{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:16:28Z","timestamp":1792145788193,"version":"4.4.0"},"reference-count":133,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as a molecular mechanism underlying the increased risk of mental disorder associated with early life adversity (ELA). The goal of this study was to examine the association of ELA with oxytocin receptor gene (\n                    <jats:italic>OXTR)<\/jats:italic>\n                    methylation among young adults. Drawing from a 21-year longitudinal cohort, we compared adulthood\n                    <jats:italic>OXTR<\/jats:italic>\n                    methylation frequency of 46 adults (23 males and 23 females) selected for high or low ELA exposure based on childhood socioeconomic status and exposure to physical and sexual abuse during childhood and adolescence. Associations between\n                    <jats:italic>OXTR<\/jats:italic>\n                    methylation and teacher-rated childhood trajectories of anxiousness were also assessed. ELA exposure was associated with one significant CpG site in the first intron among females, but not among males. Similarly, childhood trajectories of anxiousness were related to one significant CpG site within the promoter region among females, but not among males. This study suggests that females might be more sensitive to the impact of ELA on\n                    <jats:italic>OXTR<\/jats:italic>\n                    methylation than males.\n                  <\/jats:p>","DOI":"10.1038\/s41598-017-07950-x","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T09:50:18Z","timestamp":1501581018000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness"],"prefix":"10.1038","volume":"7","author":[{"given":"J. P.","family":"Gouin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q. Q.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Booij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boivin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"H\u00e9bert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ouellet-Morin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Szyf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E.","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Turecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Vitaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"7950_CR1","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1017\/S0033291715002743","volume":"46","author":"M Li","year":"2016","unstructured":"Li, M., D\u2019Arcy, C. & Meng, X. Maltreatment in childhood substantially increases the risk of adult depression and anxiety in prospective cohort studies: systematic review, meta-analysis, and proportional attributable fractions. Psychol Med. \n                           46, 717\u2013730, doi:10.1017\/S0033291715002743 (2016).","journal-title":"Psychol Med."},{"key":"7950_CR2","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/intjepid\/31.2.359","volume":"31","author":"SE Gilman","year":"2002","unstructured":"Gilman, S. E., Kawachi, I., Fitzmaurice, G. M. & Buka, S. L. Socioeconomic status in childhood and the lifetime risk of major depression. Int J Epidemiol. \n                           31, 359\u2013367 (2002).","journal-title":"Int J Epidemiol."},{"key":"7950_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.physbeh.2011.08.019","volume":"106","author":"A Danese","year":"2012","unstructured":"Danese, A. & McEwen, B. S. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiology & behavior. \n                           106, 29\u201339, doi:10.1016\/j.physbeh.2011.08.019 (2012).","journal-title":"Physiology & behavior."},{"key":"7950_CR4","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neuroscience.2013.07.069","volume":"264","author":"PE Lutz","year":"2014","unstructured":"Lutz, P. E. & Turecki, G. DNA methylation and childhood maltreatment: from animal models to human studies. Neuroscience. \n                           264, 142\u2013156, doi:10.1016\/j.neuroscience.2013.07.069 (2014).","journal-title":"Neuroscience."},{"key":"7950_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1467-8624.2012.01793.x","volume":"84","author":"M Szyf","year":"2013","unstructured":"Szyf, M. & Bick, J. DNA methylation: a mechanism for embedding early life experiences in the genome. Child Dev. \n                           84, 49\u201357, doi:10.1111\/j.1467-8624.2012.01793.x (2013).","journal-title":"Child Dev."},{"key":"7950_CR6","doi-asserted-by":"publisher","first-page":"4905","DOI":"10.1093\/emboj\/17.17.4905","volume":"17","author":"A Razin","year":"1998","unstructured":"Razin, A. CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J. \n                           17, 4905\u20134908, doi:10.1093\/emboj\/17.17.4905 (1998).","journal-title":"EMBO J."},{"key":"7950_CR7","doi-asserted-by":"crossref","unstructured":"Hochberg, Z. et al. Child health, developmental plasticity, and epigenetic programming. Endocr Rev. 32, 159\u2013224, doi:er.2009-0039 (2011).","DOI":"10.1210\/er.2009-0039"},{"key":"7950_CR8","doi-asserted-by":"crossref","unstructured":"Szyf, M. Early life, the epigenome and human health. Acta Paediatr. 98, 1082\u20131084, doi:APA1382 (2009).","DOI":"10.1111\/j.1651-2227.2009.01382.x"},{"key":"7950_CR9","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/nn1276","volume":"7","author":"IC Weaver","year":"2004","unstructured":"Weaver, I. C. et al. Epigenetic programming by maternal behavior. Nat Neurosci. \n                           7, 847\u2013854, doi:10.1038\/nn1276 (2004).","journal-title":"Nat Neurosci."},{"key":"7950_CR10","doi-asserted-by":"crossref","unstructured":"Champagne, F. A. et al. Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring. Endocrinology. 147, 2909\u20132915, doi:en.2005\u20131119 (2006).","DOI":"10.1210\/en.2005-1119"},{"key":"7950_CR11","doi-asserted-by":"crossref","unstructured":"Korosi, A. et al. Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone. J Neurosci. 30, 703\u2013713, doi:30\/2\/703 (2010).","DOI":"10.1523\/JNEUROSCI.4214-09.2010"},{"key":"7950_CR12","doi-asserted-by":"crossref","unstructured":"Roth, T. L., Lubin, F. D., Funk, A. J. & Sweatt, J. D. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry. 65, 760\u2013769, doi:S0006-3223(08)01530-8 (2009).","DOI":"10.1016\/j.biopsych.2008.11.028"},{"key":"7950_CR13","doi-asserted-by":"crossref","unstructured":"Murgatroyd, C. et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci. 12, 1559\u20131566, doi:nn.2436 (2009).","DOI":"10.1038\/nn.2436"},{"key":"7950_CR14","doi-asserted-by":"publisher","first-page":"15626","DOI":"10.1523\/JNEUROSCI.1470-12.2012","volume":"32","author":"N Provencal","year":"2012","unstructured":"Provencal, N. et al. The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J Neurosci. \n                           32, 15626\u201315642, doi:10.1523\/JNEUROSCI.1470-12.2012 (2012).","journal-title":"J Neurosci."