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These genes are also present in other species, but presence\/absence, as well as functionality\/non-functionality are species-dependent. Molecular mechanisms and forces that created this species divergence were unknown. Utilizing genomic information available from GenBank and Ensembl databases, gene order maps were constructed of a chromosomal region surrounding the<jats:italic>ABO<\/jats:italic>and<jats:italic>GBGT1<\/jats:italic>genes from a variety of vertebrate species. Both similarities and differences were observed in their chromosomal organization. Interestingly, the<jats:italic>ABO<\/jats:italic>and<jats:italic>GBGT1<\/jats:italic>genes were found located at the boundaries of chromosomal fragments that seem to have been inverted\/translocated during species evolution. Genetic alterations, such as deletions and duplications, are prevalent at the ends of rearranged chromosomal fragments, which may partially explain the species-dependent divergence of those clinically important glycosyltransferase genes.<\/jats:p>","DOI":"10.1038\/s41598-017-09765-2","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T14:17:18Z","timestamp":1503065838000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evolutionary divergence of the ABO and GBGT1 genes specifying the ABO and FORS blood group systems through chromosomal rearrangements"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9690-7034","authenticated-orcid":false,"given":"Fumiichiro","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"key":"9765_CR1","unstructured":"Schenkel-Brunner, H. 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