{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:33:34Z","timestamp":1793298814404,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Protoc"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1038\/s41596-026-01338-w","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:02:25Z","timestamp":1774267345000},"page":"4347-4376","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preparation of an activatable benzothiadiazole-based nanoprobe for multispectral optoacoustic and NIR-II fluorescence dual-mode imaging of liver injury"],"prefix":"10.1038","volume":"21","author":[{"given":"Yinglong","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8729-6865","authenticated-orcid":false,"given":"Chaobang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6739-0694","authenticated-orcid":false,"given":"Shuizhu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-8360","authenticated-orcid":false,"given":"Yanli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"1338_CR1","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/nrclinonc.2014.134","volume":"11","author":"TE Yankeelov","year":"2014","unstructured":"Yankeelov, T. E., Abramson, R. G. & Quarles, C. C. Quantitative multimodality imaging in cancer research and therapy. Nat. Rev. Clin. Oncol. 11, 670\u2013680 (2014).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"1338_CR2","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.1039\/C8CS00234G","volume":"47","author":"S He","year":"2018","unstructured":"He, S., Song, J., Qu, J. & Cheng, Z. Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics. Chem. Soc. Rev. 47, 4258\u20134278 (2018).","journal-title":"Chem. Soc. Rev."},{"key":"1338_CR3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/s41566-024-01391-5","volume":"18","author":"F Wang","year":"2024","unstructured":"Wang, F. et al. In vivo NIR-II fluorescence imaging for biology and medicine. Nat. Photon. 18, 535\u2013547 (2024).","journal-title":"Nat. Photon."},{"key":"1338_CR4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s43586-024-00301-x","volume":"4","author":"EL Schmidt","year":"2024","unstructured":"Schmidt, E. L. et al. Near-infrared II fluorescence imaging. Nat. Rev. Methods Primers 4, 23 (2024).","journal-title":"Nat. Rev. Methods Primers"},{"key":"1338_CR5","doi-asserted-by":"publisher","first-page":"10111","DOI":"10.1002\/anie.201913149","volume":"59","author":"J Ouyang","year":"2020","unstructured":"Ouyang, J. et al. Nanoaggregate probe for breast cancer metastasis through multispectral optoacoustic tomography and aggregation-induced NIR-I\/II fluorescence imaging. Angew. Chem. Int. Ed. 59, 10111\u201310121 (2020).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1338_CR6","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1038\/s41596-024-00983-3","volume":"19","author":"Y Chen","year":"2024","unstructured":"Chen, Y., Yang, Y. & Zhang, F. Noninvasive in vivo microscopy of single neutrophils in the mouse brain via NIR-II fluorescent nanomaterials. Nat. Protoc. 19, 2386\u20132407 (2024).","journal-title":"Nat. Protoc."},{"key":"1338_CR7","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1126\/science.1216210","volume":"335","author":"LV Wang","year":"2012","unstructured":"Wang, L. V. & Hu, S. Photoacoustic tomography: in vivo imaging from organelles to organs. Science 335, 1458\u20131462 (2012).","journal-title":"Science"},{"key":"1338_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39610-2","volume":"14","author":"Y Wu","year":"2023","unstructured":"Wu, Y. et al. Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging. Nat. Commun. 14, 3918 (2023).","journal-title":"Nat. Commun."},{"key":"1338_CR9","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nphoton.2015.29","volume":"9","author":"A Taruttis","year":"2015","unstructured":"Taruttis, A. & Ntziachristos, V. Advances in real-time multispectral optoacoustic imaging and its applications. Nat. Photon. 9, 219\u2013227 (2015).","journal-title":"Nat. Photon."},{"key":"1338_CR10","doi-asserted-by":"publisher","first-page":"1807960","DOI":"10.1002\/adfm.201807960","volume":"29","author":"Y Wu","year":"2019","unstructured":"Wu, Y. et al. A nanoprobe for diagnosing and mapping lymphatic metastasis of tumor using 3D multispectral optoacoustic tomography owing to aggregation\/deaggregation induced spectral change. Adv. Funct. Mater. 29, 1807960 (2019).","journal-title":"Adv. Funct. Mater."},{"key":"1338_CR11","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/nprot.2011.351","volume":"6","author":"D Razansky","year":"2011","unstructured":"Razansky, D., Buehler, A. & Ntziachristos, V. Volumetric real-time multispectral optoacoustic tomography of biomarkers. Nat. Protoc. 