{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:40:25Z","timestamp":1790487625134,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tissue inhibitor of metalloproteases (TIMPs) are inhibitors of matrix metalloproteinases (MMPs) that regulate tissue extracellular matrix (ECM) turnover. TIMP4 is highly expressed in adipose tissue, its levels are further elevated following high-fat diet, but its role in obesity is unknown. Eight-week old wild-type (WT) and <jats:italic>Timp4<\/jats:italic>-knockout (<jats:italic>Timp4<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) mice received chow or high fat diet (HFD) for twelve weeks. <jats:italic>Timp4<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice exhibited a higher food intake but lower body fat gain. Adipose tissue of <jats:italic>Timp4<\/jats:italic><jats:sup>\n                  <jats:italic>\u2212\/\u2013<\/jats:italic>\n                <\/jats:sup>-HFD mice showed reduced hypertrophy and fibrosis compared to WT-HFD mice. <jats:italic>Timp4<\/jats:italic><jats:sup>\n                  <jats:italic>\u2212\/\u2013<\/jats:italic>\n                <\/jats:sup>-HFD mice were also protected from HFD-induced liver and skeletal muscle triglyceride accumulation and dyslipidemia. <jats:italic>Timp4<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>-HFD mice exhibited reduced basic metabolic rate and energy expenditure, but increased respiratory exchange ratio. Increased free fatty acid excretion was detected in <jats:italic>Timp4<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>-HFD compared to WT-HFD mice. CD36 protein, the major fatty acid transporter in the small intestine, increased with HFD in WT but not in <jats:italic>Timp4<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice, despite a similar rise in <jats:italic>Cd36<\/jats:italic> mRNA in both genotypes. Consistently, HFD increased enterocyte lipid content only in WT but not in <jats:italic>Timp4<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice. Our study reveals that absence of TIMP4 can impair lipid absorption and the high fat diet-induced obesity in mice possibly by regulating the proteolytic processing of CD36 protein in the intestinal enterocytes.<\/jats:p>","DOI":"10.1038\/s41598-017-05951-4","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T07:55:47Z","timestamp":1500364547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption"],"prefix":"10.1038","volume":"7","author":[{"given":"Siva S. V. P.","family":"Sakamuri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Takawale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Hernandez-Anzaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesam","family":"Bahitham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Fernandez-Patron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zamaneh","family":"Kassiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"5951_CR1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11684-015-0410-2","volume":"9","author":"L Gan","year":"2015","unstructured":"Gan, L., Xiang, W., Xie, B. & Yu, L. Molecular mechanisms of fatty liver in obesity. Frontiers of medicine \n                           9, 275\u2013287, doi:10.1007\/s11684-015-0410-2 (2015).","journal-title":"Frontiers of medicine"},{"key":"5951_CR2","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.3390\/nu5041218","volume":"5","author":"B Klop","year":"2013","unstructured":"Klop, B., Elte, J. W. & Cabezas, M. C. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients \n                           5, 1218\u20131240, doi:10.3390\/nu5041218 (2013).","journal-title":"Nutrients"},{"key":"5951_CR3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s11684-013-0262-6","volume":"7","author":"J Ye","year":"2013","unstructured":"Ye, J. Mechanisms of insulin resistance in obesity. Frontiers of medicine \n                           7, 14\u201324, doi:10.1007\/s11684-013-0262-6 (2013).","journal-title":"Frontiers of medicine"},{"key":"5951_CR4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1467-789X.2011.00914.x","volume":"13","author":"JA Dorresteijn","year":"2012","unstructured":"Dorresteijn, J. A., Visseren, F. L. & Spiering, W. Mechanisms linking obesity to hypertension. Obesity reviews: an official journal of the International Association for the Study of Obesity \n                           13, 17\u201326, doi:10.1111\/j.1467-789X.2011.00914.x (2012).","journal-title":"Obesity reviews: an official journal of the International Association for the Study of Obesity"},{"key":"5951_CR5","doi-asserted-by":"publisher","first-page":"943162","DOI":"10.1155\/2014\/943162","volume":"2014","author":"J Kaur","year":"2014","unstructured":"Kaur, J. A comprehensive review on metabolic syndrome. Cardiology research and practice \n                           2014, 943162, doi:10.1155\/2014\/943162 (2014).","journal-title":"Cardiology research and practice"},{"key":"5951_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.5114\/aoms.2013.33181","volume":"9","author":"M Coelho","year":"2013","unstructured":"Coelho, M., Oliveira, T. & Fernandes, R. Biochemistry of adipose tissue: an endocrine