{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:40:30Z","timestamp":1789371630106,"version":"build-2803163510"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rift Valley fever virus (RVFV) leads to varied clinical manifestations in animals and in humans that range from moderate fever to fatal illness, suggesting that host immune responses are important determinants of the disease severity. We investigated the immune basis for the extreme susceptibility of MBT\/Pas mice that die with mild to acute hepatitis by day 3 post-infection compared to more resistant BALB\/cByJ mice that survive up to a week longer. Lower levels of neutrophils observed in the bone marrow and blood of infected MBT\/Pas mice are unlikely to be causative of increased RVFV susceptibility as constitutive neutropenia in specific mutant mice did not change survival outcome. However, whereas MBT\/Pas mice mounted an earlier inflammatory response accompanied by higher amounts of interferon (IFN)-\u03b1 in the serum compared to BALB\/cByJ mice, they failed to prevent high viral antigen load. Several immunological alterations were uncovered in infected MBT\/Pas mice compared to BALB\/cByJ mice, including low levels of leukocytes that expressed type I IFN receptor subunit 1 (IFNAR1) in the blood, spleen and liver, delayed leukocyte activation and decreased percentage of IFN-\u03b3-producing leukocytes in the blood. These observations are consistent with the complex mode of inheritance of RVFV susceptibility in genetic studies.<\/jats:p>","DOI":"10.1038\/s41598-017-07543-8","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T10:02:42Z","timestamp":1501149762000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models"],"prefix":"10.1038","volume":"7","author":[{"given":"Rashida","family":"Lathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Simon-Chazottes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Jouvion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oph\u00e9lie","family":"Godon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Malissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Flamand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-8936","authenticated-orcid":false,"given":"Pierre","family":"Bruhns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Panthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,2]]},"reference":[{"key":"7543_CR1","doi-asserted-by":"publisher","first-page":"e0144570","DOI":"10.1371\/journal.pone.0144570","volume":"11","author":"PM Munyua","year":"2016","unstructured":"Munyua, P. M. et al. Predictive factors and risk mapping for Rift Valley fever epidemics in Kenya. PLoS One \n                           11, e0144570, doi:10.1371\/journal.pone.0144570 (2016).","journal-title":"PLoS One"},{"key":"7543_CR2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3390\/v3050493","volume":"3","author":"T Ikegami","year":"2011","unstructured":"Ikegami, T. & Makino, S. The pathogenesis of Rift Valley fever. Viruses \n                           3, 493\u2013519, doi:10.3390\/v3050493 (2011).","journal-title":"Viruses"},{"key":"7543_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1051\/vetres\/2010033","volume":"41","author":"M Pepin","year":"2010","unstructured":"Pepin, M., Bouloy, M., Bird, B. H., Kemp, A. & Paweska, J. Rift Valley fever virus(Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention. Vet. Res. \n                           41, 61 (2010).","journal-title":"Vet. Res."},{"key":"7543_CR4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.molimm.2015.02.001","volume":"66","author":"G Lorenzo","year":"2015","unstructured":"Lorenzo, G., Lopez-Gil, E., Warimwe, G. M. & Brun, A. Understanding Rift Valley fever: contributions of animal models to disease characterization and control. Mol. Immunol. \n                           66, 78\u201388, doi:10.1016\/j.molimm.2015.02.001 (2015).","journal-title":"Mol. Immunol."},{"key":"7543_CR5","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.virusres.2011.10.023","volume":"163","author":"TM Ross","year":"2012","unstructured":"Ross, T. M., Bhardwaj, N., Bissel, S. J., Hartman, A. L. & Smith, D. R. Animal models of Rift Valley fever virus infection. Virus Res. \n                           163, 417\u2013423, doi:10.1016\/j.virusres.2011.10.023 (2012).","journal-title":"Virus Res."