{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:52:22Z","timestamp":1784605942871,"version":"3.55.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nitric oxide (NO) has been known to promote physiological angiogenesis to treat peripheral arterial diseases (PAD) by increasing the vascular endothelial growth factor (VEGF) level in endothelial cells (ECs) and preventing platelet adherence and leukocyte chemotaxis. However, the ongoing ischemic event during peripheral ischemia produces superoxide and diminishes the NO bioavailability by forming toxic peroxynitrite anion. Here we disclose an efficacious hybrid molecule 4-(5-Amino-1,2,3-oxadiazol-3-yl)-2,2,6,6-tetramethyl-1-piperidinol (SA-2) containing both antioxidant and NO donor functionalities that provide a therapeutic level of NO necessary to promote angiogenesis and to protect ECs against hydrogen peroxide-induced oxidative stress. Compound SA-2 scavenged reactive oxygen species, inhibited proliferation and migration of smooth muscle cells (SMCs) and promoted the tube formation from ECs. Copolymer poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with SA-2 provided a sustained release of NO over days, improved aqueous stability in serum, protected ECs against oxidative stress, and enhanced angiogenesis under stress conditions as compared to that of the control in the <jats:italic>in vitro<\/jats:italic> matrigel tube formation assay. These results indicated the potential use of SA-2 nanoparticles as an alternative therapy to treat PAD.<\/jats:p>","DOI":"10.1038\/s41598-017-08441-9","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T10:00:53Z","timestamp":1502704853000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Hybrid Nitric Oxide Donor and its Carrier for the Treatment of Peripheral Arterial Diseases"],"prefix":"10.1038","volume":"7","author":[{"given":"Duong Q.","family":"Le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneetta E.","family":"Kuriakose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dat X.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kytai T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchismita","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"8441_CR1","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1161\/01.cir.0000441139.02102.80","volume":"129","author":"AS Go","year":"2014","unstructured":"Go, A. S. et al. Heart disease and stroke statistics\u20132014 update: a report from the American Heart Association. Circulation \n                           129, e28\u2013e292 (2014).","journal-title":"Circulation"},{"key":"8441_CR2","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1177\/1358863X9700200315","volume":"2","author":"TA Whitehill","year":"1997","unstructured":"Whitehill, T. A. Role of revascularization in the treatment of claudication. Vasc. Med. \n                           2, 252\u2013256 (1997).","journal-title":"Vasc. Med."},{"key":"8441_CR3","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.gene.2013.03.097","volume":"525","author":"A Grochot-Przeczek","year":"2013","unstructured":"Grochot-Przeczek, A., Dulak, J. & Jozkowicz, A. Therapeutic angiogenesis for revascularization in peripheral artery disease. Gene \n                           525, 220\u2013228 (2013).","journal-title":"Gene"},{"key":"8441_CR4","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1053\/euhj.2000.2372","volume":"22","author":"R Tabibiazar","year":"2001","unstructured":"Tabibiazar, R. & Rockson, S. G. Angiogenesis and the ischaemic heart. Eur. Heart J. \n                           22, 903\u2013918 (2001).","journal-title":"Eur. Heart J."},{"key":"8441_CR5","first-page":"264","volume":"18","author":"A Nessa","year":"2009","unstructured":"Nessa, A. et al. Angiogenesis-a novel therapeutic approach for ischemic heart disease. Mymensingh Med. J. \n                           18, 264\u2013272 (2009).","journal-title":"Mymensingh Med. J."},{"key":"8441_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ejvs.2004.03.021","volume":"28","author":"DJ Collinson","year":"2004","unstructured":"Collinson, D. J. & Donnelly, R. Therapeutic angiogenesis in peripheral arterial disease: can biotechnology produce an effective collateral circulation? Eur. J. Vasc. Endovasc. Surg. \n                           28, 9\u201323 (2004).","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"8441_CR7","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.niox.2012.03.003","volume":"26","author":"JD Allen","year":"2012","unstructured":"Allen, J. D., Giordano, T. & Kevil, C. G. Nitrite and Nitric Oxide Metabolism in Peripheral Artery Disease. Nitric Oxide \n                           26, 217\u2013222 (2012).","journal-title":"Nitric Oxide"},{"key":"8441_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1161\/hh0102.102330","volume":"90","author":"LJ Ignarro","year":"2002","unstructured":"Ignarro, L. J., Napoli, C. & Loscalzo, J. Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview. Circ. Res. \n                           90, 21\u201328 (2002).","journal-title":"Circ. Res."},{"key":"8441_CR9","doi-asserted-by":"publisher","first-page":"656247","DOI":"10.1155\/2012\/656247","volume":"2012","author":"G Williams","year":"2012","unstructured":"Williams, G. et al. Nitric oxide manipulation: a therapeutic target for peripheral arterial disease? Cardiol. Res. Pract. \n                           2012, 656247 (2012).","journal-title":"Cardiol. Res. Pract."},{"key":"8441_CR10","doi-asserted-by":"crossref","unstructured":"Forstermann, U. & Sessa, W.C. Nitric oxide synthases: regulation and function. Eur. Heart J. 33, 829\u2013837, 837a\u2013837d (2012).","DOI":"10.1093\/eurheartj\/ehr304"},{"key":"8441_CR11","first-page":"1873","volume-title":"Front. Biosci. (Landmark Ed.)","author":"E Gkaliagkousi","year":"2011","unstructured":"Gkaliagkousi, E. & Ferro, A. Nitric oxide signalling in the regulation of cardiovascular and platelet function. Front. Biosci. (Landmark Ed.) \n                           16, 1873\u20131897 (2011)."},{"key":"8441_CR12","doi-asserted-by":"publisher","first-page":"9161","DOI":"10.1073\/pnas.1202916109","volume":"109","author":"C Coletta","year":"2012","unstructured":"Coletta, C. et al. Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation. Proc. Natl. Acad. Sci. USA \n                           109, 9161\u20139166 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"8441_CR13","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1172\/JCI22493","volume":"115","author":"MR Duranski","year":"2005","unstructured":"Duranski, M. R. et al. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J. Clin. Invest. \n                           115, 1232\u20131240 (2005).","journal-title":"J. Clin. Invest."},{"key":"8441_CR14","doi-asserted-by":"publisher","first-page":"13683","DOI":"10.1073\/pnas.0402927101","volume":"101","author":"A Webb","year":"2004","unstructured":"Webb, A. et al. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc. Natl. Acad. Sci. USA \n                           101, 13683\u201313688 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"8441_CR15","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.niox.2009.01.002","volume":"20","author":"JD Allen","year":"2009","unstructured":"Allen, J. D. et al. Plasma nitrite response and arterial reactivity differentiate vascular health and performance. Nitric Oxide \n                           20, 231\u2013237 (2009).","journal-title":"Nitric Oxide"},{"key":"8441_CR16","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.3349\/ymj.2016.57.6.1329","volume":"57","author":"MC Nguyen","year":"2016","unstructured":"Nguyen, M. C. et al. Arginase Inhibition Restores Peroxynitrite-Induced Endothelial Dysfunction via L-Arginine-Dependent Endothelial Nitric Oxide Synthase Phosphorylation. Yonsei Med. J. \n                           57, 1329\u20131338 (2016).","journal-title":"Yonsei Med. J."},{"key":"8441_CR17","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/jcbfm.2011.185","volume":"32","author":"JN Mayo","year":"2012","unstructured":"Mayo, J. N. et al. Nitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemia. J. Cereb. Blood Flow Metab. \n                           32, 825\u2013834 (2012).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"8441_CR18","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3350\/kjhep.2011.17.4.251","volume":"17","author":"YH Paik","year":"2011","unstructured":"Paik, Y. H. & Brenner, D. A. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Korean J. Hepatol. \n                           17, 251\u2013257 (2011).","journal-title":"Korean J. Hepatol."},{"key":"8441_CR19","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.3390\/nu5082969","volume":"5","author":"Y Wang","year":"2013","unstructured":"Wang, Y., Chun, O. K. & Song, W. O. Plasma and dietary antioxidant status as cardiovascular disease risk factors: a review of human studies. Nutrients \n                           5, 2969\u20133004 (2013).","journal-title":"Nutrients"},{"key":"8441_CR20","first-page":"13","volume":"2014","author":"M Pacurari","year":"2014","unstructured":"Pacurari, M., Kafoury, R., Tchounwou, P. B. & Ndebele, K. The Renin-Angiotensin-Aldosterone System in Vascular Inflammation and Remodeling. Int. J. Inflam. \n                           2014, 13 (2014).","journal-title":"Int. J. Inflam."