{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:39:21Z","timestamp":1777052361868,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alpha (\u03b1)-thalassaemia is one of the most prevalent hereditary blood disorders, commonly affecting Southeast Asian people, with the highest incidence (30\u201340%) being seen in northern Thailand. However, this high incidence was estimated without consideration of the variations between ethnic populations and the geographical location of the populations. To address this issue, a total of 688 samples from 13 different northern Thai ethnic groups (30 villages) categorized into three linguistic groups were genotyped for deletional alpha-thalassaemia (-\u03b1<jats:sup>3.7<\/jats:sup>, -\u03b1<jats:sup>4.2<\/jats:sup>, --<jats:sup>SEA<\/jats:sup> and --<jats:sup>THAI<\/jats:sup>) and\/or non-deletional alpha-thalassaemia (\u03b1<jats:sup>CS<\/jats:sup> and \u03b1<jats:sup>PS<\/jats:sup>) via multiplex gap-PCR and dot-blot hybridization, respectively. Alpha<jats:sup>+<\/jats:sup>(-\u03b1<jats:sup>3.7<\/jats:sup>, -\u03b1<jats:sup>4.2<\/jats:sup>, \u03b1<jats:sup>CS<\/jats:sup> and \u03b1<jats:sup>PS<\/jats:sup>) and alpha\u00b0-thalassaemia (--<jats:sup>SEA<\/jats:sup> and --<jats:sup>THAI<\/jats:sup>) allele frequencies (with 95% Confidence Interval) were the highest in the Sino-Tibetan group [0.13 (0.08\u20130.18)] and the Tai-Kadai group [0.03 (0.02\u20130.05)], respectively. With regards to ethnicity, the varying allele frequency of \u03b1<jats:sup>+<\/jats:sup> and \u03b1\u00b0-thalassaemia amongst a variety of ethnic groups was observed. The highest \u03b1<jats:sup>+<\/jats:sup>-thalassaemia allele frequency was found in the Paluang [0.21 (0.10\u20130.37)] while \u03b1\u00b0-thalassaemia allele frequency was the highest in the Yuan [0.04 (0.01\u20130.10)]. These detailed results of alpha thalassaemia allele frequency and genetic diversity amongst the northern Thai ethnic groups demonstrate the need for ethnicity based thalassaemia prevention programs.<\/jats:p>","DOI":"10.1038\/s41598-017-04957-2","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T11:24:10Z","timestamp":1498735450000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand"],"prefix":"10.1038","volume":"7","author":[{"given":"Mattapong","family":"Kulaphisit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatupol","family":"Kampuansai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamonlak","family":"Leecharoenkiat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Methi","family":"Wathikthinnakon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoroong","family":"Kangwanpong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thongperm","family":"Munkongdee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saovaros","family":"Svasti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suthat","family":"Fucharoen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-9852","authenticated-orcid":false,"given":"Duncan R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pathrapol","family":"Lithanatudom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,5]]},"reference":[{"key":"4957_CR1","first-page":"498","volume":"134","author":"S Fucharoen","year":"2011","unstructured":"Fucharoen, S. & Winichagoon, P. 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