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However, results in different studies have been contradictory. Therefore, we conducted a meta-analysis containing 6455 AD cases and 6304 controls from 26 independent case\u2013control studies to determine whether there was an association between the LRP1 C766T polymorphism and AD susceptibility. The combined analysis showed that there was no significant association between LRP1 C766T polymorphism and AD susceptibility (TT\u2009+\u2009CT versus CC: OR\u2009=\u20090.920, 95% CI\u2009=\u20090.817\u20131.037,<jats:italic>P<\/jats:italic>\u2009=\u20090.172). In subgroup analysis, significant decreased AD susceptibility was found among Asian population in allele model (T versus C: OR\u2009=\u20090.786, 95% CI\u2009=\u20090.635\u20130.974,<jats:italic>P<\/jats:italic>\u2009=\u20090.028) and dominant model (TT\u2009+\u2009CT versus CC: OR\u2009=\u20090.800, 95% CI\u2009=\u20090.647\u20130.990,<jats:italic>P<\/jats:italic>\u2009=\u20090.040). Moreover, T allele of LRP1 C766T was statistically associated with late onset of AD (LOAD) (T versus C: OR\u2009=\u20090.858, 95% CI\u2009=\u20090.748\u20130.985,<jats:italic>P<\/jats:italic>\u2009=\u20090.029; TT\u2009+\u2009CT versus CC: OR\u2009=\u20090.871, 95% CI\u2009=\u20090.763\u20130.994,<jats:italic>P<\/jats:italic>\u2009=\u20090.040). In conclusion, our meta-analysis suggested that LRP1 C766T polymorphism was associated with lower risk of AD in Asian, and could reduce LOAD risk especially. Considering some limitations of our meta-analysis, further large-scale studies should be done to reach a more comprehensive understanding.<\/jats:p>","DOI":"10.1038\/s41598-017-08335-w","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T13:54:41Z","timestamp":1502373281000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between LRP1 C766T polymorphism and Alzheimer\u2019s disease susceptibility: a meta-analysis"],"prefix":"10.1038","volume":"7","author":[{"given":"Yun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqiong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibiao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Kuai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitong","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"8335_CR1","doi-asserted-by":"crossref","unstructured":"2016 Alzheimer\u2019s disease facts and figures. 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