{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T08:44:25Z","timestamp":1794041065921,"version":"4.8.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mueller polarimetric imaging enables the detection and quantification of modifications of the collagen fibers in the uterine cervix due to the development of a precancerous lesion. This information is not accessible through the use of the classic colposcope, a low magnification microscope used in current practice for cervical cancer screening. However, the\n                    <jats:italic>in vivo<\/jats:italic>\n                    application of Mueller polarimetric imaging poses an instrumental challenge: the device should be sufficiently compact, while still being able to perform fast and accurate acquisition of Mueller matrices in real-world conditions. In this study, the first wide field Mueller Polarimetric Colposcope (MPC) for the\n                    <jats:italic>in vivo<\/jats:italic>\n                    analysis of uterine cervix is presented. The MPC has been fabricated by grafting a miniaturized Mueller polarimetric imager on a classic colposcope. This new imaging tool performs the fast acquisition of Mueller polarimetric images, thus eliminating any blurring effects due to patient movements. It can be easily used by a practitioner with little change to their existing practice. Finally, the MPC was tested\n                    <jats:italic>in vivo<\/jats:italic>\n                    on a number of patients in the field.\n                  <\/jats:p>","DOI":"10.1038\/s41598-017-02645-9","type":"journal-article","created":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T11:50:46Z","timestamp":1495453846000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["In vivo imaging of uterine cervix with a Mueller polarimetric colposcope"],"prefix":"10.1038","volume":"7","author":[{"given":"J\u00e9r\u00e9my","family":"Vizet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Rehbinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislas","family":"Deby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Roussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Nazac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranya","family":"Soufan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Genestie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Haie-Meder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Pierangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,1]]},"reference":[{"key":"2645_CR1","doi-asserted-by":"publisher","first-page":"110801","DOI":"10.1117\/1.3652896","volume":"16","author":"N Ghosh","year":"2011","unstructured":"Ghosh, N. & Vitkin, I. A. Tissue polarimetry: concepts, challenges, applications, and outlook. Journal of biomedical optics 16, 110801\u201311080129, doi:10.1117\/1.3652896 (2011).","journal-title":"Journal of biomedical optics"},{"key":"2645_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1117\/1.1484498","volume":"7","author":"SL Jacques","year":"2002","unstructured":"Jacques, S. L., Ramella-Roman, J. C. & Lee, K. Imaging skin pathology with polarized light. Journal of biomedical optics 7, 329\u2013340, doi:10.1117\/1.1484498 (2002).","journal-title":"Journal of biomedical optics"},{"key":"2645_CR3","doi-asserted-by":"crossref","unstructured":"Smith, M. H., Burke, P. D., Lompado, A., Tanner, E. A. & Hillman, L. W. Mueller matrix imaging polarimetry in dermatology. In BiOS 2000 The International Symposium on Biomedical Optics 210\u2013216 (International Society for Optics and Photonics, 2000).","DOI":"10.1117\/12.384904"},{"key":"2645_CR4","doi-asserted-by":"crossref","unstructured":"Smith, M. H. Interpreting mueller matrix images of tissues. In BiOS 2001 The International Symposium on Biomedical Optics 82\u201389 (International Society for Optics and Photonics, 2001).","DOI":"10.1117\/12.434690"},{"key":"2645_CR5","unstructured":"Wang, W. et al. Investigation on the potential of mueller matrix imaging for digital staining. Journal of biophotonics 9999 (2015)."