{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:20:06Z","timestamp":1789712406835,"version":"4.0.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Data"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dry eye disease (DED) is a common disease associated with disorder of tear secretion. Research on risk factors for DED, such as depression, arthritis, thyroid disease, stroke and diabetes, is important to facilitate its diagnosis and prognosis. We created a dataset on risk factors for DED (DrDED) with public access that can provide up-to-date and validated data acquired from systematically searched and screened, high-quality studies. The established DrDED contained 119 studies published between 2000 and 2022. The range of the study sample size was from 43 to 4,871,504. The study types were, as follows: cross-sectional (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200992), retrospective cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099), prospective cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), and case-control (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098) studies. Data from eligible studies were collected and presented for the present study, including the publication information, study characteristics, definition and prevalence of the disease, and risk factors for DED, together with the strength of association. With the publication of new relevant studies, the DrDED will be updated, and the data will be made accessible to the users.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td>Design Type(s)<\/jats:td>\n                            <jats:td>Dataset creation objective<\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td>Measurement Type(s)<\/jats:td>\n                            <jats:td>Patient outcome \u2022 scientific publication \u2022 risk factors \u2022 dry eye disease<\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td>Technology Type(s)<\/jats:td>\n                            <jats:td>Digital curation \u2022 documenting \u2022 meta-analysis<\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td>Factor Type(s)<\/jats:td>\n                            <jats:td>Depression \u2022 arthritis \u2022 thyroid disease \u2022 stroke disease \u2022 diabetes<\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td>Sample Characteristic(s)<\/jats:td>\n                            <jats:td>Homo sapiens \u2022 dry eye disease \u2022 global<\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1038\/s41597-023-01931-8","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T04:05:54Z","timestamp":1673409954000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A literature-derived dataset on risk factors for dry eye disease"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3071-2805","authenticated-orcid":false,"given":"Wanju","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuiliang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangcao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7701-5794","authenticated-orcid":false,"given":"Yanning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"1931_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","volume":"5","author":"The definition and classification of dry eye disease","year":"2007","unstructured":"The definition and classification of dry eye disease. report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 5, 75\u201392 (2007).","journal-title":"Ocul Surf."},{"key":"1931_CR2","doi-asserted-by":"publisher","first-page":"Des7","DOI":"10.1167\/iovs.17-23475","volume":"59","author":"J Shimazaki","year":"2018","unstructured":"Shimazaki, J. Definition and Diagnostic Criteria of Dry Eye Disease: Historical Overview and Future Directions. Invest Ophthalmol Vis Sci. 59, Des7\u2013des12 (2018).","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"1931_CR3","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2147\/OPTH.S5555","volume":"3","author":"JL Gayton","year":"2009","unstructured":"Gayton, J. L. Etiology, prevalence, and treatment of dry eye disease. Clin Ophthalmol. 3, 405\u2013412 (2009).","journal-title":"Clin Ophthalmol."},{"key":"1931_CR4","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.4103\/ijo.IJO_1796_20","volume":"69","author":"S Chatterjee","year":"2021","unstructured":"Chatterjee, S., Agrawal, D., Sanowar, G. & Kandoi, R. Prevalence of symptoms of dry eye disease in an urban Indian population. Indian J Ophthalmol. 