},{"key":"7950_CR15","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1017\/S0954579411000605","volume":"24","author":"OY Naumova","year":"2012","unstructured":"Naumova, O. Y. et al. Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents. Dev Psychopathol. \n                           24, 143\u2013155, doi:10.1017\/S0954579411000605 (2012).","journal-title":"Dev Psychopathol."},{"key":"7950_CR16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1467-8624.2011.01641.x","volume":"84","author":"MJ Essex","year":"2013","unstructured":"Essex, M. J. et al. Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence. Child Dev. \n                           84, 58\u201375, doi:10.1111\/j.1467-8624.2011.01641.x (2013).","journal-title":"Child Dev."},{"key":"7950_CR17","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1093\/ije\/dyr147","volume":"41","author":"N Borghol","year":"2012","unstructured":"Borghol, N. et al. Associations with early-life socio-economic position in adult DNA methylation. Int J Epidemiol. \n                           41, 62\u201374, doi:10.1093\/ije\/dyr147 (2012).","journal-title":"Int J Epidemiol."},{"key":"7950_CR18","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1001\/archgenpsychiatry.2011.2287","volume":"69","author":"B Labonte","year":"2012","unstructured":"Labonte, B. et al. Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry. \n                           69, 722\u2013731, doi:10.1001\/archgenpsychiatry.2011.2287 (2012).","journal-title":"Arch Gen Psychiatry."},{"key":"7950_CR19","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nn.2270","volume":"12","author":"PO McGowan","year":"2009","unstructured":"McGowan, P. O. et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci. \n                           12, 342\u2013348, doi:10.1038\/nn.2270 (2009).","journal-title":"Nat Neurosci."},{"key":"7950_CR20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2011.01641.x","author":"MJ Essex","year":"2011","unstructured":"Essex, M. J. et al. Epigenetic Vestiges of Early Developmental Adversity: Childhood Stress Exposure and DNA Methylation in Adolescence. Child Dev. doi:10.1111\/j.1467-8624.2011.01641.x (2011).","journal-title":"Child Dev"},{"key":"7950_CR21","doi-asserted-by":"crossref","unstructured":"Labonte, B. et al. Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry \n                           72. 41\u201348, doi:S0006-3223(12)00132-1 (2012).","DOI":"10.1016\/j.biopsych.2012.01.034"},{"key":"7950_CR22","doi-asserted-by":"publisher","first-page":"e30148","DOI":"10.1371\/journal.pone.0030148","volume":"7","author":"AR Tyrka","year":"2012","unstructured":"Tyrka, A. R., Price, L. H., Marsit, C., Walters, O. C. & Carpenter, L. L. Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PLoS One. \n                           7, e30148, doi:10.1371\/journal.pone.0030148PONE-D-11-16545 (2012).","journal-title":"PLoS One."},{"key":"7950_CR23","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.1038\/tp.2011.60","volume":"1","author":"N Perroud","year":"2011","unstructured":"Perroud, N. et al. Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma. Transl Psychiatry. \n                           1, e59, doi:10.1038\/tp.2011.60 (2011).","journal-title":"Transl Psychiatry."},{"key":"7950_CR24","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/ajmg.b.31028","volume":"153B","author":"SR Beach","year":"2010","unstructured":"Beach, S. R., Brody, G. H., Todorov, A. A., Gunter, T. D. & Philibert, R. A. Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. Am J Med Genet B Neuropsychiatr Genet. \n                           153B, 710\u2013713, doi:10.1002\/ajmg.b.31028 (2010).","journal-title":"Am J Med Genet B Neuropsychiatr Genet."},{"key":"7950_CR25","doi-asserted-by":"publisher","first-page":"e207","DOI":"10.1038\/tp.2012.140","volume":"3","author":"N Perroud","year":"2013","unstructured":"Perroud, N. et al. Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene. Transl Psychiatry. \n                           3, e207, doi:10.1038\/tp.2012.140 (2013).","journal-title":"Transl Psychiatry."},{"key":"7950_CR26","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1017\/S0954579412000806","volume":"24","author":"J Bick","year":"2012","unstructured":"Bick, J. et al. Childhood adversity and DNA methylation of genes involved in the hypothalamus-pituitary-adrenal axis and immune system: whole-genome and candidate-gene associations. Dev Psychopathol. \n                           24, 1417\u20131425, doi:10.1017\/S0954579412000806 (2012).","journal-title":"Dev Psychopathol."},{"key":"7950_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nn.3275","volume":"16","author":"T Klengel","year":"2013","unstructured":"Klengel, T. et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci. \n                           16, 33\u201341, doi:10.1038\/nn.3275 (2013).","journal-title":"Nat Neurosci."},{"key":"7950_CR28","doi-asserted-by":"publisher","first-page":"e0119061","DOI":"10.1371\/journal.pone.0119061","volume":"10","author":"L Booij","year":"2015","unstructured":"Booij, L. et al. DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: a study in depressed patients and healthy controls. PloS one. \n                           10, e0119061, doi:10.1371\/journal.pone.0119061 (2015).","journal-title":"PloS one."},{"key":"7950_CR29","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1017\/S0954579415000991","volume":"27","author":"AR Tyrka","year":"2015","unstructured":"Tyrka, A. R. et al. Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5). Dev Psychopathol. \n                           27, 1637\u20131645, doi:10.1017\/S0954579415000991 (2015).","journal-title":"Dev Psychopathol."},{"key":"7950_CR30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pnpbp.2013.01.006","volume":"44","author":"HJ Kang","year":"2013","unstructured":"Kang, H. J. et al. Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression. Prog Neuropsychopharmacol Biol Psychiatry. \n                           44, 23\u201328, doi:10.1016\/j.pnpbp.2013.01.006 (2013).","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"7950_CR31","doi-asserted-by":"publisher","first-page":"e2085","DOI":"10.1371\/journal.pone.0002085","volume":"3","author":"PO McGowan","year":"2008","unstructured":"McGowan, P. O. et al. Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS One. \n                           3, e2085, doi:10.1371\/journal.pone.0002085 (2008).","journal-title":"PLoS One."