},{"key":"8441_CR21","doi-asserted-by":"publisher","first-page":"11324","DOI":"10.3390\/ijms150711324","volume":"15","author":"CM Steyers 3rd","year":"2014","unstructured":"Steyers, C. M. 3rd & Miller, F. J. Jr. Endothelial dysfunction in chronic inflammatory diseases. Int. J. Mol. Sci. \n                           15, 11324\u201311349 (2014).","journal-title":"Int. J. Mol. Sci."},{"key":"8441_CR22","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jacc.2008.04.019","volume":"52","author":"T Gori","year":"2008","unstructured":"Gori, T. & Parker, J. D. Nitrate-induced toxicity and preconditioning: a rationale for reconsidering the use of these drugs. J. Am. Coll. Cardiol. \n                           52, 251\u2013254 (2008).","journal-title":"J. Am. Coll. Cardiol."},{"key":"8441_CR23","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jacc.2010.07.037","volume":"57","author":"A Liuni","year":"2011","unstructured":"Liuni, A. et al. Coadministration of atorvastatin prevents nitroglycerin-induced endothelial dysfunction and nitrate tolerance in healthy humans. J. Am. Coll. Cardiol. \n                           57, 93\u201398 (2011).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"Suppl 11","key":"8441_CR24","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1097\/00005344-198906152-00004","volume":"14","author":"M Feelisch","year":"1989","unstructured":"Feelisch, M., Ostrowski, J. & Noack, E. On the mechanism of NO release from sydnonimines. J. Cardiovasc. Pharmacol. \n                           14(Suppl 11), S13\u201322 (1989).","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"8441_CR25","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.bmcl.2015.12.030","volume":"26","author":"S Acharya","year":"2016","unstructured":"Acharya, S. et al. Design and synthesis of novel hybrid sydnonimine and prodrug useful for glaucomatous optic neuropathy. Bioorg. Med. Chem. Lett. \n                           26, 1490\u20131494 (2016).","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"8441_CR26","doi-asserted-by":"publisher","first-page":"8306","DOI":"10.1073\/pnas.122225199","volume":"99","author":"Z Chen","year":"2002","unstructured":"Chen, Z., Zhang, J. & Stamler, J. S. Identification of the enzymatic mechanism of nitroglycerin bioactivation. Proc. Natl. Acad. Sci. USA. \n                           99, 8306\u20138311 (2002).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"8441_CR27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jdiacomp.2012.02.005","volume":"26","author":"M Khazaei","year":"2012","unstructured":"Khazaei, M., Salehi, E., Rashidi, B., Javanmard, S. H. & Fallahzadeh, A. R. Role of peroxisome proliferator-activated receptor beta agonist on angiogenesis in hindlimb ischemic diabetic rats. J. Diabetes Complications \n                           26, 137\u2013140 (2012).","journal-title":"J. Diabetes Complications"},{"key":"8441_CR28","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0967-2109(98)00026-X","volume":"6","author":"D Johnson","year":"1998","unstructured":"Johnson, D. Endothelial damage due to ischemia and reperfusion is prevented with SIN-1. Cardiovasc. Surg. \n                           6, 367\u2013372 (1998).","journal-title":"Cardiovasc. Surg."},{"key":"8441_CR29","doi-asserted-by":"publisher","first-page":"11317","DOI":"10.1074\/jbc.271.19.11317","volume":"271","author":"WS Shin","year":"1996","unstructured":"Shin, W. S. et al. Nitric Oxide Attenuates Vascular Smooth Muscle Cell Activation by Interferon-\u03b3: The Role of Constitutive NF-\u03baB Activity. J. Biol. Chem. \n                           271, 11317\u201311324 (1996).","journal-title":"J. Biol. Chem."