{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:13:01Z","timestamp":1770527581218,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enhanced carotid body (CB) chemoreflex function is strongly related to cardiorespiratory disorders and disease progression in heart failure (HF). The mechanisms underlying CB sensitization during HF are not fully understood, however previous work indicates blood flow <jats:italic>per se<\/jats:italic> can affect CB function. Then, we hypothesized that the CB-mediated chemoreflex drive will be enhanced only in low output HF but not in high output HF. Myocardial infarcted rats and aorto-caval fistulated rats were used as a low output HF model (MI-CHF) and as a high output HF model (AV-CHF), respectively. Blood flow supply to the CB region was decreased only in MI-CHF rats compared to Sham and AV-CHF rats. MI-CHF rats exhibited a significantly enhanced hypoxic ventilatory response compared to AV-CHF rats. However, apnea\/hypopnea incidence was similarly increased in both MI-CHF and AV-CHF rats compared to control. Kruppel-like factor 2 expression, a flow sensitive transcription factor, was reduced in the CBs of MI-CHF rats but not in AV-CHF rats. Our results indicate that in the setting of HF, potentiation of the CB chemoreflex is strongly associated with a reduction in cardiac output and may not be related to other pathophysiological consequences of HF.<\/jats:p>","DOI":"10.1038\/s41598-017-08142-3","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T14:40:33Z","timestamp":1502203233000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2562-806X","authenticated-orcid":false,"given":"Rodrigo","family":"Del Rio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo S.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Lucero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Arce-Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah J.","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold D.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"8142_CR1","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1053\/euhj.2001.2783","volume":"22","author":"WJ Remme","year":"2001","unstructured":"Remme, W. J., Swedberg, K., Task Force for the, D. & Treatment of Chronic Heart Failure, E. So. C. Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J \n                           22, 1527\u20131560, doi:10.1053\/euhj.2001.2783 (2001).","journal-title":"Eur Heart J"},{"key":"8142_CR2","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.jacc.2013.11.053","volume":"63","author":"AP Ambrosy","year":"2014","unstructured":"Ambrosy, A. P. et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol \n                           63, 1123\u20131133, doi:10.1016\/j.jacc.2013.11.053 (2014).","journal-title":"J Am Coll Cardiol"},{"key":"8142_CR3","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1093\/eurheartj\/ehi166","volume":"26","author":"K Swedberg","year":"2005","unstructured":"Swedberg, K. et al. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J \n                           26, 1115\u20131140, doi:10.1093\/eurheartj\/ehi204 (2005).","journal-title":"Eur Heart J"},{"key":"8142_CR4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1152\/japplphysiol.00832.2009","volume":"108","author":"M Esler","year":"2010","unstructured":"Esler, M. The 2009 Carl Ludwig Lecture: Pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management. Journal of applied physiology \n                           108, 227\u2013237, doi:10.1152\/japplphysiol.00832.2009 (2010).","journal-title":"Journal of applied physiology"},{"key":"8142_CR5","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1161\/hc3101.093699","volume":"104","author":"P Ponikowski","year":"2001","unstructured":"Ponikowski, P. et al. Peripheral chemoreceptor hypersensitivity: an ominous sign in patients with chronic heart failure. Circulation \n                           104, 544\u2013549 (2001).","journal-title":"Circulation"},{"key":"8142_CR6","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1007\/s11906-013-0368-x","volume":"15","author":"HD Schultz","year":"2013","unstructured":"Schultz, H. D., Marcus, N. J. & Del Rio, R. Role of the carotid body in the pathophysiology of heart failure. Current hypertension reports \n                           15, 356\u2013362, doi:10.1007\/s11906-013-0368-x (2013).","journal-title":"Current hypertension reports"},{"key":"8142_CR7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.resp.2006.12.006","volume":"157","author":"R Iturriaga","year":"2007","unstructured":"Iturriaga, R., Varas, R. & Alcayaga, J. Electrical and pharmacological properties of petrosal ganglion neurons that innervate the carotid body. Respiratory physiology & neurobiology \n                           157, 130\u2013139, doi:10.1016\/j.resp.2006.12.006 (2007).","journal-title":"Respiratory physiology & neurobiology"},{"key":"8142_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.brainresrev.2004.05.007","volume":"47","author":"R Iturriaga","year":"2004","unstructured":"Iturriaga, R. & Alcayaga, J. Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals. Brain Research Reviews \n                           47, 46\u201353, doi:10.1016\/j.brainresrev.2004.05.007 (2004).","journal-title":"Brain Research Reviews"},{"key":"8142_CR9","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","volume":"74","author":"C Gonzalez","year":"1994","unstructured":"Gonzalez, C., Almaraz, L., Obeso, A. & Rigual, R. Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol Rev \n                           74, 829\u2013898 (1994).","journal-title":"Physiol Rev"},{"key":"8142_CR10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nn812","volume":"5","author":"R Pardal","year":"2002","unstructured":"Pardal, R. & Lopez-Barneo, J. Low glucose-sensing cells in the carotid body. Nature neuroscience \n                           5, 197\u2013198, doi:10.1038\/nn812 (2002).","journal-title":"Nature neuroscience"},{"key":"8142_CR11","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1113\/jphysiol.2010.200584","volume":"589","author":"Y Ding","year":"2011","unstructured":"Ding, Y., Li, Y. L. & Schultz, H. D. Role of blood flow in carotid body chemoreflex function in heart failure. J Physiol \n                           589, 245\u2013258, doi:10.1113\/jphysiol.2010.200584 (2011).","journal-title":"J Physiol"},{"key":"8142_CR12","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1113\/jphysiol.2013.266221","volume":"592","author":"NJ Marcus","year":"2014","unstructured":"Marcus, N. J., Rio, R., Schultz, E. P., Xia, X.-H. & Schultz, H. D. Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure. The Journal of Physiology \n                           592, 391\u2013408, doi:10.1113\/jphysiol.2013.266221 (2014).","journal-title":"The Journal of Physiology"},{"key":"8142_CR13","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1016\/j.jacc.2013.07.079","volume":"62","author":"R Del Rio","year":"2013","unstructured":"Del Rio, R., Marcus, N. J. & Schultz, H. D. Carotid chemoreceptor ablation improves survival in heart failure: rescuing autonomic control of cardiorespiratory function. J Am Coll Cardiol \n                           62, 2422\u20132430, doi:10.1016\/j.jacc.2013.07.079 (2013).","journal-title":"J Am Coll Cardiol"},{"key":"8142_CR14","doi-asserted-by":"publisher","first-page":"R303","DOI":"10.1152\/ajpregu.00629.2009","volume":"298","author":"Y Ding","year":"2010","unstructured":"Ding, Y., Li, Y. L., Zimmerman, M. C. & Schultz, H. D. Elevated mitochondrial superoxide contributes to enhanced chemoreflex in heart failure rabbits. American journal of physiology. Regulatory, integrative and comparative physiology \n                           298, R303\u2013311, doi:10.1152\/ajpregu.00629.2009 (2010).","journal-title":"American journal of physiology. Regulatory, integrative and comparative physiology"},{"key":"8142_CR15","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1093\/cvr\/cvn350","volume":"81","author":"Y Ding","year":"2009","unstructured":"Ding, Y., Li, Y. L., Zimmerman, M. C., Davisson, R. L. & Schultz, H. D. Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits. Cardiovasc Res \n                           81, 678\u2013685, doi:10.1093\/cvr\/cvn350 (2009).","journal-title":"Cardiovasc Res"},{"key":"8142_CR16","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.cardiores.2007.04.006","volume":"75","author":"YL Li","year":"2007","unstructured":"Li, Y. L., Gao, L., Zucker, I. H. & Schultz, H. D. NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits. Cardiovasc Res \n                           75, 546\u2013554, doi:10.1016\/j.cardiores.2007.04.006 (2007).","journal-title":"Cardiovasc Res"},{"key":"8142_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.cardiores.2006.03.017","volume":"71","author":"YL Li","year":"2006","unstructured":"Li, Y. L. et al. Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits. Cardiovasc Res \n                           71, 129\u2013138, doi:10.1016\/j.cardiores.2006.03.017 (2006).","journal-title":"Cardiovasc Res"},{"key":"8142_CR18","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S0002-9440(10)63002-7","volume":"167","author":"RJ Dekker","year":"2005","unstructured":"Dekker, R. J. et al. Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. The American journal of pathology \n                           167, 609\u2013618, doi:10.1016\/S0002-9440(10)63002-7 (2005).","journal-title":"The American journal of pathology"},{"key":"8142_CR19","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/978-94-007-4584-1_52","volume":"758","author":"HD Schultz","year":"2012","unstructured":"Schultz, H. D. & Marcus, N. J. Heart failure and carotid body chemoreception. Advances in experimental medicine and biology \n                           758, 387\u2013395, doi:10.1007\/978-94-007-4584-1_52 (2012).","journal-title":"Advances in experimental medicine and biology"},{"key":"8142_CR20","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1161\/HYPERTENSIONAHA.113.02535","volume":"63","author":"KK Haack","year":"2014","unstructured":"Haack, K. K., Marcus, N. J., Del Rio, R., Zucker, I. H. & Schultz, H. D. Simvastatin treatment attenuates increased