{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:28:39Z","timestamp":1782361719237,"version":"3.54.5"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Relationship between radiation-induced skin ulceration (RSU) and variables in percutaneous coronary interventions (PCI) was rarely reported. RSU is a severe complication in PCIs, especially for chronic total occlusion (CTO) lesions. We investigated the RSUs and their risk factors in patients receiving CTO PCIs over a 2-year period. Data were analyzed using chi-square tests, t-tests and receiver operating characteristic (ROC) curve. Of 238 patients, 11 patients (4.6%) had RSUs all at right upper back. RSUs were significantly associated with use of left anterior oblique (LAO) views (100% vs. 47.1%, p\u2009&lt;\u20090.001), retrograde techniques (36.3% vs. 7.9%, p\u2009=\u20090.012), or a procedure time (PT) defined as a time duration between the first and last angiograms of\u2009&gt;\u2009120, 180, or 240\u2009minutes (p\u2009&lt;\u20090.05). ROC analysis showed a long PT was an accurate predictor of RSUs (AUC\u2009=\u20090.88; p\u2009&lt;\u20090.001) at a cut-off of 130\u2009minutes (sensitivity\u2009=\u20090.91, specificity\u2009=\u20090.81). The results showed risk factors for RSUs containing use of large LAO views, retrograde techniques, and prolonged PTs. This study suggests that, to minimize RSU, interventionalists should limit PT to roughly 2\u2009hours in fixed LAO views.<\/jats:p>","DOI":"10.1038\/s41598-017-08945-4","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T11:46:51Z","timestamp":1502365611000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Risk Factors For Radiation-Induced Skin Ulceration in Percutaneous Coronary Interventions of Chronic Total Occluded Lesions: A 2-Year Observational Study"],"prefix":"10.1038","volume":"7","author":[{"given":"Chi-Cheng","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Che","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yee","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Yuan","family":"Mar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hwa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Shan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5432-9897","authenticated-orcid":false,"given":"Ching-Jiunn","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"8945_CR1","unstructured":"Mortality and global health estimates, Global health observatory data of World Health Organization (WHO). http:\/\/www.who.int\/gho\/mortality_burden_disease\/en\/. 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Am J Cardiol \n                           104, 1241\u20134 (2009).","journal-title":"Am J Cardiol"},{"key":"8945_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jacc.2014.04.040","volume":"64","author":"S George","year":"2014","unstructured":"George, S. et al. Long-term follow-up of elective chronic total coronary occlusion angioplasty: analysis from the UK, Central Cardiac Audit Database. J Am Coll Cardiol \n                           64, 235\u201343 (2014).","journal-title":"J Am Coll Cardiol"},{"key":"8945_CR5","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ijcard.2014.04.004","volume":"174","author":"A El Sabbagh","year":"2014","unstructured":"El Sabbagh, A. et al. Angiographic success and procedural complications in patients undergoing retrograde percutaneous coronary chronic total occlusion interventions: a weighted meta-analysis of 3,482 patients from 26 studies. 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Circ J. \n                           70, 44\u20138 (2006).","journal-title":"Circ J."},{"key":"8945_CR8","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1097\/SAP.0b013e3181d6e2d3","volume":"65","author":"MD David Otterburn","year":"2010","unstructured":"David Otterburn, M. D. & Albert Losken, M. D. Iatrogenic fluoroscopy injury to the skin. Ann Plast Surg \n                           65, 462\u20135 (2010).","journal-title":"Ann Plast Surg"},{"key":"8945_CR9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/ccd.21284","volume":"71","author":"S Suzuki","year":"2008","unstructured":"Suzuki, S. et al. Patients\u2019 skin dose during percutaneous coronary intervention for chronic total occlusion. Catheter Cardiovasc Interv \n                           71, 160\u20134 (2008).","journal-title":"Catheter Cardiovasc Interv"},{"key":"8945_CR10","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/ccd.21481","volume":"71","author":"Shigeru Suzuki.","year":"2008","unstructured":"Shigeru Suzuki. et al. Methods to reduce patients\u2019 maximum skin dose during percutaneous coronary intervention for chronic total occlusion. Catheter Cardiovasc Interv \n                           71, 792\u20138 (2008).","journal-title":"Catheter Cardiovasc Interv"},{"key":"8945_CR11","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/ccd.20830","volume":"68","author":"K Chida","year":"2006","unstructured":"Chida, K. et al. Indicators of the maximum radiation dose to the skin during percutaneous coronary intervention in different target vessels. 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Circulation \n                           104, 1779\u201384 (2001).","journal-title":"Circulation"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08945-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08945-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08945-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T08:49:11Z","timestamp":1671785351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-08945-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,16]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["8945"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-08945-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,16]]},"assertion":[{"value":"9 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"8408"}}