{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:31:38Z","timestamp":1792114298448,"version":"4.4.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The characteristics of <jats:italic>Mycoplasma pneumonia<\/jats:italic> (<jats:italic>M. pneumoniae<\/jats:italic>)-associated bronchiolitis obliterans (BO) are not well known. We retrospectively reviewed 17 patients with <jats:italic>M. pneumoniae<\/jats:italic>\u2013associated BO. All patients had <jats:italic>M. pneumoniae<\/jats:italic>\u2013associated acute bronchiolitis prior to the development of BO. In the acute bronchiolitis stage, all patients had fever and cough; six patients also had wheezing and dyspnoea. BO was diagnosed approximately 1.5\u20138 months later based on clinical manifestations and chest high-resolution computed tomography (HRCT) findings. All patients presented with wheezing and\/or dyspnoea at the time of diagnosis of BO. HRCT findings included mosaic attenuation, pronounced air trapping, central bronchiectasis and emphysema, according to disease severity. Lung function tests revealed mild to severe airway obstruction. Fourteen of 17 patients had a greater than 12% increase in forced expiratory volume in 1\u2009second values after taking salbutamol. All patients had positive allergy test results and family or personal history of atopic disease. Four patients had a history of asthma before <jats:italic>M. pneumonia<\/jats:italic> bronchiolitis. Asthma was diagnosed before, at the time of or after the diagnosis of BO in 11 cases. <jats:italic>M. pneumoniae<\/jats:italic>\u2013associated BO may therefore develop following <jats:italic>M. pneumonia<\/jats:italic> bronchiolitis and overlap with asthma.<\/jats:p>","DOI":"10.1038\/s41598-017-08861-7","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T15:40:08Z","timestamp":1502379608000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Mycoplasma pneumoniae\u2013Associated Bronchiolitis Obliterans Following Acute Bronchiolitis"],"prefix":"10.1038","volume":"7","author":[{"given":"Chengsong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"8861_CR1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1089\/ped.2010.0034","volume":"23","author":"KJ Smith","year":"2010","unstructured":"Smith, K. J. et al. Diagnosis of Bronchiolitis Obliterans with Computed Tomography in Children. Pediatric Allergy Immunology & Pulmonology \n                           23, 253\u2013259 (2010).","journal-title":"Pediatric Allergy Immunology & Pulmonology"},{"key":"8861_CR2","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1002\/ppul.20472","volume":"41","author":"JA Castro-Rodriguez","year":"2006","unstructured":"Castro-Rodriguez, J. A., Daszenies, C., Garcia, M., Meyer, R. & Gonzales, R. Adenovirus pneumonia in infants and factors for developing bronchiolitis obliterans: a 5-year follow-up. Pediatric pulmonology \n                           41, 947\u2013953, doi:10.1002\/ppul.20472 (2006).","journal-title":"Pediatric pulmonology"},{"key":"8861_CR3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/00005382-199904000-00003","volume":"14","author":"L Zhang","year":"1999","unstructured":"Zhang, L., Irion, K., da Silva Porto, N. & Abreu e Silva, F. High-resolution computed tomography in pediatric patients with postinfectious bronchiolitis obliterans. Journal of thoracic imaging \n                           14, 85\u201389 (1999).","journal-title":"Journal of thoracic imaging"},{"key":"8861_CR4","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1378\/chest.115.4.1188","volume":"115","author":"ED Chan","year":"1999","unstructured":"Chan, E. D. et al. Mycoplasma pneumoniae-associated bronchiolitis causing severe restrictive lung disease in adults: report of three cases and literature review. Chest \n                           115, 1188\u20131194 (1999).","journal-title":"Chest"},{"key":"8861_CR5","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/ppul.21405","volume":"46","author":"T Bandeira","year":"2011","unstructured":"Bandeira, T. et al. Clinical, radiological, and physiological differences between obliterative bronchiolitis and problematic severe asthma in adolescents and young adults: the early origins of the overlap syndrome? Pediatric pulmonology \n                           46, 573\u2013580 (2011).","journal-title":"Pediatric pulmonology"},{"key":"8861_CR6","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1378\/chest.120.4.1101","volume":"120","author":"CK Kim","year":"2001","unstructured":"Kim, C. K. et al. Bronchiolitis obliterans in the 1990s in Korea and the