{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:46:19Z","timestamp":1792622779827,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T00:00:00Z","timestamp":1493164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T00:00:00Z","timestamp":1493164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Xipayi Kui Jie\u2019an (KJA), a type of traditional Uygur medicine (TUM), has shown promising therapeutic effects in Ulcerative colitis (UC). Owing to the complexity of TUM, the pharmacological mechanism of KJA remains vague. Therefore, the identification of complex molecular mechanisms is a major challenge and a new method is urgently needed to address this problem. In this study, we established a feasible pharmacological model based on systems pharmacology to identify potential compounds and targets. We also applied compound-target and target-diseases network analysis to evaluate the action mechanisms. According to the predicted results, 12 active compounds were selected and these compounds were also identified by HPLC-ESI-MS\/MS analysis. The main components were tannins, this result is consistent with the prediction. The active compounds interacted with 22 targets. Two targets including PTGS2 and PPARG were demonstrated to be the main targets associated with UC. Systematic analysis of the constructed networks revealed that these targets were mainly involved in NF-\u03baB signaling pathway. Furthermore, KJA could also regulate the CD4\u2009+\u2009CD25\u2009+\u2009Foxp3\u2009+\u2009Treg cells. In conclusion, this systems pharmacology-based approach not only explained that KJA could alleviate the UC by regulating its candidate targets, but also gave new insights into the potential novel therapeutic strategies for UC.<\/jats:p>","DOI":"10.1038\/s41598-017-01335-w","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T10:39:56Z","timestamp":1492684796000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A Systems Pharmacology Approach to Determine Active Compounds and Action Mechanisms of Xipayi KuiJie\u2019an enema for Treatment of Ulcerative colitis"],"prefix":"10.1038","volume":"7","author":[{"given":"Wei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meicun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teigang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"1335_CR1","first-page":"1144","volume":"2012","author":"T Tanaka","year":"2011","unstructured":"Tanaka, T. Development of an Inflammation-Associated Colorectal Cancer Model and Its Application for Research on Carcinogenesis and Chemoprevention. International Journal of Inflammation 2012, 1144\u20131149 (2011).","journal-title":"International Journal of Inflammation"},{"key":"1335_CR2","first-page":"826178","volume":"2012","author":"VRM Lombardi","year":"2012","unstructured":"Lombardi, V. R. M., Etcheverr\u00eda, I., Carrera, I., Cacabelos, R. & Chac\u00f3n, A. R. Prevention of Chronic Experimental Colitis Induced by Dextran Sulphate Sodium (DSS) in Mice Treated with FR91. Biomed Research International 2012, 826178\u2013826178 (2012).","journal-title":"Biomed Research International"},{"key":"1335_CR3","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1046\/j.1365-2745.2002.01460.x","volume":"32","author":"G Sclano","year":"2002","unstructured":"Sclano, G. Asthma, nasal polyposis and ulcerative colitis: a new perspective. Clinical & Experimental Allergy Journal of the British Society for Allergy & Clinical Immunology 32, 1144\u20131149 (2002).","journal-title":"Clinical & Experimental Allergy Journal of the British Society for Allergy & Clinical Immunology"},{"key":"1335_CR4","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.1093\/carcin\/bgt309","volume":"34","author":"J Fang","year":"2013","unstructured":"Fang, J. et al. Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involves suppression of oxidative stress and inflammatory cytokines. Carcinogenesis 34, 2833\u20132841, doi:10.1093\/carcin\/bgt309 (2013).","journal-title":"Carcinogenesis"},{"key":"1335_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-015-0672-x","volume":"15","author":"K Yunusi","year":"2015","unstructured":"Yunusi, K. et al. Uygur Medicine Xipayi Kui Jie\u2019an Affects Gene Expression profiles in intestinal tissue Lesions in a Rat Model of Ulcerative Colitis. Bmc Complementary & Alternative Medicine 15, 1\u20138 (2015).","journal-title":"Bmc Complementary & Alternative Medicine"},{"key":"1335_CR6","unstructured":"Committee CP. Drug Standards of the Ministry of Public Health of thePeople\u2019s Republic of China. In: Book Drug Standards of the Ministry ofPublic Health of the People\u2019s Republic of China. City: Uygur PharmaceuticalSection (1998)."