},{"key":"8441_CR30","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.msec.2015.09.003","volume":"58","author":"AC Goodfriend","year":"2016","unstructured":"Goodfriend, A. C. et al. Thermally processed polymeric microparticles for year-long delivery of dexamethasone. Mater. Sci. Eng. C Mater. Biol. Appl. \n                           58, 595\u2013600 (2016).","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"8441_CR31","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1166\/jnn.2012.5131","volume":"12","author":"S Kona","year":"2012","unstructured":"Kona, S. et al. Targeted biodegradable nanoparticles for drug delivery to smooth muscle cells. J Nanosci Nanotechnol \n                           12, 236\u2013244 (2012).","journal-title":"J Nanosci Nanotechnol"},{"key":"8441_CR32","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1002\/jbm.a.34040","volume":"100","author":"JU Menon","year":"2012","unstructured":"Menon, J. U. et al. Effects of surfactants on the properties of PLGA nanoparticles. J. Biomed. Mater. Res. A \n                           100, 1998\u20132005 (2012).","journal-title":"J. Biomed. Mater. Res. A"},{"key":"8441_CR33","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1166\/jnn.2011.3802","volume":"11","author":"B Shah","year":"2011","unstructured":"Shah, B., Kona, S., Gilbertson, T. A. & Nguyen, K. T. Effects of poly-(lactide-co-glycolide) nanoparticles on electrophysiological properties of enteroendocrine cells. J Nanosci Nanotechnol \n                           11, 3533\u20133542 (2011).","journal-title":"J Nanosci Nanotechnol"},{"key":"8441_CR34","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.niox.2013.09.004","volume":"35","author":"J Lei","year":"2013","unstructured":"Lei, J., Vodovotz, Y., Tzeng, E. & Billiar, T. R. Nitric oxide, a protective molecule in the cardiovascular system. Nitric Oxide \n                           35, 175\u2013185 (2013).","journal-title":"Nitric Oxide"},{"key":"8441_CR35","doi-asserted-by":"publisher","first-page":"e109017","DOI":"10.1371\/journal.pone.0109017","volume":"9","author":"T Maruhashi","year":"2014","unstructured":"Maruhashi, T. et al. Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells. PLoS One \n                           9, e109017 (2014).","journal-title":"PLoS One"},{"key":"8441_CR36","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3109\/10715762.2014.983096","volume":"49","author":"B Fiuza","year":"2015","unstructured":"Fiuza, B. et al. Impact of SIN-1-derived peroxynitrite flux on endothelial cell redox homeostasis and bioenergetics: protective role of diphenyl diselenide via induction of peroxiredoxins. Free Radic. Res. \n                           49, 122\u2013132 (2015).","journal-title":"Free Radic. Res."},{"key":"8441_CR37","doi-asserted-by":"publisher","first-page":"696","DOI":"10.18433\/J3CC9K","volume":"18","author":"JC Oishi","year":"2015","unstructured":"Oishi, J. C. et al. In vitro Treatment with cis-[Ru(H-dcbpy-)2(Cl)(NO)] Improves the Endothelial Function in Aortic Rings with Endothelial Dysfunction. J. Pharm. Pharm. Sci. \n                           18, 696\u2013704 (2015).","journal-title":"J. Pharm. Pharm. Sci."},{"key":"8441_CR38","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/j.freeradbiomed.2015.11.002","volume":"89","author":"I Sadowska-Bartosz","year":"2015","unstructured":"Sadowska-Bartosz, I., Gajewska, A., Skolimowski, J., Szewczyk, R. & Bartosz, G. Nitroxides protect against peroxynitrite-induced nitration and oxidation. Free Radic. Biol. Med. \n                           89, 1165\u20131175 (2015).","journal-title":"Free Radic. Biol. Med."},{"key":"8441_CR39","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/xen.12195","volume":"22","author":"HS Park","year":"2015","unstructured":"Park, H. S. et al. Beneficial effect of a nitric oxide donor in an ex vivo model of pig-to-human pulmonary xenotransplantation. Xenotransplantation \n                           22, 391\u2013398 (2015).","journal-title":"Xenotransplantation"},{"key":"8441_CR40","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1111\/bph.12572","volume":"171","author":"A Das","year":"2014","unstructured":"Das, A. et al. Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation. Br. J. Pharmacol. \n                           171, 2321\u20132334 (2014).","journal-title":"Br. J. Pharmacol."},{"key":"8441_CR41","doi-asserted-by":"publisher","first-page":"e0158672","DOI":"10.1371\/journal.pone.0158672","volume":"11","author":"Y Dong","year":"2016","unstructured":"Dong, Y. et al. Nitrative Stress Participates in Endothelial Progenitor Cell Injury in Hyperhomocysteinemia. PLoS One \n                           11, e0158672 (2016).","journal-title":"PLoS One"},{"key":"8441_CR42","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.ijpharm.2016.08.014","volume":"511","author":"B Kwon","year":"2016","unstructured":"Kwon, B. et al. H2O2-responsive antioxidant polymeric nanoparticles as therapeutic agents for peripheral arterial disease. Int. J. Pharm. \n                           511, 1022\u20131032 (2016).","journal-title":"Int. J. Pharm."