},{"key":"2645_CR6","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1364\/OE.19.001582","volume":"19","author":"A Pierangelo","year":"2011","unstructured":"Pierangelo, A. et al. Ex-vivo characterization of human colon cancer by mueller polarimetric imaging. Optics express 19, 1582\u20131593, doi:10.1364\/OE.19.001582 (2011).","journal-title":"Optics express"},{"key":"2645_CR7","doi-asserted-by":"publisher","first-page":"0660091","DOI":"10.1117\/1.JBO.17.6.066009","volume":"17","author":"A Pierangelo","year":"2012","unstructured":"Pierangelo, A. et al. Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral mueller imaging. Journal of biomedical optics 17, 0660091\u20130660096, doi:10.1117\/1.JBO.17.6.066009 (2012).","journal-title":"Journal of biomedical optics"},{"key":"2645_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1364\/OPN.23.10.000026","volume":"23","author":"T Novikova","year":"2012","unstructured":"Novikova, T., Pierangelo, A., De Martino, A., Benali, A. & Validire, P. Polarimetric imaging for cancer diagnosis and staging. Optics and photonics news 23, 26, doi:10.1364\/OPN.23.10.000026 (2012).","journal-title":"Optics and photonics news"},{"key":"2645_CR9","doi-asserted-by":"publisher","first-page":"241103","DOI":"10.1063\/1.4811414","volume":"102","author":"T Novikova","year":"2013","unstructured":"Novikova, T. et al. The origins of polarimetric image contrast between healthy and cancerous human colon tissue. Applied Physics Letters 102, 241103, doi:10.1063\/1.4811414 (2013).","journal-title":"Applied Physics Letters"},{"key":"2645_CR10","doi-asserted-by":"publisher","first-page":"10200","DOI":"10.1364\/OE.18.010200","volume":"18","author":"M-R Antonelli","year":"2010","unstructured":"Antonelli, M.-R. et al. Mueller matrix imaging of human colon tissue for cancer diagnostics: how monte carlo modeling can help in the interpretation of experimental data. Optics express 18, 10200\u201310208, doi:10.1364\/OE.18.010200 (2010).","journal-title":"Optics express"},{"key":"2645_CR11","doi-asserted-by":"publisher","first-page":"046014","DOI":"10.1117\/1.JBO.18.4.046014","volume":"18","author":"A Pierangelo","year":"2013","unstructured":"Pierangelo, A. et al. Multispectral mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas. Journal of biomedical optics 18, 046014\u2013046014, doi:10.1117\/1.JBO.18.4.046014 (2013).","journal-title":"Journal of biomedical optics"},{"key":"2645_CR12","doi-asserted-by":"publisher","first-page":"14120","DOI":"10.1364\/OE.21.014120","volume":"21","author":"A Pierangelo","year":"2013","unstructured":"Pierangelo, A. et al. Polarimetric imaging of uterine cervix: a case study. Optics express 21, 14120\u201314130, doi:10.1364\/OE.21.014120 (2013).","journal-title":"Optics express"},{"key":"2645_CR13","doi-asserted-by":"publisher","first-page":"22561","DOI":"10.1364\/OE.22.022561","volume":"22","author":"S Bancelin","year":"2014","unstructured":"Bancelin, S. et al. Determination of collagen fiber orientation in histological slides using mueller microscopy and validation by second harmonic generation imaging. Optics express 22, 22561\u201322574, doi:10.1364\/OE.22.022561 (2014).","journal-title":"Optics express"},{"key":"2645_CR14","doi-asserted-by":"publisher","first-page":"071113","DOI":"10.1117\/1.JBO.21.7.071113","volume":"21","author":"J Rehbinder","year":"2016","unstructured":"Rehbinder, J. et al. Ex vivo mueller polarimetric imaging of the uterine cervix: a first statistical evaluation. Journal of biomedical optics 21, 071113\u2013071113, doi:10.1117\/1.JBO.21.7.071113 (2016).","journal-title":"Journal of biomedical optics"},{"key":"2645_CR15","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1364\/OE.17.001600","volume":"17","author":"P Shukla","year":"2009","unstructured":"Shukla, P. & Pradhan, A. Mueller