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Owing to technological limitations, however,\n                    <jats:italic>in vivo<\/jats:italic>\n                    atlases detailing hypothalamic anatomy are currently lacking in the literature. In this work we aim to overcome this shortcoming by generating a high-resolution\n                    <jats:italic>in vivo<\/jats:italic>\n                    anatomical atlas of the human hypothalamic region. A minimum deformation averaging (MDA) pipeline was employed to produce a normalized, high-resolution template from multimodal magnetic resonance imaging (MRI) datasets. This template was used to delineate hypothalamic (n\u2009=\u200913) and extrahypothalamic (n\u2009=\u200912) gray and white matter structures. The reliability of the atlas was evaluated as a measure for voxel-wise volume overlap among raters. Clinical application was demonstrated by superimposing the atlas into datasets of patients diagnosed with a hypothalamic lesion (n\u2009=\u20091) or undergoing hypothalamic (n\u2009=\u20091) and forniceal (n\u2009=\u20091) deep brain stimulation (DBS). The present template serves as a substrate for segmentation of brain structures, specifically those featuring low contrast. Conversely, the segmented hypothalamic atlas may inform DBS programming procedures and may be employed in volumetric studies.\n                  <\/jats:p>","DOI":"10.1038\/s41597-020-00644-6","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T06:03:26Z","timestamp":1600149806000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":143,"title":["A high-resolution in vivo magnetic resonance imaging atlas of the human hypothalamic region"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3153-1045","authenticated-orcid":false,"given":"Clemens","family":"Neudorfer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-8226","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Germann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin J. B.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-5195","authenticated-orcid":false,"given":"Alexandre","family":"Boutet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M.","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"644_CR1","doi-asserted-by":"crossref","unstructured":"Nieuwenhuys, R., Voogd, J. & Huijzen, C. van. The Human Central Nervous System. A Synopsis and Atlas 4th edn (Springer Berlin Heidelberg, 2008).","DOI":"10.1007\/978-3-540-34686-9"},{"key":"644_CR2","unstructured":"Saper, C. B. In The human nervous system (eds. Mai, J. 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