organ. Archives of medical science: AMS \n                           9, 191\u2013200, doi:10.5114\/aoms.2013.33181 (2013).","journal-title":"Archives of medical science: AMS"},{"key":"5951_CR7","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s11154-014-9301-0","volume":"15","author":"N Kloting","year":"2014","unstructured":"Kloting, N. & Bluher, M. Adipocyte dysfunction, inflammation and metabolic syndrome. Reviews in endocrine & metabolic disorders \n                           15, 277\u2013287, doi:10.1007\/s11154-014-9301-0 (2014).","journal-title":"Reviews in endocrine & metabolic disorders"},{"key":"5951_CR8","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1007\/s00018-010-0263-4","volume":"67","author":"EC Mariman","year":"2010","unstructured":"Mariman, E. C. & Wang, P. Adipocyte extracellular matrix composition, dynamics and role in obesity. Cellular and molecular life sciences: CMLS \n                           67, 1277\u20131292, doi:10.1007\/s00018-010-0263-4 (2010).","journal-title":"Cellular and molecular life sciences: CMLS"},{"key":"5951_CR9","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1242\/jcs.023820","volume":"123","author":"C Frantz","year":"2010","unstructured":"Frantz, C., Stewart, K. M. & Weaver, V. M. The extracellular matrix at a glance. Journal of cell science \n                           123, 4195\u20134200, doi:10.1242\/jcs.023820 (2010).","journal-title":"Journal of cell science"},{"key":"5951_CR10","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/cphy.c140045","volume":"5","author":"A Takawale","year":"2015","unstructured":"Takawale, A., Sakamuri, S. S. & Kassiri, Z. Extracellular matrix communication and turnover in cardiac physiology and pathology. Comprehensive Physiology \n                           5, 687\u2013719, doi:10.1002\/cphy.c140045 (2015).","journal-title":"Comprehensive Physiology"},{"key":"5951_CR11","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.2337\/diabetes.51.4.1093","volume":"51","author":"E Maquoi","year":"2002","unstructured":"Maquoi, E., Munaut, C., Colige, A., Collen, D. & Lijnen, H. R. Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes \n                           51, 1093\u20131101 (2002).","journal-title":"Diabetes"},{"key":"5951_CR12","doi-asserted-by":"publisher","first-page":"11888","DOI":"10.1074\/jbc.M209196200","volume":"278","author":"C Chavey","year":"2003","unstructured":"Chavey, C. et al. Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. The Journal of biological chemistry \n                           278, 11888\u201311896, doi:10.1074\/jbc.M209196200 (2003).","journal-title":"The Journal of biological chemistry"},{"key":"5951_CR13","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1016\/j.jnutbio.2012.12.005","volume":"24","author":"PR Biga","year":"2013","unstructured":"Biga, P. R. et al. Gelatinases impart susceptibility to high-fat diet-induced obesity in mice. The Journal of nutritional biochemistry \n                           24, 1462\u20131468, doi:10.1016\/j.jnutbio.2012.12.005 (2013).","journal-title":"The Journal of nutritional biochemistry"},{"key":"5951_CR14","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.1210\/en.2014-1037","volume":"155","author":"JT Lee","year":"2014","unstructured":"Lee, J. T. et al. Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. Endocrinology \n                           155, 3409\u20133420, doi:10.1210\/en.2014-1037 (2014).","journal-title":"Endocrinology"},{"key":"5951_CR15","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1007\/s11033-015-3861-2","volume":"42","author":"CL Shih","year":"2015","unstructured":"Shih, C. L. & Ajuwon, K. M. Inhibition of MMP-13 prevents diet-induced obesity in mice and suppresses adipogenesis in 3T3-L1 preadipocytes. Molecular biology reports \n                           42, 1225\u20131232, doi:10.1007\/s11033-015-3861-2 (2015).","journal-title":"Molecular biology reports"},{"key":"5951_CR16","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.2337\/db10-0073","volume":"59","author":"TH Chun","year":"2010","unstructured":"Chun, T. H. et al. Genetic link between obesity and MMP14-dependent adipogenic collagen turnover. Diabetes \n                           59, 2484\u20132494, doi:10.2337\/db10-0073 (2010).","journal-title":"Diabetes"},{"key":"5951_CR17","doi-asserted-by":"publisher","first-page":"6417","DOI":"10.1016\/j.febslet.2005.10.033","volume":"579","author":"S Kralisch","year":"2005","unstructured":"Kralisch, S. et al. Proinflammatory adipocytokines induce TIMP-1 expression in 3T3-L1 adipocytes. FEBS letters \n                           579, 6417\u20136422, doi:10.1016\/j.febslet.2005.10.033 (2005).","journal-title":"FEBS letters"},{"key":"5951_CR18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1530\/eje.1.02328","volume":"156","author":"S Kralisch","year":"2007","unstructured":"Kralisch, S. et al. Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans. European journal of endocrinology\/European Federation of Endocrine Societies \n                           156, 257\u2013261, doi:10.1530\/eje.1.02328 (2007).","journal-title":"European journal of endocrinology\/European Federation of Endocrine Societies"},{"key":"5951_CR19","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1007\/s00125-011-2093-9","volume":"54","author":"B Meissburger","year":"2011","unstructured":"Meissburger, B., Stachorski, L., Roder, E., Rudofsky, G. & Wolfrum, C. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans. Diabetologia \n                           54, 1468\u20131479, doi:10.1007\/s00125-011-2093-9 (2011).","journal-title":"Diabetologia"},{"key":"5951_CR20","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1267\/thro03020249","volume":"89","author":"HR Lijnen","year":"2003","unstructured":"Lijnen, H. R., Demeulemeester, D., Van Hoef, B., Collen, D. & Maquoi, E. Deficiency of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) impairs nutritionally induced obesity in mice. Thrombosis and haemostasis \n                           89, 249\u2013255, doi:10.1267\/thro03020249 (2003).","journal-title":"Thrombosis and haemostasis"},{"key":"5951_CR21","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1210\/en.2010-1029","volume":"152","author":"DM Jaworski","year":"2011","unstructured":"Jaworski, D. M. et al. Sexually dimorphic diet-induced insulin resistance in obese tissue inhibitor of metalloproteinase-2 (TIMP-2)-deficient mice. Endocrinology \n                           152, 1300\u20131313, doi:10.1210\/en.2010-1029 (2011).","journal-title":"Endocrinology"},{"key":"5951_CR22","doi-asserted-by":"publisher","first-page":"454","DOI":"10.2337\/db11-0613","volume":"61","author":"R Menghini","year":"2012","unstructured":"Menghini, R. et al. TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice. Diabetes \n                           61, 454\u2013462, doi:10.2337\/db11-0613 (2012).","journal-title":"Diabetes"},{"key":"5951_CR23","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1053\/j.gastro.2008.10.079","volume":"136","author":"R Menghini","year":"2009","unstructured":"Menghini, R. et al. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology \n                           136, 663\u2013672.e664, doi:10.1053\/j.gastro.2008.10.079 (2009).","journal-title":"Gastroenterology"},{"key":"5951_CR24","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.yexcr.2015.05.006","volume":"335","author":"LM Mejia-Cristobal","year":"2015","unstructured":"Mejia-Cristobal, L. M. et al. Tissue inhibitor of metalloproteases-4 (TIMP-4) modulates adipocyte differentiation in vitro. Experimental cell research \n                           335, 207\u2013215, doi:10.1016\/j.yexcr.2015.05.006 (2015).","journal-title":"Experimental cell research"},{"key":"5951_CR25","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1002\/hep.25961","volume":"56","author":"AD Quiroga","year":"2012","unstructured":"Quiroga, A. D. et al. Deficiency of carboxylesterase 1\/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. Hepatology (Baltimore, Md.) \n                           56, 2188\u20132198, doi:10.1002\/hep.25961 (2012).","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"5951_CR26","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1177\/41.3.7679127","volume":"41","author":"PC Dolber","year":"1993","unstructured":"Dolber, P. C. & Spach, M. S. Conventional and confocal fluorescence microscopy of collagen fibers in the heart. The journal of histochemistry and cytochemistry: official journal of the Histochemistry Society \n                           41, 465\u2013469 (1993).","journal-title":"The journal of histochemistry and cytochemistry: official journal of the Histochemistry Society"},{"key":"5951_CR27","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/nprot.2013.055","volume":"8","author":"A Mehlem","year":"2013","unstructured":"Mehlem, A., Hagberg, C. E., Muhl, L., Eriksson, U. & Falkevall, A. Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease. Nature protocols \n                           8, 1149\u20131154, doi:10.1038\/nprot.2013.055 (2013).","journal-title":"Nature protocols"},{"key":"5951_CR28","doi-asserted-by":"publisher","unstructured":"Kassiri, Z. et al. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circ Res \n                           97, 380\u2013390, doi:10.1161\/01.RES.0000178789.16929.cf (2005).","DOI":"10.1161\/01.RES.0000178789.16929.cf"},{"key":"5951_CR29","doi-asserted-by":"crossref","unstructured":"Kraus, D., Yang, Q. & Kahn, B. B. Lipid Extraction from Mouse Feces. Bio-protocol \n                           5 (2015).","DOI":"10.21769\/BioProtoc.1375"},{"key":"5951_CR30","doi-asserted-by":"crossref","first-page":"C126","DOI":"10.1152\/ajpcell.2001.280.1.C126","volume":"280","author":"T Ma","year":"2001","unstructured":"Ma, T. et al. