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The underlying cortical neurochemical changes are unknown. We performed proton Magnetic Resonance Spectroscopy (1H-MRS) on 17 consecutive tertiary clinic-recruited psychotropic-na\u00efve Rome III FD-PDS female and 17 age-sex matched healthy controls. Voxels were placed on bilateral pgACC, left insula and SSC. Water-suppressed spectra were acquired using PRESS with short echo time (TE) (T\u2009=\u200924 ms) to separately quantify glutamate (Glu) and glutamine (Gln). Main outcome measure was regional Glu\/Cr\u2009+\u2009PCr. Severity of depression, anxiety, somatization, and dyspepsia were also assessed. We found significantly increased SSC Glu\/Cr\u2009+\u2009PCr in FD-PDS subjects compared to controls. SSC Glu\/Cr\u2009+\u2009PCr correlated significantly with postprandial distress chronicity, dyspeptic symptoms severity and anxiety. The SSC Glu\/Cr\u2009+\u2009PCr - dyspepsia correlations became insignificant after controlling for anxiety but were independent of depression. Gln\/Glu ratio, which indicates glial Glu cycling failure, was unchanged. No between-group differences were noted in other regional metabolite concentrations. Our findings suggested enhanced SSC glutamate transmission in FD-PDS that was linked to post-prandial distress chronicity and severity and anxiety.<\/jats:p>","DOI":"10.1038\/s41598-017-04405-1","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T15:01:15Z","timestamp":1497452475000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Increased Glutamate in Somatosensory Cortex in Functional Dyspepsia"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-6434","authenticated-orcid":false,"given":"Arthur D. 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