{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:08:46Z","timestamp":1793066926910,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The responses of neurons in mouse primary visual cortex (V1) to visual stimuli depend on behavioral states. Specifically, surround suppression is reduced during locomotion. Although locomotion-induced vasoactive intestinal polypeptide positive (VIP) interneuron depolarization can account for the reduction of surround suppression, the functions of VIP cell depolarization are not fully understood. Here we utilize a firing rate model and a computational model to elucidate the potential functions of VIP cell depolarization during locomotion. Our analyses suggest 1) that surround suppression sharpens the visual responses in V1 to a stationary scene, 2) that depolarized VIP cells enhance V1 responses to moving objects by reducing self-induced surround suppression and 3) that during locomotion V1 neuron responses to some features of the moving objects can be selectively enhanced. Thus, VIP cells regulate surround suppression to allow pyramidal neurons to optimally encode visual information independent of behavioral state.<\/jats:p>","DOI":"10.1038\/s41598-017-01830-0","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T06:32:34Z","timestamp":1494225154000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Visual processing mode switching regulated by VIP cells"],"prefix":"10.1038","volume":"7","author":[{"given":"Jung Hoon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Mihalas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,12]]},"reference":[{"key":"1830_CR1","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1126\/science.1254126","volume":"345","author":"S Zhang","year":"2014","unstructured":"Zhang, S. et al. Long-range and local circuits for top-down modulation of visual cortex processing. Science (80-.) \n                           345, 660\u2013665, doi:10.1126\/science.1254126 (2014).","journal-title":"Science (80-.)"},{"key":"1830_CR2","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.cell.2014.01.050","volume":"156","author":"Y Fu","year":"2014","unstructured":"Fu, Y. et al. A cortical circuit for gain control by behavioral state. Cell \n                           156, 1139\u201352, doi:10.1016\/j.cell.2014.01.050 (2014).","journal-title":"Cell"},{"key":"1830_CR3","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature17187","volume":"531","author":"AR Mardinly","year":"2016","unstructured":"Mardinly, A. R. et al. Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons. 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