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. American journal of physiology. Cell physiology \n                           280, C126\u2013134 (2001).","journal-title":"American journal of physiology. Cell physiology"},{"key":"5951_CR31","doi-asserted-by":"publisher","first-page":"re3","DOI":"10.1126\/scisignal.272re3","volume":"2","author":"RL Silverstein","year":"2009","unstructured":"Silverstein, R. L. & Febbraio, M. CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. Science signaling \n                           2, re3, doi:10.1126\/scisignal.272re3 (2009).","journal-title":"Science signaling"},{"key":"5951_CR32","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1172\/JCI21514","volume":"115","author":"VA Drover","year":"2005","unstructured":"Drover, V. A. et al. CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. The Journal of clinical investigation \n                           115, 1290\u20131297, doi:10.1172\/jci21514 (2005).","journal-title":"The Journal of clinical investigation"},{"key":"5951_CR33","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.mvr.2014.08.004","volume":"95","author":"MH Santamaria","year":"2014","unstructured":"Santamaria, M. H., Chen, A. Y., Chow, J., Munoz, D. C. & Schmid-Schonbein, G. W. Cleavage and reduced CD36 ectodomain density on heart and spleen macrophages in the spontaneously hypertensive rat. Microvascular research \n                           95, 131\u2013142, doi:10.1016\/j.mvr.2014.08.004 (2014).","journal-title":"Microvascular research"},{"key":"5951_CR34","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1161\/CIRCGENETICS.115.001249","volume":"9","author":"KY DeLeon-Pennell","year":"2016","unstructured":"DeLeon-Pennell, K. Y. et al. CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac Remodeling. Circulation. Cardiovascular genetics \n                           9, 14\u201325, doi:10.1161\/CIRCGENETICS.115.001249 (2016).","journal-title":"Circulation. Cardiovascular genetics"},{"key":"5951_CR35","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbrc.2005.01.103","volume":"329","author":"D Demeulemeester","year":"2005","unstructured":"Demeulemeester, D., Collen, D. & Lijnen, H. R. Effect of matrix metalloproteinase inhibition on adipose tissue development. Biochemical and biophysical research communications \n                           329, 105\u2013110, doi:10.1016\/j.bbrc.2005.01.103 (2005).","journal-title":"Biochemical and biophysical research communications"},{"key":"5951_CR36","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1161\/hq0302.104522","volume":"22","author":"HR Lijnen","year":"2002","unstructured":"Lijnen, H. R. et al. Matrix metalloproteinase inhibition impairs adipose tissue development in mice. Arteriosclerosis, thrombosis, and vascular biology \n                           22, 374\u2013379 (2002).","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"5951_CR37","doi-asserted-by":"publisher","first-page":"e0132910","DOI":"10.1371\/journal.pone.0132910","volume":"10","author":"E Fjaere","year":"2015","unstructured":"Fjaere, E. et al. Tissue Inhibitor Of Matrix Metalloproteinase-1 Is Required for High-Fat Diet-Induced Glucose Intolerance and Hepatic Steatosis in Mice. PloS one \n                           10, e0132910, doi:10.1371\/journal.pone.0132910 (2015).","journal-title":"PloS one"},{"key":"5951_CR38","doi-asserted-by":"publisher","unstructured":"Koskivirta, I. et al. Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload. J Biol Chem \n                           285, 24487\u201324493, doi:10.1074\/jbc.M110.136820 (2010).","DOI":"10.1074\/jbc.M110.136820"},{"key":"5951_CR39","doi-asserted-by":"publisher","first-page":"G1011","DOI":"10.1152\/ajpgi.00047.2006","volume":"291","author":"IP Alwayn","year":"2006","unstructured":"Alwayn, I. P. et al. Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. American journal of physiology. Gastrointestinal and liver physiology \n                           291, G1011\u20131019, doi:10.1152\/ajpgi.00047.2006 (2006).","journal-title":"American journal of physiology. Gastrointestinal and liver physiology"},{"key":"5951_CR40","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3945\/an.113.003798","volume":"4","author":"AV Contreras","year":"2013","unstructured":"Contreras, A. V., Torres, N. & Tovar, A. R. PPAR-alpha as a key nutritional and environmental sensor for metabolic adaptation. Advances in nutrition (Bethesda, Md.) \n                           4, 439\u2013452, doi:10.3945\/an.113.003798 (2013).","journal-title":"Advances in nutrition (Bethesda, Md.)"},{"key":"5951_CR41","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1749-6632.2011.06303.x","volume":"1243","author":"H Sampath","year":"2011","unstructured":"Sampath, H. & Ntambi, J. M. The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation. Annals of the New York Academy of Sciences \n                           1243, 47\u201353, doi:10.1111\/j.1749-6632.2011.06303.x (2011).","journal-title":"Annals of the New York Academy of Sciences"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-05951-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-05951-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-05951-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T07:13:46Z","timestamp":1671779626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-05951-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,24]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["5951"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-05951-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,24]]},"assertion":[{"value":"13 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"6210"}}