{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:51:02Z","timestamp":1787615462722,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical significance of elevated baseline serum potassium (K<jats:sup>+<\/jats:sup>) levels in hospitalised patients is rarely described. Hence, we performed a retrospective study assessing the significance of elevated K<jats:sup>+<\/jats:sup> levels in a one-year admission cohort. Adult patients without hypokalaemia or end-stage renal disease were included. Adverse outcomes were all-cause mortality, hospital-acquired acute kidney injury, and events of arrhythmia. In total, 17,777 patients were included in the study cohort, and a significant difference (P\u2009&lt;\u20090.001) was observed in mortality according to baseline serum K<jats:sup>+<\/jats:sup> levels. The adjusted hazard ratios (HRs) and associated 95% confidence intervals (CIs) of all-cause mortality for K<jats:sup>+<\/jats:sup> levels above the reference range of 3.6\u20134.0\u2009mmol\/L were as follows: 4.1\u20134.5\u2009mmol\/L, adjusted HR 1.075 (95% CI 0.981\u20131.180); 4.6\u20135.0\u2009mmol\/L, adjusted HR 1.261 (1.105\u20131.439); 5.1\u20135.5\u2009mmol\/L, adjusted HR 1.310 (1.009\u20131.700); &gt;5.5\u2009mmol\/L, adjusted HR 2.119 (1.532\u20132.930). Moreover, the risks of in-hospital acute kidney injury and arrhythmia were higher in patients with serum K<jats:sup>+<\/jats:sup> levels above 4.0\u2009mmol\/L and 5.5\u2009mmol\/L, respectively. In conclusion, increased serum K<jats:sup>+<\/jats:sup> levels, including mild elevations may be related to worse prognosis. Close monitoring and prompt correction of underlying causes or hyperkalaemia itself is warranted for admitted patients.<\/jats:p>","DOI":"10.1038\/s41598-017-02681-5","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T09:52:14Z","timestamp":1495187534000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients"],"prefix":"10.1038","volume":"7","author":[{"given":"Sehoon","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Ha","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Jun","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Young","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yon Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Wan","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Suk","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-9962","authenticated-orcid":false,"given":"Sejoong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"2681_CR1","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.amjmed.2012.06.037","volume":"126","author":"G Liamis","year":"2013","unstructured":"Liamis, G. et al. 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