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However, there remain important knowledge gaps in our understanding of this property in healthy and diseased skeletal muscle, which hinder its translation into clinical application. Here, we report the permittivity of gastrocnemius muscle in healthy wild type mice and murine models of spinal muscular atrophy, muscular dystrophy, diabetes, amyotrophic lateral sclerosis and in a model of myofiber hypertrophy. Data were measured ex vivo from 10\u2009kHz to 1\u2009MHz using the four-electrode impedance technique. Additional quantitative histology information were obtained. Ultimately, the normative data reported will offer the scientific community the opportunity to develop more accurate models for the validation and prediction of experimental observations in both pre-clinical and clinical neuromuscular disease research.<\/jats:p>","DOI":"10.1038\/s41597-019-0045-2","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T11:04:25Z","timestamp":1555585465000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Permittivity of ex vivo healthy and diseased murine skeletal muscle from 10\u2009kHz to 1\u2009MHz"],"prefix":"10.1038","volume":"6","author":[{"given":"J. A.","family":"Nagy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"DiDonato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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Dr. Rutkove is also a member of the company\u2019s Board of Directors. Dr. Sanchez serves as a consultant to Myolex, Inc., and Impedimed, Inc., a company that develop impedance technology for research and clinical use. Dr. Sanchez and Dr. Rutkove are Co-Founders of Haystack Diagnostics, Inc., a company that commercializes needle impedance technology. Haystack Diagnostics, Inc., has the option to license patented needle impedance technology of which Dr. Sanchez and Dr. Rutkove are named inventors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"37"}}