respiratory variability and apnea\/hypopnea index in rats with chronic heart failure. Hypertension \n                           63, 1041\u20131049, doi:10.1161\/HYPERTENSIONAHA.113.02535 (2014).","journal-title":"Hypertension"},{"key":"8142_CR21","doi-asserted-by":"crossref","unstructured":"Marcus, N., Ding, Y., Del Rio, R. & Schultz, H. Reduced Carotid Body KLF2 Expression Contributes to Autonomic and Respiratory Dysfunction in Chronic Heart Failure. The FASEB Journal \n                           29 (2015).","DOI":"10.1096\/fasebj.29.1_supplement.829.3"},{"key":"8142_CR22","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1113\/expphysiol.2014.079566","volume":"100","author":"R Del Rio","year":"2015","unstructured":"Del Rio, R., Andrade, D. C., Marcus, N. J. & Schultz, H. D. Selective carotid body ablation in experimental heart failure: a new therapeutic tool to improve cardiorespiratory control. Exp Physiol \n                           100, 136\u2013142, doi:10.1113\/expphysiol.2014.079566 (2015).","journal-title":"Exp Physiol"},{"key":"8142_CR23","doi-asserted-by":"publisher","unstructured":"Toledo, C. et al. Contribution of peripheral and central chemoreceptors to sympatho-excitation in heart failure. The Journal of Physiology, n\/a-n\/a, 10.1113\/JP272075 (2016).","DOI":"10.1113\/JP272075"},{"key":"8142_CR24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jjcc.2011.12.006","volume":"59","author":"T Kishi","year":"2012","unstructured":"Kishi, T. Heart failure as an autonomic nervous system dysfunction. J Cardiol \n                           59, 117\u2013122, doi:10.1016\/j.jjcc.2011.12.006 (2012).","journal-title":"J Cardiol"},{"key":"8142_CR25","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1161\/CIRCRESAHA.114.302589","volume":"114","author":"VG Florea","year":"2014","unstructured":"Florea, V. G. & Cohn, J. N. The Autonomic Nervous System and Heart Failure. Circulation Research \n                           114, 1815\u20131826, doi:10.1161\/circresaha.114.302589 (2014).","journal-title":"Circulation Research"},{"key":"8142_CR26","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.autneu.2012.10.017","volume":"175","author":"CN May","year":"2013","unstructured":"May, C. N., Yao, S. T., Booth, L. C. & Ramchandra, R. Cardiac sympathoexcitation in heart failure. Autonomic Neuroscience \n                           175, 76\u201384, doi:10.1016\/j.autneu.2012.10.017 (2013).","journal-title":"Autonomic Neuroscience"},{"key":"8142_CR27","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1016\/j.jacc.2009.05.015","volume":"54","author":"F Triposkiadis","year":"2009","unstructured":"Triposkiadis, F. et al. The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. J Am Coll Cardiol \n                           54, 1747\u20131762, doi:10.1016\/j.jacc.2009.05.015 (2009).","journal-title":"J Am Coll Cardiol"},{"key":"8142_CR28","doi-asserted-by":"crossref","unstructured":"van Empel, V. & Brunner-La Rocca, H.-P. In Inflammation in Heart Failure (ed Raffaele Altara) 3\u201318 (Academic Press, 2015).","DOI":"10.1016\/B978-0-12-800039-7.00001-3"},{"key":"8142_CR29","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1161\/CIRCHEARTFAILURE.112.969071","volume":"5","author":"MM Redfield","year":"2012","unstructured":"Redfield, M. M. et al. Phosphodiesterase-5 Inhibition in Diastolic Heart Failure: The RELAX Trial Rationale and Design. Circulation. Heart failure \n                           5, 653\u2013659, doi:10.1161\/CIRCHEARTFAILURE.112.969071 (2012).","journal-title":"Circulation. Heart failure"},{"key":"8142_CR30","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1161\/CIRCULATIONAHA.106.632745","volume":"114","author":"BA Borlaug","year":"2006","unstructured":"Borlaug, B. A. et al. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation \n                           114, 2138\u20132147, doi:10.1161\/circulationaha.106.632745 (2006).","journal-title":"Circulation"},{"key":"8142_CR31","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1152\/jn.01055.2003","volume":"93","author":"MJ Cato","year":"2005","unstructured":"Cato, M. J. & Toney, G. M. Angiotensin II Excites Paraventricular Nucleus Neurons That Innervate the Rostral Ventrolateral Medulla: An In Vitro Patch-Clamp Study in Brain Slices. Journal of neurophysiology \n                           93, 403\u2013413, doi:10.1152\/jn.01055.2003 (2005).","journal-title":"Journal of neurophysiology"},{"key":"8142_CR32","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/hr.2011.208","volume":"35","author":"H Kumagai","year":"2012","unstructured":"Kumagai, H. et al. Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure. Hypertens Res \n                           35, 132\u2013141 (2012).","journal-title":"Hypertens Res"},{"key":"8142_CR33","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1523\/JNEUROSCI.23-12-05041.2003","volume":"23","author":"D-P Li","year":"2003","unstructured":"Li, D.-P., Chen, S.-R. & Pan, H.