},{"key":"7543_CR6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.virol.2010.08.016","volume":"407","author":"DR Smith","year":"2010","unstructured":"Smith, D. R. et al. The pathogenesis of Rift Valley fever virus in the mouse model. Virology \n                           407, 256\u2013267, doi:10.1016\/j.virol.2010.08.016 (2010).","journal-title":"Virology"},{"key":"7543_CR7","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.virol.2012.05.012","volume":"431","author":"C Reed","year":"2012","unstructured":"Reed, C. et al. Ultrastructural study of Rift Valley fever virus in the mouse model. Virology \n                           431, 58\u201370, doi:10.1016\/j.virol.2012.05.012 (2012).","journal-title":"Virology"},{"key":"7543_CR8","doi-asserted-by":"publisher","first-page":"e2874","DOI":"10.1371\/journal.pntd.0002874","volume":"8","author":"KA Dodd","year":"2014","unstructured":"Dodd, K. A. et al. Rift Valley fever virus encephalitis is associated with an ineffective systemic immune response and activated T cell infiltration into the CNS in an immunocompetent mouse model. PLoS Negl. Trop. Dis. \n                           8, e2874, doi:10.1371\/journal.pntd.0002874 (2014).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"7543_CR9","doi-asserted-by":"publisher","first-page":"e1529","DOI":"10.1371\/journal.pntd.0001529","volume":"6","author":"KK Gray","year":"2012","unstructured":"Gray, K. K. et al. Chemotactic and inflammatory responses in the liver and brain are associated with pathogenesis of Rift Valley fever virus infection in the mouse. PLoS Negl. Trop. Dis. \n                           6, e1529, doi:10.1371\/journal.pntd.0001529 (2012).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"7543_CR10","doi-asserted-by":"publisher","first-page":"e25027","DOI":"10.1371\/journal.pone.0025027","volume":"6","author":"P Jansen van Vuren","year":"2011","unstructured":"Jansen van Vuren, P., Tiemessen, C. T. & Paweska, J. T. Anti-nucleocapsid protein immune responses counteract pathogenic effects of Rift Valley fever virus infection in mice. PLoS One \n                           6, e25027, doi:10.1371\/journal.pone.0025027 (2011).","journal-title":"PLoS One"},{"key":"7543_CR11","doi-asserted-by":"publisher","first-page":"6146","DOI":"10.4049\/jimmunol.1000949","volume":"185","author":"TZ do Valle","year":"2010","unstructured":"do Valle, T. Z. et al. A new mouse model reveals a critical role for host innate immunity in resistance to Rift Valley fever. J. Immunol. \n                           185, 6146\u20136156, doi:10.4049\/jimmunol.1000949 (2010).","journal-title":"J. Immunol."},{"key":"7543_CR12","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/gene.2014.79","volume":"16","author":"S Tokuda","year":"2015","unstructured":"Tokuda, S. et al. The genetic basis for susceptibility to Rift Valley fever disease in MBT\/Pas mice. Genes Immun. \n                           16, 206\u2013212, doi:10.1038\/gene.2014.79 (2015).","journal-title":"Genes Immun."},{"key":"7543_CR13","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1126\/science.284.5421.1835","volume":"284","author":"FP Siegal","year":"1999","unstructured":"Siegal, F. P. et al. The nature of the principal type 1 interferon-producing cells in human blood. Science \n                           284, 1835\u20131837 (1999).","journal-title":"Science"},{"key":"7543_CR14","first-page":"71","volume":"316","author":"G Uze","year":"2007","unstructured":"Uze, G., Schreiber, G., Piehler, J. & Pellegrini, S. The receptor of the type I interferon family. Curr. Top. Microbiol. Immunol. \n                           316, 71\u201395 (2007).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"7543_CR15","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/ni1582","volume":"9","author":"E Vivier","year":"2008","unstructured":"Vivier, E., Tomasello, E., Baratin, M., Walzer, T. & Ugolini, S. Functions of natural killer cells. Nat. Immunol. \n                           9, 503\u2013510, doi:10.1038\/ni1582 (2008).","journal-title":"Nat. Immunol."},{"key":"7543_CR16","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1084\/jem.182.4.1045","volume":"182","author":"JS Orange","year":"1995","unstructured":"Orange, J. S., Wang, B., Terhorst, C. & Biron, C. A. Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J. Exp. Med. \n                           182, 1045\u20131056 (1995).","journal-title":"J. Exp. Med."},{"key":"7543_CR17","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/01.shk.0000158960.93832.de","volume":"23","author":"P Zhang","year":"2005","unstructured":"Zhang, P. et al. The granulopoietic cytokine response and enhancement of granulopoiesis in mice during endotoxemia. Shock \n                           23, 344\u2013352 (2005).","journal-title":"Shock"},{"key":"7543_CR18","doi-asserted-by":"publisher","first-page":"14933","DOI":"10.1128\/JVI.79.23.14933-14944.2005","volume":"79","author":"TM Tumpey","year":"2005","unstructured":"Tumpey, T. M. et al. Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice. J. Virol. \n                           79, 14933\u201314944, doi:10.1128\/JVI.79.23.14933-14944.2005 (2005).","journal-title":"J. Virol."},{"key":"7543_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/ni880","volume":"4","author":"DM Andrews","year":"2003","unstructured":"Andrews, D. M., Scalzo, A. A., Yokoyama, W. M., Smyth, M. J. & Degli-Esposti, M. A. Functional interactions between dendritic cells and NK cells during viral infection. Nat. Immunol. \n                           4, 175\u2013181, doi:10.1038\/ni880 (2003).","journal-title":"Nat. Immunol."},{"key":"7543_CR20","doi-asserted-by":"publisher","first-page":"9798","DOI":"10.1128\/JVI.78.18.9798-9806.2004","volume":"78","author":"A Billecocq","year":"2004","unstructured":"Billecocq, A. et al. NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription. J. Virol. \n                           78, 9798\u20139806, doi:10.1128\/JVI.78.18.9798-9806.2004 (2004).","journal-title":"J. Virol."},{"key":"7543_CR21","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1371\/journal.ppat.0040013","volume":"4","author":"N Le May","year":"2008","unstructured":"Le May, N. et al. A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells. PLoS Pathog. \n                           4, e13, doi:10.1371\/journal.ppat.0040013 (2008).","journal-title":"PLoS Pathog."},{"key":"7543_CR22","doi-asserted-by":"publisher","unstructured":"Wuerth, J. D. & Weber, F. Phleboviruses and the type I interferon response. Viruses \n                           8, doi:10.3390\/v8060174 (2016).","DOI":"10.3390\/v8060174"},{"key":"7543_CR23","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1099\/vir.0.042754-0","volume":"93","author":"E Ayari-Fakhfakh","year":"2012","unstructured":"Ayari-Fakhfakh, E. et al. MBT\/Pas mouse: a relevant model for the evaluation of Rift Valley fever vaccines. J. Gen. Virol. \n                           93, 1456\u20131464, doi:10.1099\/vir.0.042754-0 (2012).","journal-title":"J. Gen. Virol."},{"key":"7543_CR24","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1084\/jem.190.12.1769","volume":"190","author":"J Yang","year":"1999","unstructured":"Yang, J. et al. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration. J. Exp. Med. \n                           190, 1769\u20131782 (1999).","journal-title":"J. Exp. Med."},{"key":"7543_CR25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1084\/jem.194.2.205","volume":"194","author":"EE Eriksson","year":"2001","unstructured":"Eriksson, E. E., Xie, X., Werr, J., Thoren, P. & Lindbom, L. Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo. J. Exp. Med. \n                           194, 205\u2013218 (2001).","journal-title":"J. Exp. Med."},{"key":"7543_CR26","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nri2156","volume":"7","author":"K Ley","year":"2007","unstructured":"Ley, K., Laudanna, C., Cybulsky, M. I. & Nourshargh, S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat. Rev. Immunol. \n                           7, 678\u2013689, doi:10.1038\/nri2156 (2007).","journal-title":"Nat. Rev. Immunol."},{"key":"7543_CR27","doi-asserted-by":"publisher","first-page":"40906","DOI":"10.1074\/jbc.M400808200","volume":"279","author":"R Yucel","year":"2004","unstructured":"Yucel, R., Kosan, C., Heyd, F. & Moroy, T. Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development. J. Biol. Chem. \n                           279, 40906\u201340917, doi:10.1074\/jbc.M400808200 (2004).","journal-title":"J. Biol. Chem."},{"key":"7543_CR28","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1002\/eji.201242589","volume":"42","author":"D Ordonez-Rueda","year":"2012","unstructured":"Ordonez-Rueda, D. et al. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia. Eur. J. Immunol. \n                           42, 2395\u20132408, doi:10.1002\/eji.201242589 (2012).","journal-title":"Eur. J. Immunol."},{"key":"7543_CR29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nri3787","volume":"15","author":"F McNab","year":"2015","unstructured":"McNab, F., Mayer-Barber, K., Sher, A., Wack, A. & O\u2019Garra, A. Type I interferons in infectious disease. Nat. Rev. Immunol. \n                           15, 87\u2013103, doi:10.1038\/nri3787 (2015).","journal-title":"Nat. Rev. Immunol."},{"key":"7543_CR30","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1128\/JVI.75.3.1371-1377.2001","volume":"75","author":"M Bouloy","year":"2001","unstructured":"Bouloy, M. et al. Genetic evidence for an interferon-antagonistic function of Rift Valley fever virus nonstructural protein NSs. J. Virol. \n                           75, 1371\u20131377, doi:10.1128\/JVI.75.3.1371-1377.2001 (2001).","journal-title":"J. Virol."},{"key":"7543_CR31","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nri3581","volume":"14","author":"LB Ivashkiv","year":"2014","unstructured":"Ivashkiv, L. B. & Donlin, L. T. Regulation of type I interferon responses. Nat. Rev. Immunol. \n                           14, 36\u201349, doi:10.1038\/nri3581 (2014).","journal-title":"Nat. Rev. Immunol."},{"key":"7543_CR32","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.4049\/jimmunol.165.5.2764","volume":"165","author":"KL Davenpeck","year":"2000","unstructured":"Davenpeck, K. L., Brummet, M. E., Hudson, S. A., Mayer, R. J. & Bochner, B. S. Activation of human leukocytes reduces surface P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and adhesion to P-selectin in vitro. J. Immunol. \n                           165, 2764\u20132772 (2000).","journal-title":"J. Immunol."},{"key":"7543_CR33","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1046\/j.1537-2995.2002.00045.x","volume":"42","author":"B Jilma","year":"2002","unstructured":"Jilma, B. et al. Rapid down modulation of P-selectin glycoprotein ligand-1 (PSGL-1, CD162) by G-CSF in humans. Transfusion (Paris) \n                           42, 328\u2013333 (2002).","journal-title":"Transfusion (Paris)"},{"key":"7543_CR34","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1023\/B:JOCI.0000018064.13793.83","volume":"24","author":"C Marsik","year":"2004","unstructured":"Marsik, C. et al. Endotoxin down-modulates P-selectin glycoprotein ligand-1 (PSGL-1, CD162) on neutrophils in humans. J. Clin. Immunol. \n                           24, 62\u201365, doi:10.1023\/B:JOCI.0000018064.13793.83 (2004).","journal-title":"J. Clin. Immunol."},{"key":"7543_CR35","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.immuni.2006.08.014","volume":"25","author":"AH van Boxel-Dezaire","year":"2006","unstructured":"van Boxel-Dezaire, A. H., Rani, M. R. & Stark, G. R. Complex modulation of cell type-specific signaling in response to type I interferons. Immunity \n                           25, 361\u2013372, doi:10.1016\/j.immuni.2006.08.014 (2006).","journal-title":"Immunity"},{"key":"7543_CR36","doi-asserted-by":"publisher","first-page":"e1004086","DOI":"10.1371\/journal.ppat.1004086","volume":"10","author":"AK Pinto","year":"2014","unstructured":"Pinto, A. K. et al. Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis. PLoS Pathog. \n                           10, e1004086, doi:10.1371\/journal.ppat.1004086 (2014).","journal-title":"PLoS Pathog."},{"key":"7543_CR37","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1016\/S0021-9258(18)83104-0","volume":"264","author":"R Hattori","year":"1989","unstructured":"Hattori, R., Hamilton, K. K., Fugate, R. D., McEver, R. P. & Sims, P. J. Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140. J. Biol. Chem. \n                           264, 7768\u20137771 (1989).","journal-title":"J. Biol. Chem."},{"key":"7543_CR38","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1172\/JCI118018","volume":"96","author":"DE Lorant","year":"1995","unstructured":"Lorant, D. E. et al. Activation of polymorphonuclear leukocytes reduces their adhesion to P-selectin and causes redistribution of ligands for P-selectin on their surfaces. J. Clin. Invest. \n                           96, 171\u2013182, doi:10.1172\/JCI118018 (1995).","journal-title":"J. Clin. Invest."