{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:40:43Z","timestamp":1760013643685,"version":"build-2065373602"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Data"],"DOI":"10.1038\/s41597-025-05914-9","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:17:33Z","timestamp":1760012253000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive images and serum biomarkers for biliary atresia and other cholestasis in pediatrics"],"prefix":"10.1038","volume":"12","author":[{"given":"Shuyi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongshang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyixue","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiqiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"5914_CR1","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1016\/S0140-6736(09)60946-6","volume":"374","author":"JL Hartley","year":"2009","unstructured":"Hartley, J. L., Davenport, M. & Kelly, D. A. Biliary atresia. Lancet 374, 1704\u20131713, https:\/\/doi.org\/10.1016\/S0140-6736(09)60946-6 (2009).","journal-title":"Lancet"},{"key":"5914_CR2","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.jhep.2016.04.032","volume":"65","author":"HJ Verkade","year":"2016","unstructured":"Verkade, H. J. et al. Biliary atresia and other cholestatic childhood diseases: Advances and future challenges. J Hepatol 65, 631\u2013642, https:\/\/doi.org\/10.1016\/j.jhep.2016.04.032 (2016).","journal-title":"J Hepatol"},{"key":"5914_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41572-024-00533-x","volume":"10","author":"PKH Tam","year":"2024","unstructured":"Tam, P. K. H. et al. Biliary atresia. Nat Rev Dis Primers 10, 47, https:\/\/doi.org\/10.1038\/s41572-024-00533-x (2024).","journal-title":"Nat Rev Dis Primers"},{"key":"5914_CR4","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1002\/hep.29905","volume":"68","author":"JA Bezerra","year":"2018","unstructured":"Bezerra, J. A. et al. Biliary Atresia: Clinical and Research Challenges for the Twenty-First Century. Hepatology 68, 1163\u20131173, https:\/\/doi.org\/10.1002\/hep.29905 (2018).","journal-title":"Hepatology"},{"key":"5914_CR5","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1542\/peds.2008-1949","volume":"123","author":"MO Serinet","year":"2009","unstructured":"Serinet, M. O. et al. Impact of age at Kasai operation on its results in late childhood and adolescence: a rational basis for biliary atresia screening. Pediatrics 123, 1280\u20131286, https:\/\/doi.org\/10.1542\/peds.2008-1949 (2009).","journal-title":"Pediatrics"},{"key":"5914_CR6","doi-asserted-by":"publisher","unstructured":"Liao, F. M. et al. Direct Bilirubin and Risk of Biliary Atresia. Pediatrics 149, https:\/\/doi.org\/10.1542\/peds.2021-053073 (2022).","DOI":"10.1542\/peds.2021-053073"},{"key":"5914_CR7","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1001\/jama.2020.0837","volume":"323","author":"S Harpavat","year":"2020","unstructured":"Harpavat, S. et al. Diagnostic Yield of Newborn Screening for Biliary Atresia Using Direct or Conjugated Bilirubin Measurements. JAMA 323, 1141\u20131150, https:\/\/doi.org\/10.1001\/jama.2020.0837 (2020).","journal-title":"JAMA"},{"key":"5914_CR8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ebiom.2018.07.025","volume":"34","author":"R Dong","year":"2018","unstructured":"Dong, R. et al. Development and Validation of Novel Diagnostic Models for Biliary Atresia in a Large Cohort of Chinese Patients. EBioMedicine 34, 223\u2013230, https:\/\/doi.org\/10.1016\/j.ebiom.2018.07.025 (2018).","journal-title":"EBioMedicine"},{"key":"5914_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s002470050017","volume":"30","author":"AP Tan Kendrick","year":"2000","unstructured":"Tan Kendrick, A. P. et al. Making the diagnosis of biliary atresia using the triangular cord sign and gallbladder length. Pediatr Radiol 30, 69\u201373, https:\/\/doi.org\/10.1007\/s002470050017 (2000).","journal-title":"Pediatr Radiol"},{"key":"5914_CR10","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/s00247-020-04840-9","volume":"51","author":"M Napolitano","year":"2021","unstructured":"Napolitano, M. et al. Practical approach to imaging diagnosis of biliary atresia, Part 1: prenatal ultrasound and magnetic resonance imaging, and postnatal ultrasound. Pediatr Radiol 51, 314\u2013331, https:\/\/doi.org\/10.1007\/s00247-020-04840-9 (2021).","journal-title":"Pediatr Radiol"},{"key":"5914_CR11","doi-asserted-by":"publisher","first-page":"W73","DOI":"10.2214\/AJR.15.15336","volume":"206","author":"L Zhou","year":"2016","unstructured":"Zhou, L. et al. Ultrasound for the Diagnosis of Biliary Atresia: A Meta-Analysis. AJR Am J Roentgenol 206, W73\u201382, https:\/\/doi.org\/10.2214\/AJR.15.15336 (2016).","journal-title":"AJR Am J Roentgenol"},{"key":"5914_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21466-z","volume":"12","author":"W Zhou","year":"2021","unstructured":"Zhou, W. et al. Ensembled deep learning model outperforms human experts in diagnosing biliary atresia from sonographic gallbladder images. Nat Commun 12, 1259, https:\/\/doi.org\/10.1038\/s41467-021-21466-z (2021).","journal-title":"Nat Commun"},{"key":"5914_CR13","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1002\/ijc.34248","volume":"151","author":"Z Jin","year":"2022","unstructured":"Jin, Z. et al. Thy-Wise: An interpretable machine learning model for the evaluation of thyroid nodules. Int J Cancer 151, 2229\u20132243, https:\/\/doi.org\/10.1002\/ijc.34248 (2022).","journal-title":"Int J Cancer"},{"key":"5914_CR14","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1109\/JBHI.2021.3085019","volume":"25","author":"A Saleh","year":"2021","unstructured":"Saleh, A. et al. A Deep Learning Localization Method for Measuring Abdominal Muscle Dimensions in Ultrasound Images. IEEE J Biomed Health Inform 25, 3865\u20133873, https:\/\/doi.org\/10.1109\/JBHI.2021.3085019 (2021).","journal-title":"IEEE J Biomed Health Inform"},{"key":"5914_CR15","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.jacr.2019.06.004","volume":"16","author":"Z Akkus","year":"2019","unstructured":"Akkus, Z. et al. A Survey of Deep-Learning Applications in Ultrasound: Artificial Intelligence-Powered Ultrasound for Improving Clinical Workflow. J Am Coll Radiol 16, 1318\u20131328, https:\/\/doi.org\/10.1016\/j.jacr.2019.06.004 (2019).","journal-title":"J Am Coll Radiol"},{"key":"5914_CR16","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1007\/s00330-019-06407-1","volume":"30","author":"JH Lee","year":"2020","unstructured":"Lee, J. H. et al. Deep learning with ultrasonography: automated classification of liver fibrosis using a deep convolutional neural network. Eur Radiol 30, 1264\u20131273, https:\/\/doi.org\/10.1007\/s00330-019-06407-1 (2020).","journal-title":"Eur Radiol"},{"key":"5914_CR17","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1007\/s00535-020-01725-4","volume":"55","author":"Y Minoda","year":"2020","unstructured":"Minoda, Y. et al. Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors. J Gastroenterol 55, 1119\u20131126, https:\/\/doi.org\/10.1007\/s00535-020-01725-4 (2020).","journal-title":"J Gastroenterol"},{"key":"5914_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/00005176-200408000-00001","volume":"39","author":"V Moyer","year":"2004","unstructured":"Moyer, V. et al. Guideline for the evaluation of cholestatic jaundice in infants: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 39, 115\u2013128, https:\/\/doi.org\/10.1097\/00005176-200408000-00001 (2004).","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"5914_CR19","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.27274026","author":"S Liu","year":"2025","unstructured":"Liu, S. et al. Comprehensive ultrasound images and serum biochemical indicators for biliary atresia and other pediatric cholestatic diseases. Figshare https:\/\/doi.org\/10.6084\/m9.figshare.27274026 (2025)."}],"container-title":["Scientific Data"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41597-025-05914-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41597-025-05914-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41597-025-05914-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:17:33Z","timestamp":1760012253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41597-025-05914-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5914"],"URL":"https:\/\/doi.org\/10.1038\/s41597-025-05914-9","relation":{"references":[{"id-type":"doi","id":"10.6084\/m9.figshare.27274026","asserted-by":"subject"}]},"ISSN":["2052-4463"],"issn-type":[{"value":"2052-4463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"assertion":[{"value":"11 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1634"}}