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To study the effects of maternal androgen excess in obese dams on metabolism, placental function and fetal growth, female C57Bl6J mice were fed a control (CD) or a high fat\/high sucrose (HF\/HS) diet for 4\u201310 weeks, and then mated. On gestational day (GD) 15.5\u201317.5, dams were injected with dihydrotestosterone (CD-DHT, HF\/HS-DHT) or a vehicle (CD-Veh, HF\/HS-Veh). HF\/HS dams had higher fat content, both before mating and on GD18.5, with no difference in glucose homeostasis, whereas the insulin sensitivity was higher in DHT-exposed dams. Compared to the CD groups, the livers from HF\/HS dams weighed more on GD18.5, the triglyceride content was higher, and there was a dysregulation of liver enzymes related to lipogenesis and higher mRNA expression of<jats:italic>Fitm1<\/jats:italic>. Fetuses from HF\/HS-Veh dams had lower liver triglyceride content and mRNA expression of<jats:italic>Srebf1c<\/jats:italic>. Maternal DHT exposure, regardless of diet, decreased fetal liver<jats:italic>Pparg<\/jats:italic>mRNA expression and increased placental androgen receptor protein expression. Maternal diet-induced obesity, together with androgen excess, affects maternal and fetal liver function as demonstrated by increased triglyceride content and dysfunctional expression of enzymes and transcription factors involved in<jats:italic>de novo<\/jats:italic>lipogenesis and fat storage.<\/jats:p>","DOI":"10.1038\/s41598-017-08559-w","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T13:31:47Z","timestamp":1502199107000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams"],"prefix":"10.1038","volume":"7","author":[{"given":"Romina","family":"Fornes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Maliqueo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Hadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"Jimenez-Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Ebefors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Nystr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernand","family":"Labrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Jansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Benrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-1502","authenticated-orcid":false,"given":"Elisabet","family":"Stener-Victorin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"8559_CR1","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1002\/oby.21033","volume":"23","author":"G Navarro","year":"2015","unstructured":"Navarro, G., Allard, C., Xu, W. 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