{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:06:18Z","timestamp":1793480778606,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Stringent regulation of antiviral signaling and cellular autophagy is critical for the host response to virus infection. However, little is known how these cellular processes are regulated in the absence of type I interferon signaling. Here, we show that ATF3 is induced following Japanese encephalitis virus (JEV) infection, and regulates cellular antiviral and autophagy pathways in the absence of type I interferons in mouse neuronal cells. We have identified new targets of ATF3 and show that it binds to the promoter regions of\n                    <jats:italic>Stat1, Irf9<\/jats:italic>\n                    ,\n                    <jats:italic>Isg15<\/jats:italic>\n                    and\n                    <jats:italic>Atg5<\/jats:italic>\n                    thereby inhibiting cellular antiviral signaling and autophagy. Consistent with these observations, ATF3-depleted cells showed enhanced antiviral responses and induction of robust autophagy. Furthermore, we show that JEV replication was significantly reduced in ATF3-depleted cells. Our findings identify ATF3 as a negative regulator of antiviral signaling and cellular autophagy in mammalian cells, and demonstrate its important role in JEV life cycle.\n                  <\/jats:p>","DOI":"10.1038\/s41598-017-08584-9","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T09:54:26Z","timestamp":1502704466000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["ATF3 negatively regulates cellular antiviral signaling and autophagy in the absence of type I interferons"],"prefix":"10.1038","volume":"7","author":[{"given":"Vikas","family":"Sood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran Bala","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhurjhoti","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parashar","family":"Dhapola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utsav","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetaka","family":"Kitajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3376-3659","authenticated-orcid":false,"given":"Manjula","family":"Kalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhanshu","family":"Vrati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"8584_CR1","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.immuni.2013.05.007","volume":"38","author":"D Goubau","year":"2013","unstructured":"Goubau, D., Deddouche, S. & Reis e Sousa, C. Cytosolic sensing of viruses. Immunity \n                           38, 855\u2013869 (2013).","journal-title":"Immunity"},{"key":"8584_CR2","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nri2314","volume":"8","author":"AJ Sadler","year":"2008","unstructured":"Sadler, A. J. & Williams, B. R. Interferon-inducible antiviral effectors. Nat Rev Immunol \n                           8, 559\u2013568 (2008).","journal-title":"Nat Rev Immunol"},{"key":"8584_CR3","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nri1900","volume":"6","author":"K Honda","year":"2006","unstructured":"Honda, K. & Taniguchi, T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol \n                           6, 644\u2013658 (2006).","journal-title":"Nat Rev Immunol"},{"key":"8584_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.immuni.2012.03.013","volume":"36","author":"GR Stark","year":"2012","unstructured":"Stark, G. R. & Darnell, J. E. Jr. The JAK-STAT pathway at twenty. Immunity \n                           36, 503\u2013514 (2012).","journal-title":"Immunity"},{"key":"8584_CR5","doi-asserted-by":"publisher","first-page":"20059","DOI":"10.1074\/jbc.R700016200","volume":"282","author":"C Schindler","year":"2007","unstructured":"Schindler, C., Levy, D. E. & Decker, T. JAK-STAT signaling: from interferons to cytokines. J Biol Chem \n                           282, 20059\u201320063 (2007).","journal-title":"J Biol Chem"},{"key":"8584_CR6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/nrrheum.2009.237","volume":"6","author":"JC Hall","year":"2010","unstructured":"Hall, J. C. & Rosen, A. Type I interferons: crucial participants in disease amplification in autoimmunity. Nat Rev Rheumatol \n                           