{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:51:26Z","timestamp":1787003486935,"version":"build-2736575974"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3 in plasma and myocardium of DCM patients and evaluated their effects on NFAT luciferase activity in neonatal mouse cardiomyocytes. Elevated circulating Wnt5a (n\u2009=\u2009102) was associated with increased pulmonary artery pressures, decreased right ventricular function and adverse outcome, with a stronger association in more severely affected patients. A higher Wnt5a\/sFRP3 ratio (n\u2009=\u200925) was found in the right ventricle\n                    <jats:italic>vs<\/jats:italic>\n                    . the left ventricle and was correlated with NFAT activation as well as pulmonary artery pressures. Wnt5a induced NFAT activation and sFRP3 release in cardiomyocytes\n                    <jats:italic>in vitro<\/jats:italic>\n                    , while sFRP3 antagonized Wnt5a. Wnt5a is associated with right ventricular dysfunction and adverse outcome in DCM patients and may promote the progression of DCM through NFAT signaling.\n                  <\/jats:p>","DOI":"10.1038\/s41598-017-03625-9","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T07:22:12Z","timestamp":1496906532000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy"],"prefix":"10.1038","volume":"7","author":[{"given":"Aurelija","family":"Abraityte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida G.","family":"Lunde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik T.","family":"Askevold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika E.","family":"Michelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Yndestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnt","family":"Fiane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Andreassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svend","family":"Aakhus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen P.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Gullestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar","family":"Broch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"3625_CR1","doi-asserted-by":"crossref","unstructured":"Liu, L. & Eisen, H. J. Epidemiology of heart failure and scope of the problem. Cardiology clinics \n                           32, 1\u20138 vii (2014).","DOI":"10.1016\/j.ccl.2013.09.009"},{"key":"3625_CR2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1248\/bpb.b212023","volume":"36","author":"A Sanbe","year":"2013","unstructured":"Sanbe, A. Dilated cardiomyopathy: a disease of the myocardium. Biological & pharmaceutical bulletin \n                           36, 18\u201322 (2013).","journal-title":"Biological & pharmaceutical bulletin"},{"key":"3625_CR3","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1113\/jphysiol.2012.235382","volume":"591","author":"K Dawson","year":"2013","unstructured":"Dawson, K., Aflaki, M. & Nattel, S. Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential. The Journal of physiology \n                           591, 1409\u20131432 (2013).","journal-title":"The Journal of physiology"},{"key":"3625_CR4","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1748-1716.2011.02309.x","volume":"204","author":"P ter Horst","year":"2012","unstructured":"ter Horst, P., Smits, J. F. & Blankesteijn, W. M. The Wnt\/Frizzled pathway as a therapeutic target for cardiac hypertrophy: where do we stand? Acta physiologica (Oxford, England) \n                           204, 110\u2013117 (2012).","journal-title":"Acta physiologica (Oxford, England)"},{"key":"3625_CR5","doi-asserted-by":"crossref","unstructured":"Le Dour, C. et al. Decreased WNT\/beta-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a\/C gene. Human molecular genetics (2017).","DOI":"10.1093\/hmg\/ddw389"},{"key":"3625_CR6","doi-asserted-by":"crossref","unstructured":"Hou, N. et al. Transcription Factor 7-like 2 Mediates Canonical Wnt\/beta-Catenin Signaling and c-Myc Upregulation in Heart Failure. Circulation. Heart failure \n                           9 (2016).","DOI":"10.1161\/CIRCHEARTFAILURE.116.003010"},{"key":"3625_CR7","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/S0008-6363(99)00376-4","volume":"45","author":"H Schumann","year":"2000","unstructured":"Schumann, H., Holtz, J., Zerkowski, H. R. & Hatzfeld, M. Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression. Cardiovascular research \n                           45, 720\u2013728 (2000).","journal-title":"Cardiovascular research"},{"key":"3625_CR8","doi-asserted-by":"crossref","unstructured":"Lu, D. et al. Dkk3 prevents familial dilated cardiomyopathy development through Wnt pathway. Laboratory investigation; a journal of technical methods and pathology (2015).","DOI":"10.1038\/labinvest.2015.145"},{"key":"3625_CR9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1161\/01.RES.0000109415.17511.18","volume":"94","author":"BJ Wilkins","year":"2004","unstructured":"Wilkins, B. J. et al. Calcineurin\/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res \n                           94, 110\u2013118 (2004).","journal-title":"Circ Res"},{"key":"3625_CR10","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1093\/cvr\/cvq217","volume":"88","author":"M Tang","year":"2010","unstructured":"Tang, M. et al. Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts. Cardiovascular research \n                           88, 424\u2013433 (2010).","journal-title":"Cardiovascular research"},{"key":"3625_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ejheart.2003.07.007","volume":"6","author":"H Diedrichs","year":"2004","unstructured":"Diedrichs, H., Chi, M., Boelck, B., Mehlhorn, U. & Schwinger, R. H. Increased regulatory activity of the calcineurin\/NFAT pathway in human heart failure. European journal of heart failure \n                           6, 3\u20139 (2004).","journal-title":"European journal of heart failure"},{"key":"3625_CR12","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1016\/j.febslet.2014.05.039","volume":"588","author":"M Hagenmueller","year":"2014","unstructured":"Hagenmueller, M. et al. Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy by regulating the Wnt\/PCP pathway. FEBS letters \n                           588, 2230\u20132237 (2014).","journal-title":"FEBS letters"},{"key":"3625_CR13","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1210\/me.2010-0037","volume":"24","author":"EW Bradley","year":"2010","unstructured":"Bradley, E. W. & Drissi, M. H. WNT5A regulates chondrocyte differentiation through differential use of the CaN\/NFAT and IKK\/NF-kappaB pathways. Molecular endocrinology (Baltimore, Md.) \n                           24, 1581\u20131593 (2010).","journal-title":"Molecular endocrinology (Baltimore, Md.)"},{"key":"3625_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1593\/neo.121312","volume":"15","author":"H Griesmann","year":"2013","unstructured":"Griesmann, H. et al. WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer. Neoplasia (New York, N.Y.) \n                           15, 11\u201322 (2013).","journal-title":"Neoplasia (New York, N.Y.)"},{"key":"3625_CR15","doi-asserted-by":"crossref","unstructured":"Abraityte, A. et al. Wnt5a is elevated in heart failure and affects cardiac fibroblast function. Journal of molecular medicine (2017).","DOI":"10.1007\/s00109-017-1529-1"},{"key":"3625_CR16","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/joim.12175","volume":"275","author":"ET Askevold","year":"2014","unstructured":"Askevold, E. T. et al. The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure. Journal of internal medicine \n                           275, 621\u2013630 (2014).","journal-title":"Journal of internal medicine"},{"key":"3625_CR17","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ydbio.2007.03.011","volume":"306","author":"D Qian","year":"2007","unstructured":"Qian, D. et al. Wnt5a functions in planar cell polarity regulation in mice. Developmental biology \n                           306, 121\u2013133 (2007).","journal-title":"Developmental biology"},{"key":"3625_CR18","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1158\/2326-6066.CIR-14-0167","volume":"3","author":"A Holtzhausen","year":"2015","unstructured":"Holtzhausen, A. et al. Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy. Cancer immunology research \n                           3, 1082\u20131095 (2015).","journal-title":"Cancer immunology research"},{"key":"3625_CR19","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1016\/j.biomaterials.2013.01.066","volume":"34","author":"A Yamada","year":"2013","unstructured":"Yamada, A., Iwata, T., Yamato, M., Okano, T. & Izumi, Y. Diverse functions of secreted frizzled-related proteins in the osteoblastogenesis of human multipotent mesenchymal stromal cells. Biomaterials \n                           34, 3270\u20133278 (2013).","journal-title":"Biomaterials"},{"key":"3625_CR20","doi-asserted-by":"publisher","first-page":"e18674","DOI":"10.1371\/journal.pone.0018674","volume":"6","author":"EJ Ekstrom","year":"2011","unstructured":"Ekstrom, E. J., Sherwood, V. & Andersson, T. Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion. PloS one \n                           6, e18674 (2011).","journal-title":"PloS one"},{"key":"3625_CR21","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1080\/08977190802442013","volume":"26","author":"W Liu","year":"2008","unstructured":"Liu, W. et al. Coordinated molecular control of otic capsule differentiation: functional role of Wnt5a signaling and opposition by sfrp3 activity. Growth factors (Chur, Switzerland) \n                           26, 343\u2013354 (2008).","journal-title":"Growth factors (Chur, Switzerland)"},{"key":"3625_CR22","doi-asserted-by":"publisher","first-page":"13610","DOI":"10.1074\/jbc.M112.381046","volume":"288","author":"B Li","year":"2013","unstructured":"Li, B. et al. Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+\/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways. The Journal of biological chemistry \n                           288, 13610\u201313619 (2013).","journal-title":"The Journal of biological chemistry"},{"key":"3625_CR23","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1161\/CIRCULATIONAHA.106.632208","volume":"114","author":"NF Voelkel","year":"2006","unstructured":"Voelkel, N. F. et al. Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation \n                           114, 1883\u20131891 (2006).","journal-title":"Circulation"},{"key":"3625_CR24","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1093\/ejechocard\/jer138","volume":"12","author":"M Pavlicek","year":"2011","unstructured":"Pavlicek, M. et al. Right ventricular systolic function assessment: rank of echocardiographic methods vs. cardiac magnetic resonance imaging. European journal of echocardiography: the journal of the Working Group on Echocardiography of the European Society of Cardiology \n                           12, 871\u2013880 (2011).","journal-title":"European journal of echocardiography: the journal of the Working Group on Echocardiography of the European Society of Cardiology"},{"key":"3625_CR25","doi-asserted-by":"publisher","first-page":"16623","DOI":"10.1074\/jbc.M109.098236","volume":"285","author":"M Oh","year":"2010","unstructured":"Oh, M., Dey, A., Gerard, R. D., Hill, J. A. & Rothermel, B. A. The CCAAT\/enhancer binding protein beta (C\/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1\u20134. The Journal of biological chemistry \n                           285, 16623\u201316631 (2010).","journal-title":"The Journal of biological chemistry"},{"key":"3625_CR26","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1161\/CIRCHEARTFAILURE.114.001958","volume":"8","author":"K Okada","year":"2015","unstructured":"Okada, K. et al. Wnt\/beta-Catenin Signaling Contributes to Skeletal Myopathy in Heart Failure via Direct Interaction With Forkhead Box O. Circulation. Heart failure \n                           8, 799\u2013808 (2015).","journal-title":"Circulation. Heart failure"},{"key":"3625_CR27","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.carpath.2014.12.002","volume":"24","author":"XH Xi","year":"2015","unstructured":"Xi, X. H. et al. Activation of Wnt\/beta-catenin\/GSK3beta signaling during the development of diabetic cardiomyopathy. Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology \n                           24, 179\u2013186 (2015).","journal-title":"Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology"},{"key":"3625_CR28","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1161\/HYPERTENSIONAHA.114.04467","volume":"65","author":"M Zhang","year":"2015","unstructured":"Zhang, M. et al. Calcium\/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy. Hypertension \n                           65, 335\u2013344 (2015).","journal-title":"Hypertension"},{"key":"3625_CR29","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1161\/01.CIR.102.14.1718","volume":"102","author":"DL Moraes","year":"2000","unstructured":"Moraes, D. L., Colucci, W. S. & Givertz, M. M. Secondary pulmonary hypertension in chronic heart failure: the role of the endothelium in pathophysiology and management. Circulation \n                           102, 1718\u20131723 (2000).","journal-title":"Circulation"},{"key":"3625_CR30","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1253\/circj.CJ-13-1120","volume":"78","author":"A Hirashiki","year":"2014","unstructured":"Hirashiki, A. et al. Prognostic value of pulmonary hypertension in ambulatory patients with non-ischemic dilated cardiomyopathy. Circulation journal: official journal of the Japanese Circulation Society \n                           78, 1245\u20131253 (2014).","journal-title":"Circulation journal: official journal of the Japanese Circulation Society"},{"key":"3625_CR31","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1161\/CIRCULATIONAHA.110.976969","volume":"124","author":"H Laeremans","year":"2011","unstructured":"Laeremans, H. et al. Blocking of frizzled signaling with a homologous peptide fragment of wnt3a\/wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarction. Circulation \n                           124, 1626\u20131635 (2011).","journal-title":"Circulation"},{"key":"3625_CR32","doi-asserted-by":"crossref","unstructured":"Hermans, K. et al. UM206, a Peptide Fragment of Wnt5a, Attenuates Adverse Remodeling after Myocardial Infarction in Swine. The FASEB Journal \n                           29 (2015).","DOI":"10.1096\/fasebj.29.1_supplement.942.12"},{"key":"3625_CR33","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1093\/infdis\/169.2.420","volume":"169","author":"P Aukrust","year":"1994","unstructured":"Aukrust, P. et al. Serum levels of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptors in human immunodeficiency virus type 1 infection\u2013correlations to clinical, immunologic, and virologic parameters. The Journal of infectious diseases \n                           169, 420\u2013424 (1994).","journal-title":"The Journal of infectious diseases"},{"key":"3625_CR34","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/S0002-9149(98)00872-8","volume":"83","author":"P Aukrust","year":"1999","unstructured":"Aukrust, P. et al. Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. The American journal of cardiology \n                           83, 376\u2013382 (1999).","journal-title":"The American journal of cardiology"},{"key":"3625_CR35","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1242\/jcs.026096","volume":"121","author":"P Bovolenta","year":"2008","unstructured":"Bovolenta, P., Esteve, P., Ruiz, J. M., Cisneros, E. & Lopez-Rios, J. Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. Journal of cell science \n                           121, 737\u2013746 (2008).","journal-title":"Journal of cell science"},{"key":"3625_CR36","doi-asserted-by":"publisher","first-page":"4083","DOI":"10.1242\/dev.032524","volume":"136","author":"Y Mii","year":"2009","unstructured":"Mii, Y. & Taira, M. Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range. Development (Cambridge, England) \n                           136, 4083\u20134088 (2009).","journal-title":"Development (Cambridge, England)"},{"key":"3625_CR37","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S0092-8674(00)81921-2","volume":"88","author":"L Leyns","year":"1997","unstructured":"Leyns, L., Bouwmeester, T., Kim, S. H., Piccolo, S. & De Robertis, E. M. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell \n                           88, 747\u2013756 (1997).","journal-title":"Cell"},{"key":"3625_CR38","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1002\/jcb.20284","volume":"93","author":"GM Boland","year":"2004","unstructured":"Boland, G. M., Perkins, G., Hall, D. J. & Tuan, R. S. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. Journal of cellular biochemistry \n                           93, 1210\u20131230 (2004).","journal-title":"Journal of cellular biochemistry"},{"key":"3625_CR39","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0092-8674(00)81922-4","volume":"88","author":"S Wang","year":"1997","unstructured":"Wang, S., Krinks, M., Lin, K., Luyten, F. P. & Moos, M. Jr. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell \n                           88, 757\u2013766 (1997).","journal-title":"Cell"},{"key":"3625_CR40","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ccl.2012.03.005","volume":"30","author":"TM Kolb","year":"2012","unstructured":"Kolb, T. M. & Hassoun, P. M. Right ventricular dysfunction in chronic lung disease. Cardiology clinics \n                           30, 243\u2013256 (2012).","journal-title":"Cardiology clinics"},{"key":"3625_CR41","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/1873-3468.12038","volume":"590","author":"J Takahashi","year":"2016","unstructured":"Takahashi, J., Orcholski, M. & Yuan, K. & de Jesus Perez, V. PDGF-dependent beta-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension. FEBS letters \n                           590, 101\u2013109 (2016).","journal-title":"FEBS letters"},{"key":"3625_CR42","doi-asserted-by":"publisher","first-page":"L103","DOI":"10.1152\/ajplung.00070.2012","volume":"304","author":"XM Yu","year":"2013","unstructured":"Yu, X. M. et al. Wnt5a inhibits hypoxia-induced pulmonary arterial smooth muscle cell proliferation by downregulation of beta-catenin. American journal of physiology. Lung cellular and molecular physiology \n                           304, L103\u2013111 (2013).","journal-title":"American journal of physiology. Lung cellular and molecular physiology"},{"key":"3625_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2016.02.017","volume":"148","author":"Z Kang","year":"2016","unstructured":"Kang, Z. et al. Ponatinib attenuates experimental pulmonary arterial hypertension by modulating Wnt signaling and vasohibin-2\/vasohibin-1. Life sciences \n                           148, 1\u20138 (2016).","journal-title":"Life sciences"},{"key":"3625_CR44","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1177\/1535370215584889","volume":"240","author":"Y Jin","year":"2015","unstructured":"Jin, Y. et al. Wnt5a attenuates hypoxia-induced pulmonary arteriolar remodeling and right ventricular hypertrophy in mice. Experimental biology and medicine \n                           240, 1742\u20131751 (2015).","journal-title":"Experimental biology and medicine"},{"key":"3625_CR45","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.apjtm.2015.10.002","volume":"8","author":"J He","year":"2015","unstructured":"He, J., Cai, Y., Luo, L. M. & Wang, R. Expression of Wnt and NCX1 and its correlation with cardiomyocyte apoptosis in mouse with myocardial hypertrophy. Asian Pacific journal of tropical medicine \n                           8, 930\u2013936 (2015).","journal-title":"Asian Pacific journal of tropical medicine"},{"key":"3625_CR46","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1084\/jem.20160675","volume":"214","author":"HA Baarsma","year":"2017","unstructured":"Baarsma, H. A. et al. