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T.S., M.A. and F.H. are employed by Nextcea, Inc., which holds patent rights to the di-22:6-BMP and 2,2\u2032-di-22:6-BMP biomarkers for neurological diseases involving lysosomal dysfunction (US: 8,313,949; Japan: 5,702,363; and Europe: EP2419742). All other authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"A subset of patient samples that were used in Gomes et al. (2023) were additionally used in this work. All participants gave written informed consent. All relevant ethics committees including the Comite Etico de Investigacion Clinica del Area Sanitaria de Gipuzkoa, Donostia Ospitalea, San Sebastian, Spain (JRM-LRR-2018-01); the Comite Etico de Investigacion Clinica del Hospital Clinic de Barcelona, Spain (CPMP\/ICH\/135\/95); the Ethics Committee of the Medical University of Vienna, Austria (EK Nr: 1844\/2019); and the North East - Newcastle & North Tyneside 2 Research Ethics Committee, United Kingdom (20\/YH\/0081) gave ethical approval for this work.","order":2,"name":"Ethics","label":"Ethics declarations","group":{"name":"EthicsHeading","label":"Ethics"}}]}}