},{"key":"7950_CR32","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13148-016-0219-0","volume":"8","author":"L Cao-Lei","year":"2016","unstructured":"Cao-Lei, L. et al. DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13(1\/2) years: Project Ice Storm. Clin Epigenetics. \n                           8, 54, doi:10.1186\/s13148-016-0219-0 (2016).","journal-title":"Clin Epigenetics."},{"key":"7950_CR33","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1080\/15592294.2015.1063771","volume":"10","author":"L Cao-Lei","year":"2015","unstructured":"Cao-Lei, L. et al. DNA methylation mediates the impact of exposure to prenatal maternal stress on BMI and central adiposity in children at age 13(1\/2) years: Project Ice Storm. Epigenetics. \n                           10, 749\u2013761, doi:10.1080\/15592294.2015.1063771 (2015).","journal-title":"Epigenetics."},{"key":"7950_CR34","doi-asserted-by":"publisher","first-page":"e830","DOI":"10.1038\/tp.2016.95","volume":"6","author":"R Kumsta","year":"2016","unstructured":"Kumsta, R. et al. Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry. \n                           6, e830, doi:10.1038\/tp.2016.95 (2016).","journal-title":"Transl Psychiatry."},{"key":"7950_CR35","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1146\/annurev-psych-010213-115110","volume":"65","author":"CS Carter","year":"2014","unstructured":"Carter, C. S. Oxytocin pathways and the evolution of human behavior. Annual review of psychology. \n                           65, 17\u201339, doi:10.1146\/annurev-psych-010213-115110 (2014).","journal-title":"Annual review of psychology."},{"key":"7950_CR36","unstructured":"Bartz, J. A., Zaki, J., Bolger, N. & Ochsner, K. N. Social effects of oxytocin in humans: context and person matter. Trends Cogn Sci. 15, 301\u2013309, doi:S1364-6613(11)00083-0 (2011)."},{"key":"7950_CR37","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neures.2010.06.007","volume":"68","author":"H Matsushita","year":"2010","unstructured":"Matsushita, H. et al. Oxytocin mediates the antidepressant effects of mating behavior in male mice. Neurosci Res. \n                           68, 151\u2013153, doi:10.1016\/j.neures.2010.06.007 (2010).","journal-title":"Neurosci Res."},{"key":"7950_CR38","doi-asserted-by":"crossref","unstructured":"Waldherr, M. & Neumann, I. D. Centrally released oxytocin mediates mating-induced anxiolysis in male rats. Proc Natl Acad Sci USA \n                           104, 16681\u201316684, doi:0705860104 (2007).","DOI":"10.1073\/pnas.0705860104"},{"key":"7950_CR39","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/0024-3205(87)90600-X","volume":"41","author":"R Arletti","year":"1987","unstructured":"Arletti, R. & Bertolini, A. Oxytocin acts as an antidepressant in two animal models of depression. Life Sci. \n                           41, 1725\u20131730 (1987).","journal-title":"Life Sci."},{"key":"7950_CR40","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00213-010-1815-x","volume":"210","author":"S Chaviaras","year":"2010","unstructured":"Chaviaras, S., Mak, P., Ralph, D., Krishnan, L. & Broadbear, J. H. Assessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test. Psychopharmacology (Berl). \n                           210, 35\u201343, doi:10.1007\/s00213-010-1815-x (2010).","journal-title":"Psychopharmacology (Berl)."},{"key":"7950_CR41","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1097\/PSY.0b013e3181de8678","volume":"72","author":"GJ Norman","year":"2010","unstructured":"Norman, G. J. et al. Social interaction prevents the development of depressive-like behavior post nerve injury in mice: a potential role for oxytocin. Psychosomatic medicine. \n                           72, 519\u2013526, doi:10.1097\/PSY.0b013e3181de8678 (2010).","journal-title":"Psychosomatic medicine."},{"key":"7950_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3109\/10253890.2011.605486","volume":"15","author":"AJ Grippo","year":"2012","unstructured":"Grippo, A. J. et al. Peripheral oxytocin administration buffers autonomic but not behavioral responses to environmental stressors in isolated prairie voles. Stress. \n                           15, 149\u2013161, doi:10.3109\/10253890.2011.605486 (2012).","journal-title":"Stress."},{"key":"7950_CR43","doi-asserted-by":"crossref","unstructured":"Parker, K. J. et al. Preliminary evidence that plasma oxytocin levels are elevated in major depression. Psychiatry Res. 178, 359\u2013362, doi:S0165-1781(09)00362-X (2010).","DOI":"10.1016\/j.psychres.2009.09.017"},{"key":"7950_CR44","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.psyneuen.2007.01.009","volume":"32","author":"G Scantamburlo","year":"2007","unstructured":"Scantamburlo, G. et al. Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology. \n                           32, 407\u2013410 (2007).","journal-title":"Psychoneuroendocrinology."},{"key":"7950_CR45","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jpsychires.2013.12.012","volume":"51","author":"KW Yuen","year":"2014","unstructured":"Yuen, K. W. et al. Plasma oxytocin concentrations are lower in depressed vs. healthy control women and are independent of cortisol. J Psychiatr Res. \n                           51, 30\u201336, doi:10.1016\/j.jpsychires.2013.12.012 (2014).","journal-title":"J Psychiatr Res."},{"key":"7950_CR46","doi-asserted-by":"crossref","unstructured":"Cyranowski, J. M. et al. Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosom Med. 70, 967\u2013975, doi:70\/9\/967 (2008).","DOI":"10.1097\/PSY.0b013e318188ade4"},{"key":"7950_CR47","doi-asserted-by":"crossref","unstructured":"Tabak, B. A., McCullough, M. E., Szeto, A., Mendez, A. J. & McCabe, P. M. Oxytocin indexes relational distress following interpersonal harms in women. Psychoneuroendocrinology. 36, 115\u2013122, doi:S0306-4530(10)00172-1 (2011).","DOI":"10.1016\/j.psyneuen.2010.07.004"},{"key":"7950_CR48","doi-asserted-by":"publisher","first-page":"21437","DOI":"10.1073\/pnas.0909579106","volume":"106","author":"SM Rodrigues","year":"2009","unstructured":"Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P. & Keltner, D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci USA \n                           106, 21437\u201321441, doi:10.1073\/pnas.0909579106 (2009).","journal-title":"Proc Natl Acad Sci USA"},{"key":"7950_CR49","doi-asserted-by":"publisher","first-page":"15118","DOI":"10.1073\/pnas.1113137108","volume":"108","author":"S Saphire-Bernstein","year":"2011","unstructured":"Saphire-Bernstein, S., Way, B. M., Kim, H. S., Sherman, D. K. & Taylor, S. E. Oxytocin receptor gene (OXTR) is related to psychological resources. Proc Natl Acad Sci USA \n                           108, 15118\u201315122, doi:10.1073\/pnas.1113137108 (2011).","journal-title":"Proc Natl Acad Sci USA"},{"key":"7950_CR50","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jad.2010.04.014","volume":"127","author":"Y Kawamura","year":"2010","unstructured":"Kawamura, Y. et al. The association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A. Journal of Affective Disorders. \n                           127, 31\u201337, doi:10.1016\/j.jad.2010.04.014 (2010).","journal-title":"Journal of Affective Disorders."