{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:42:00Z","timestamp":1793371320742,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Ministry of Economic Development of the Russian Federation","award":["139-15-2025-006: IGK 000000C313925P3S0002"],"award-info":[{"award-number":["139-15-2025-006: IGK 000000C313925P3S0002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Data"],"DOI":"10.1038\/s41597-026-07953-2","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:34:14Z","timestamp":1786120454000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Glioblastoma MRI Dataset with Standardized Preprocessing, Expert-Validated Segmentation, and MGMT Profiling"],"prefix":"10.1038","volume":"13","author":[{"given":"Elena","family":"Filimonova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Zoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil","family":"Rzaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya","family":"Schukina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Carretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bianconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Cofano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Morello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Armocida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Spetzger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safwan","family":"Roumia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Di Napoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Pio","family":"Fochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Intern\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Curcio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Rustici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Angileri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Mazzatenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Signorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"Porta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Garbossa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Sao Khue","family":"Luu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Benedichuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan","family":"Shakoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bair","family":"Tuchinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Colamaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"7953_CR1","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis, D. N. et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-Oncology 23, 1231\u20131251 (2021).","journal-title":"Neuro-Oncology"},{"key":"7953_CR2","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1109\/TMI.2014.2377694","volume":"34","author":"BH Menze","year":"2015","unstructured":"Menze, B. H. et al. The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS). IEEE Trans. Med. Imaging 34, 1993\u20132024 (2015).","journal-title":"IEEE Trans. Med. Imaging"},{"key":"7953_CR3","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41416-021-01387-w","volume":"125","author":"G Singh","year":"2021","unstructured":"Singh, G. et al. Radiomics and radiogenomics in gliomas: a contemporary update. Br J Cancer 125, 641\u2013657 (2021).","journal-title":"Br J Cancer"},{"key":"7953_CR4","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.trecan.2020.02.010","volume":"6","author":"M Butler","year":"2020","unstructured":"Butler, M. et al. MGMT Status as a Clinical Biomarker in Glioblastoma. Trends in Cancer 6, 380\u2013391 (2020).","journal-title":"Trends in Cancer"},{"key":"7953_CR5","doi-asserted-by":"publisher","first-page":"119673","DOI":"10.1016\/j.bbamcr.2024.119673","volume":"1871","author":"R Shaw","year":"2024","unstructured":"Shaw, R., Basu, M., Karmakar, S. & Ghosh, M. K. MGMT in TMZ-based glioma therapy: Multifaceted insights and clinical trial perspectives. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1871, 119673 (2024).","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"key":"7953_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nrneurol.2009.197","volume":"6","author":"M Weller","year":"2010","unstructured":"Weller, M., Stupp, R. & Reifenberger, G. MGMT promoter methylation in malignant gliomas: Ready for personalized medicine? Nature Reviews Neurology 6, 39\u201351 (2010).","journal-title":"Nature Reviews Neurology"},{"key":"7953_CR7","doi-asserted-by":"crossref","unstructured":"Le Guillou Horn, X. M. et al. From Voxel to Gene: A Scoping Review on MRI Radiogenomics\u2019 Artificial Intelligence Predictions in Adult Gliomas and Glioblastomas-The Promise of Virtual Biopsy? Biomedicines 12 (2024).","DOI":"10.20944\/preprints202408.0169.v1"},{"key":"7953_CR8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3390\/diagnostics15030251","volume":"15","author":"A