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Here we show that H<jats:sub>2<\/jats:sub>S donors, including sodium hydrogen sulphide (NaHS), GYY\u00a04137 and diallyltrisulfide (DATS), synergistically enhanced the anti-cancer effect of a green tea polyphenol (\u2212)-epigallocatechin-3-<jats:italic>O<\/jats:italic>-gallate (EGCG) against multiple myeloma cells without affecting normal cells. NaHS significantly potentiated the anti-cancer effect of EGCG and prolonged survival in a mouse xenograft model. In this mechanism, H<jats:sub>2<\/jats:sub>S enhanced apoptotic cell death through cyclic guanosine monophosphate (cGMP)\/acid sphingomyelinase pathway induced by EGCG. Moreover, NaHS reduced the enzyme activity of cyclic nucleotide phosphodiesterase that is known as cGMP negative regulator. In conclusion, we identified H<jats:sub>2<\/jats:sub>S as a gasotransmitter that potentiates EGCG-induced cancer cell death.<\/jats:p>","DOI":"10.1038\/s41598-017-06879-5","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T09:30:35Z","timestamp":1500629435000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells"],"prefix":"10.1038","volume":"7","author":[{"given":"Jaehoon","family":"Bae","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motofumi","family":"Kumazoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuya","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"6879_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/aje\/kwp187","volume":"170","author":"T Naganuma","year":"2009","unstructured":"Naganuma, T. et al. 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