{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:10:56Z","timestamp":1762341056197,"version":"build-2065373602"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100024886","name":"Friedrich-Loeffler-Institut","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100024886","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Data"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Trichomonas<\/jats:italic>\n                    vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, the most prevalent non-viral sexually transmitted infection, with significant impact on public health and economy. Here, we present a chromosome-level genome of\n                    <jats:italic>T. vaginalis<\/jats:italic>\n                    strain IR-78 (ATCC 50138), assembled using short and long-read sequencing technologies as well as chromatin conformation capture sequencing (Hi-C). The assembled genome is 173.3\u2009Mb in size, with an N50 scaffold length of 26.4\u2009Mb. The assembly is anchored in six super-scaffolds, corresponding to the six chromosomes of\n                    <jats:italic>T. vaginalis<\/jats:italic>\n                    , covering 93.5% of the genome. A total of 43,326 protein-coding genes were predicted, of which 95.4% were annotated using multiple databases, including Gene Ontology, eggNOG, and KEGG. Among these, 16,656 genes encoded hypothetical proteins. This high-quality genome assembly provides an additional resource for ongoing research on\n                    <jats:italic>T. vaginalis<\/jats:italic>\n                    pathogenesis, drug resistance, and host-parasite interactions. It furthermore enables comparative genomic studies to assess genomic variety across different\n                    <jats:italic>Trichomonas<\/jats:italic>\n                    species.\n                  <\/jats:p>","DOI":"10.1038\/s41597-025-06182-3","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:57:24Z","timestamp":1762340244000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chromosome-level genome assembly of Trichomonas vaginalis strain IR-78 (ATCC 50138)"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2068-6081","authenticated-orcid":false,"given":"Mostafa Y.","family":"Abdel-Glil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Solle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Neubauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa D.","family":"Sprague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"6182_CR1","unstructured":"WHO. World Health Organization (WHO) https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/trichomoniasis, Accessed 02.09.2025 (2025)."},{"key":"6182_CR2","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1051\/parasite\/2025051","volume":"32","author":"W Tian","year":"2025","unstructured":"Tian, W. et al. Systematic review and meta-analysis of the global prevalence and infection risk factors of Trichomonas vaginalis. Parasite 32, 56, https:\/\/doi.org\/10.1051\/parasite\/2025051 (2025).","journal-title":"Parasite"},{"key":"6182_CR3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1439-0272.2010.01119.x","volume":"43","author":"E Ozdemir","year":"2011","unstructured":"Ozdemir, E., Kele\u015ftemur, N. & Kaplan, M. Trichomonas vaginalis as a rare cause of male factor infertility at a hospital in East Anatolia. Andrologia 43, 283\u2013285, https:\/\/doi.org\/10.1111\/j.1439-0272.2010.01119.x (2011).","journal-title":"Andrologia"},{"key":"6182_CR4","doi-asserted-by":"publisher","unstructured":"Ib\u00e1\u00f1ez-Escribano, A. & Nogal-Ruiz, J. J. The Past, Present, and Future in the Diagnosis of a Neglected Sexually Transmitted Infection: Trichomoniasis. Pathogens 13, https:\/\/doi.org\/10.3390\/pathogens13020126 (2024).","DOI":"10.3390\/pathogens13020126"},{"key":"6182_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105250","volume":"106","author":"M Harfouche","year":"2024","unstructured":"Harfouche, M. et al. Epidemiology of Trichomonas vaginalis infection in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions. EBioMedicine 106, 105250, https:\/\/doi.org\/10.1016\/j.ebiom.2024.105250 (2024).","journal-title":"EBioMedicine"},{"key":"6182_CR6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1126\/science.1132894","volume":"315","author":"JM Carlton","year":"2007","unstructured":"Carlton, J. M. et al. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science (New York, N.Y.) 315, 207\u2013212, https:\/\/doi.org\/10.1126\/science.1132894 (2007).","journal-title":"Science (New York, N.Y.)"},{"key":"6182_CR7","doi-asserted-by":"publisher","unstructured":"Mohammadi, K. et al. Unexpected intron plasticity and trans-splicing capability suggest spliceosome diversification in the evolutionarily divergent protozoan parasite Trichomonas vaginalis. Int J Parasitol, https:\/\/doi.org\/10.1016\/j.ijpara.2025.08.011 (2025).","DOI":"10.1016\/j.ijpara.2025.08.011"},{"key":"6182_CR8","doi-asserted-by":"publisher","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","volume":"34","author":"S Chen","year":"2018","unstructured":"Chen, S., Zhou, Y., Chen, Y. & Gu, J. fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics 34, i884\u2013i890, https:\/\/doi.org\/10.1093\/bioinformatics\/bty560 (2018).","journal-title":"Bioinformatics"},{"key":"6182_CR9","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s41587-019-0072-8","volume":"37","author":"M Kolmogorov","year":"2019","unstructured":"Kolmogorov, M., Yuan, J., Lin, Y. & Pevzner, P. A. Assembly of long, error-prone reads using repeat graphs. 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