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However, the comparative roles of each CKD-MBD biomarker remained undetermined on long-term peritoneal dialysis (PD) patients. This retrospective study, employing a population-based database, aimed to evaluate the performance and provide the best evidence of each biomarker of CKD-MBD as predictor of all-cause mortality. Throughout the 8-year study period, total 12,116 PD patients were included in this study. Cox proportional regression and Kaplan-Meier method were used for survival analysis. For Cox regression model, baseline measurements and time-varying covariates were used for analysis. In Cox regression model using time-dependent covariates, serum calcium level of \u22679.5\u2009mg\/dL was associated with increased mortality. For phosphorus, serum levels of either \u22676.5\u2009mg\/dL or &lt;3.5\u2009mg\/dL were associated with increased mortality. For parathyroid hormone (PTH), higher serum levels were not associated increased mortality. For alkaline phosphatase (ALP), mortality increased at levels \u2267100\u2009IU\/L. Our findings suggested that the detrimental effect of ALP on survival was more consistent, while serum calcium, phosphorus and PTH may have a less prominent effect on mortality. This study provided additional information for manipulating CKD-MBD biomarkers in PD patients.<\/jats:p>","DOI":"10.1038\/s41598-017-00080-4","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T11:07:42Z","timestamp":1487588862000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Roles of Serum Calcium, Phosphorus, PTH and ALP on Mortality in Peritoneal Dialysis Patients: A Nationwide, Population-based Longitudinal Study Using TWRDS 2005\u20132012"],"prefix":"10.1038","volume":"7","author":[{"given":"Chung-Te","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Chung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chin","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi-Hsien","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Cheng","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai-Szu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,24]]},"reference":[{"key":"80_CR1","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1053\/j.ajkd.2008.03.020","volume":"52","author":"F Tentori","year":"2008","unstructured":"Tentori, F. et al. Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis \n                           52, 519\u2013530, doi:10.1053\/j.ajkd.2008.03.020 (2008).","journal-title":"Am J Kidney Dis"},{"key":"80_CR2","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/j.1542-4758.2007.00190.x","volume":"11","author":"N Kimata","year":"2007","unstructured":"Kimata, N. et al. Association of mineral metabolism factors with all-cause and cardiovascular mortality in haemodialysis patients: the Japan dialysis outcomes and practice patterns study. Hemodial Int \n                           11, 340\u2013348, doi:10.1111\/j.1542-4758.2007.00190.x (2007).","journal-title":"Hemodial Int"},{"key":"80_CR3","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1681\/ASN.2004040275","volume":"16","author":"Y Slinin","year":"2005","unstructured":"Slinin, Y., Foley, R. N. & Collins, A. J. Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in haemodialysis patients: the USRDS waves 1, 3, and 4 study. J Am Soc Nephrol \n                           16, 1788\u20131793, doi:10.1681\/ASN.2004040275 (2005).","journal-title":"J Am Soc Nephrol"},{"key":"80_CR4","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1111\/j.1523-1755.2005.00185.x","volume":"67","author":"EW Young","year":"2005","unstructured":"Young, E. W. et al. Predictors and consequences of altered mineral metabolism: the Dialysis Outcomes and Practice Patterns Study. Kidney Int \n                           67, 1179\u20131187, doi:10.1111\/j.1523-1755.2005.00185.x (2005).","journal-title":"Kidney Int"},{"key":"80_CR5","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","volume":"15","author":"GA Block","year":"2004","unstructured":"Block, G. A. et al. Mineral metabolism, mortality, and morbidity in maintenance haemodialysis. 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