decomposition images for cervical tissue: Potential for discriminating normal and dysplastic states. Optics express 17, 1600\u20131609, doi:10.1364\/OE.17.001600 (2009).","journal-title":"Optics express"},{"key":"2645_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1364\/OL.38.000211","volume":"38","author":"N Das","year":"2013","unstructured":"Das, N. et al. Probing multifractality in tissue refractive index: prospects for precancer detection. Optics letters 38, 211\u2013213, doi:10.1364\/OL.38.000211 (2013).","journal-title":"Optics letters"},{"key":"2645_CR17","unstructured":"Nazac, A. Imagerie polarim\u00e9trique pour le diagnostic de n\u00e9oplasies intra \u00e9pith\u00e9liales du col ut\u00e9rin: \u00e9tude de conisations et de lames histologiques de tissus conjonctifs. Ph.D. thesis (2013)."},{"key":"2645_CR18","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1529\/biophysj.106.089839","volume":"92","author":"D Arifler","year":"2007","unstructured":"Arifler, D., Pavlova, I., Gillenwater, A. & Richards-Kortum, R. Light scattering from collagen fiber networks: micro-optical properties of normal and neoplastic stroma. Biophysical journal 92, 3260\u201374, doi:10.1529\/biophysj.106.089839 (2007).","journal-title":"Biophysical journal"},{"key":"2645_CR19","first-page":"626","volume":"91","author":"MF Mitchell","year":"1998","unstructured":"Mitchell, M. F., Schottenfeld, D., Tortolero-Luna, G., Cantor, S. B. & Richards-Kortum, R. Colposcopy for the diagnosis of squamous intraepithelial lesions: a meta-analysis. Obstetrics & Gynecology 91, 626\u2013631 (1998).","journal-title":"Obstetrics & Gynecology"},{"key":"2645_CR20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2307\/3583258","volume":"6","author":"OB Olaniyan","year":"2002","unstructured":"Olaniyan, O. B. Validity of colposcopy in the diagnosis of early cervical neoplasia: a review. African journal of reproductive health 6, 59\u201369, doi:10.2307\/3583258 (2002).","journal-title":"African journal of reproductive health"},{"key":"2645_CR21","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1590\/S0104-42302002000200033","volume":"48","author":"FFB Tuon","year":"2002","unstructured":"Tuon, F. F. B., Bittencourt, M. S., Panichi, M. A. & Pinto, \u00c1. P. Sensibility and specificity of cytology and colposcopy exams with the histological evaluation of cervical intraepithelial lesions. Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira 48, 140\u2013144 (2002).","journal-title":"Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"},{"key":"2645_CR22","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/S0090-8258(03)00082-9","volume":"89","author":"LS Massad","year":"2003","unstructured":"Massad, L. S. & Collins, Y. C. Strength of correlations between colposcopic impression and biopsy histology. Gynecologic oncology 89, 424\u2013428, doi:10.1016\/S0090-8258(03)00082-9 (2003).","journal-title":"Gynecologic oncology"},{"key":"2645_CR23","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/00128360-200407000-00009","volume":"8","author":"M Sideri","year":"2004","unstructured":"Sideri, M. et al. Interobserver variability of colposcopic interpretations and consistency with final histologic results. Journal of lower genital tract disease 8, 212\u2013216, doi:10.1097\/00128360-200407000-00009 (2004).","journal-title":"Journal of lower genital tract disease"},{"key":"2645_CR24","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/S0002-9378(03)00413-7","volume":"188","author":"TA-LTSA Group","year":"2003","unstructured":"Group, T. A.