},{"key":"7950_CR51","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.psyneuen.2009.05.006","volume":"34","author":"B Costa","year":"2009","unstructured":"Costa, B. et al. Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology. \n                           34, 1506\u20131514, doi:10.1016\/j.psyneuen.2009.05.006 (2009).","journal-title":"Psychoneuroendocrinology."},{"key":"7950_CR52","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.3389\/fpsyg.2015.01133","volume":"6","author":"OA McInnis","year":"2015","unstructured":"McInnis, O. A., McQuaid, R. J., Matheson, K. & Anisman, H. The moderating role of an oxytocin receptor gene polymorphism in the relation between unsupportive social interactions and coping profiles: implications for depression. Front Psychol. \n                           6, 1133, doi:10.3389\/fpsyg.2015.01133 (2015).","journal-title":"Front Psychol."},{"key":"7950_CR53","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1017\/S0954579411000162","volume":"23","author":"B Bradley","year":"2011","unstructured":"Bradley, B. et al. Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene. Development and psychopathology. \n                           23, 439\u2013452, doi:10.1017\/S0954579411000162 (2011).","journal-title":"Development and psychopathology."},{"key":"7950_CR54","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3389\/fnins.2013.00128","volume":"7","author":"RJ McQuaid","year":"2013","unstructured":"McQuaid, R. J., McInnis, O. A., Stead, J. D., Matheson, K. & Anisman, H. A paradoxical association of an oxytocin receptor gene polymorphism: early-life adversity and vulnerability to depression. Front Neurosci. \n                           7, 128, doi:10.3389\/fnins.2013.00128 (2013).","journal-title":"Front Neurosci."},{"key":"7950_CR55","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.psyneuen.2010.07.003","volume":"36","author":"RJ Thompson","year":"2011","unstructured":"Thompson, R. J., Parker, K. J., Hallmayer, J. F., Waugh, C. E. & Gotlib, I. H. Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology. \n                           36, 144\u2013147, doi:10.1016\/j.psyneuen.2010.07.003 (2011).","journal-title":"Psychoneuroendocrinology."},{"key":"7950_CR56","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jpsychires.2014.08.021","volume":"59","author":"AJ Myers","year":"2014","unstructured":"Myers, A. J. et al. Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress. J Psychiatr Res. \n                           59, 93\u2013100, doi:10.1016\/j.jpsychires.2014.08.021 (2014).","journal-title":"J Psychiatr Res."},{"key":"7950_CR57","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S0018-506X(03)00154-5","volume":"44","author":"KL Bales","year":"2003","unstructured":"Bales, K. L. & Carter, C. S. Sex differences and developmental effects of oxytocin on aggression and social behavior in prairie voles (Microtus ochrogaster). Horm Behav. \n                           44, 178\u2013184 (2003).","journal-title":"Horm Behav."},{"key":"7950_CR58","doi-asserted-by":"crossref","unstructured":"Champagne, F. A. & Meaney, M. J. Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty. Behav Neurosci. 121, 1353\u20131363, doi:2007-18058-021 (2007).","DOI":"10.1037\/0735-7044.121.6.1353"},{"key":"7950_CR59","doi-asserted-by":"crossref","unstructured":"Francis, D. D., Champagne, F. C. & Meaney, M. J. Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat. J Neuroendocrinol. 12, 1145\u20131148, doi:599 (2000).","DOI":"10.1046\/j.1365-2826.2000.00599.x"},{"key":"7950_CR60","doi-asserted-by":"crossref","unstructured":"Francis, D. D., Young, L. J., Meaney, M. J. & Insel, T. R. Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors: gender differences. J Neuroendocrinol. 14, 349\u2013353, doi:776 (2002).","DOI":"10.1046\/j.0007-1331.2002.00776.x"},{"key":"7950_CR61","doi-asserted-by":"crossref","unstructured":"Champagne, F. A. & Meaney, M. J. Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model. Biol Psychiatry. 59, 1227\u20131235, doi:S0006-3223(05)01370-3 (2006).","DOI":"10.1016\/j.biopsych.2005.10.016"},{"key":"7950_CR62","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/neuro.08.025.2009","volume":"3","author":"JP Curley","year":"2009","unstructured":"Curley, J. P., Davidson, S., Bateson, P. & Champagne, F. A. Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice. Front Behav Neurosci. \n                           3, 25, doi:10.3389\/neuro.08.025.2009 (2009).","journal-title":"Front Behav Neurosci."},{"key":"7950_CR63","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3389\/neuro.08.017.2009","volume":"3","author":"TH Ahern","year":"2009","unstructured":"Ahern, T. H. & Young, L. J. The impact of early life family structure on adult social attachment, alloparental behavior, and the neuropeptide systems regulating affiliative behaviors in the monogamous prairie vole (microtus ochrogaster). Front Behav Neurosci. \n                           3, 17, doi:10.3389\/neuro.08.017.2009 (2009).","journal-title":"Front Behav Neurosci."},{"key":"7950_CR64","doi-asserted-by":"crossref","unstructured":"Lukas, M., Bredewold, R., Neumann, I. D. & Veenema, A. H. Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Neuropharmacology. 58, 78\u201387, doi:S0028-3908(09)00174-9 (2010).","DOI":"10.1016\/j.neuropharm.2009.06.020"},{"key":"7950_CR65","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fpsyt.2011.00024","volume":"2","author":"KL Bales","year":"2011","unstructured":"Bales, K. L., Boone, E., Epperson, P., Hoffman, G. & Carter, C. S. Are behavioral effects of early experience mediated by oxytocin? Front Psychiatry. \n                           2, 24, doi:10.3389\/fpsyt.2011.00024 (2011).","journal-title":"Front Psychiatry."},{"key":"7950_CR66","doi-asserted-by":"crossref","unstructured":"Todeschin, A. S. et al. Effects of neonatal handling on social memory, social interaction, and number of oxytocin and vasopressin neurons in rats. Horm Behav. 