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Our study introduces a fully automated method that yields significant features related to respiratory deficits, dysphonia, imprecise articulation and dysrhythmia from acoustic microphone data of natural connected speech for predicting early and distinctive patterns of neurodegeneration. We compared speech recordings of 50 subjects with rapid eye movement sleep behaviour disorder (RBD), 30 newly diagnosed, untreated PD patients and 50 healthy controls, and showed that subliminal parkinsonian speech deficits can be reliably captured even in RBD patients, which are at high risk of developing PD or other synucleinopathies. Thus, automated vocal analysis should soon be able to contribute to screening and diagnostic procedures for prodromal parkinsonian neurodegeneration in natural environments.<\/jats:p>","DOI":"10.1038\/s41598-017-00047-5","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T15:10:01Z","timestamp":1485529801000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":198,"title":["Automated analysis of connected speech reveals early biomarkers of Parkinson\u2019s disease in patients with rapid eye movement sleep behaviour disorder"],"prefix":"10.1038","volume":"7","author":[{"given":"Jan","family":"Hlavni\u010dka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"\u010cmejla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Tykalov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"\u0160onka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ev\u017een","family":"R\u016f\u017ei\u010dka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rusz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"47_CR1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/jpho.2000.0122","volume":"28","author":"RD Kent","year":"2000","unstructured":"Kent, R. 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