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As atherosclerosis is a chronic inflammatory process with features of autoimmune disease, we investigated the impact of hematopoietic Bim deficiency on plaque formation and parameters of plaque stability. <jats:italic>Bim<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> or wild type bone marrow transplanted <jats:italic>ldlr<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice were fed a Western type diet (WTD) for 5 or 10 weeks, after which they were immunophenotyped and atherosclerotic lesions were analyzed. <jats:italic>Bim<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> transplanted mice displayed splenomegaly and overt lymphocytosis. CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells were more activated (increased CD69 and CD71 expression, increased interferon gamma production). B cells were elevated by 147%, with a shift towards the pro-atherogenic IgG-producing B2 cell phenotype, resulting in a doubling of anti-oxLDL IgG1 antibody titers in serum of <jats:italic>bim<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice. <jats:italic>Bim<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice displayed massive intraplaque accumulation of Ig complexes and of lesional T cells, although this did not translate in changes in plaque size or stability features (apoptotic cell and macrophage content). The surprising lack in plaque phenotype despite the profound pro-atherogenic immune effects may be attributable to the sharp reduction of serum cholesterol levels in WTD fed <jats:italic>bim<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice.<\/jats:p>","DOI":"10.1038\/s41598-017-02771-4","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T11:40:29Z","timestamp":1496403629000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Leukocyte Bim deficiency does not impact atherogenesis in ldlr\n                     \u2212\/\u2212 mice, despite a pronounced induction of autoimmune inflammation"],"prefix":"10.1038","volume":"7","author":[{"given":"Lieve","family":"Temmerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijke M.","family":"Westra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1242-1959","authenticated-orcid":false,"given":"Ilze","family":"Bot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart J. M.","family":"van Vlijmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niek","family":"van Bree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Bot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim L. L.","family":"Habets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom G. H.","family":"Keulers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-5918","authenticated-orcid":false,"given":"Johan","family":"van der Vlag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Cotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo J. C.","family":"van Berkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik A. L.","family":"Biessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"2771_CR1","doi-asserted-by":"publisher","unstructured":"Ruparelia, N., Chai, J. T., Fisher, E. A. & Choudhury, R. P. 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