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Using an unbiased genomics approach to identify gene expression changes across the entire longitudinal course of muscle atrophy affords the opportunity to (1) establish acute responses to denervation, (2) detect pathways that mediate rapid loss of muscle mass within the first week after denervation, and (3) capture the molecular phenotype of chronically atrophied muscle at a stage when it is largely resistant to recovery.<\/jats:p>","DOI":"10.1038\/s41597-019-0185-4","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T10:03:28Z","timestamp":1569319408000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Longitudinal RNA-Seq analysis of acute and chronic neurogenic skeletal muscle atrophy"],"prefix":"10.1038","volume":"6","author":[{"given":"Jeffrey T.","family":"Ehmsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riki","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifa","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2105-1061","authenticated-orcid":false,"given":"Giovanni","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1215-3373","authenticated-orcid":false,"given":"Ahmet","family":"H\u00f6ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"185_CR1","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1016\/j.biocel.2013.05.036","volume":"45","author":"O Schakman","year":"2013","unstructured":"Schakman, O., Kalista, S., Barb\u00e9, C., Loumaye, A. & Thissen, J. 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