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The cytotoxic effect of low-dose Cadmium (Cd) was tested <jats:italic>in vitro<\/jats:italic> and <jats:italic>ex vivo<\/jats:italic> on synoviocytes, the mesenchymal key effector cells of inflammation and proliferation in arthritis. The anti-inflammatory and anti-proliferative effects of Cd were tested <jats:italic>in vivo<\/jats:italic> by intra-articular injection in the adjuvant induced arthritis rat joints, where the clinical scores and the consequences of arthritis were evaluated. Cell death through apoptosis was highly induced by Cd in inflammatory synoviocytes (80% reduction of cell viability, p\u2009&lt;\u20090.01). TNF plus IL-17 cytokine combination induced a two-fold increase of Cd cell content by enhancing the ZIP-8 importer and the MT-1 homeostasis regulator expression. Addition of Cd reduced IL-6 production in TNF plus IL-17-activated synoviocytes (up to 83%, p\u2009&lt;\u20090.05) and in <jats:italic>ex-vivo<\/jats:italic> synovium biopsies (up to 94%, p\u2009&lt;\u20090.01). Cd-injection in rat joints improved arthritis, reducing clinical scores (arthritic score reduced from 4 to 2, p\u2009&lt;\u20090.01), inflammatory cell recruitment (up to 50%, p\u2009&lt;\u20090.01) and protecting from bone\/cartilage destruction. This proof of concept study is supported by the limited Cd spread in body reservoirs, with low-dose Cd providing a safe risk\/benefit ratio, without toxic effects on other cell types and organs.<\/jats:p>","DOI":"10.1038\/s41598-017-02611-5","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T11:19:34Z","timestamp":1495192774000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Protective effect of low dose intra-articular cadmium on inflammation and joint destruction in arthritis"],"prefix":"10.1038","volume":"7","author":[{"given":"Paola","family":"Bonaventura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Courbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Lamboux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Lavocat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1177-9497","authenticated-orcid":false,"given":"Hubert","family":"Marotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Albar\u00e8de","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Miossec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"2611_CR1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0092-8674(00)81109-5","volume":"85","author":"M Feldmann","year":"1996","unstructured":"Feldmann, M., Brennan, F. 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