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One strategy to achieve this is the addition of prebiotics to sows\u2019 diet, as their microbiota will be transferred. Transmission of microbiota to the offspring occurs at birth and during lactation but a transfer might also occur during gestation. The objectives of this study were to determine whether and when (before and\/or after birth) a maternal transfer of the microbiota occurs, and to observe the impact of wheat bran (WB) in sows\u2019 diet on their faecal microbiota, their offspring\u2019s microbiota and fermentation profile. Sequencing was performed on DNA extracted from umbilical cord blood, meconium, sows\u2019 faeces and piglets\u2019 colon content. Short-chain fatty acid production was determined in piglets\u2019 distal gut. Different bacteria (mostly Proteobacteria, followed by Firmicutes) were found in the umbilical cord blood, suggesting a maternal transfer occurring already during gestation. Less butyrate was produced in the caecum of WB piglets and a lower concentration of valerate was observed in all intestinal parts of WB piglets. Maternal wheat bran supplementation affected microbiota of sows and piglets differently.<\/jats:p>","DOI":"10.1038\/s41598-017-07228-2","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T11:34:15Z","timestamp":1501587255000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Modulation of piglets\u2019 microbiota: differential effects by a high wheat bran maternal diet during gestation and lactation"],"prefix":"10.1038","volume":"7","author":[{"given":"Julie","family":"Leblois","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Massart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Wavreille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Bindelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Everaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"7228_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1017\/S0007114507691818","volume":"98","author":"F Fava","year":"2007","unstructured":"Fava, F. et al. 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