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M.A.E., M.A.M., W.L., C.W., Z.L., Y. Li and Y. Lai are the inventors on those patents. L.F., J. Lai, J. Li, Y. Lai, L.W., Y.Z., C.L., L.L. and M.A.E. are BGI employees. All other authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}