{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:54:32Z","timestamp":1791644072371,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To assess the correlation between penile hypersensitivity and premature ejaculation (PE), a total of 420 consecutive subjects attending our andrologic clinic for suspected PE were enrolled. The entire cohort was asked to complete the self-report intravaginal ejaculation latency time (IELT) by stopwatch. According to the IELT, the subjects were classified into 3 groups. Vibratory thresholds were recorded at the glans penis and penile shaft using a biothesiometer. We found that vibratory thresholds in the glans penis and penile shaft were significantly lower in both mild and severe PE group than in the control group (3.81\u2009\u00b1\u20090.57 and 3.54\u2009\u00b1\u20090.43 vs 4.73\u2009\u00b1\u20090.77 for glans penis p\u2009=\u20090.000; 3.64\u2009\u00b1\u20090.52 and 3.37\u2009\u00b1\u20090.50 vs 4.62\u2009\u00b1\u20090.69 for penile shaft p\u2009=\u20090.002). The vibratory threshold decreased as the disease aggravated. In the mild and severe PE groups, a significant positive correlation was detected between the mean values of IELT and the vibratory thresholds. Furthermore, in the receiver operating characteristics curve analysis, the area under the curve of the glans penis and penile shaft vibratory thresholds predicting severe PE were 0.852 and 0.893 respectively. Our study established a dose-dependent association between penile vibratory threshold and PE. Therefore, the vibratory threshold can serve as a potential marker for predicting the severity of PE.<\/jats:p>","DOI":"10.1038\/s41598-017-09155-8","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T08:26:30Z","timestamp":1504081590000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Significance of penile hypersensitivity in premature ejaculation"],"prefix":"10.1038","volume":"7","author":[{"given":"Liqiang","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengtian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"9155_CR1","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.eururo.2010.02.020","volume":"57","author":"K Hatzimouratidis","year":"2010","unstructured":"Hatzimouratidis, K. et al. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. European urology \n                           57, 804\u2013814, doi:10.1016\/j.eururo.2010.02.020 (2010).","journal-title":"European urology"},{"key":"9155_CR2","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/aja.2010.9","volume":"12","author":"HJ Park","year":"2010","unstructured":"Park, H. J. et al. Prevalence of premature ejaculation in young and middle-aged men in Korea: a multicenter internet-based survey from the Korean Andrological Society. Asian journal of andrology \n                           12, 880\u2013889, doi:10.1038\/aja.2010.9 (2010).","journal-title":"Asian journal of andrology"},{"key":"9155_CR3","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/j.1464-410X.2008.07755.x","volume":"102","author":"CG McMahon","year":"2008","unstructured":"McMahon, C. G. et al. An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation. BJU international \n                           102, 338\u2013350, doi:10.1111\/j.1464-410X.2008.07755.x (2008).","journal-title":"BJU international"},{"key":"9155_CR4","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1111\/jsm.12524","volume":"11","author":"EC Serefoglu","year":"2014","unstructured":"Serefoglu, E. C. et al. An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation. The journal of sexual medicine \n                           11, 1423\u20131441, doi:10.1111\/jsm.12524 (2014).","journal-title":"The journal of sexual medicine"},{"key":"9155_CR5","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1111\/jsm.12504","volume":"11","author":"SE Althof","year":"2014","unstructured":"Althof, S. E. et al. An update of the International Society of Sexual Medicine\u2019s guidelines for the diagnosis and treatment of premature ejaculation (PE). The journal of sexual medicine \n                           11, 1392\u20131422, doi:10.1111\/jsm.12504 (2014).","journal-title":"The journal of sexual medicine"},{"issue":"Suppl 4","key":"9155_CR6","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1743-6109.2006.00305.x","volume":"3","author":"CF Donatucci","year":"2006","unstructured":"Donatucci, C. F. Etiology of ejaculation and pathophysiology of premature ejaculation. 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Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. The journal of sexual medicine \n                           6, 276\u2013284, doi:10.1111\/j.1743-6109.2008.01033.x (2009).","journal-title":"The journal of sexual medicine"},{"key":"9155_CR9","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/S0090-4295(01)01428-5","volume":"58","author":"C Ozcan","year":"2001","unstructured":"Ozcan, C. et al. Auditory event-related potentials in patients with premature ejaculation. Urology \n                           58, 1025\u20131029 (2001).","journal-title":"Urology"},{"key":"9155_CR10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0166-4328(97)00183-6","volume":"92","author":"MD Waldinger","year":"1998","unstructured":"Waldinger, M. D., Berendsen, H. H., Blok, B. F., Olivier, B. & Holstege, G. 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