56, 93\u2013100, doi:S0018-506X(09)00058-0 (2009).","DOI":"10.1016\/j.yhbeh.2009.03.006"},{"key":"7950_CR67","doi-asserted-by":"crossref","unstructured":"Winkelmann-Duarte, E. C. et al. Plastic changes induced by neonatal handling in the hypothalamus of female rats. Brain Res. 1170, 20\u201330, doi:S0006-8993(07)01656-3 (2007).","DOI":"10.1016\/j.brainres.2007.07.030"},{"key":"7950_CR68","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.ijdevneu.2004.03.003","volume":"23","author":"JT Winslow","year":"2005","unstructured":"Winslow, J. T. Neuropeptides and non-human primate social deficits associated with pathogenic rearing experience. Int. J. Dev. Neurosci. \n                           23, 245\u2013251 (2005).","journal-title":"Int. J. Dev. Neurosci."},{"key":"7950_CR69","doi-asserted-by":"crossref","unstructured":"Heim, C. et al. Lower CSF oxytocin concentrations in women with a history of childhood abuse. Mol Psychiatry. 14, 954\u2013958, doi:mp2008112 (2009).","DOI":"10.1038\/mp.2008.112"},{"key":"7950_CR70","doi-asserted-by":"crossref","unstructured":"Meinlschmidt, G. & Heim, C. Sensitivity to intranasal oxytocin in adult men with early parental separation. Biol Psychiatry. 61, 1109\u20131111, doi:S0006-3223(06)01113-9 (2007).","DOI":"10.1016\/j.biopsych.2006.09.007"},{"key":"7950_CR71","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1093\/scan\/nsr067","volume":"7","author":"MJ Bakermans-Kranenburg","year":"2012","unstructured":"Bakermans-Kranenburg, M. J., van Ijzendoorn, M. H., Riem, M. M., Tops, M. & Alink, L. R. Oxytocin decreases handgrip force in reaction to infant crying in females without harsh parenting experiences. Soc Cogn Affect Neurosci. \n                           7, 951\u2013957, doi:10.1093\/scan\/nsr067 (2012).","journal-title":"Soc Cogn Affect Neurosci."},{"key":"7950_CR72","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1093\/scan\/nsu020","volume":"9","author":"S Grimm","year":"2014","unstructured":"Grimm, S. et al. Early life stress modulates oxytocin effects on limbic system during acute psychosocial stress. Soc Cogn Affect Neurosci. \n                           9, 1828\u20131835, doi:10.1093\/scan\/nsu020 (2014).","journal-title":"Soc Cogn Affect Neurosci."},{"key":"7950_CR73","doi-asserted-by":"crossref","unstructured":"Wismer Fries, A. B., Ziegler, T. E., Kurian, J. R., Jacoris, S. & Pollak, S. D. Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior. Proc Natl Acad Sci USA \n                           102, 17237\u201317240, doi:102\/47\/17237 (2005).","DOI":"10.1073\/pnas.0504767102"},{"key":"7950_CR74","first-page":"97","volume":"39","author":"A Kiss","year":"2005","unstructured":"Kiss, A. & Mikkelsen, J. D. Oxytocin\u2013anatomy and functional assignments: a minireview. Endocr Regul. \n                           39, 97\u2013105 (2005).","journal-title":"Endocr Regul."},{"key":"7950_CR75","doi-asserted-by":"publisher","unstructured":"Kusui, C. et al. DNA Methylation of the Human Oxytocin Receptor Gene Promoter Regulates Tissue-Specific Gene Suppression. Biochemical and Biophysical Research Communications. 289, 681\u2013686, doi:10.1006\/bbrc.2001.6024 (2001).","DOI":"10.1006\/bbrc.2001.6024"},{"key":"7950_CR76","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1741-7015-7-62","volume":"7","author":"SG Gregory","year":"2009","unstructured":"Gregory, S. G. et al. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med. \n                           7, 62, doi:10.1186\/1741-7015-7-62 (2009).","journal-title":"BMC Med."},{"key":"7950_CR77","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1017\/S0954579413000497","volume":"26","author":"MR Dadds","year":"2014","unstructured":"Dadds, M. R. et al. Methylation of the oxytocin receptor gene and oxytocin blood levels in the development of psychopathy. Dev Psychopathol. \n                           26, 33\u201340, doi:10.1017\/S0954579413000497 (2014).","journal-title":"Dev Psychopathol."},{"key":"7950_CR78","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/mp.2014.95","volume":"19","author":"CA Cecil","year":"2014","unstructured":"Cecil, C. A. et al. Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study. Mol Psychiatry. \n                           19, 1071\u20131077, doi:10.1038\/mp.2014.95 (2014).","journal-title":"Mol Psychiatry."},{"key":"7950_CR79","doi-asserted-by":"publisher","first-page":"e88673","DOI":"10.1371\/journal.pone.0088673","volume":"9","author":"YR Kim","year":"2014","unstructured":"Kim, Y. R., Kim, J. H., Kim, M. J. & Treasure, J. Differential methylation of the oxytocin receptor gene in patients with anorexia nervosa: a pilot study. PloS one. \n                           9, e88673, doi:10.1371\/journal.pone.0088673 (2014).","journal-title":"PloS one."},{"key":"7950_CR80","doi-asserted-by":"publisher","first-page":"e150","DOI":"10.1038\/tp.2012.77","volume":"2","author":"E Unternaehrer","year":"2012","unstructured":"Unternaehrer, E. et al. Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress. Transl Psychiatry. \n                           2, e150, doi:10.1038\/tp.2012.77 (2012).","journal-title":"Transl Psychiatry."},{"key":"7950_CR81","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3389\/fnhum.2012.00280","volume":"6","author":"A Jack","year":"2012","unstructured":"Jack, A., Connelly, J. J. & Morris, J. P. DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli. Frontiers in human neuroscience. \n                           6, 280, doi:10.3389\/fnhum.2012.00280 (2012).","journal-title":"Frontiers in human neuroscience."},{"key":"7950_CR82","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.1073\/pnas.1422096112","volume":"112","author":"MH Puglia","year":"2015","unstructured":"Puglia, M. H., Lillard, T. S., Morris, J. P. & Connelly, J. J. Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain. Proceedings of the National Academy of Sciences of the United States of America. \n                           112, 3308\u20133313, doi:10.1073\/pnas.1422096112 (2015).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America."},{"key":"7950_CR83","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1038\/npp.2015.2","volume":"40","author":"C Ziegler","year":"2015","unstructured":"Ziegler, C. et al. Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology. \n                           40, 1528\u20131538, doi:10.1038\/npp.2015.2 (2015).","journal-title":"Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology."},{"key":"7950_CR84","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.psyneuen.2016.04.008","volume":"69","author":"M Kimmel","year":"2016","unstructured":"Kimmel, M. et al. Oxytocin receptor DNA methylation in postpartum depression. Psychoneuroendocrinology. \n                           69, 150\u2013160, doi:10.1016\/j.psyneuen.2016.04.008 (2016).","journal-title":"Psychoneuroendocrinology."