{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:16:14Z","timestamp":1792044974966,"version":"4.4.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) has been recognized as an important gasotransmitter exerting various physiological effects, especially in the cardiovascular system. Herein we investigated the cardioprotective effects of a novel long-term and slow-releasing H\n                    <jats:sub>2<\/jats:sub>\n                    S donor, DATS-MSN, using\n                    <jats:italic>in vivo<\/jats:italic>\n                    myocardial ischemia\/reperfusion (I\/R) models and\n                    <jats:italic>in vitro<\/jats:italic>\n                    hypoxia\/reoxygenation cardiomyocyte models. Unlike the instant-releasing pattern of sodium hydrosulphide (NaHS), the release of H\n                    <jats:sub>2<\/jats:sub>\n                    S from DATS-MSN was quite slow and continuous both in the cell culture medium and in rat plasma (elevated H\n                    <jats:sub>2<\/jats:sub>\n                    S concentrations during 24\u2009h and 72\u2009h reperfusion). Correspondingly, DATS-MSN demonstrated superior cardioprotective effects over NaHS in I\/R models, which were associated with greater survival rates, reduced CK-MB and troponin I levels, decreased cardiomyocyte apoptosis index, increased antioxidant enzyme activities, inhibited myocardial inflammation, greater reduction in the infarct area and preserved cardiac ejection fraction. Some of these effects of DATS-MSN were also found to be superior to classic slow-releasing H\n                    <jats:sub>2<\/jats:sub>\n                    S donor, GYY4137. In\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments, cardiomyocytes injury was also found to be relived with the use of DATS-MSN compared to NaHS after the hypoxia\/reoxygenation processes. The present work provides a novel long-term and slow-releasing H\n                    <jats:sub>2<\/jats:sub>\n                    S donor and an insight into how the release patterns of H\n                    <jats:sub>2<\/jats:sub>\n                    S donors affect its physiological functionality.\n                  <\/jats:p>","DOI":"10.1038\/s41598-017-03941-0","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T10:37:40Z","timestamp":1496918260000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["A Long-Term and Slow-Releasing Hydrogen Sulfide Donor Protects against Myocardial Ischemia\/Reperfusion Injury"],"prefix":"10.1038","volume":"7","author":[{"given":"Xiaotian","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7777-9700","authenticated-orcid":false,"given":"Sheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiechun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfa","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liewen","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"3941_CR1","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1152\/ajpheart.00339.2009","volume":"298","author":"L Yao","year":"2010","unstructured":"Yao, L., Huang, X., Wang, Y. et al. 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