United States. Chest \n                           120, 1101\u20131106 (2001).","journal-title":"Chest"},{"key":"8861_CR7","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S0954-6111(06)80274-X","volume":"85","author":"MB Prabhu","year":"1991","unstructured":"Prabhu, M. B., Barber, D. & Cockcroft, D. W. Bronchiolitis obliterans and Mycoplasma pneumonia. Respiratory medicine \n                           85, 535\u2013537 (1991).","journal-title":"Respiratory medicine"},{"key":"8861_CR8","first-page":"471","volume":"144","author":"DB Coultas","year":"1986","unstructured":"Coultas, D. B., Samet, J. M. & Butler, C. Bronchiolitis obliterans due to Mycoplasma pneumoniae. The Western journal of medicine \n                           144, 471\u2013474 (1986).","journal-title":"The Western journal of medicine"},{"key":"8861_CR9","doi-asserted-by":"crossref","unstructured":"Tanaka, H. Correlation between Radiological and Pathological Findings in Patients withMycoplasma pneumoniaePneumonia. Frontiers in Microbiology \n                           7 (2016).","DOI":"10.3389\/fmicb.2016.00695"},{"key":"8861_CR10","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1136\/thx.2008.108027","volume":"64","author":"PG Gibson","year":"2009","unstructured":"Gibson, P. G. & Simpson, J. L. The overlap syndrome of asthma and COPD: what are its features and how important is it? Thorax \n                           64, 728\u2013735, doi:10.1136\/thx.2008.108027 (2009).","journal-title":"Thorax"},{"key":"8861_CR11","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0022-3476(71)80218-4","volume":"78","author":"WP Glezen","year":"1971","unstructured":"Glezen, W. P. et al. Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice. The Journal of pediatrics \n                           78, 397\u2013406 (1971).","journal-title":"The Journal of pediatrics"},{"key":"8861_CR12","first-page":"34","volume":"110","author":"S Rollins","year":"1986","unstructured":"Rollins, S., Colby, T. & Clayton, F. Open lung biopsy in Mycoplasma pneumoniae pneumonia. Archives of pathology & laboratory medicine \n                           110, 34\u201341 (1986).","journal-title":"Archives of pathology & laboratory medicine"},{"key":"8861_CR13","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1164\/ajrccm.158.3.9711092","volume":"158","author":"M Kraft","year":"1998","unstructured":"Kraft, M. et al. Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma. Am J Respir Crit Care Med \n                           158, 998\u20131001 (1998).","journal-title":"Am J Respir Crit Care Med"},{"key":"8861_CR14","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1164\/rccm.200602-189OC","volume":"174","author":"A Barbato","year":"2006","unstructured":"Barbato, A. et al. Epithelial damage and angiogenesis in the airways of children with asthma. American journal of respiratory and critical care medicine \n                           174, 975\u2013981, doi:10.1164\/rccm.200602-189OC (2006).","journal-title":"American journal of respiratory and critical care medicine"},{"key":"8861_CR15","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/j.1600-065X.2011.01030.x","volume":"242","author":"ST Holgate","year":"2011","unstructured":"Holgate, S. T. The sentinel role of the airway epithelium in asthma pathogenesis. Immunological reviews \n                           242, 205\u2013219, doi:10.1111\/j.1600-065X.2011.01030.x (2011).","journal-title":"Immunological reviews"},{"key":"8861_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/ACI.0b013e328013d61b","volume":"7","author":"TL Hackett","year":"2007","unstructured":"Hackett, T. L. & Knight, D. A. The role of epithelial injury and repair in the origins of asthma. Current opinion in allergy and clinical immunology \n                           7, 63\u201368, doi:10.1097\/ACI.0b013e328013d61b (2007).","journal-title":"Current opinion in allergy and clinical immunology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08861-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08861-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08861-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T08:38:17Z","timestamp":1671784697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08861-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,16]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["8861"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-08861-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,16]]},"assertion":[{"value":"14 February 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"8478"}}