{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:25:39Z","timestamp":1787138739895,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Data"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Experimental evolution through selection experiments is a vital tool for exploring the special features of polygenic traits. Here, we provide liver transcriptome data from a paternally selected marathon mouse model (DUhTP), characterized by exceptional running performance, and unselected controls (DUC), both descended from the same polygenic background. To study training responses, both lines were either challenged by three weeks of high-speed treadmill training or remained sedentary. For each condition, eight animals were used for liver tissue isolation and next-generation sequencing. Raw sequencing files were submitted to the ArrayExpress collection under accession number E-MTAB-12071. High data quality was confirmed by appropriate mean read lengths, high mean quality scores, and low duplication rates after adapter trimming. With an average of 16.9 million reads per sample mapping to 19,930 genes, the dataset enables comprehensive gene expression analyses. A multiQC report for the dataset, together with a sample-by-gene count matrix, is available on Figshare. The provided data offer a valuable resource for research in polygenic traits associated with physical activity.<\/jats:p>","DOI":"10.1038\/s41597-026-07935-4","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:24:37Z","timestamp":1787135077000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of genotype and exercise on hepatic gene expression in phenotype-selected marathon mice"],"prefix":"10.1038","volume":"13","author":[{"given":"Anne-Marie","family":"Galow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frieder","family":"Hadlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nares","family":"Trakooljul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Walz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hoeflich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Brenmoehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"7935_CR1","doi-asserted-by":"crossref","unstructured":"Boulding, E. Experimental Evolution. Concepts, Methods, and Applications of Selection Experiments. Theodore Garland Jr and Michael R. Rose, editors. Integrative and Comparative Biology - INTEGR COMP BIOL 50 (2010).","DOI":"10.1093\/icb\/icq093"},{"key":"7935_CR2","unstructured":"Schueler, L. Mouse strain Fzt:DU and its use as model in animal breeding research. Archiv fuer Tierzucht (German D.R.) 28 (1985)."},{"key":"7935_CR3","doi-asserted-by":"publisher","first-page":"595","DOI":"10.5194\/aab-47-595-2004","volume":"47","author":"G Dietl","year":"2004","unstructured":"Dietl, G., Langhammer, M. & Renne, U. Model simulations for genetic random drift in the outbred strain Fzt:DU. Archives Animal Breeding 47, 595\u2013604 (2004).","journal-title":"Archives Animal Breeding"},{"key":"7935_CR4","doi-asserted-by":"publisher","first-page":"513","DOI":"10.5194\/aab-43-513-2000","volume":"43","author":"H Falkenberg","year":"2000","unstructured":"Falkenberg, H., Langhammer, M. & Renne, U. Comparison of biochemical blood traits after long-term selection on high or low locomotory activity in mice. Archives Animal Breeding 43, 513\u2013522 (2000).","journal-title":"Archives Animal Breeding"},{"key":"7935_CR5","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1249\/MSS.0b013e31827e0fca","volume":"45","author":"J Brenmoehl","year":"2013","unstructured":"Brenmoehl, J. et al. Metabolic Adaptations in the Liver of Born Long-Distance Running Mice. Medicine & Science in Sports & Exercise 45, 841 (2013).","journal-title":"Medicine & Science in Sports & Exercise"},{"key":"7935_CR6","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1159\/000442399","volume":"8","author":"J Brenmoehl","year":"2015","unstructured":"Brenmoehl, J. et al. Dynamics of Fat Mass in DUhTP Mice Selected for Running Performance \u2013 Fat Mobilization in a Walk. Obes Facts 8, 373\u2013385 (2015).","journal-title":"Obes Facts"},{"key":"7935_CR7","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00360-016-1036-7","volume":"187","author":"J Brenmoehl","year":"2017","unstructured":"Brenmoehl, J. et al. Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice. J Comp Physiol B 187, 361\u2013373 (2017).","journal-title":"J Comp Physiol B"},{"key":"7935_CR8","doi-asserted-by":"publisher","first-page":"e0146748","DOI":"10.1371\/journal.pone.0146748","volume":"11","author":"D Ohde","year":"2016","unstructured":"Ohde, D. et al. Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone. PLoS One 11, e0146748 (2016).","journal-title":"PLoS One"},{"key":"7935_CR9","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.3390\/cells12151925","volume":"12","author":"J Brenmoehl","year":"2023","unstructured":"Brenmoehl, J. et al. Metabolic Pathway Modeling in Muscle of Male Marathon Mice (DUhTP) and Controls (DUC)\u2014A Possible Role of Lactate Dehydrogenase in Metabolic Flexibility. Cells 12, 1925 (2023).","journal-title":"Cells"},{"key":"7935_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-022-01248-9","volume":"20","author":"SE Palma-Vera","year":"2022","unstructured":"Palma-Vera, S. E. et al. Genomic characterization of the world\u2019s longest selection experiment in mouse reveals the complexity of polygenic traits. BMC Biology 20, 52 (2022).","journal-title":"BMC Biology"},{"key":"7935_CR11","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3390\/cells10040736","volume":"10","author":"C Walz","year":"2021","unstructured":"Walz, C. et al. Control of Protein and Energy Metabolism in the Pituitary Gland in Response to Three-Week Running Training in Adult Male Mice. Cells 10, 736 (2021).","journal-title":"Cells"},{"key":"7935_CR12","doi-asserted-by":"publisher","first-page":"3418","DOI":"10.3390\/cells10123418","volume":"10","author":"J Brenmoehl","year":"2021","unstructured":"Brenmoehl, J. et al. Central Suppression of the GH\/IGF Axis and Abrogation of Exercise-Related mTORC1\/2 Activation in the Muscle of Phenotype-Selected Male Marathon Mice (DUhTP). Cells 10, 3418 (2021).","journal-title":"Cells"},{"key":"7935_CR13","unstructured":"N Trakooljul, J Brenmoehl & A Hoeflich RNA-Seq of the liver of mice after 3-week treadmill training versus sedentary control. 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