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Implant material stiffness and shape influence the longevity of implantations. This study, using 3D finite element analysis, aimed to evaluate the effects of material stiffness variations of anatomically shaped artificial meniscal implant in the knee joint. Finite element simulations were conducted on five different cases including intact knee, medial meniscectomized knee, and the knee joint with the meniscal implant with three distinct material stiffness. Cartilage contact pressures, compression stresses, shear stresses, and implant kinematics (medial-lateral and posterior-anterior displacement) were evaluated for an axial compressive load of 1150\u2009N at full extension. Compared to the meniscectomized knee, the knee joint with the meniscal implant induced lower peak cartilage contact pressure and reduced the cartilage regions loaded with contact pressures greater than the peak cartilage contact pressure induced by the intact knee. Results of the current study also demonstrate that cartilage contact pressures and implant displacement are sensitive to the implant material stiffness. The meniscal implant with a stiffness of 11\u2009MPa restores the intact knee contact mechanics, thereby reducing the risk of physiological damage to the articular cartilage.<\/jats:p>","DOI":"10.1038\/s41598-017-06271-3","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T06:36:15Z","timestamp":1500014175000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Evaluating the effects of material properties of artificial meniscal implant in the human knee joint using finite element analysis"],"prefix":"10.1038","volume":"7","author":[{"given":"Duraisamy","family":"Shriram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Praveen Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6682-9768","authenticated-orcid":false,"given":"Fangsen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Han Dave","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-2405","authenticated-orcid":false,"given":"Karupppasamy","family":"Subburaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"6271_CR1","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1302\/0301-620X.88B12.18140","volume":"88","author":"ID McDermott","year":"2006","unstructured":"McDermott, I. 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