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Indices (0\u20131) of the roles of ageing (ARD), genetics (GRD) and exogenous (ERD) variables in deaths due to disease were established, and the sum of ARD, GRD and ERD was 1 (value of each indices was &lt;1). Results showed that ageing plays an important role in death from chronic disease; exogenous factors may contribute more to the pattern of chronic disease than genetic factors (ARD, GRC and ERD were 0.818, 0.058 and 0.124 respectively for all non-communicable diseases). In descending order, ERD for non-communicable diseases were breast cancer, leukaemia, cancer of the cervix uteri and uterus, liver cancer, nephritis and nephropathy, stomach cancer, lung cancer, diabetes, cerebrovascular disease, coronary heart disease, COPD, and Alzheimer\u2019s disease, while a smaller ERD indicated a tendency of natural death. An understanding of the aforementioned complex relationships of specific non-communicable diseases will be beneficial in designing primary prevention measures for non-communicable diseases in China.<\/jats:p>","DOI":"10.1038\/s41598-017-08539-0","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T09:09:40Z","timestamp":1502269780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model"],"prefix":"10.1038","volume":"7","author":[{"given":"Liu","family":"Hui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"8539_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2188\/jea.JE20160010","volume":"26","author":"H Nakatani","year":"2016","unstructured":"Nakatani, H. 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