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Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin cancer. SKH-1 hairless and immunocompetent mice (<jats:italic>n<\/jats:italic>\u2009=\u2009180) were fed AIN-93G or AIN-93G\u2009+\u200910% <jats:italic>tangerine<\/jats:italic> or red tomato powder for 35 weeks. From weeks 11\u201320, mice (<jats:italic>n<\/jats:italic>\u2009=\u2009120) were exposed to 2240\u2009J\/m<jats:sup>2<\/jats:sup> UV-B light, 3x\/week, and tumors were tracked weekly. Control mice were fed the same diets but not exposed to UV. Tumor number was significantly lower in male mice consuming red tomato diets (1.73\u2009\u00b1\u20090.50, <jats:italic>P<\/jats:italic>\u2009=\u20090.015) or pooled tomato diets (2.03\u2009\u00b1\u20090.45, <jats:italic>P<\/jats:italic>\u2009=\u20090.017) compared to controls (4.04\u2009\u00b1\u20090.65). Carotenoid levels in plasma and skin were quantitated, with total lycopene higher in skin of <jats:italic>tangerine<\/jats:italic> fed animals despite a lower dose. Metabolomic analyses elucidated compounds derived from tomato glycoalkaloids (including tomatidine and hydroxylated-tomatidine) as significantly different metabolites in skin after tomato exposure. Here, we describe that tomato consumption can modulate risk for keratinocyte carcinomas; however, the role of the newly identified specific phytochemicals possibly responsible for this action require further investigation.<\/jats:p>","DOI":"10.1038\/s41598-017-05568-7","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T11:12:18Z","timestamp":1499253138000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-0088","authenticated-orcid":false,"given":"Jessica L.","family":"Cooperstone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen L.","family":"Tober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken M.","family":"Riedl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Teegarden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9379-0264","authenticated-orcid":false,"given":"Morgan J.","family":"Cichon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana M.","family":"Oberyszyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,11]]},"reference":[{"key":"5568_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev.nutr.24.012003.132320","volume":"24","author":"H Sies","year":"2004","unstructured":"Sies, H. & Stahl, W. 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