},{"key":"1335_CR7","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1007\/s00436-008-1325-5","volume":"104","author":"AA Aivazi","year":"2009","unstructured":"Aivazi, A. A. & Vijayan, V. A. Larvicidal activity of oak Quercus infectoria Oliv. (Fagaceae) gall extracts against Anopheles stephensi Liston. Parasitology research 104, 1289\u20131293, doi:10.1007\/s00436-008-1325-5 (2009).","journal-title":"Parasitology research"},{"key":"1335_CR8","first-page":"893","volume":"32","author":"Y Guo Xia","year":"2009","unstructured":"Guo Xia, Y. & Kerim, A. Effect of Uyghur compound Xipayi Kuijie\u2019an on the ultrastructure of small intestinal epithelial cell in Rat Model of Ulcerative Colitis. Journal of Xinjiang Medical University 32, 893\u2013895 (2009).","journal-title":"Journal of Xinjiang Medical University"},{"key":"1335_CR9","first-page":"29","volume":"29","author":"M Iminjan","year":"2011","unstructured":"Iminjan, M., Yunus, K., Hizbilla, M., Hupur, H. & Li, Y. Experimental Study of Effects of Uygur Medicine Xipayi Kuijie\u2019an on Colon Mucosa Apoptosis and the Mechanism of Treating Ulcerative Colitis. Keji Daobao\/Science & Technology Review 29, 29\u201335 (2011).","journal-title":"Keji Daobao\/Science & Technology Review"},{"key":"1335_CR10","first-page":"219","volume":"17","author":"H Upur","year":"2011","unstructured":"Upur, H. et al. The histologic effects of the Uyghur medicine xipayi kuijiean on ulcerative colitis in rats. Journal of the Australian Traditional-Medicine Society 17, 219 (2011).","journal-title":"Journal of the Australian Traditional-Medicine Society"},{"key":"1335_CR11","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1093\/bib\/bbt035","volume":"15","author":"C Huang","year":"2013","unstructured":"Huang, C. et al. Systems pharmacology in drug discovery and therapeutic insight for herbal medicines. Briefings in Bioinformatics 15, 710\u2013733, doi:10.1093\/bib\/bbt035 (2013).","journal-title":"Briefings in Bioinformatics"},{"key":"1335_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.compbiomed.2014.05.007","volume":"53","author":"B Li","year":"2014","unstructured":"Li, B. et al. Systems pharmacology-based approach for dissecting the addition and subtraction theory of traditional Chinese medicine: An example using Xiao-Chaihu-Decoction and Da-Chaihu-Decoction. Computers in Biology & Medicine 53, 19\u201329, doi:10.1016\/j.compbiomed.2014.05.007 (2014).","journal-title":"Computers in Biology & Medicine"},{"key":"1335_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1758-2946-6-13","volume":"6","author":"J Ru","year":"2014","unstructured":"Ru, J. et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. Journal of cheminformatics 6, 1 (2014).","journal-title":"Journal of cheminformatics"},{"key":"1335_CR14","doi-asserted-by":"crossref","unstructured":"Pei, T. et al. Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula. Journal of ethnopharmacology (2016).","DOI":"10.1016\/j.jep.2016.06.001"},{"key":"1335_CR15","doi-asserted-by":"crossref","unstructured":"Zheng, C. et al. A novel systems pharmacology platform to dissect action mechanisms of traditional Chinese medicines for bovine viral diarrhea disease. European Journal of Pharmaceutical Sciences (2016).","DOI":"10.1016\/j.ejps.2016.05.018"},{"key":"1335_CR16","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1021\/ci1004948","volume":"51","author":"C Ma","year":"2011","unstructured":"Ma, C., Wang, L. & Xie, X. Q. GPU accelerated chemical similarity calculation for compound library comparison. Journal of chemical information and modeling 51, 1521\u20131527, doi:10.1021\/ci1004948 (2011).","journal-title":"Journal of chemical information and modeling"},{"key":"1335_CR17","doi-asserted-by":"publisher","first-page":"e37608","DOI":"10.1371\/journal.pone.0037608","volume":"7","author":"H Yu","year":"2012","unstructured":"Yu, H. et al. A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data. PLoS One 7, e37608, doi:10.1371\/journal.pone.0037608 (2012).","journal-title":"PLoS One"},{"key":"1335_CR18","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","volume":"27","author":"ME Smoot","year":"2011","unstructured":"Smoot, M. E., Ono, K., Ruscheinski, J., Wang, P.-L. & Ideker, T. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 27, 431\u2013432, doi:10.1093\/bioinformatics\/btq675 (2011).","journal-title":"Bioinformatics"},{"key":"1335_CR19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.intimp.2012.10.022","volume":"15","author":"T Sha","year":"2013","unstructured":"Sha, T., Igaki, K., Yamasaki, M., Watanabe, T. & Tsuchimori, N. Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice. International immunopharmacology 15, 23\u201329, doi:10.1016\/j.intimp.2012.10.022 (2013).","journal-title":"International immunopharmacology"},{"key":"1335_CR20","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1016\/j.molimm.2010.06.007","volume":"47","author":"Y Li","year":"2010","unstructured":"Li, Y. et al. Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6\/STAT3 signaling pathway and down-regulation of IL-17. Molecular Immunology 47, 2467\u20132474, doi:10.1016\/j.molimm.2010.06.007 (2010).","journal-title":"Molecular Immunology"},{"key":"1335_CR21","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1248\/cpb.31.2593","volume":"14","author":"M Nishizawa","year":"1983","unstructured":"Nishizawa, M., Yamagishi, T., Nonaka, G. & Nishioka, I. ChemInform Abstract: tannins and related compounds. part 9. isolation and characterization of polygalloylglucoses from turkish galls (quercus infectoria). Tannins and related compounds. XII. Isolation and characterization of galloylglucoses from Paeoniae Radix and their effects on urea-nitrogen concentration in rat serum. Chemical & Pharmaceutical Bulletin 14, 2593\u20132600 (1983).","journal-title":"Chemical & Pharmaceutical Bulletin"},{"key":"1335_CR22","unstructured":"Hasmida, M. N., Nur Syukriah, A. R., Liza, M. S. & Mohd Azizi, C. Y. Effect of different extraction techniques on total phenolic content and antioxidant activity of Quercus infectoria galls. International Food Research Journal (2014)."},{"key":"1335_CR23","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","volume":"380","author":"I Ord\u00e1s","year":"2012","unstructured":"Ord\u00e1s, I., Eckmann, L., Talamini, M., Baumgart, D. C. & Sandborn, W. J. Ulcerative colitis. Lancet 380, 1606\u20131619, doi:10.1016\/S0140-6736(12)60150-0 (2012).","journal-title":"Lancet"},{"key":"1335_CR24","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S2221-1691(14)60205-7","volume":"4","author":"S Shrestha","year":"2014","unstructured":"Shrestha, S. et al. Pharmacognostic studies of insect gall of Quercus infectoria Olivier (Fagaceae). Asian Pacific Journal of Tropical Biomedicine 4, 35\u201339, doi:10.1016\/S2221-1691(14)60205-7 (2014).","journal-title":"Asian Pacific Journal of Tropical Biomedicine"},{"key":"1335_CR25","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1136\/gut.2006.093484","volume":"55","author":"L Dubuquoy","year":"2006","unstructured":"Dubuquoy, L. et al. PPAR\u03b3 as a new therapeutic target in inflammatory bowel diseases. Gut 55, 1341\u20131349, doi:10.1136\/gut.2006.093484 (2006).","journal-title":"Gut"},{"key":"1335_CR26","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/34184","volume":"391","author":"C Jiang","year":"1998","unstructured":"Jiang, C., Ting, A. T. & Seed, B. PPAR-\u03b3 agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 82\u201386, doi:10.1038\/35154 (1998).","journal-title":"Nature"},{"key":"1335_CR27","doi-asserted-by":"crossref","unstructured":"Rousseaux, C. et al. The 5-aminosalicylic acid (5-ASA) anti-neoplastic effect in the intestine is mediated by PPAR\u03b3. Carcinogenesis bgt245 (2013).","DOI":"10.1093\/carcin\/bgt245"},{"key":"1335_CR28","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.2174\/13894501113149990162","volume":"14","author":"B Bertin","year":"2013","unstructured":"Bertin, B., Dubuquoy, L., Colombel, J.-F. & Desreumaux, P. PPAR-gamma in ulcerative colitis: a novel target for intervention. Current drug targets 14, 1501\u20131507, doi:10.2174\/13894501113149990162 (2013).","journal-title":"Current drug targets"},{"key":"1335_CR29","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1084\/jem.193.7.827","volume":"193","author":"P Desreumaux","year":"2001","unstructured":"Desreumaux, P. et al. Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)\/Peroxisome Proliferator\u2013Activated Receptor \u03b3 (Ppar\u03b3) Heterodimer A Basis for New Therapeutic Strategies. The Journal of experimental medicine 193, 827\u2013838, doi:10.1084\/jem.193.7.827 (2001).","journal-title":"The Journal of experimental medicine"},{"key":"1335_CR30","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1084\/jem.20041948","volume":"201","author":"C Rousseaux","year":"2005","unstructured":"Rousseaux, C. et al. Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator\u2013activated receptor-\u03b3. The Journal of experimental medicine 201, 1205\u20131215, doi:10.1084\/jem.20041948 (2005).","journal-title":"The Journal of experimental medicine"},{"key":"1335_CR31","unstructured":"Su, C. et al. In Cytokines and Cell Homeostasis in the Gastrointestinal Tract: Proceedings of the Falk Symposium 113 Held in Regensburg, Germany, 16\u201318 September, 1999. 13 (Kluwer Academic Publishers)."},{"key":"1335_CR32","doi-asserted-by":"crossref","unstructured":"Feagan, B. G. & MacDonald, J. K. Oral 5 - aminosalicylic acid for maintenance of remission in ulcerative colitis. The Cochrane Library (2012).","DOI":"10.1002\/14651858.CD000544.pub3"},{"key":"1335_CR33","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1053\/j.gastro.2007.12.012","volume":"134","author":"JD Lewis","year":"2008","unstructured":"Lewis, J. D. et al. Rosiglitazone for active ulcerative colitis: a randomized placebo-controlled trial. Gastroenterology 134, 688\u2013695, doi:10.1053\/j.gastro.2007.12.012 (2008).","journal-title":"Gastroenterology"},{"key":"1335_CR34","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1038\/ajg.2009.749","volume":"105","author":"G Pedersen","year":"2010","unstructured":"Pedersen, G. & Brynskov, J. Topical rosiglitazone treatment improves ulcerative colitis by restoring peroxisome proliferator-activated receptor-\u03b3 activity. The American journal of gastroenterology 105, 1595\u20131603, doi:10.1038\/ajg.2009.749 (2010).","journal-title":"The American journal of gastroenterology"},{"key":"1335_CR35","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1136\/gut.48.4.468","volume":"48","author":"PJ Roberts","year":"2001","unstructured":"Roberts, P. J., Morgan, K., Miller, R., Hunter, J. O. & Middleton, S. J. Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease. Gut 48, 468\u2013472, doi:10.1136\/gut.48.4.468 (2001).","journal-title":"Gut"},{"key":"1335_CR36","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/onc.2009.421","volume":"29","author":"D Wang","year":"2009","unstructured":"Wang, D. & Dubois, R. N. The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene 29, 781\u2013788, doi:10.1038\/onc.2009.421 (2009).","journal-title":"Oncogene"},{"key":"1335_CR37","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1124\/mol.113.089573","volume":"85","author":"M Rodr\u00edguez","year":"2014","unstructured":"Rodr\u00edguez, M. et al. Polarization of the innate immune response by prostaglandin E2: a puzzle of receptors and signals. Molecular pharmacology 85, 187\u2013197, doi:10.1124\/mol.113.089573 (2014).","journal-title":"Molecular pharmacology"},{"key":"1335_CR38","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1365-2796.2008.01953.x","volume":"263","author":"I Atreya","year":"2008","unstructured":"Atreya, I., Atreya, R. & Neurath, M. NF\u2010\u03baB in inflammatory bowel disease. Journal of internal medicine 263, 591\u2013596, doi:10.1111\/j.1365-2796.2008.01953.x (2008).","journal-title":"Journal of internal medicine"},{"key":"1335_CR39","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/MOG.0b013e328324f857","volume":"25","author":"ME Spehlmann","year":"2009","unstructured":"Spehlmann, M. E. & Eckmann, L. Nuclear factor-kappa B in intestinal protection and destruction. Current opinion in gastroenterology 25, 92\u201399, doi:10.1097\/MOG.0b013e328324f857 (2009).","journal-title":"Current opinion in gastroenterology"},{"key":"1335_CR40","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/cr.2010.175","volume":"21","author":"A Wullaert","year":"2011","unstructured":"Wullaert, A., Bonnet, M. C. & Pasparakis, M. NF-\u03baB in the regulation of epithelial homeostasis and inflammation. Cell research 21, 146\u2013158, doi:10.1038\/cr.2010.175 (2011).","journal-title":"Cell research"},{"key":"1335_CR41","doi-asserted-by":"publisher","unstructured":"Ren, T. et al. An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-\u03baB signaling pathway. Scientific reports 5, 10.1038\/srep09047 (2015).","DOI":"10.1038\/srep09047"},{"key":"1335_CR42","doi-asserted-by":"publisher","first-page":"6142","DOI":"10.1074\/jbc.M113.517599","volume":"289","author":"R Glauben","year":"2014","unstructured":"Glauben, R., Sonnenberg, E., Wetzel, M., Mascagni, P. & Siegmund, B. Histone deacetylase inhibitors modulate interleukin 6-dependent CD4+ T cell polarization in vitro and in vivo. Journal of Biological Chemistry 289, 6142\u20136151, doi:10.1074\/jbc.M113.517599 (2014).","journal-title":"Journal of Biological Chemistry"},{"key":"1335_CR43","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.clim.2012.09.001","volume":"145","author":"F Shi","year":"2012","unstructured":"Shi, F. et al. Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis. Clinical Immunology 145, 230\u2013240, doi:10.1016\/j.clim.2012.09.001 (2012).","journal-title":"Clinical Immunology"},{"key":"1335_CR44","doi-asserted-by":"publisher","first-page":"e23522","DOI":"10.1371\/journal.pone.0023522","volume":"6","author":"NP Singh","year":"2011","unstructured":"Singh, N. P. et al. Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis. PLoS One 6, e23522, doi:10.1371\/journal.pone.0023522 (2011).","journal-title":"PLoS One"},{"key":"1335_CR45","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/mi.2013.97","volume":"7","author":"A Malik","year":"2013","unstructured":"Malik, A., Sharma, D., St, C. J., Dybas, L. A. & Mansfield, L. S. Contrasting immune responses mediate Campylobacter jejuni-induced colitis and autoimmunity. Mucosal Immunology 7, 802\u2013817, doi:10.1038\/mi.2013.97 (2013).","journal-title":"Mucosal Immunology"},{"key":"1335_CR46","doi-asserted-by":"publisher","first-page":"6034","DOI":"10.1210\/jc.2003-031080","volume":"88","author":"CJ Owen","year":"2003","unstructured":"Owen, C. J. et al. Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome. Journal of Clinical Endocrinology & Metabolism 88, 6034\u20136039, doi:10.1210\/jc.2003-031080 (2003).","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"1335_CR47","doi-asserted-by":"publisher","first-page":"32681","DOI":"10.1074\/jbc.M002577200","volume":"275","author":"SW Chung","year":"2000","unstructured":"Chung, S. W. et al. Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B. Journal of Biological Chemistry 275, 32681\u201332687, doi:10.1074\/jbc.M002577200 (2000).","journal-title":"Journal of Biological Chemistry"},{"key":"1335_CR48","doi-asserted-by":"publisher","first-page":"28181","DOI":"10.1074\/jbc.M303141200","volume":"278","author":"R Hong","year":"2003","unstructured":"Hong, R., Pownall, H. J. & Lodish, H. F. Troglitazone Antagonizes Tumor Necrosis Factor-\u03b1-induced Reprogramming of Adipocyte Gene Expression by Inhibiting the Transcriptional Regulatory Functions of NF-\u03baB. Journal of Biological Chemistry 278, 28181\u201328192, doi:10.1074\/jbc.M303141200 (2003).","journal-title":"Journal of Biological Chemistry"},{"key":"1335_CR49","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/S0016-5085(03)00271-3","volume":"124","author":"L Dubuquoy","year":"2003","unstructured":"Dubuquoy, L. et al. Impaired expression of peroxisome proliferator-activated receptor \u03b3 in ulcerative colitis. Gastroenterology 124, 1265\u20131276, doi:10.1016\/S0016-5085(03)00271-3 (2003).","journal-title":"Gastroenterology"},{"key":"1335_CR50","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/ni1018","volume":"5","author":"D Kelly","year":"2004","unstructured":"Kelly, D. et al. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nature Immunology 5, 104\u2013112, doi:10.1038\/ni1018 (2004).","journal-title":"Nature Immunology"},{"key":"1335_CR51","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/1440-1681.12321","volume":"42","author":"Y Lin","year":"2014","unstructured":"Lin, Y. et al. Transplantation of human umbilical mesenchymal stem cells attenuates dextran sulfate sodium-induced colitis in mice. Clinical & Experimental Pharmacology & Physiology 42, 76\u201386, doi:10.1111\/1440-1681.12321 (2014).","journal-title":"Clinical & Experimental Pharmacology & Physiology"}],"updated-by":[{"DOI":"10.1038\/s41598-018-21978-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-01335-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-01335-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-01335-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T03:52:49Z","timestamp":1671767569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-01335-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,26]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["1335"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-01335-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,26]]},"assertion":[{"value":"7 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2018","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A correction to this article has been published and is linked from the HTML and PDF\u00a0versions of this paper. The error has been fixed in the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"1189"}}