},{"key":"7950_CR85","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jpsychires.2015.03.012","volume":"65","author":"I Reiner","year":"2015","unstructured":"Reiner, I. et al. Methylation of the oxytocin receptor gene in clinically depressed patients compared to controls: The role of OXTR rs53576 genotype. J Psychiatr Res. \n                           65, 9\u201315, doi:10.1016\/j.jpsychires.2015.03.012 (2015).","journal-title":"J Psychiatr Res."},{"key":"7950_CR86","doi-asserted-by":"publisher","unstructured":"Simons, R. L., Lei, M. K., Beach, S. R., Cutrona, C. E. & Philibert, R. A. Methylation of the oxytocin receptor gene mediates the effect of adversity on negative schemas and depression. Dev Psychopathol. 1\u201312, doi:10.1017\/S0954579416000420 (2016).","DOI":"10.1017\/S0954579416000420"},{"key":"7950_CR87","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.yhbeh.2015.05.022","volume":"77","author":"AK Beery","year":"2016","unstructured":"Beery, A. K., McEwen, L. M., MacIsaac, J. L., Francis, D. D. & Kobor, M. S. Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats. Horm Behav. \n                           77, 42\u201352, doi:10.1016\/j.yhbeh.2015.05.022 (2016).","journal-title":"Horm Behav."},{"key":"7950_CR88","doi-asserted-by":"publisher","unstructured":"Needham, B. L. et al. Life Course Socioeconomic Status and DNA Methylation in Genes Related to Stress Reactivity and Inflammation: The Multi-Ethnic Study of Atherosclerosis. Epigenetics. 00\u201300, doi:10.1080\/15592294.2015.1085139 (2015).","DOI":"10.1080\/15592294.2015.1085139"},{"key":"7950_CR89","doi-asserted-by":"publisher","unstructured":"Unternaehrer, E. et al. Childhood maternal care is associated with DNA methylation of the genes for brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) in peripheral blood cells in adult men and women. Stress. 1\u201311, doi:10.3109\/10253890.2015.1038992 (2015).","DOI":"10.3109\/10253890.2015.1038992"},{"key":"7950_CR90","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/cdev.12493","volume":"87","author":"EL Smearman","year":"2016","unstructured":"Smearman, E. L. et al. Oxytocin Receptor Genetic and Epigenetic Variations: Association With Child Abuse and Adult Psychiatric Symptoms. Child Dev. \n                           87, 122\u2013134, doi:10.1111\/cdev.12493 (2016).","journal-title":"Child Dev."},{"key":"7950_CR91","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1073\/pnas.0510310103","volume":"103","author":"S Saxonov","year":"2006","unstructured":"Saxonov, S., Berg, P. & Brutlag, D. L. A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc Natl Acad Sci USA \n                           103, 1412\u20131417, doi:10.1073\/pnas.0510310103 (2006).","journal-title":"Proc Natl Acad Sci USA"},{"key":"7950_CR92","doi-asserted-by":"publisher","first-page":"R195","DOI":"10.1093\/hmg\/ddp409","volume":"18","author":"GC Hon","year":"2009","unstructured":"Hon, G. C., Hawkins, R. D. & Ren, B. Predictive chromatin signatures in the mammalian genome. Hum Mol Genet. \n                           18, R195\u2013201, doi:10.1093\/hmg\/ddp409 (2009).","journal-title":"Hum Mol Genet."},{"key":"7950_CR93","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1126\/science.281.5373.60","volume":"281","author":"EM Blackwood","year":"1998","unstructured":"Blackwood, E. M. & Kadonaga, J. T. Going the distance: a current view of enhancer action. Science. \n                           281, 60\u201363 (1998).","journal-title":"Science."},{"key":"7950_CR94","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1755-8794-7-13","volume":"7","author":"M Suderman","year":"2014","unstructured":"Suderman, M. et al. Childhood abuse is associated with methylation of multiple loci in adult DNA. BMC Med Genomics. \n                           7, 13, doi:10.1186\/1755-8794-7-13 (2014).","journal-title":"BMC Med Genomics."},{"key":"7950_CR95","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1192\/bjp.bp.114.162081","volume":"208","author":"I Ouellet-Morin","year":"2016","unstructured":"Ouellet-Morin, I. et al. Effects of the MAOA gene and levels of exposure to violence on antisocial outcomes. The British journal of psychiatry: the journal of mental science. \n                           208, 42\u201348, doi:10.1192\/bjp.bp.114.162081 (2016).","journal-title":"The British journal of psychiatry: the journal of mental science."},{"key":"7950_CR96","doi-asserted-by":"crossref","unstructured":"Straus, M. A., Hamby, S. L., Boney-McCoy, S., Sugarman, D. B. The Revised Conflict Tactics Scales (CTS2). Development and preliminary psychometric data. J Fam Issues. 17 (1996).","DOI":"10.1177\/019251396017003001"},{"key":"7950_CR97","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","volume":"14","author":"VJ Felitti","year":"1998","unstructured":"Felitti, V. J. et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med. \n                           14, 245\u2013258 (1998).","journal-title":"Am J Prev Med."},{"key":"7950_CR98","unstructured":"Finkelhor, D. Sexually victimized children. (Free Press, 1979)."},{"key":"7950_CR99","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1001\/archpsyc.1997.01830130068014","volume":"54","author":"LC Masse","year":"1997","unstructured":"Masse, L. C. & Tremblay, R. E. Behavior of boys in kindergarten and the onset of substance use during adolescence. Arch Gen Psychiatry. \n                           54, 62\u201368 (1997).","journal-title":"Arch Gen Psychiatry."},{"key":"7950_CR100","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/1467-8624.00086","volume":"70","author":"D Nagin","year":"1999","unstructured":"Nagin, D. & Tremblay, R. E. Trajectories of boys\u2019 physical aggression, opposition, and hyperactivity on the path to physically violent and nonviolent juvenile delinquency. Child Dev. \n                           70, 1181\u20131196 (1999).","journal-title":"Child Dev."},{"key":"7950_CR101","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature11247","volume":"489","author":"EP Consortium","year":"2012","unstructured":"Consortium, E. P. An integrated encyclopedia of DNA elements in the human genome. Nature. \n                           489, 57\u201374, doi:10.1038\/nature11247 (2012).","journal-title":"Nature."},{"key":"7950_CR102","doi-asserted-by":"publisher","unstructured":"Karolchik, D., Hinrichs, A. S. & Kent, W. J. The UCSC Genome Browser. Curr Protoc Bioinformatics. Chapter 1, Unit1 4, doi:10.1002\/0471250953.bi0104s40 (2012).","DOI":"10.1002\/0471250953.bi0104s40"},{"key":"7950_CR103","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1101\/gr.136184.111","volume":"22","author":"SG Landt","year":"2012","unstructured":"Landt, S. G. et al. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. \n                           22, 1813\u20131831, doi:10.1101\/gr.136184.111 (2012).","journal-title":"Genome Res."},{"key":"7950_CR104","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1016\/S0021-9258(18)42526-4","volume":"267","author":"J Rouleau","year":"1992","unstructured":"Rouleau, J., Tanigawa, G. & Szyf, M. The mouse DNA methyltransferase 5\u2032-region. A unique housekeeping gene promoter. J Biol Chem. \n                           267, 7368\u20137377 (1992).","journal-title":"J Biol Chem."},{"key":"7950_CR105","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3758\/BF03206553","volume":"36","author":"KJ Preacher","year":"2004","unstructured":"Preacher, K. J. & Hayes, A. F. SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behav Res Methods Instrum Comput. \n                           36, 717\u2013731 (2004).","journal-title":"Behav Res Methods Instrum Comput."},{"key":"7950_CR106","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/bmsp.12028","volume":"67","author":"AF Hayes","year":"2014","unstructured":"Hayes, A. F. & Preacher, K. J. Statistical mediation analysis with a multicategorical independent variable. Br J Math Stat Psychol. \n                           67, 451\u2013470, doi:10.1111\/bmsp.12028 (2014).","journal-title":"Br J Math Stat Psychol."},{"key":"7950_CR107","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","volume":"112","author":"J Cohen","year":"1992","unstructured":"Cohen, J. A power primer. Psychol Bull. \n                           112, 155\u2013159 (1992).","journal-title":"Psychol Bull."},{"key":"7950_CR108","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.edurev.2010.12.001","volume":"6","author":"JTE Richardson","year":"2011","unstructured":"Richardson, J. T. E. Eta squared and partial eta squared as measures of effect size in educational research. Educational Research Review. \n                           6, 135\u2013147 (2011).","journal-title":"Educational Research Review."},{"key":"7950_CR109","doi-asserted-by":"publisher","unstructured":"Needham, B. L. et al. Life Course Socioeconomic Status and DNA Methylation in Genes Related to Stress Reactivity and Inflammation: The Multi-Ethnic Study of Atherosclerosis. Epigenetics. 0, doi:10.1080\/15592294.2015.1085139 (2015).","DOI":"10.1080\/15592294.2015.1085139"},{"key":"7950_CR110","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3109\/10253890.2015.1038992","volume":"18","author":"E Unternaehrer","year":"2015","unstructured":"Unternaehrer, E. et al. Childhood maternal care is associated with DNA methylation of the genes for brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) in peripheral blood cells in adult men and women. Stress. \n                           18, 451\u2013461, doi:10.3109\/10253890.2015.1038992 (2015).","journal-title":"Stress."},{"key":"7950_CR111","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.neuroscience.2005.05.025","volume":"135","author":"S Uhl-Bronner","year":"2005","unstructured":"Uhl-Bronner, S., Waltisperger, E., Martinez-Lorenzana, G., Condes Lara, M. & Freund-Mercier, M. J. Sexually dimorphic expression of oxytocin binding sites in forebrain and spinal cord of the rat. Neuroscience. \n                           135, 147\u2013154, doi:10.1016\/j.neuroscience.2005.05.025 (2005).","journal-title":"Neuroscience."},{"key":"7950_CR112","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fnins.2013.00083","volume":"7","author":"R Kumsta","year":"2013","unstructured":"Kumsta, R., Hummel, E., Chen, F. S. & Heinrichs, M. Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience. Front Neurosci. \n                           7, 83, doi:10.3389\/fnins.2013.00083 (2013).","journal-title":"Front Neurosci."},{"key":"7950_CR113","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.biopsych.2014.02.006","volume":"77","author":"R Yehuda","year":"2015","unstructured":"Yehuda, R. et al. Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder. Biol Psychiatry. \n                           77, 356\u2013364, doi:10.1016\/j.biopsych.2014.02.006 (2015).","journal-title":"Biol Psychiatry."},{"key":"7950_CR114","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1017\/S1461145713000102","volume":"16","author":"PA Melas","year":"2013","unstructured":"Melas, P. A. et al. Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities. Int J Neuropsychopharmacol. \n                           16, 1513\u20131528, doi:10.1017\/S1461145713000102 (2013).","journal-title":"Int J Neuropsychopharmacol."},{"key":"7950_CR115","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jpsychires.2014.06.011","volume":"57","author":"A Mart\u00edn-Blanco","year":"2014","unstructured":"Mart\u00edn-Blanco, A. et al. Association between methylation of the glucocorticoid receptor gene, childhood maltreatment, and clinical severity in borderline personality disorder. Journal of Psychiatric Research. \n                           57, 34\u201340, doi:10.1016\/j.jpsychires.2014.06.011 (2014).","journal-title":"Journal of Psychiatric Research."},{"key":"7950_CR116","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nrg3230","volume":"13","author":"PA Jones","year":"2012","unstructured":"Jones, P. A. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet. \n                           13, 484\u2013492, doi:10.1038\/nrg3230 (2012).","journal-title":"Nat Rev Genet."},{"key":"7950_CR117","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.bpsc.2015.10.003","volume":"1","author":"LH Rubin","year":"2016","unstructured":"Rubin, L. H. et al. Sex and diagnosis specific associations between DNA methylation of the oxytocin receptor gene with emotion processing and temporal-limbic and prefrontal brain volumes in psychotic disorders. Biol Psychiatry Cogn Neurosci Neuroimaging. \n                           1, 141\u2013151, doi:10.1016\/j.bpsc.2015.10.003 (2016).","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging."},{"key":"7950_CR118","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jpsychires.2013.12.011","volume":"51","author":"HC Tseng","year":"2014","unstructured":"Tseng, H. C. et al. Sex-specific associations between plasma oxytocin levels and schizotypal personality features in healthy individuals. J Psychiatr Res. \n                           51, 37\u201341, doi:10.1016\/j.jpsychires.2013.12.011 (2014).","journal-title":"J Psychiatr Res."