6, 40\u201349 (2010).","journal-title":"Nat Rev Rheumatol"},{"key":"8584_CR7","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nri3845","volume":"15","author":"L Zitvogel","year":"2015","unstructured":"Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M. J. & Kroemer, G. Type I interferons in anticancer immunity. Nat Rev Immunol \n                           15, 405\u2013414 (2015).","journal-title":"Nat Rev Immunol"},{"key":"8584_CR8","doi-asserted-by":"publisher","first-page":"683","DOI":"10.4161\/auto.23921","volume":"9","author":"H Schmeisser","year":"2013","unstructured":"Schmeisser, H. et al. Type I interferons induce autophagy in certain human cancer cell lines. Autophagy \n                           9, 683\u2013696 (2013).","journal-title":"Autophagy"},{"key":"8584_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1089\/jir.2013.0128","volume":"34","author":"H Schmeisser","year":"2014","unstructured":"Schmeisser, H., Bekisz, J. & Zoon, K. C. New function of type I IFN: induction of autophagy. J Interferon Cytokine Res \n                           34, 71\u201378 (2014).","journal-title":"J Interferon Cytokine Res"},{"key":"8584_CR10","doi-asserted-by":"publisher","first-page":"3963","DOI":"10.1074\/jbc.273.7.3963","volume":"273","author":"T Noda","year":"1998","unstructured":"Noda, T. & Ohsumi, Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem \n                           273, 3963\u20133966 (1998).","journal-title":"J Biol Chem"},{"key":"8584_CR11","doi-asserted-by":"publisher","first-page":"23433","DOI":"10.1074\/jbc.C500169200","volume":"280","author":"X Long","year":"2005","unstructured":"Long, X., Ortiz-Vega, S., Lin, Y. & Avruch, J. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem \n                           280, 23433\u201323436 (2005).","journal-title":"J Biol Chem"},{"key":"8584_CR12","doi-asserted-by":"publisher","first-page":"28319","DOI":"10.1074\/jbc.M109.024406","volume":"284","author":"A Sengupta","year":"2009","unstructured":"Sengupta, A., Molkentin, J. D. & Yutzey, K. E. FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem \n                           284, 28319\u201328331 (2009).","journal-title":"J Biol Chem"},{"key":"8584_CR13","doi-asserted-by":"publisher","first-page":"39107","DOI":"10.1074\/jbc.M112.412569","volume":"287","author":"X Xiong","year":"2012","unstructured":"Xiong, X., Tao, R., DePinho, R. A. & Dong, X. C. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J Biol Chem \n                           287, 39107\u201339114 (2012).","journal-title":"J Biol Chem"},{"key":"8584_CR14","doi-asserted-by":"publisher","first-page":"4860","DOI":"10.1038\/onc.2008.117","volume":"27","author":"S Polager","year":"2008","unstructured":"Polager, S., Ofir, M. & Ginsberg, D. E2F1 regulates autophagy and the transcription of autophagy genes. Oncogene \n                           27, 4860\u20134864 (2008).","journal-title":"Oncogene"},{"key":"8584_CR15","doi-asserted-by":"publisher","first-page":"6229","DOI":"10.1128\/MCB.02246-06","volume":"27","author":"K Tracy","year":"2007","unstructured":"Tracy, K. et al. BNIP3 is an RB\/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol \n                           27, 6229\u20136242 (2007).","journal-title":"Mol Cell Biol"},{"key":"8584_CR16","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/emboj.2009.364","volume":"29","author":"A Criollo","year":"2010","unstructured":"Criollo, A. et al. The IKK complex contributes to the induction of autophagy. Embo J \n                           29, 619\u2013631 (2010).","journal-title":"Embo J"},{"key":"8584_CR17","doi-asserted-by":"publisher","first-page":"194","DOI":"10.4161\/cc.11.1.18669","volume":"11","author":"A Criollo","year":"2012","unstructured":"Criollo, A. et al. Autophagy is required for the activation of NFkappaB. Cell Cycle \n                           11, 194\u2013199 (2012).","journal-title":"Cell Cycle"},{"key":"8584_CR18","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/nature07986","volume":"458","author":"DR Green","year":"2009","unstructured":"Green, D. R. & Kroemer, G. Cytoplasmic functions of the tumour suppressor p53. Nature \n                           458, 1127\u20131130 (2009).","journal-title":"Nature"},{"key":"8584_CR19","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ceb.2009.12.001","volume":"22","author":"MC Maiuri","year":"2010","unstructured":"Maiuri, M. C. et al. Autophagy regulation by p53. Curr Opin Cell Biol \n                           22, 181\u2013185 (2010).","journal-title":"Curr Opin Cell Biol"},{"key":"8584_CR20","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1124\/mol.113.090092","volume":"85","author":"H Lin","year":"2014","unstructured":"Lin, H. et al. Activating transcription factor 3 protects against pressure-overload heart failure via the autophagy molecule Beclin-1 pathway. Mol Pharmacol \n                           85, 682\u2013691 (2014).","journal-title":"Mol Pharmacol"},{"key":"8584_CR21","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00109-014-1132-7","volume":"92","author":"A Aguirre","year":"2014","unstructured":"Aguirre, A. et al. Defective autophagy impairs ATF3 activity and worsens lung injury during endotoxemia. J Mol Med (Berl) \n                           92, 665\u2013676 (2014).","journal-title":"J Mol Med (Berl)"},{"key":"8584_CR22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nature04768","volume":"441","author":"M Gilchrist","year":"2006","unstructured":"Gilchrist, M. et al. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature \n                           441, 173\u2013178 (2006).","journal-title":"Nature"},{"key":"8584_CR23","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.4049\/jimmunol.179.6.3622","volume":"179","author":"MM Whitmore","year":"2007","unstructured":"Whitmore, M. M. et al. Negative regulation of TLR-signaling pathways by activating transcription factor-3. J Immunol \n                           179, 3622\u20133630 (2007).","journal-title":"J Immunol"},{"key":"8584_CR24","first-page":"321","volume":"7","author":"T Hai","year":"1999","unstructured":"Hai, T., Wolfgang, C. D., Marsee, D. K., Allen, A. E. & Sivaprasad, U. ATF3 and stress responses. Gene Expr \n                           7, 321\u2013335 (1999).","journal-title":"Gene Expr"},{"key":"8584_CR25","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/cdd.2008.74","volume":"15","author":"L Turchi","year":"2008","unstructured":"Turchi, L. et al. Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway. Cell Death Differ \n                           15, 1472\u20131480 (2008).","journal-title":"Cell Death Differ"},{"key":"8584_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026848","volume":"6","author":"Y Tanaka","year":"2011","unstructured":"Tanaka, Y. et al. Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway. PLoS One \n                           6, e26848 (2011).","journal-title":"PLoS One"},{"key":"8584_CR27","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/ni.2784","volume":"15","author":"D De Nardo","year":"2013","unstructured":"De Nardo, D. et al. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol \n                           15, 152\u2013160 (2013).","journal-title":"Nat Immunol"},{"key":"8584_CR28","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1084\/jem.20072254","volume":"205","author":"M Gilchrist","year":"2008","unstructured":"Gilchrist, M. et al. Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation. J Exp Med \n                           205, 2349\u20132357 (2008).","journal-title":"J Exp Med"},{"key":"8584_CR29","doi-asserted-by":"publisher","first-page":"4446","DOI":"10.4049\/jimmunol.1500204","volume":"195","author":"LI Labzin","year":"2015","unstructured":"Labzin, L. I. et al. ATF3 Is a Key Regulator of Macrophage IFN Responses. J Immunol \n                           195, 4446\u20134455 (2015).","journal-title":"J Immunol"},{"key":"8584_CR30","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature04734","volume":"441","author":"H Kato","year":"2006","unstructured":"Kato, H. et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature \n                           441, 101\u2013105 (2006).","journal-title":"Nature"},{"issue":"Pt 7","key":"8584_CR31","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1099\/0022-1317-80-7-1665","volume":"80","author":"S Vrati","year":"1999","unstructured":"Vrati, S., Agarwal, V., Malik, P., Wani, S. A. & Saini, M. Molecular characterization of an Indian isolate of Japanese encephalitis