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We have previously described that\n                    <jats:italic>DDIT4<\/jats:italic>\n                    expression is an independent prognostic factor for tripe negative breast cancer resistant to neoadjuvant chemotherapy. We herein report that high\n                    <jats:italic>DDIT4<\/jats:italic>\n                    expression is related to the outcome (recurrence-free survival, time to progression and overall survival) in several cancer types. We performed\n                    <jats:italic>in silico<\/jats:italic>\n                    analysis in online platforms, in pooled datasets from KM Plotter and meta-analysis of individual datasets from SurvExpress. High levels of\n                    <jats:italic>DDIT4<\/jats:italic>\n                    were significantly associated with a worse prognosis in acute myeloid leukemia, breast cancer, glioblastoma multiforme, colon, skin and lung cancer. Conversely, a high\n                    <jats:italic>DDIT4<\/jats:italic>\n                    expression was associated with an improved prognostic in gastric cancer.\n                    <jats:italic>DDIT4<\/jats:italic>\n                    was not associated with the outcome of ovarian cancers. Analysis with data from the Cell Miner Tool in 60 cancer cell lines indicated that although rapamycin activity was correlated with levels of\n                    <jats:italic>MTOR<\/jats:italic>\n                    , it is not influenced by\n                    <jats:italic>DDIT4<\/jats:italic>\n                    expression. In summary,\n                    <jats:italic>DDIT4<\/jats:italic>\n                    might serve as a novel prognostic biomarker in several malignancies.\n                    <jats:italic>DDIT4<\/jats:italic>\n                    activity could be responsible for resistance to mTOR inhibitors and is a potential candidate for the development of targeted therapy.\n                  <\/jats:p>","DOI":"10.1038\/s41598-017-01207-3","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T05:53:37Z","timestamp":1493704417000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7744-1635","authenticated-orcid":false,"given":"Joseph A.","family":"Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-0267","authenticated-orcid":false,"given":"Christian","family":"Rolfo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis E.","family":"Raez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhajaira M.","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leny","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Williams","family":"Fajardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida D.","family":"Morante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia P.","family":"Neciosup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisse","family":"Bretel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Balko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry L.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,8]]},"reference":[{"key":"1207_CR1","doi-asserted-by":"publisher","first-page":"5834","DOI":"10.1128\/MCB.25.14.5834-5845.2005","volume":"25","author":"A Sofer","year":"2005","unstructured":"Sofer, A., Lei, K., Johannessen, C. M. & Ellisen, L. W. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol. \n                           25, 5834\u20135845, doi:10.1128\/MCB.25.14.5834-5845.2005 (2005).","journal-title":"Mol Cell Biol."},{"key":"1207_CR2","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/nm.2157","volume":"16","author":"T Yoshida","year":"2010","unstructured":"Yoshida, T. et al. Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med. \n                           16, 767\u2013773, doi:10.1038\/nm.2157 (2010).","journal-title":"Nat Med."},{"key":"1207_CR3","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1016\/j.cellsig.2013.08.038","volume":"25","author":"MD Dennis","year":"2013","unstructured":"Dennis, M. D., McGhee, N. K., Jefferson, L. S. & Kimball, S. R. 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