69, 1061\u20131066 (2021).","journal-title":"Indian J Ophthalmol."},{"key":"1931_CR5","doi-asserted-by":"crossref","unstructured":"Tsubota, K. et al. Defining Dry Eye from a Clinical Perspective. Int J Mol Sci. 21 (2020).","DOI":"10.3390\/ijms21239271"},{"key":"1931_CR6","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1159\/000525696","volume":"65","author":"Y Cai","year":"2022","unstructured":"Cai, Y., Wei, J., Zhou, J. & Zou, W. Prevalence and Incidence of Dry Eye Disease in Asia: A Systematic Review and Meta-Analysis. Ophthalmic Res. 65, 647\u2013658 (2022).","journal-title":"Ophthalmic Res."},{"key":"1931_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jtos.2020.04.005","volume":"19","author":"J Vehof","year":"2021","unstructured":"Vehof, J., Snieder, H., Jansonius, N. & Hammond, C. J. Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands. Ocul Surf. 19, 83\u201393 (2021).","journal-title":"Ocul Surf."},{"key":"1931_CR8","doi-asserted-by":"crossref","unstructured":"Kuo, M. T., Fang, P. C., Kuo, S. F., Chen, A. & Huang, Y. T. Tear Proteomics Study of Dry Eye Disease: Which Eye Do You Adopt as the Representative Eye for the Study? Int J Mol Sci. 22 (2021).","DOI":"10.3390\/ijms22010422"},{"key":"1931_CR9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/ICL.0000000000000687","volume":"47","author":"EJ Kuklinski","year":"2021","unstructured":"Kuklinski, E. J. et al. Associations Between Systemic Omega-3 Fatty Acid Levels With Moderate-to-Severe Dry Eye Disease Signs and Symptoms at Baseline in the Dry Eye Assessment and Management Study. Eye Contact Lens. 47, 2\u20137 (2021).","journal-title":"Eye Contact Lens."},{"key":"1931_CR10","doi-asserted-by":"publisher","first-page":"e1236","DOI":"10.1111\/aos.14782","volume":"99","author":"H Shokr","year":"2021","unstructured":"Shokr, H., Wolffsohn, J. S., Trave Huarte, S., Scarpello, E. & Gherghel, D. Dry eye disease is associated with retinal microvascular dysfunction and possible risk for cardiovascular disease. Acta Ophthalmol. 99, e1236\u2013e1242 (2021).","journal-title":"Acta Ophthalmol."},{"key":"1931_CR11","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/JCP.0000000000001382","volume":"41","author":"JJ Rakofsky","year":"2021","unstructured":"Rakofsky, J. J., Rakofsky, S. I. & Dunlop, B. W. Dry Those Crying Eyes: The Role of Depression and Antidepressants in Dry Eye Disease. J Clin Psychopharmacol. 41, 295\u2013303 (2021).","journal-title":"J Clin Psychopharmacol."},{"key":"1931_CR12","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.jtos.2020.07.016","volume":"18","author":"R Tandon","year":"2020","unstructured":"Tandon, R. et al. Association of dry eye disease and sun exposure in geographically diverse adult (\u226540 years) populations of India: The SEED (sun exposure, environment and dry eye disease) study - Second report of the ICMR-EYE SEE study group. Ocul Surf. 18, 718\u2013730 (2020).","journal-title":"Ocul Surf."},{"key":"1931_CR13","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","volume":"15","author":"JP Craig","year":"2017","unstructured":"Craig, J. P. et al. TFOS DEWS II Definition and Classification Report. Ocul Surf. 15, 276\u2013283 (2017).","journal-title":"Ocul Surf."},{"key":"1931_CR14","first-page":"2746","volume":"60","author":"JP Craig","year":"2019","unstructured":"Craig, J. P. & Wang, M. T. Factors predisposing the Asian eye to dry eye disease. Invest Ophthalmol Vis Sci. 60, 2746 (2019).","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"1931_CR15","doi-asserted-by":"publisher","first-page":"101409","DOI":"10.1016\/j.clae.2021.01.004","volume":"44","author":"MTM Wang","year":"2021","unstructured":"Wang, M. T. M., Muntz, A., Mamidi, B., Wolffsohn, J. S. & Craig, J. P. Modifiable lifestyle risk factors for dry eye disease. Cont Lens Anterior Eye. 44, 101409 (2021).","journal-title":"Cont Lens Anterior Eye."},{"key":"1931_CR16","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.c.6009355.v1","author":"Yang","year":"2022","unstructured":"Yang, et al. DrDED, a dataset on literature on risk factors for dry eye disease, Figshare., https:\/\/doi.org\/10.6084\/m9.figshare.c.6009355.v1 (2022)."},{"key":"1931_CR17","unstructured":"Higgins, J. P. T. & Altman, D. G. Chapter 8. Assessing risk of bias in included studies. In: Higgins J. P. T., Green S. 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