6, 1121\u20131129 (2011).","journal-title":"Nat. Protoc."},{"key":"1338_CR12","doi-asserted-by":"publisher","first-page":"1902504","DOI":"10.1002\/adma.201902504","volume":"31","author":"B Guo","year":"2019","unstructured":"Guo, B. et al. Precise deciphering of brain vasculatures and microscopic tumors with dual NIR-II fluorescence and photoacoustic imaging. Adv. Mater. 31, 1902504 (2019).","journal-title":"Adv. Mater."},{"key":"1338_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202418378","volume":"64","author":"B Hu","year":"2025","unstructured":"Hu, B. et al. NIR-II fluorescence\/photoacoustic dual ratiometric probes with unique recognition site for quantitatively visualizing H2S2 in vivo. Angew. Chem. Int. Ed. 64, e202418378 (2025).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1338_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.458","volume":"5","author":"M Liang","year":"2024","unstructured":"Liang, M. et al. Furan-modified thiadiazolo quinoxaline as an electron acceptor for constructing second near-infrared aggregation-induced emission fluorophores for beyond 1300 nm fluorescence\/photoacoustic imaging and photothermal therapy. Aggregate 5, e458 (2024).","journal-title":"Aggregate"},{"key":"1338_CR15","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1021\/jacs.7b10334","volume":"140","author":"Q Yang","year":"2018","unstructured":"Yang, Q. et al. Donor engineering for NIR-II molecular fluorophores with enhanced fluorescent performance. J. Am. Chem. Soc. 140, 1715\u20131724 (2018).","journal-title":"J. Am. Chem. Soc."},{"key":"1338_CR16","doi-asserted-by":"publisher","first-page":"13681","DOI":"10.1021\/acsnano.0c05885","volume":"14","author":"S Li","year":"2020","unstructured":"Li, S. et al. In vivo real-time pharmaceutical evaluations of near-infrared II fluorescent nanomedicine bound polyethylene glycol ligands for tumor photothermal ablation. ACS Nano 14, 13681\u201313690 (2020).","journal-title":"ACS Nano"},{"key":"1338_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15269","volume":"8","author":"AL Antaris","year":"2017","unstructured":"Antaris, A. L. et al. A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging. Nat. Commun. 8, 15269 (2017).","journal-title":"Nat. Commun."},{"key":"1338_CR18","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1016\/j.chempr.2019.07.015","volume":"5","author":"J Qi","year":"2019","unstructured":"Qi, J. et al. Boosting fluorescence\u2013photoacoustic\u2013Raman properties in one fluorophore for precise cancer surgery. Chem 5, 2657\u20132677 (2019).","journal-title":"Chem"},{"key":"1338_CR19","doi-asserted-by":"publisher","first-page":"1706856","DOI":"10.1002\/adma.201706856","volume":"30","author":"J Qi","year":"2018","unstructured":"Qi, J. et al. Real-time and high-resolution bioimaging with bright aggregation-induced emission dots in short-wave infrared region. Adv. Mater. 30, 1706856 (2018).","journal-title":"Adv. Mater."},{"key":"1338_CR20","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/s41565-024-01618-0","volume":"19","author":"B Li","year":"2024","unstructured":"Li, B. et al. Photothermal therapy of tuberculosis using targeting pre-activated macrophage membrane-coated nanoparticles. Nat. Nanotechnol. 19, 834\u2013845 (2024).","journal-title":"Nat. Nanotechnol."},{"key":"1338_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06499-1","volume":"9","author":"Y Wu","year":"2018","unstructured":"Wu, Y. et al. Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography. Nat. Commun. 9, 3983 (2018).","journal-title":"Nat. Commun."},{"key":"1338_CR22","doi-asserted-by":"publisher","first-page":"2310818","DOI":"10.1002\/adfm.202310818","volume":"34","author":"Z Hu","year":"2024","unstructured":"Hu, Z., Feng, L. & Yang, P. 2,1,3-Benzothiadiazole derivative small molecule fluorophores for NIR-II bioimaging. Adv. Funct. Mater. 34, 2310818 (2024).","journal-title":"Adv. Funct. Mater."},{"key":"1338_CR23","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1176\/appi.ajp.2013.13050709","volume":"171","author":"CS Voican","year":"2014","unstructured":"Voican, C. S., Corruble, E., Naveau, S. & Perlemuter, G. Antidepressant-induced liver injury: a review for clinicians. Am. J. Psychiat. 171, 404\u2013415 (2014).","journal-title":"Am. J. Psychiat."},{"key":"1338_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-230X-14-12","volume":"14","author":"Y Liu","year":"2014","unstructured":"Liu, Y. et al. Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. BMC Gastroenterol. 14, 12 (2014).","journal-title":"BMC Gastroenterol."},{"key":"1338_CR25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000450878","volume":"24","author":"S Carvalhana","year":"2017","unstructured":"Carvalhana, S. et al. Acute liver failure due to trazodone and diazepam. GE Port. J. Gastroenterol. 24, 40\u201342 (2017).","journal-title":"GE Port. J. Gastroenterol."},{"key":"1338_CR26","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1053\/j.gastro.2008.06.048","volume":"135","author":"KH Moon","year":"2008","unstructured":"Moon, K. H. et al. Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion. Gastroenterology 135, 1344\u20131357 (2008).","journal-title":"Gastroenterology"},{"key":"1338_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15095-1","volume":"11","author":"Y Li","year":"2020","unstructured":"Li, Y. et al. Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels. Nat. Commun. 11, 1255 (2020).","journal-title":"Nat. Commun."},{"key":"1338_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10056-9","volume":"10","author":"S Gao","year":"2019","unstructured":"Gao, S. et al. Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics. Nat. Commun. 10, 2206 (2019).","journal-title":"Nat. Commun."},{"key":"1338_CR29","doi-asserted-by":"publisher","first-page":"11718","DOI":"10.1021\/acs.chemrev.5b00263","volume":"115","author":"J Mei","year":"2015","unstructured":"Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y. & Tang, B. Z. Aggregation-induced emission: together we shine, united we soar!. Chem. Rev. 115, 11718\u201311940 (2015).","journal-title":"Chem. Rev."},{"key":"1338_CR30","doi-asserted-by":"publisher","first-page":"9812","DOI":"10.1002\/anie.201913249","volume":"59","author":"Z Guo","year":"2020","unstructured":"Guo, Z., Yan, C. & Zhu, W. H. High-performance quinoline-malononitrile core as a building block for the diversity-oriented synthesis of AIEgens. Angew. Chem. Int. Ed. 59, 9812\u20139825 (2020).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1338_CR31","doi-asserted-by":"publisher","first-page":"5429","DOI":"10.1002\/adma.201401356","volume":"26","author":"J Mei","year":"2014","unstructured":"Mei, J. et al. Aggregation-induced emission: the whole is more brilliant than the parts. Adv. Mater. 26, 5429\u20135479 (2014).","journal-title":"Adv. Mater."},{"key":"1338_CR32","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1039\/C9SC06567A","volume":"11","author":"Y Li","year":"2020","unstructured":"Li, Y. et al. Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm. Chem. Sci. 11, 2621\u20132626 (2020).","journal-title":"Chem. Sci."},{"key":"1338_CR33","doi-asserted-by":"publisher","first-page":"6083","DOI":"10.1002\/adma.201301938","volume":"25","author":"D Ding","year":"2013","unstructured":"Ding, D. et al. Ultrabright organic dots with aggregation-induced emission characteristics for real-time two-photon intravital vasculature imaging. Adv. Mater. 25, 6083\u20136088 (2013).","journal-title":"Adv. Mater."},{"key":"1338_CR34","doi-asserted-by":"publisher","first-page":"8125","DOI":"10.1002\/anie.201803535","volume":"57","author":"KM Harmatys","year":"2018","unstructured":"Harmatys, K. M. et al. Multipronged biomimetic approach to create optically tunable nanoparticles. Angew. Chem. Int. Ed. 57, 8125\u20138129 (2018).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1338_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202503850","volume":"64","author":"Y Wu","year":"2025","unstructured":"Wu, Y. et al. Unnatural triggers converted from tetrazine-attached sialic acid for activation of optoacoustic imaging-guided cancer theranostics. Angew. Chem. Int. Ed. 64, e202503850 (2025).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1338_CR36","doi-asserted-by":"publisher","first-page":"215907","DOI":"10.1016\/j.ccr.2024.215907","volume":"514","author":"W Pan","year":"2024","unstructured":"Pan, W. et al. Recent advances in NIR-II fluorescence\/photoacoustic dual-modality imaging probes. Coord. Chem. Rev. 514, 215907 (2024).","journal-title":"Coord. Chem. Rev."},{"key":"1338_CR37","doi-asserted-by":"publisher","first-page":"0010","DOI":"10.1038\/s41551-016-0010","volume":"1","author":"G Hong","year":"2017","unstructured":"Hong, G., Antaris, A. L. & Dai, H. Near-infrared fluorophores for biomedical imaging. Nat. Biomed. Eng. 1, 0010 (2017).","journal-title":"Nat. Biomed. Eng."