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Thus, the aim of the study was to evaluate the association of maternal lipids, leptin and adiponectin throughout pregnancy with large-for-gestational-age (LGA) births and BW z-score. A prospective cohort of 199 mothers was followed during pregnancy in Rio de Janeiro, Brazil. The statistical analyses comprised multiple logistic and linear regression. Women delivered 36 LGA and 11 small-for-gestational-age newborns. HDL-c rate of change throughout pregnancy was negatively associated with BW z-score (\u03b2\u2009=\u2009\u22121.99; p\u2009=\u20090.003) and the delivery of a LGA newborn (OR\u2009=\u20090.02; p\u2009=\u20090.043). Pregnancy baseline concentration of log leptin was positively associated (OR\u2009=\u20093.92; p\u2009=\u20090.025) with LGA births. LDL-c rate of change throughout pregnancy was positively associated with BW z-score (\u03b2\u2009=\u20090.31; p\u2009=\u20090.004). Log triglycerides and log adiponectin were not significantly associated with BW z-score or LGA birth. In conclusion, a higher log leptin pregnancy baseline concentration and a lower HDL-c rate of change during pregnancy were associated with higher odds of having a LGA newborn. These maternal biomarkers are important to foetal growth and could be used in prenatal care as an additional strategy to screen women at risk of inadequate BW.<\/jats:p>","DOI":"10.1038\/s41598-017-00941-y","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T14:03:23Z","timestamp":1491401003000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study"],"prefix":"10.1038","volume":"7","author":[{"given":"Dayana Rodrigues","family":"Farias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilla","family":"Poston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz","family":"Franco-Sena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Augusto","family":"Moura da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thatiana","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia Costa","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Kac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"941_CR1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/sj.ijo.0801602","volume":"25","author":"J Eriksson","year":"2001","unstructured":"Eriksson, J., Forsen, T., Tuomilehto, J., Osmond, C. & Barker, D. 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