virus that shows an extended lag phase during growth. J Gen Virol \n                           80(Pt 7), 1665\u20131671 (1999).","journal-title":"J Gen Virol"},{"key":"8584_CR32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr574","volume":"39","author":"JE Reid","year":"2011","unstructured":"Reid, J. E. & Wernisch, L. STEME: efficient EM to find motifs in large data sets. Nucleic Acids Res \n                           39, e126 (2011).","journal-title":"Nucleic Acids Res"},{"key":"8584_CR33","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.molcel.2012.07.030","volume":"47","author":"M Garber","year":"2012","unstructured":"Garber, M. et al. A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell \n                           47, 810\u2013822 (2012).","journal-title":"Mol Cell"},{"key":"8584_CR34","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1084\/jem.20111202","volume":"209","author":"ES Gold","year":"2012","unstructured":"Gold, E. S. et al. ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation. J Exp Med \n                           209, 807\u2013817 (2012).","journal-title":"J Exp Med"},{"key":"8584_CR35","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","volume":"32","author":"WM Schneider","year":"2014","unstructured":"Schneider, W. M., Chevillotte, M. D. & Rice, C. M. Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol \n                           32, 513\u2013545 (2014).","journal-title":"Annu Rev Immunol"},{"key":"8584_CR36","doi-asserted-by":"publisher","first-page":"11822","DOI":"10.1128\/JVI.77.21.11822-11832.2003","volume":"77","author":"RV Warke","year":"2003","unstructured":"Warke, R. V. et al. Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells. J Virol \n                           77, 11822\u201311832 (2003).","journal-title":"J Virol"},{"key":"8584_CR37","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1128\/MCB.24.3.1365-1377.2004","volume":"24","author":"HY Jiang","year":"2004","unstructured":"Jiang, H. Y. et al. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol \n                           24, 1365\u20131377 (2004).","journal-title":"Mol Cell Biol"},{"key":"8584_CR38","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.4049\/jimmunol.1302411","volume":"192","author":"X Cai","year":"2014","unstructured":"Cai, X., Xu, Y., Kim, Y. M., Loureiro, J. & Huang, Q. PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3. J Immunol \n                           192, 3383\u20133389 (2014).","journal-title":"J Immunol"},{"key":"8584_CR39","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.chom.2012.07.013","volume":"12","author":"B Yordy","year":"2012","unstructured":"Yordy, B., Iijima, N., Huttner, A., Leib, D. & Iwasaki, A. A neuron-specific role for autophagy in antiviral defense against herpes simplex virus. Cell Host Microbe \n                           12, 334\u2013345 (2012).","journal-title":"Cell Host Microbe"},{"key":"8584_CR40","doi-asserted-by":"publisher","first-page":"7835","DOI":"10.1073\/pnas.0602460103","volume":"103","author":"S Delhaye","year":"2006","unstructured":"Delhaye, S. et al. Neurons produce type I interferon during viral encephalitis. Proc Natl Acad Sci U S A \n                           103, 7835\u20137840 (2006).","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8584_CR41","doi-asserted-by":"publisher","first-page":"5908","DOI":"10.1128\/JVI.02714-05","volume":"80","author":"RJ Lin","year":"2006","unstructured":"Lin, R. J., Chang, B. L., Yu, H. P., Liao, C. L. & Lin, Y. L. Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism. J Virol \n                           80, 5908\u20135918 (2006).","journal-title":"J Virol"},{"key":"8584_CR42","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.4161\/auto.29455","volume":"10","author":"M Sharma","year":"2014","unstructured":"Sharma, M. et al. Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes. Autophagy \n                           10, 1637\u20131651 (2014).","journal-title":"Autophagy"},{"key":"8584_CR43","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1073\/pnas.0712182105","volume":"105","author":"CM Rosenberger","year":"2008","unstructured":"Rosenberger, C. M., Clark, A. E., Treuting, P. M., Johnson, C. D. & Aderem, A. ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells. Proc Natl Acad Sci USA \n                           105, 2544\u20132549 (2008).","journal-title":"Proc Natl Acad Sci USA"},{"key":"8584_CR44","doi-asserted-by":"publisher","first-page":"E5420","DOI":"10.1073\/pnas.1515369112","volume":"112","author":"M Shu","year":"2015","unstructured":"Shu, M., Du, T., Zhou, G. & Roizman, B. Role of activating transcription factor 3 in the synthesis of latency-associated transcript and maintenance of herpes simplex virus 1 in latent state in ganglia. Proc Natl Acad Sci USA \n                           112, E5420\u20135426 (2015).","journal-title":"Proc Natl Acad Sci USA"},{"key":"8584_CR45","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.virusres.2007.05.007","volume":"130","author":"HY Hwang","year":"2007","unstructured":"Hwang, H. Y. et al. Coxsackievirus B3 modulates cell death by downregulating activating transcription factor 3 in HeLa cells. Virus Res \n                           130, 10\u201317 (2007).","journal-title":"Virus Res"},{"key":"8584_CR46","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1016\/j.cellsig.2010.06.007","volume":"22","author":"JY Kim","year":"2010","unstructured":"Kim, J. Y. et al. The induction of STAT1 gene by activating transcription factor 3 contributes to pancreatic beta-cell apoptosis and its dysfunction in streptozotocin-treated mice. Cell Signal \n                           22, 1669\u20131680 (2010).","journal-title":"Cell Signal"},{"key":"8584_CR47","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1016\/j.cellsig.2009.07.011","volume":"21","author":"JY Kim","year":"2009","unstructured":"Kim, J. Y. et al. A critical role of STAT1 in streptozotocin-induced diabetic liver injury in mice: controlled by ATF3. Cell Signal \n                           21, 1758\u20131767 (2009).","journal-title":"Cell Signal"},{"key":"8584_CR48","doi-asserted-by":"publisher","first-page":"4990","DOI":"10.4049\/jimmunol.0903106","volume":"184","author":"S Filen","year":"2010","unstructured":"Filen, S. et al. Activating transcription factor 3 is a positive regulator of human IFNG gene expression. J Immunol \n                           184, 4990\u20134999 (2010).","journal-title":"J Immunol"},{"key":"8584_CR49","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.immuni.2012.11.005","volume":"38","author":"SY Liu","year":"2013","unstructured":"Liu, S. Y. et al. Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. Immunity \n                           38, 92\u2013105 (2013).","journal-title":"Immunity"},{"key":"8584_CR50","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.chom.2015.07.007","volume":"18","author":"KG Harris","year":"2015","unstructured":"Harris, K. G. et al. RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells. Cell Host Microbe \n                           18, 221\u2013232 (2015).","journal-title":"Cell Host Microbe"},{"key":"8584_CR51","doi-asserted-by":"publisher","first-page":"450","DOI":"10.4049\/jimmunol.1401108","volume":"195","author":"KS Evonuk","year":"2015","unstructured":"Evonuk, K. S. et al. Inhibition of System Xc(\u2212) Transporter Attenuates Autoimmune Inflammatory Demyelination. J Immunol \n                           195, 450\u2013463 (2015).","journal-title":"J Immunol"},{"key":"8584_CR52","doi-asserted-by":"publisher","first-page":"19193","DOI":"10.1074\/jbc.M110.113613","volume":"285","author":"K Denda-Nagai","year":"2010","unstructured":"Denda-Nagai, K. et al. Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2\/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. J Biol Chem \n                           285, 19193\u201319204 (2010).","journal-title":"J Biol Chem"},{"key":"8584_CR53","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.neuron.2013.08.013","volume":"80","author":"EK Ruzzo","year":"2013","unstructured":"Ruzzo, E. K. et al. Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. Neuron \n                           80, 429\u2013441 (2013).","journal-title":"Neuron"},{"key":"8584_CR54","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/ni.2867","volume":"15","author":"EB Heikamp","year":"2014","unstructured":"Heikamp, E. B. et al. The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex. Nat Immunol \n                           15, 457\u2013464 (2014).","journal-title":"Nat Immunol"},{"key":"8584_CR55","doi-asserted-by":"crossref","first-page":"19158","DOI":"10.1016\/S0021-9258(18)54975-9","volume":"266","author":"A Miseta","year":"1991","unstructured":"Miseta, A., Woodley, C. L., Greenberg, J. R. & Slobin, L. I. Mammalian seryl-tRNA synthetase associates with mRNA in vivo and has homology to elongation factor 1 alpha. J Biol Chem \n                           266, 19158\u201319161 (1991).","journal-title":"J Biol Chem"},{"key":"8584_CR56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019967","volume":"6","author":"Y Si","year":"2011","unstructured":"Si, Y. et al. Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes. PLoS One \n                           6, e19967 (2011).","journal-title":"PLoS One"},{"key":"8584_CR57","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.4049\/jimmunol.1100833","volume":"187","author":"DL Gibbons","year":"2011","unstructured":"Gibbons, D. L. et al. Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential. J Immunol \n                           187, 2067\u20132071 (2011).","journal-title":"J Immunol"},{"key":"8584_CR58","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1634\/stemcells.2007-0046","volume":"25","author":"I Nakano","year":"2007","unstructured":"Nakano, I. et al. Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells \n                           25, 1975\u20131984 (2007).","journal-title":"Stem Cells"},{"key":"8584_CR59","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1089\/jir.2010.0102","volume":"31","author":"DJ Vestal","year":"2011","unstructured":"Vestal, D. J. & Jeyaratnam, J. A. The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase. J Interferon Cytokine Res \n                           31, 89\u201397 (2011).","journal-title":"J Interferon Cytokine Res"},{"key":"8584_CR60","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1128\/JVI.02982-14","volume":"89","author":"M Guo","year":"2015","unstructured":"Guo, M. et al. Phosphatidylserine-specific phospholipase A1 involved in hepatitis C virus assembly through NS2 complex formation. J Virol \n                           89, 2367\u20132377 (2015).","journal-title":"J Virol"},{"key":"8584_CR61","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/SHK.0000000000000218","volume":"42","author":"A Matsushima","year":"2014","unstructured":"Matsushima, A., Ogura, H., Koh, T., Shimazu, T. & Sugimoto, H. Enhanced expression of aquaporin 9 in activated polymorphonuclear leukocytes in patients with systemic inflammatory response syndrome. Shock \n                           42, 322\u2013326 (2014).","journal-title":"Shock"},{"key":"8584_CR62","doi-asserted-by":"publisher","first-page":"12272","DOI":"10.1073\/pnas.220414397","volume":"97","author":"AJ Oliveira-Dos-Santos","year":"2000","unstructured":"Oliveira-Dos-Santos, A. J. et al. Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci USA \n                           97, 12272\u201312277 (2000).","journal-title":"Proc Natl Acad Sci USA"},{"key":"8584_CR63","doi-asserted-by":"publisher","first-page":"5175","DOI":"10.4049\/jimmunol.172.9.5175","volume":"172","author":"GX Shi","year":"2004","unstructured":"Shi, G. X., Harrison, K., Han, S. B., Moratz, C. & Kehrl, J. H. Toll-like receptor signaling alters the expression of regulator of G protein signaling proteins in dendritic cells: implications for G protein-coupled receptor signaling. J Immunol \n                           172, 5175\u20135184 (2004).","journal-title":"J Immunol"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08584-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08584-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08584-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T03:55:07Z","timestamp":1671767707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08584-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,18]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["8584"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-08584-9","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.728776740.793566997","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,18]]},"assertion":[{"value":"21 April 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"8789"}}