},{"key":"1338_CR38","doi-asserted-by":"publisher","first-page":"e202209512","DOI":"10.1002\/anie.202209512","volume":"61","author":"Y Wang","year":"2022","unstructured":"Wang, Y., Hu, Y. & Ye, D. Activatable multimodal probes for in vivo imaging and theranostics. Angew. Chem. Int. Ed. 61, e202209512 (2022).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1338_CR39","doi-asserted-by":"publisher","first-page":"1600481","DOI":"10.1002\/advs.201600481","volume":"4","author":"Y Lyu","year":"2017","unstructured":"Lyu, Y. & Pu, K. Recent advances of activatable molecular probes based on semiconducting polymer nanoparticles in sensing and imaging. Adv. Sci. 4, 1600481 (2017).","journal-title":"Adv. Sci."},{"key":"1338_CR40","doi-asserted-by":"publisher","first-page":"7924","DOI":"10.1039\/D1CS00358E","volume":"50","author":"Y Wu","year":"2021","unstructured":"Wu, Y., Zeng, F., Zhao, Y. & Wu, S. Emerging contrast agents for multispectral optoacoustic imaging and their biomedical applications. Chem. Soc. Rev. 50, 7924\u20137940 (2021).","journal-title":"Chem. Soc. Rev."},{"key":"1338_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27233-4","volume":"12","author":"J Chen","year":"2021","unstructured":"Chen, J. et al. A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging. Nat. Commun. 12, 6870 (2021).","journal-title":"Nat. Commun."},{"key":"1338_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.564","volume":"5","author":"Z Li","year":"2024","unstructured":"Li, Z. et al. Bioinspired menstrual blood-derived stem cells-conditioned medium\/polymersome nanoparticles for the treatment of carbon tetrachloride-induced acute liver failure in mice. Aggregate 5, e564 (2024).","journal-title":"Aggregate"},{"key":"1338_CR43","doi-asserted-by":"publisher","first-page":"124","DOI":"10.4103\/1319-3767.61244","volume":"16","author":"FM Sanai","year":"2010","unstructured":"Sanai, F. M. & Keeffe, E. B. Liver biopsy for histological assessment: the case against. Saudi J. Gastroenterol. 16, 124\u2013132 (2010).","journal-title":"Saudi J. Gastroenterol."},{"key":"1338_CR44","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.2967\/jnumed.117.206961","volume":"59","author":"J Salas","year":"2018","unstructured":"Salas, J. et al. Noninvasive imaging of drug-induced liver injury with 18F-DFA PET. J. Nucl. Med. 59, 1308\u20131315 (2018).","journal-title":"J. Nucl. Med."},{"key":"1338_CR45","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1002\/jmri.26057","volume":"48","author":"K Hueper","year":"2018","unstructured":"Hueper, K. et al. Assessment of liver ischemia reperfusion injury in mice using hepatic T2 mapping: comparison with histopathology. J. Magn. Reson. Imaging 48, 1586\u20131594 (2018).","journal-title":"J. Magn. Reson. Imaging"},{"key":"1338_CR46","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202406694","volume":"63","author":"C Zhang","year":"2024","unstructured":"Zhang, C. et al. Structurally modulated formation of cyanine J-aggregates with sharp and tunable spectra for multiplexed optoacoustic and fluorescence bioimaging. Angew. Chem. Int. Ed. 63, e202406694 (2024).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1338_CR47","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1038\/s41596-018-0041-6","volume":"13","author":"H Zhu","year":"2018","unstructured":"Zhu, H. et al. Synthesis of an ultrasensitive BODIPY-derived fluorescent probe for detecting HOCl in live cells. Nat. Protoc. 13, 2348\u20132361 (2018).","journal-title":"Nat. Protoc."},{"key":"1338_CR48","doi-asserted-by":"publisher","first-page":"26546","DOI":"10.1021\/acsomega.5c00613","volume":"10","author":"VVB Muccelin","year":"2025","unstructured":"Muccelin, V. V. B. et al. Stability-focused nanoparticle development: applying particle size stability as a response factor in the design of experiments. ACS Omega 10, 26546\u201326550 (2025).","journal-title":"ACS Omega"}],"container-title":["Nature Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41596-026-01338-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41596-026-01338-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41596-026-01338-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:02:41Z","timestamp":1788444161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41596-026-01338-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["1338"],"URL":"https:\/\/doi.org\/10.1038\/s41596-026-01338-w","relation":{},"ISSN":["1754-2189","1750-2799"],"issn-type":[{"value":"1754-2189","type":"print"},{"value":"1750-2799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"27 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}