422_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22842-5","volume":"12","author":"A Julien","year":"2021","unstructured":"Julien, A. et al. Direct contribution of skeletal muscle mesenchymal progenitors to bone repair. Nat. Commun. 12, 2860 (2021).","journal-title":"Nat. Commun."},{"key":"2422_CR67","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jneumeth.2017.05.020","volume":"286","author":"A Kaar","year":"2017","unstructured":"Kaar, A., Morley, S. J. & Rae, M. G. An efficient and cost-effective method of generating postnatal (P2-5) mouse primary hippocampal neuronal cultures. J. Neurosci. Methods 286, 69\u201377 (2017).","journal-title":"J. Neurosci. Methods"},{"key":"2422_CR68","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nm.2617","volume":"18","author":"G Zhang","year":"2012","unstructured":"Zhang, G. et al. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nat. Med. 18, 307\u2013314 (2012).","journal-title":"Nat. Med."}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41593-026-02422-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41593-026-02422-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41593-026-02422-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T23:04:39Z","timestamp":1793574279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41593-026-02422-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":68,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["2422"],"URL":"https:\/\/doi.org\/10.1038\/s41593-026-02422-w","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"24 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}