},{"key":"7950_CR119","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/scan\/nsr100","volume":"8","author":"M Fischer-Shofty","year":"2013","unstructured":"Fischer-Shofty, M., Levkovitz, Y. & Shamay-Tsoory, S. G. Oxytocin facilitates accurate perception of competition in men and kinship in women. Soc Cogn Affect Neurosci. \n                           8, 313\u2013317, doi:10.1093\/scan\/nsr100 (2013).","journal-title":"Soc Cogn Affect Neurosci."},{"key":"7950_CR120","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1093\/scan\/nss083","volume":"8","author":"B Ditzen","year":"2013","unstructured":"Ditzen, B. et al. Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict. Soc Cogn Affect Neurosci. \n                           8, 897\u2013902, doi:10.1093\/scan\/nss083 (2013).","journal-title":"Soc Cogn Affect Neurosci."},{"key":"7950_CR121","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00213-011-2527-6","volume":"220","author":"C Cardoso","year":"2012","unstructured":"Cardoso, C., Ellenbogen, M. A. & Linnen, A. M. Acute intranasal oxytocin improves positive self-perceptions of personality. Psychopharmacology. \n                           220, 741\u2013749, doi:10.1007\/s00213-011-2527-6 (2012).","journal-title":"Psychopharmacology."},{"key":"7950_CR122","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1192\/bjp.177.6.486","volume":"177","author":"M Piccinelli","year":"2000","unstructured":"Piccinelli, M. & Wilkinson, G. Gender differences in depression. Critical review. The British journal of psychiatry: the journal of mental science. \n                           177, 486\u2013492 (2000).","journal-title":"The British journal of psychiatry: the journal of mental science."},{"key":"7950_CR123","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/em.20357","volume":"49","author":"M Szyf","year":"2008","unstructured":"Szyf, M., McGowan, P. & Meaney, M. J. The social environment and the epigenome. Environ Mol Mutagen. \n                           49, 46\u201360, doi:10.1002\/em.20357 (2008).","journal-title":"Environ Mol Mutagen."},{"key":"7950_CR124","doi-asserted-by":"crossref","unstructured":"Suderman, M. et al. Childhood abuse is associated with methylation of multiple loci in adult DNA. Bmc Med Genomics. 7, doi:Artn 1310.1186\/1755-8794-7-13 (2014).","DOI":"10.1186\/1755-8794-7-13"},{"key":"7950_CR125","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1093\/cvr\/cvr138","volume":"91","author":"JH van Weerd","year":"2011","unstructured":"van Weerd, J. H., Koshiba-Takeuchi, K., Kwon, C. & Takeuchi, J. K. Epigenetic factors and cardiac development. Cardiovasc Res. \n                           91, 203\u2013211, doi:10.1093\/cvr\/cvr138 (2011).","journal-title":"Cardiovasc Res."},{"key":"7950_CR126","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.yhbeh.2011.12.014","volume":"61","author":"RP Ebstein","year":"2012","unstructured":"Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H. & Lai, P. S. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm Behav. \n                           61, 359\u2013379, doi:10.1016\/j.yhbeh.2011.12.014 (2012).","journal-title":"Horm Behav."},{"key":"7950_CR127","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1101\/gr.171439.113","volume":"24","author":"AL Teh","year":"2014","unstructured":"Teh, A. L. et al. The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes. Genome Res. \n                           24, 1064\u20131074, doi:10.1101\/gr.171439.113 (2014).","journal-title":"Genome Res."},{"key":"7950_CR128","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3389\/fgene.2015.00230","volume":"6","author":"YC Chagnon","year":"2015","unstructured":"Chagnon, Y. C., Potvin, O., Hudon, C. & Preville, M. DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety\/depression in older women. Front Genet. \n                           6, 230, doi:10.3389\/fgene.2015.00230 (2015).","journal-title":"Front Genet."},{"key":"7950_CR129","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3389\/fgene.2015.00243","volume":"6","author":"AF Bell","year":"2015","unstructured":"Bell, A. F. et al. Interaction between oxytocin receptor DNA methylation and genotype is associated with risk of postpartum depression in women without depression in pregnancy. Front Genet. \n                           6, 243, doi:10.3389\/fgene.2015.00243 (2015).","journal-title":"Front Genet."},{"issue":"Suppl 2","key":"7950_CR130","doi-asserted-by":"publisher","first-page":"17253","DOI":"10.1073\/pnas.1121249109","volume":"109","author":"LL Lam","year":"2012","unstructured":"Lam, L. L. et al. Factors underlying variable DNA methylation in a human community cohort. Proceedings of the National Academy of Sciences of the United States of America. \n                           109(Suppl 2), 17253\u201317260, doi:10.1073\/pnas.1121249109 (2012).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America."},{"key":"7950_CR131","doi-asserted-by":"publisher","first-page":"8302","DOI":"10.1073\/pnas.1217750110","volume":"110","author":"D Mehta","year":"2013","unstructured":"Mehta, D. et al. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proceedings of the National Academy of Sciences of the United States of America. \n                           110, 8302\u20138307, doi:10.1073\/pnas.1217750110 (2013).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America."},{"key":"7950_CR132","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.4161\/15592294.2014.970060","volume":"9","author":"ML Levesque","year":"2014","unstructured":"Levesque, M. L. et al. Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth. Epigenetics. \n                           9, 1410\u20131421, doi:10.4161\/15592294.2014.970060 (2014).","journal-title":"Epigenetics."},{"key":"7950_CR133","doi-asserted-by":"publisher","first-page":"e39501","DOI":"10.1371\/journal.pone.0039501","volume":"7","author":"D Wang","year":"2012","unstructured":"Wang, D. et al. Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PloS one. \n                           7, e39501, doi:10.1371\/journal.pone.0039501 (2012).","journal-title":"PloS one."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-07950-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-07950-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-07950-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T03:02:43Z","timestamp":1671764563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-07950-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":133,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["7950"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-07950-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]},"assertion":[{"value":"2 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"7446"}}