Leone","year":"2025","unstructured":"Leone, A. et al. Virtual Biopsy for the Prediction of MGMT Promoter Methylation in Gliomas: A Comprehensive Review of Radiomics and Deep Learning Approaches Applied to MRI. Diagnostics 15, 251 (2025).","journal-title":"Diagnostics"},{"key":"7953_CR9","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.3390\/cancers14102425","volume":"14","author":"M Caccese","year":"2022","unstructured":"Caccese, M. et al. Definition of the Prognostic Role of MGMT Promoter Methylation Value by Pyrosequencing in Newly Diagnosed IDH Wild-Type Glioblastoma Patients Treated with Radiochemotherapy: A Large Multicenter Study. Cancers 14, 2425 (2022).","journal-title":"Cancers"},{"key":"7953_CR10","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s11060-015-1738-9","volume":"122","author":"P Mur","year":"2015","unstructured":"Mur, P. et al. Impact on prognosis of the regional distribution of MGMT methylation with respect to the CpG island methylator phenotype and age in glioma patients. J Neurooncol 122, 441\u2013450 (2015).","journal-title":"J Neurooncol"},{"key":"7953_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01560-7","volume":"9","author":"S Bakas","year":"2022","unstructured":"Bakas, S. et al. The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics. Sci Data 9, 453 (2022).","journal-title":"Sci Data"},{"key":"7953_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60466-1","volume":"16","author":"M Zenk","year":"2025","unstructured":"Zenk, M. et al. Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge. Nat Commun 16, 6274 (2025).","journal-title":"Nat Commun"},{"key":"7953_CR13","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.3390\/biomedicines12112561","volume":"12","author":"MSK Luu","year":"2024","unstructured":"Luu, M. S. K. et al. Transfer Learning Approaches for Brain Metastases Screenings. Biomedicines 12, 2561 (2024).","journal-title":"Biomedicines"},{"key":"7953_CR14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/hbm.10062","volume":"17","author":"SM Smith","year":"2002","unstructured":"Smith, S. M. Fast robust automated brain extraction. Human Brain Mapping 17, 143\u2013155 (2002).","journal-title":"Human Brain Mapping"},{"key":"7953_CR15","doi-asserted-by":"publisher","unstructured":"Myronenko, A. 3D MRI brain tumor segmentation using autoencoderregularization. arXiv. Preprint posted online November 19 https:\/\/doi.org\/10.48550\/arXiv.1810.11654 (2018).","DOI":"10.48550\/arXiv.1810.11654"},{"key":"7953_CR16","doi-asserted-by":"crossref","unstructured":"Bonato, B., Nanni, L. & Bertoldo, A. Advancing Precision: A Comprehensive Review of MRI Segmentation Datasets from BraTS Challenges (2012\u20132025). Sensors (Basel) 25 (2025).","DOI":"10.3390\/s25061838"},{"key":"7953_CR17","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1109\/TCBB.2020.3033538","volume":"19","author":"J Cheng","year":"2022","unstructured":"Cheng, J. et al. Prediction of Glioma Grade Using Intratumoral and Peritumoral Radiomic Features From Multiparametric MRI Images. IEEE\/ACM Trans. Comput. Biol. and Bioinf. 19, 1084\u20131095 (2022).","journal-title":"IEEE\/ACM Trans. Comput. Biol. and Bioinf."},{"key":"7953_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2019.101896","volume":"80","author":"E Le Rhun","year":"2019","unstructured":"Le Rhun, E. et al. Molecular targeted therapy of glioblastoma. Cancer Treatment Reviews 80, 101896 (2019).","journal-title":"Cancer Treatment Reviews"},{"key":"7953_CR19","doi-asserted-by":"publisher","DOI":"10.18112\/openneuro.ds007045.v1.0.1","author":"E Filimonova","year":"2025","unstructured":"Filimonova, E. et al. Real-world Multi-Institutional Glioblastoma MRI Dataset with Standardized Preprocessing, Expert-Validated Segmentation, and MGMT Promoter Profiling. OpenNeuro https:\/\/doi.org\/10.18112\/openneuro.ds007045.v1.0.1 (2025)."}],"container-title":["Scientific Data"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41597-026-07953-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41597-026-07953-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41597-026-07953-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T20:02:32Z","timestamp":1787342552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41597-026-07953-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7953"],"URL":"https:\/\/doi.org\/10.1038\/s41597-026-07953-2","relation":{"references":[{"id-type":"doi","id":"10.18112\/openneuro.ds007045.v1.0.1","asserted-by":"subject"}]},"ISSN":["2052-4463"],"issn-type":[{"value":"2052-4463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"11 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"1213"}}