},{"key":"8441_CR43","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1248\/cpb.18.128","volume":"18","author":"K Masuda","year":"1970","unstructured":"Masuda, K., Imashiro, Y. & Kaneko, T. Mesoionic compounds. I. Synthesis of 3-dialkylaminosydnonimines. Chem. Pharm. Bull. \n                           18, 128\u2013132 (1970).","journal-title":"Chem. Pharm. Bull."},{"key":"8441_CR44","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/1098-2299(200007\/08)50:3\/4<528::AID-DDR36>3.0.CO;2-3","volume":"50","author":"A Haj-Yehia","year":"2000","unstructured":"Haj-Yehia, A. et al. Development of 3-nitratomethyl-PROXYL (NMP): A novel, bifunctional superoxide dismutase-mimic-nitric oxide-donor. Drug Dev. Res. \n                           50, 528\u2013536 (2000).","journal-title":"Drug Dev. Res."},{"key":"8441_CR45","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.nano.2009.07.008","volume":"6","author":"B Koppolu","year":"2010","unstructured":"Koppolu, B., Rahimi, M., Nattama, S., Wadajkar, A. & Nguyen, K. T. Development of multiple-layer polymeric particles for targeted and controlled drug delivery. Nanomedicine \n                           6, 355\u2013361 (2010).","journal-title":"Nanomedicine"},{"key":"8441_CR46","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1016\/j.actbio.2012.04.042","volume":"8","author":"AS Wadajkar","year":"2012","unstructured":"Wadajkar, A. S. et al. Multifunctional particles for melanoma-targeted drug delivery. Acta Biomater. \n                           8, 2996\u20133004 (2012).","journal-title":"Acta Biomater."},{"key":"8441_CR47","doi-asserted-by":"publisher","first-page":"046003","DOI":"10.1117\/1.JBO.17.4.046003","volume":"17","author":"RH Patel","year":"2012","unstructured":"Patel, R. H. et al. Multifunctionality of indocyanine green-loaded biodegradable nanoparticles for enhanced optical imaging and hyperthermia intervention of cancer. J. Biomed. Opt. \n                           17, 046003 (2012).","journal-title":"J. Biomed. Opt."},{"key":"8441_CR48","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1016\/j.actbio.2014.01.033","volume":"10","author":"JU Menon","year":"2014","unstructured":"Menon, J. U. et al. Polymeric nanoparticles for pulmonary protein and DNA delivery. Acta Biomater. \n                           10, 2643\u20132652 (2014).","journal-title":"Acta Biomater."},{"key":"8441_CR49","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1002\/jbm.a.35300","volume":"103","author":"JU Menon","year":"2015","unstructured":"Menon, J. U., Tumati, V., Hsieh, J. T., Nguyen, K. T. & Saha, D. Polymeric nanoparticles for targeted radiosensitization of prostate cancer cells. J. Biomed. Mater. Res. A \n                           103, 1632\u20131639 (2015).","journal-title":"J. Biomed. Mater. Res. A"},{"key":"8441_CR50","doi-asserted-by":"publisher","first-page":"H2894","DOI":"10.1152\/ajpheart.01230.2006","volume":"293","author":"L Ostergaard","year":"2007","unstructured":"Ostergaard, L. et al. Diminished NO release in chronic hypoxic human endothelial cells. American journal of physiology. Heart and circulatory physiology \n                           293, H2894\u20132903 (2007).","journal-title":"American journal of physiology. Heart and circulatory physiology"},{"key":"8441_CR51","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1111\/wrr.12051","volume":"21","author":"F Cianfarani","year":"2013","unstructured":"Cianfarani, F. et al. Diabetes impairs adipose tissue-derived stem cell function and efficiency in promoting wound healing. Wound Repair Regen. \n                           21, 545\u2013553 (2013).","journal-title":"Wound Repair Regen."},{"key":"8441_CR52","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jep.2012.02.025","volume":"141","author":"KM Lau","year":"2012","unstructured":"Lau, K. M. et al. Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing. J. Ethnopharmacol. \n                           141, 250\u2013256 (2012).","journal-title":"J. Ethnopharmacol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08441-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08441-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08441-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T08:56:54Z","timestamp":1671785814000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08441-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,18]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["8441"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-08441-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,18]]},"assertion":[{"value":"24 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"8692"}}