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD. The Journal of experimental medicine \n                           214, 143\u2013163 (2017).","journal-title":"The Journal of experimental medicine"},{"key":"3625_CR47","doi-asserted-by":"crossref","unstructured":"Rydell-Tormanen, K. et al. Aberrant nonfibrotic parenchyma in idiopathic pulmonary fibrosis is correlated with decreased beta-catenin inhibition and increased Wnt5a\/b interaction. Physiological reports \n                           4 (2016).","DOI":"10.14814\/phy2.12727"},{"key":"3625_CR48","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1165\/rcmb.2008-0201OC","volume":"41","author":"LJ Vuga","year":"2009","unstructured":"Vuga, L. J. et al. WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis. American journal of respiratory cell and molecular biology \n                           41, 583\u2013589 (2009).","journal-title":"American journal of respiratory cell and molecular biology"},{"key":"3625_CR49","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1172\/JCI119770","volume":"100","author":"BD Lowes","year":"1997","unstructured":"Lowes, B. D. et al. Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium. The Journal of clinical investigation \n                           100, 2315\u20132324 (1997).","journal-title":"The Journal of clinical investigation"},{"key":"3625_CR50","doi-asserted-by":"publisher","first-page":"H1351","DOI":"10.1152\/ajpheart.91526.2007","volume":"295","author":"T Urashima","year":"2008","unstructured":"Urashima, T. et al. Molecular and physiological characterization of RV remodeling in a murine model of pulmonary stenosis. American journal of physiology. Heart and circulatory physiology \n                           295, H1351\u2013h1368 (2008).","journal-title":"American journal of physiology. Heart and circulatory physiology"},{"key":"3625_CR51","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.ijcard.2014.11.003","volume":"179","author":"K Broch","year":"2015","unstructured":"Broch, K. et al. Soluble ST2 reflects hemodynamic stress in non-ischemic heart failure. International journal of cardiology \n                           179, 378\u2013384 (2015).","journal-title":"International journal of cardiology"},{"key":"3625_CR52","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"RM Lang","year":"2005","unstructured":"Lang, R. M. et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography\u2019s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography \n                           18, 1440\u20131463 (2005).","journal-title":"Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography"},{"key":"3625_CR53","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1093\/ejechocard\/jer051","volume":"12","author":"M Galderisi","year":"2011","unstructured":"Galderisi, M. et al. Recommendations of the European Association of Echocardiography: how to use echo-Doppler in clinical trials: different modalities for different purposes. European journal of echocardiography: the journal of the Working Group on Echocardiography of the European Society of Cardiology \n                           12, 339\u2013353 (2011).","journal-title":"European journal of echocardiography: the journal of the Working Group on Echocardiography of the European Society of Cardiology"},{"key":"3625_CR54","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1152\/japplphysiol.01383.2010","volume":"111","author":"IG Lunde","year":"2011","unstructured":"Lunde, I. G., Kvaloy, H., Austbo, B., Christensen, G. & Carlson, C. R. Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes. Journal of applied physiology (Bethesda, Md.: 1985) \n                           111, 1278\u20131289 (2011).","journal-title":"Journal of applied physiology (Bethesda, Md.: 1985)"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-03625-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-03625-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-03625-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:19:55Z","timestamp":1671754795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-03625-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["3625"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-03625-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,14]]},"assertion":[{"value":"9 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"3490"}}