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CaM and CML regulate a wide range of target proteins and cellular responses. While many CaM-binding proteins have been identified, few have been characterized for their specific role in plant immunity. Here, we report new data on the biological function of a CML-interacting partner, PRR2 (<jats:italic>PSEUDO-RESPONSE REGULATOR 2<\/jats:italic>), a plant specific transcription factor. Until now, the physiological relevance of PRR2 remained largely unknown. Using a reverse genetic strategy in <jats:italic>A<\/jats:italic>. <jats:italic>thaliana<\/jats:italic>, we identified PRR2 as a positive regulator of plant immunity. We propose that PRR2 contributes to salicylic acid (SA)-dependent responses when challenged with the phytopathogenic bacterium <jats:italic>Pseudomonas syringae<\/jats:italic>. <jats:italic>PRR2<\/jats:italic> is transcriptionally upregulated by SA and <jats:italic>P<\/jats:italic>. <jats:italic>syringae<\/jats:italic>, enhances SA biosynthesis and SA signalling responses; <jats:italic>e<\/jats:italic>.<jats:italic>g<\/jats:italic>. in response to <jats:italic>P<\/jats:italic>. <jats:italic>syringae<\/jats:italic>, PRR2 induces the production of SA and the accumulation of the defence-related protein PR1. Moreover, PRR2 overexpressing lines exhibit an enhanced production of camalexin, a phytoalexin that confers enhanced resistance against pathogens. Together, these data reveal the importance of PRR2 in plant immune responses against <jats:italic>P<\/jats:italic>. <jats:italic>syringae<\/jats:italic> and suggest a novel function for this particular plant specific transcription factor in plant physiology.<\/jats:p>","DOI":"10.1038\/s41598-017-07535-8","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T13:14:11Z","timestamp":1501074851000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["PRR2, a pseudo-response regulator, promotes salicylic acid and camalexin accumulation during plant immunity"],"prefix":"10.1038","volume":"7","author":[{"given":"C.","family":"Cheval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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