},{"key":"7543_CR39","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0065-2776(07)96002-2","volume":"96","author":"JR Schoenborn","year":"2007","unstructured":"Schoenborn, J. R. & Wilson, C. B. Regulation of interferon-gamma during innate and adaptive immune responses. Adv. Immunol. \n                           96, 41\u2013101, doi:10.1016\/S0065-2776(07)96002-2 (2007).","journal-title":"Adv. Immunol."},{"key":"7543_CR40","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1089\/jir.1991.11.297","volume":"11","author":"JC Morrill","year":"1991","unstructured":"Morrill, J. C., Czarniecki, C. W. & Peters, C. J. Recombinant human interferon-gamma modulates Rift Valley fever virus infection in the rhesus monkey. J. Interferon Res. \n                           11, 297\u2013304 (1991).","journal-title":"J. Interferon Res."},{"key":"7543_CR41","doi-asserted-by":"publisher","first-page":"8613","DOI":"10.4049\/jimmunol.181.12.8613","volume":"181","author":"C Elbim","year":"2008","unstructured":"Elbim, C. et al. Early divergence in neutrophil apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates. J. Immunol. \n                           181, 8613\u20138623 (2008).","journal-title":"J. Immunol."},{"key":"7543_CR42","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1089\/dna.2013.2211","volume":"32","author":"C Gabriel","year":"2013","unstructured":"Gabriel, C., Her, Z. & Ng, L. F. Neutrophils: neglected players in viral diseases. DNA Cell Biol. \n                           32, 665\u2013675, doi:10.1089\/dna.2013.2211 (2013).","journal-title":"DNA Cell Biol."},{"key":"7543_CR43","unstructured":"Bonhomme, F., Guenet, J. L. In The laboratory mouse and its wild relatives in Genetic variants and strains of the laboratory mouse (ed M. F. Lyon, Rastan, S., Brown, S. D. M.) 1577\u20131596 (Oxford University Press, 1996)."},{"key":"7543_CR44","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1534\/genetics.107.078006","volume":"177","author":"G Burgio","year":"2007","unstructured":"Burgio, G. et al. Interspecific recombinant congenic strains between C57BL\/6 and mice of the Mus spretus species: a powerful tool to dissect genetic control of complex traits. Genetics \n                           177, 2321\u20132333, doi:10.1534\/genetics.107.078006 (2007).","journal-title":"Genetics"},{"key":"7543_CR45","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/BF00352333","volume":"1","author":"X Montagutelli","year":"1991","unstructured":"Montagutelli, X., Serikawa, T. & Guenet, J. L. PCR-analyzed microsatellites: data concerning laboratory and wild-derived mouse inbred strains. Mamm. Genome \n                           1, 255\u2013259 (1991).","journal-title":"Mamm. Genome"},{"key":"7543_CR46","first-page":"123","volume":"53","author":"AM El-Akkad","year":"1978","unstructured":"El-Akkad, A. M. Rift Valley fever outbreak in Egypt. October-December 1977. J. Egypt. Public Health Assoc. \n                           53, 123\u2013128 (1978).","journal-title":"J. Egypt. Public Health Assoc."},{"key":"7543_CR47","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/0035-9203(79)90004-X","volume":"73","author":"JM Meegan","year":"1979","unstructured":"Meegan, J. M. The Rift Valley fever epizootic in Egypt 1977-78. 1. Description of the epizzotic and virological studies. Trans. R. Soc. Trop. Med. Hyg. \n                           73, 618\u2013623 (1979).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"7543_CR48","unstructured":"R. Core Team. The R project for Statistical Computing, http:\/\/www.r-project.org\/ (2015)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-07543-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-07543-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-07543-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T07:53:56Z","timestamp":1671782036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-07543-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,2]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["7543"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-07543-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,2]]},"assertion":[{"value":"21 February 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"7096"}}