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Fourteen young adults performed 45-min DR (\u221215% slope) at their maximal tolerable velocity. At pre- and 24, 48, and 72\u2009h post-exercise, T<jats:sub>2<\/jats:sub>-MRI was scanned and T<jats:sub>2<\/jats:sub>values for each muscle composing KEs and PFs at proximal, middle, and distal sites were calculated. Maximal isometric torque and rate of torque development (RTD: 0\u201330, 0\u201350, 0\u2013100, 0\u2013200\u2009ms) were also measured. Maximal torque significantly decreased in KEs (14\u201317%) and PFs (6\u20138%) at 24\u201348\u2009h post-exercise, with greater reductions for KEs. RTD in all phases, except for 0\u2013200\u2009ms in PFs, significantly decreased in KEs (11\u201342%) and PFs (13\u201323%) at least at one time point post-exercise. T<jats:sub>2<\/jats:sub>significantly increased at several sites (3\u20135%) in both muscle groups at 24 and\/or 48\u2009h post-exercise. Among the T<jats:sub>2<\/jats:sub>-increased sites, the peak effect size (Cohen\u2019s<jats:italic>d<\/jats:italic>) regarding T<jats:sub>2<\/jats:sub>change was pronounced at proximal (1.05) and middle (1.64) vastus intermedius compared to the other sites (0.72\u20130.77). These results suggest that DR induces damage in both KEs and PFs, and especially affects proximal\u2013middle sites of the vastus intermedius.<\/jats:p>","DOI":"10.1038\/s41598-017-06129-8","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T14:56:26Z","timestamp":1499871386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Localization of damage in the human leg muscles induced by downhill running"],"prefix":"10.1038","volume":"7","author":[{"given":"Sumiaki","family":"Maeo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukino","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kanehisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"key":"6129_CR1","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1007\/s00421-016-3437-4","volume":"116","author":"M Giandolini","year":"2016","unstructured":"Giandolini, M. et al. 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