-L. T. S. A. A randomized trial on the management of low-grade squamous intraepithelial lesion cytology interpretations. American journal of obstetrics and gynecology 188, 1393\u20131400, doi:10.1016\/S0002-9378(03)00413-7 (2003).","journal-title":"American journal of obstetrics and gynecology"},{"key":"2645_CR25","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1111\/j.1471-0528.2012.03444.x","volume":"119","author":"M Underwood","year":"2012","unstructured":"Underwood, M. et al. Accuracy of colposcopy-directed punch biopsies: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics & Gynaecology 119, 1293\u20131301, doi:10.1111\/j.1471-0528.2012.03444.x (2012).","journal-title":"BJOG: An International Journal of Obstetrics & Gynaecology"},{"key":"2645_CR26","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1002\/pssc.200777805","volume":"5","author":"M Anastasiadou","year":"2008","unstructured":"Anastasiadou, M. et al. Polarimetric imaging for the diagnosis of cervical cancer. physica status solidi (c) 5, 1423\u20131426, doi:10.1002\/(ISSN)1610-1642 (2008).","journal-title":"physica status solidi (c)"},{"key":"2645_CR27","doi-asserted-by":"publisher","first-page":"043901","DOI":"10.1103\/PhysRevLett.109.043901","volume":"109","author":"J Fade","year":"2012","unstructured":"Fade, J. & Alouini, M. Depolarization remote sensing by orthogonality breaking. Physical review letters 109, 043901, doi:10.1103\/PhysRevLett.109.043901 (2012).","journal-title":"Physical review letters"},{"key":"2645_CR28","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.1364\/OL.34.003409","volume":"34","author":"J Desroches","year":"2009","unstructured":"Desroches, J., Pagnoux, D., Louradour, F. & Barth\u00e9l\u00e9my, A. Fiber-optic device for endoscopic polarization imaging. Optics letters 34, 3409\u20133411, doi:10.1364\/OL.34.003409 (2009).","journal-title":"Optics letters"},{"key":"2645_CR29","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1117\/1.1483314","volume":"7","author":"A Myakov","year":"2002","unstructured":"Myakov, A. et al. Fiber optic probe for polarized reflectance spectroscopy in vivo: design and performance. Journal of biomedical optics 7, 388\u2013397, doi:10.1117\/1.1483314 (2002).","journal-title":"Journal of biomedical optics"},{"key":"2645_CR30","doi-asserted-by":"crossref","unstructured":"Qi, J. & Elson, D. S. A high definition mueller polarimetric endoscope for tissue characterisation. Scientific reports 6 (2016).","DOI":"10.1038\/srep25953"},{"key":"2645_CR31","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1364\/OE.23.003047","volume":"23","author":"S Manhas","year":"2015","unstructured":"Manhas, S. et al. Demonstration of full 4\u2009\u00d7\u20094 mueller polarimetry through an optical fiber for endoscopic applications. Optics express 23, 3047\u20133054 (2015).","journal-title":"Optics express"},{"key":"2645_CR32","doi-asserted-by":"publisher","first-page":"071106","DOI":"10.1117\/1.JBO.21.7.071106","volume":"21","author":"J Vizet","year":"2016","unstructured":"Vizet, J. et al. Optical fiber-based full mueller polarimeter for endoscopic imaging using a two-wavelength simultaneous measurement method. Journal of biomedical optics 21, 071106\u2013071106, doi:10.1117\/1.JBO.21.7.071106 (2016).","journal-title":"Journal of biomedical optics"},{"key":"2645_CR33","doi-asserted-by":"publisher","first-page":"014029","DOI":"10.1117\/1.3065545","volume":"14","author":"MF Wood","year":"2009","unstructured":"Wood, M. F., Ghosh, N., Moriyama, E. H., Wilson, B. C. & Vitkin, I. A. Proof-of-principle demonstration of a mueller matrix decomposition method for polarized light tissue characterization in vivo. Journal of biomedical optics 14, 014029\u2013014029, doi:10.1117\/1.3065545 (2009).","journal-title":"Journal of biomedical optics"},{"key":"2645_CR34","doi-asserted-by":"publisher","first-page":"21339","DOI":"10.1364\/OE.16.021339","volume":"16","author":"K Twietmeyer","year":"2008","unstructured":"Twietmeyer, K., Chipman, R. A., Elsner, A. E., Zhao, Y. & VanNasdale, D. Mueller matrix retinal imager with optimized polarization conditions. Optics express 16, 21339\u201321354, doi:10.1364\/OE.16.021339 (2008).","journal-title":"Optics express"},{"key":"2645_CR35","doi-asserted-by":"crossref","unstructured":"Shafi, M. & Nazeer, S. Colposcopy: a practical guide (Cambridge University Press, 2012).","DOI":"10.1017\/CBO9781139136433"},{"key":"2645_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1366\/12-06883","volume":"67","author":"E Garcia-Caurel","year":"2013","unstructured":"Garcia-Caurel, E., De Martino, A., Gaston, J.