-L. Angiotensin II Stimulates Spinally Projecting Paraventricular Neurons through Presynaptic Disinhibition. The Journal of Neuroscience \n                           23, 5041\u20135049 (2003).","journal-title":"The Journal of Neuroscience"},{"key":"8142_CR34","doi-asserted-by":"publisher","first-page":"7823","DOI":"10.3892\/mmr.2015.4434","volume":"12","author":"B Xu","year":"2015","unstructured":"Xu, B. & Li, H. Brain mechanisms of sympathetic activation in heart failure: Roles of the reninangiotensin system, nitric oxide and proinflammatory cytokines (Review). Mol Med Rep \n                           12, 7823\u20137829, doi:10.3892\/mmr.2015.4434 (2015).","journal-title":"Mol Med Rep"},{"key":"8142_CR35","doi-asserted-by":"publisher","first-page":"H843","DOI":"10.1152\/ajpheart.00170.2013","volume":"305","author":"NM Sharma","year":"2013","unstructured":"Sharma, N. M., Llewellyn, T. L., Zheng, H. & Patel, K. P. Angiotensin II-mediated posttranslational modification of nNOS in the PVN of rats with CHF: role for PIN. American journal of physiology. Heart and circulatory physiology \n                           305, H843\u2013855, doi:10.1152\/ajpheart.00170.2013 (2013).","journal-title":"American journal of physiology. Heart and circulatory physiology"},{"key":"8142_CR36","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1590\/S0100-879X2011007500088","volume":"44","author":"VA Braga","year":"2011","unstructured":"Braga, V. A. et al. Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension. Brazilian Journal of Medical and Biological Research \n                           44, 871\u2013876 (2011).","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"8142_CR37","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/S1357-2725(02)00306-0","volume":"35","author":"MJ McKinley","year":"2003","unstructured":"McKinley, M. J. et al. The brain renin\u2013angiotensin system: location and physiological roles. The International Journal of Biochemistry & Cell Biology \n                           35, 901\u2013918, doi:10.1016\/S1357-2725(02)00306-0 (2003).","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"8142_CR38","doi-asserted-by":"crossref","first-page":"R1665","DOI":"10.1152\/ajpregu.2001.280.6.R1665","volume":"280","author":"H Shigematsu","year":"2001","unstructured":"Shigematsu, H. et al. Endogenous angiotensin II in the NTS contributes to sympathetic activation in rats with aortocaval shunt. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology \n                           280, R1665\u2013R1673 (2001).","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"key":"8142_CR39","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/j.1469-7793.1998.773bj.x","volume":"510","author":"AM Allen","year":"1998","unstructured":"Allen, A. M. Angiotensin AT(1) receptor-mediated excitation of rat carotid body chemoreceptor afferent activity. The Journal of Physiology \n                           510, 773\u2013781, doi:10.1111\/j.1469-7793.1998.773bj.x (1998).","journal-title":"The Journal of Physiology"},{"key":"8142_CR40","doi-asserted-by":"publisher","first-page":"729497","DOI":"10.1155\/2011\/729497","volume":"2011","author":"Z Abassi","year":"2011","unstructured":"Abassi, Z., Goltsman, I., Karram, T., Winaver, J. & Hoffman, A. Aortocaval fistula in rat: a unique model of volume-overload congestive heart failure and cardiac hypertrophy. Journal of biomedicine & biotechnology \n                           2011, 729497, doi:10.1155\/2011\/729497 (2011).","journal-title":"Journal of biomedicine & biotechnology"},{"key":"8142_CR41","doi-asserted-by":"publisher","first-page":"R1473","DOI":"10.1152\/ajpregu.91008.2008","volume":"296","author":"PN Ainslie","year":"2009","unstructured":"Ainslie, P. N. & Duffin, J. Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol \n                           296, R1473\u2013R1495, doi:10.1152\/ajpregu.91008.2008 (2009).","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"8142_CR42","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1152\/japplphysiol.01240.2009","volume":"108","author":"DK Mulkey","year":"2010","unstructured":"Mulkey, D. K., Wenker, I. C. & Kr\u00e9neisz, O. Current ideas on central chemoreception by neurons and glial cells in the retrotrapezoid nucleus. J Appl Physiol \n                           108, 1433\u20131439, doi:10.1152\/japplphysiol.01240.2009 (2010).","journal-title":"J Appl Physiol"},{"key":"8142_CR43","doi-asserted-by":"publisher","unstructured":"Hawkins, V. E. et al. Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe. Elife doi:10.7554\/eLife.25232 (2017).","DOI":"10.7554\/eLife.25232"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08142-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08142-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08142-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T08:33:03Z","timestamp":1671784383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08142-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,14]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["8142"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-08142-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,14]]},"assertion":[{"value":"16 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"8035"}}