-P. & Yan, L. Application of spectroscopic ellipsometry and mueller ellipsometry to optical characterization. Applied spectroscopy 67, 1\u201321, doi:10.1366\/12-06883 (2013).","journal-title":"Applied spectroscopy"},{"key":"2645_CR37","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1364\/AO.38.003490","volume":"38","author":"E Compain","year":"1999","unstructured":"Compain, E., Poirier, S. & Drevillon, B. General and self-consistent method for the calibration of polarization modulators, polarimeters, and mueller-matrix ellipsometers. Applied optics 38, 3490\u20133502, doi:10.1364\/AO.38.003490 (1999).","journal-title":"Applied optics"},{"key":"2645_CR38","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1364\/OL.28.000616","volume":"28","author":"A De Martino","year":"2003","unstructured":"De Martino, A., Kim, Y.-K., Garcia-Caurel, E., Laude, B. & Dr\u00e9villon, B. Optimized mueller polarimeter with liquid crystals. Optics letters 28, 616\u2013618, doi:10.1364\/OL.28.000616 (2003).","journal-title":"Optics letters"},{"key":"2645_CR39","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1364\/JOSAA.13.001106","volume":"13","author":"S-Y Lu","year":"1996","unstructured":"Lu, S.-Y. & Chipman, R. A. Interpretation of mueller matrices based on polar decomposition. JOSA A 13, 1106\u20131113, doi:10.1364\/JOSAA.13.001106 (1996).","journal-title":"JOSA A"},{"key":"2645_CR40","doi-asserted-by":"publisher","first-page":"044036","DOI":"10.1117\/1.2960934","volume":"13","author":"N Ghosh","year":"2008","unstructured":"Ghosh, N., Wood, M. F. & Vitkin, I. A. Mueller matrix decomposition for extraction of individual polarization parameters from complex turbid media exhibiting multiple scattering, optical activity, and linear birefringence. Journal of biomedical optics 13, 044036\u2013044036, doi:10.1117\/1.2960934 (2008).","journal-title":"Journal of biomedical optics"},{"key":"2645_CR41","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1364\/BOE.4.002433","volume":"4","author":"J Qi","year":"2013","unstructured":"Qi, J., Ye, M., Singh, M., Clancy, N. T. & Elson, D. S. Narrow band 3\u2009\u00d7\u20093 mueller polarimetric endoscopy. Biomedical optics express 4, 2433\u20132449, doi:10.1364\/BOE.4.002433 (2013).","journal-title":"Biomedical optics express"},{"key":"2645_CR42","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1364\/JOSAA.26.001109","volume":"26","author":"R Ossikovski","year":"2009","unstructured":"Ossikovski, R. Analysis of depolarizing mueller matrices through a symmetric decomposition. JOSA A 26, 1109\u20131118, doi:10.1364\/JOSAA.26.001109 (2009).","journal-title":"JOSA A"},{"key":"2645_CR43","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1364\/OL.36.002330","volume":"36","author":"R Ossikovski","year":"2011","unstructured":"Ossikovski, R. Differential matrix formalism for depolarizing anisotropic media. Optics letters 36, 2330\u20132332, doi:10.1364\/OL.36.002330 (2011).","journal-title":"Optics letters"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-02645-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-02645-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-02645-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T14:57:03Z","timestamp":1750258623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-02645-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,1]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["2645"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-02645-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,1]]},"assertion":[{"value":"12 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"2471"}}